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公开(公告)号:US11041754B2
公开(公告)日:2021-06-22
申请号:US16848922
申请日:2020-04-15
Applicant: Leidos, Inc.
Inventor: Augie Ifarraguerri , Brian Gorin , J. Frank Camacho , Noah Christian , Robert Rice
Abstract: A system and process scans a target area at a distance of 3-30 m for one or more materials. Scanning is performed by a coherent transmit beam aimed with the help of a thermal camera. The active source of the beam is a supercontinuum (SC) laser. The transmitted source beam is modulated by a high-speed Fourier-transform spectrometer prior to interaction with the target. Target reflected source beam is detected by an infrared detector, along with a reference portion of the transmitted source beam, as a series of interferograms; passed through a digitizer for digitizing the interferograms; and processed to producing spectrograms, wherein the spectrograms are indicative of one or more materials on the target.
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公开(公告)号:US11033622B2
公开(公告)日:2021-06-15
申请号:US15989750
申请日:2018-05-25
Applicant: Leidos, Inc.
Inventor: Gabriel M. Gutierrez , Vinayaka Kotraiah , Timothy W. Phares , James Pannucci
IPC: A61K39/395 , C12N15/00 , C07K7/06 , C07K14/705 , C07K16/28 , C07K7/08 , A61K39/39 , A61P35/00 , A61K31/7105 , A61K35/17 , A61K39/00 , A61K45/06 , A61K38/00 , A61K35/76 , A61P33/06 , A61P31/04
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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公开(公告)号:US10955523B1
公开(公告)日:2021-03-23
申请号:US15804695
申请日:2017-11-06
Applicant: Leidos, Inc.
Inventor: Peter N. Mikhalevsky
Abstract: An underwater navigation algorithm (UNA) uses acoustic signals transmitted in the ocean from sources at known positions to compute a position underwater for a vehicle that requires no initial a priori position or any ocean sound speed information or any initial GPS position that would require surfacing. The UNA consists of two parts, (1) the Cold Start Algorithm (CSA) and (2) the CSA with Modeling (CSAM). The underwater vehicle needs to be equipped with only a single hydrophone acoustic receiver and an onboard processor. The CSA requires only measuring the travel time of the end of the arrival coda (EOC) from each of the sources to compute a position. The CSAM is a post CSA procedure to calculate a higher accuracy position using the CSA position. CSAM utilizes the CSA position and a 4D sound speed field derived from an ocean 4D General Circulation Model (GCM) constrained using Ocean Acoustic Tomography (OAT) in the ocean area of operation and further includes (1) computing a modeled result with an acoustic propagation modeling code that is compared with the received acoustic data using a known procedure called “bulk shifting” and/or (2) a new proposed procedure that uses calculated group speeds from the 4D sound speed field, to provide a higher accuracy estimate of the receiver position.
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公开(公告)号:US10799555B2
公开(公告)日:2020-10-13
申请号:US15906481
申请日:2018-02-27
Applicant: Leidos, Inc.
Inventor: Gabriel M. Gutierrez , Vinayaka Kotraiah , James Pannucci , Ramses Ayala
IPC: A61K38/10 , A61K39/015 , A61K38/16 , A61K39/00 , A61K35/17 , A61K38/19 , A61P33/06 , A61P31/20 , A61P37/04 , A61P35/04 , A61K45/06 , C07K7/08 , C07K14/00 , A61K39/39 , A61K48/00
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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公开(公告)号:US20200316577A1
公开(公告)日:2020-10-08
申请号:US16883425
申请日:2020-05-26
Inventor: Wayne E. Jones , Jian Liu , William E. Bernier , Julia B. Tollin , Danielle McCarthy , Emilly Obuya , Jared DeCoste
IPC: B01J31/38 , B01J21/06 , B01J31/16 , B01J35/00 , B01J37/08 , C02F1/32 , C02F1/72 , D01D5/00 , C04B35/622 , B01J23/42 , C04B35/624 , C04B35/626 , B01J23/06 , B01J35/10 , C04B35/628
Abstract: Mixed-phase TiO2 nanofibers prepared via a sol-gel technique followed by electrospinning and calcination are provided as photocatalysts. The calcination temperature is adjusted to control the rutile phase fraction in TiO2 nanofibers relative to the anatase phase. Post-calcined TiO2 nanofibers composed of 38 wt % rutile and 62 wt % anatase exhibited the highest initial rate constant of UV photocatalysis. This can be attributed to the combined influences of the fibers' specific surface areas and their phase compositions.
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公开(公告)号:US10458931B1
公开(公告)日:2019-10-29
申请号:US15622939
申请日:2017-06-14
Applicant: Leidos, Inc.
Inventor: Rex David Richardson , William L. Hicks , Mark Alan Peressini
IPC: G01N23/22
Abstract: A scan head design uses 1:1 (one-to-one) imaging micro-lens arrays to transfer the object plane X-ray image from a CR-plate onto a linear photosensor. The scan-head includes a housing having therein, an array of red light emitting diodes (LEDs), a red-absorbing filter, a microlens array, an infrared-filter, and a sensor. The housing faces the CR-plate and the scan-head is translated across the CR-plate to read out the X-ray image therein. The scan head is compact and provides for improved spatial resolution and reduced power requirements.
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公开(公告)号:US10148058B1
公开(公告)日:2018-12-04
申请号:US15438951
申请日:2017-02-22
Applicant: Leidos, Inc. , U.S. Department of the Air Force
Inventor: Sean McDaniel , Gary Cook
Abstract: Solid state lasers emitting at first and a second wavelengths include an additional a conversion amplifier for converting photons having the first wavelength into photons having the second wavelength, thereby improving output efficiency of a preferred wavelength. Erbium lasing materials such as erbium doped garnets and fluorides, are employed, along with the conversion amplifier formed of a transition metal doped II-VI semiconductor, e.g., Cr:ZnSe.
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公开(公告)号:US10106238B2
公开(公告)日:2018-10-23
申请号:US15916839
申请日:2018-03-09
Applicant: Leidos, Inc.
Inventor: Nahid Sidki , Weicheng Shen , Suk Lee , Andrew Genduso
Abstract: A system of modular components can be used with existing sensor suites to fuse data and determine the operating environment (surface contacts/tracks) for an autonomous marine vehicle and feed an autonomy decision engine to improve the vessel arbitration process in deciding which way to turn, how fast to go, obstacle avoidance, and mission monitoring. The system includes the ability to obey the set of navigation rules published by the International Maritime Organization, generally referred to as COLREGS (collision regulations).
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公开(公告)号:US10104581B2
公开(公告)日:2018-10-16
申请号:US15854113
申请日:2017-12-26
Applicant: Leidos, Inc.
Inventor: Rebecca K. Harrington
Abstract: A process for selecting an optimal individual user solution including an optimal rate allocation and associated price for a predetermined bandwidth of cellular network resources includes application of an iterative process and selection from multiple proposed user solutions. The inputs to the iterative process include at least an initial user bid, an initial network rate allocation, a generated user utility function and the cost data. The user utility function includes multiple application user functions. Optimal solution selection includes comparing each multiple proposed user rate allocation with the initial network rate allocation for the user and selecting the closest multiple proposed user rate allocation to the initial network rate allocation. The process may be applied to aggregated cellular carrier scenarios.
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公开(公告)号:US10098950B2
公开(公告)日:2018-10-16
申请号:US15705333
申请日:2017-09-15
Applicant: Leidos, Inc.
Inventor: Gabriel M. Gutierrez , Vinayaka Kotraiah , James Pannucci , Ramses Ayala
IPC: A61K6/00 , A61K39/00 , A61K39/002 , A61K39/015 , A61K39/395 , A61K45/00 , A61K45/06 , C07K1/00 , C07K16/00 , C07K16/18 , C07K16/20 , A61K39/39 , A61K38/16 , A61K38/10 , C07K7/08
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.
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