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    FLOW MEASUREMENT THROUGH OCT
    61.
    发明申请
    FLOW MEASUREMENT THROUGH OCT 审中-公开

    公开(公告)号：WO2022133200A1

    公开(公告)日：2022-06-23

    申请号：PCT/US2021/064011

    申请日：2021-12-17

    Applicant: LIGHTLAB IMAGING, INC.

    Inventor： BLABER, Justin, Akira ,  GOPINATH, Ajay ,  CHIU, Wei

    IPC: A61B5/00 ,  A61B5/0215 ,  A61B5/026

    Abstract: The present disclosure provides systems and methods for determining a mean transit time of a bolus within the blood vessel by passing the bolus through the blood vessel while an intravascular imaging probe is held stationary. The probe may collect a plurality of image frames as the bolus passes the probe. The cross-sectional area of the bolus within the images frames may be determined by segmenting each image frame by thresholding, creating a vessel mask, and creating a contrast mask by applying an element-wise AND operator to the thresholded image and the vessel mask. The cross- sectional area of the bolus for the image frames may be plotted on an area dilution curve. Various fits may be applied to and various points may be identified on the area dilution curve. The various fits and points may be used to determine the mean transit time.

    AUTOMATED FLUID DELIVERY CATHETER AND SYSTEM
    63.
    发明申请
    AUTOMATED FLUID DELIVERY CATHETER AND SYSTEM 审中-公开
    自动流体输送管和系统

    公开(公告)号：WO2014077880A1

    公开(公告)日：2014-05-22

    申请号：PCT/US2013/030146

    申请日：2013-03-11

    Applicant: LIGHTLAB IMAGING, INC.

    Inventor： PETROFF, Christopher

    IPC: A61B5/00 ,  A61M25/00 ,  A61B5/0215 ,  A61B8/12

    CPC classification number: A61B5/0073 ,  A61B5/0066 ,  A61B5/0215 ,  A61B5/6852 ,  A61B8/12 ,  A61M39/10 ,  A61M39/24 ,  A61M2025/0024 ,  A61M2025/0035 ,  A61M2039/242

    Abstract: In part, the invention relates to catheters, methods, and blood clearing technologies suitable for use in an optical coherence tomography system. The optical coherence tomography system includes a control system, a probe including a catheter defining a lumen and a rotatable optical fiber located within the lumen, a fluid cartridge holder in communication with the lumen of the probe, a pump to move fluid from the fluid cartridge to the lumen of the probe; and a motor configured to rotate and pull the optical fiber through the lumen of a blood vessel. The pump and the motor are controlled by the control system. The catheter can include a wall that bounds the lumen of the probe, which defines a flush port and includes a valve in fluid communication with the flush port, the valve configured to permit fluid from the lumen to pass through the wall.

    Abstract translation: 部分地，本发明涉及适用于光学相干断层摄影系统的导管，方法和血液清除技术。 光学相干断层摄影系统包括控制系统，包括限定内腔的导管和位于内腔内的可旋转光纤的探针，与探针的内腔连通的流体盒保持器，用于将流体从流体盒 到探头的内腔; 以及电动机，其构造成使光纤旋转并拉动通过血管的内腔。 泵和电机由控制系统控制。 导管可以包括限定探针的内腔的壁，该壁限定了冲洗口，并且包括与冲洗口流体连通的阀，所述阀构造成允许来自内腔的流体通过壁。

    OPTICAL COHERENCE TOMOGRAPHY CONTROL SYSTEMS AND METHODS
    64.
    发明申请
    OPTICAL COHERENCE TOMOGRAPHY CONTROL SYSTEMS AND METHODS 审中-公开
    光学相干控制系统和方法

    公开(公告)号：WO2014036084A1

    公开(公告)日：2014-03-06

    申请号：PCT/US2013/056988

    申请日：2013-08-28

    Applicant: LIGHTLAB IMAGING, INC.

    Inventor： ADLER, Desmond

    IPC: A61B5/00 ,  G01B9/02 ,  H01S3/107

    CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/0084 ,  G01B9/02004 ,  G01B9/02067 ,  H01S3/0092 ,  H01S3/1062 ,  H01S3/1396 ,  H01S5/183

    Abstract: In part, the invention relates to methods, devices, and systems suitable for controlling a light source (7). The light source is configured for use in a data collection system such as an optical coherence tomography system (5). The light source (7) can be controlled with a drive waveform (10, 22, 55, 70). Linearizing and symmetrizing parameters of the light source (7) such as forward (35, 60, 75) and backward (33, 63, 77) scan durations is achieved using a suitable drive waveform (22, 55, 70). Phase, amplitude, and other parameters for different harmonics of a fundamental wave can be identified that improve operating parameters such as the duty cycle and peak frequency matching between scans. The fundamental wave and one or more of such harmonics can be combined to generate the suitable drive wave form (10, 22, 55, 70). The light source (7) can include a tunable light source that includes or is in optical communication with a tunable filter (9).

    Abstract translation: 本发明的一部分涉及适于控制光源（7）的方法，装置和系统。 光源被配置用于诸如光学相干断层摄影系统（5）的数据采集系统中。 光源（7）可以用驱动波形（10,22,55,70）来控制。 使用适当的驱动波形（22,55,70）实现光源（7）的线性化和对称性参数，例如前进（35,60,75）和后退（33,63,77）扫描持续时间。 可以确定基波不同谐波的相位，幅度和其他参数，以改善扫描之间的工作参数，如占空比和峰值频率匹配。 基波和这些谐波中的一个或多个可以组合以产生合适的驱动波形（10,22,55,70）。 光源（7）可以包括可调谐光源，其包括或者与可调谐滤光器（9）光学通信。

    DATA ENCODERS FOR MEDICAL DEVICES AND RELATED METHODS
    65.
    发明申请
    DATA ENCODERS FOR MEDICAL DEVICES AND RELATED METHODS 审中-公开
    医疗器械的数据编码器及相关方法

    公开(公告)号：WO2014014560A1

    公开(公告)日：2014-01-23

    申请号：PCT/US2013/042209

    申请日：2013-05-22

    Applicant: LIGHTLAB IMAGING, INC.

    Inventor： WINSTON, David ,  MURRAY, Paul ,  GRINBERG, Victor ,  DAVIDSON, Marc

    IPC: A61B5/00 ,  A61B8/08 ,  A61B8/12 ,  A61B8/00

    CPC classification number: A61B5/0066 ,  A61B5/0035 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/4416 ,  A61B8/4438 ,  A61B2560/0223 ,  A61B2560/0228 ,  A61B2560/0233 ,  A61B2560/0238 ,  A61B2562/08 ,  A61B2562/085 ,  A61B2562/226 ,  A61B2562/227 ,  A61B2562/228 ,  G06F19/00

    Abstract: In part, the invention relates to systems, methods, and devices that store and retrieve information associated with an imaging probe such as an ultrasound probe, as optical coherence tomography probe, a multimodal probe and other probes. The information mat is stored' relates to one or more measurable properties for a specific imaging probe. Thus, when each probe is manufactured there can be variations in its length, brightness., angular alignment of its constituent elements, and various other probe specific measurements, hi turn, these measurements can be used to calibrate or otherwise use a given probe with a system that collects, stores, or otherwise processes information collected using each probe.

    Abstract translation: 部分地，本发明涉及存储和检索与诸如超声探头的成像探针相关联的信息的系统，方法和装置，作为光学相干断层扫描探针，多峰探针和其他探针。 信息垫被存储“涉及特定成像探针的一个或多个可测量特性。 因此，当制造每个探针时，其长度，亮度，其组成元件的角度对准和各种其它探针特异性测量可能存在变化。可以使用这些测量来校准或以其它方式使用给定探针， 系统收集，存储或以其他方式处理使用每个探针收集的信息。

    INTENSITY NOISE REDUCTION METHODS AND APPARATUS FOR INTERFEROMETRIC SENSING AND IMAGING SYSTEMS
    66.
    发明申请
    INTENSITY NOISE REDUCTION METHODS AND APPARATUS FOR INTERFEROMETRIC SENSING AND IMAGING SYSTEMS 审中-公开
    强度噪声减少方法和装置用于干涉式感测和成像系统

    公开(公告)号：WO2011116196A1

    公开(公告)日：2011-09-22

    申请号：PCT/US2011/028826

    申请日：2011-03-17

    Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M. ,  GRINBERG, Victor

    Inventor： SCHMITT, Joseph, M. ,  GRINBERG, Victor

    IPC: G01B9/02 ,  G11B20/24 ,  H03G3/32 ,  H04B10/00

    CPC classification number: G01B9/02055 ,  G01B9/02004 ,  G01B9/02044 ,  G01B9/02074 ,  G01B9/02083 ,  H03G3/3084 ,  H04B10/616 ,  H04B10/671

    Abstract: In part, aspects of the invention relate to methods, apparatus, and systems for intensity and/or pattern line noise reduction in a data collection system such as an optical coherence tomography system that uses an electromagnetic radiation source and interferometric principles. In one embodiment, the noise is intensity noise or line pattern noise and the source is a laser such as a swept laser. One or more attenuators responsive to one or more control signals can be used in conjunction with an analog or digital feedback network in one embodiment.

    Abstract translation: 部分地，本发明的方面涉及数据采集系统中的强度和/或图案线噪声降低的方法，装置和系统，例如使用电磁辐射源和干涉原理的光学相干断层摄影系统。 在一个实施例中，噪声是强度噪声或线图案噪声，并且源是诸如扫描激光器的激光器。 在一个实施例中，响应于一个或多个控制信号的一个或多个衰减器可以与模拟或数字反馈网络结合使用。

    OPTO-ACOUSTIC IMAGING DEVICES AND METHODS
    68.
    发明申请
    OPTO-ACOUSTIC IMAGING DEVICES AND METHODS 审中-公开
    光声成像装置和方法

    公开(公告)号：WO2008057573A2

    公开(公告)日：2008-05-15

    申请号：PCT/US2007/023493

    申请日：2007-11-08

    Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M. ,  PETERSEN, Christopher ,  OHASHI, Toru ,  NAKAMATSU, Tetsuya

    Inventor： SCHMITT, Joseph, M. ,  PETERSEN, Christopher ,  OHASHI, Toru ,  NAKAMATSU, Tetsuya

    IPC: A61B5/00 ,  A61B8/12

    CPC classification number: A61B5/0066 ,  A61B5/0095 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461

    Abstract: In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.

    Abstract translation: 在一个方面，本发明涉及探针。 所述探针包括护套，位于所述护套内的柔性的，双向可旋转的光学子系统，所述光学子系统包括传输光纤，所述光学子系统能够沿着第一光束传输和收集预定波长范围的光，所述第一光束具有 预定光束大小。 探头还包括超声子系统，超声子系统位于护套内并适于沿具有第二预定光束尺寸的第二光束传播预定频率范围的能量，其中第一和第二光束的一部分在期间与区域重叠 扫描。

    CALCIUM ARC COMPUTATION RELATIVE TO LUMEN CENTER
    69.
    发明申请
    CALCIUM ARC COMPUTATION RELATIVE TO LUMEN CENTER 审中-公开

    公开(公告)号：WO2022226314A1

    公开(公告)日：2022-10-27

    申请号：PCT/US2022/025961

    申请日：2022-04-22

    Applicant: LIGHTLAB IMAGING, INC.

    Inventor： CONNELLY, Timothy, Preston ,  GRIFFIN, Christopher, Erik ,  LI, Shimin

    IPC: G06T7/00 ,  G06T7/60

    Abstract: Methods, systems, and apparatus, including computer-readable storage media for calculating lumen-centered calcium arcs. A method includes receiving, by one or more processors, an image frame and an identification of a region of plaque in the image frame. The image frame is taken while the imaging device is in a lumen depicted in the image frame. The one or more processors identify a lumen-center of the lumen in the image frame, and generate a lumen-centered arc having a coverage angle centered on the lumen-center, using at least the lumen-center.

    STENT EXPANSION DISPLAY, SYSTEMS, AND METHODS
    70.
    发明申请
    STENT EXPANSION DISPLAY, SYSTEMS, AND METHODS 审中-公开

    公开(公告)号：WO2019232078A1

    公开(公告)日：2019-12-05

    申请号：PCT/US2019/034434

    申请日：2019-05-29

    Applicant: LIGHTLAB IMAGING, INC.

    Inventor： GOPINATH, Ajay ,  SAVIDGE, Kyle ,  STEINBRECHER, Robert

    IPC: G06T7/13 ,  G06T7/62

    Abstract: In part, the disclosure relates to systems and methods to assess stent / scaffold expansion in a vessel on an expedited time scale after stent / scaffold placement and expansion. In one embodiment, the method generates a first representation of a stented segment of the blood vessel indicative of a level of stent expansion; determines using the detected stent struts, a first end of the stent and a second end of the stent; and generate a second representation of the segment of the blood vessel by interpolating a lumen profile using an offset distance from the first end and the second end.

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