公开(公告)号：WO2011041710A3

公开(公告)日：2011-04-07

申请号：PCT/US2010/051172

申请日：2010-10-01

Applicant: MARTEK BIOSCIENCES CORPORATION ,  PANKER, Cynthia, A. ,  BILLARD, Michael, Ames ,  RYAN, Alan ,  DANGI, Bindi

Inventor： PANKER, Cynthia, A. ,  BILLARD, Michael, Ames ,  RYAN, Alan ,  DANGI, Bindi

IPC: A61K31/232 ,  A61P3/06

Abstract: The present invention is directed to an oral dosage form comprising a gel capsule comprising, (a) plasticizer; (b) gelatin; (c) water; and (d) greater than 850 mg DHA ethyl ester, wherein less than about 2% (wt/wt) of the total fatty acid content of the dosage form is EPA, wherein the total weight of the capsule is about 1 g and wherein the capsule is stable at about 25°C at 60% relative humidity.

公开(公告)号：WO2009035551A1

公开(公告)日：2009-03-19

申请号：PCT/US2008/010454

申请日：2008-09-08

Applicant: MARTEK BIOSCIENCES CORPORATION ,  LIPPMEIER, James, Casey ,  PFEIFER, Joseph, W. ,  HANSEN, Jon, Milton ,  APT, Kirk, E. ,  BARCLAY, William, Robert ,  BEHRENS, Paul, Warren ,  MARTIN, David, Christian

Inventor： LIPPMEIER, James, Casey ,  PFEIFER, Joseph, W. ,  HANSEN, Jon, Milton ,  APT, Kirk, E. ,  BARCLAY, William, Robert ,  BEHRENS, Paul, Warren ,  MARTIN, David, Christian

IPC: C12P7/64 ,  C12P1/04

CPC classification number: C12P7/6472 ,  C10L1/02 ,  C10L1/026 ,  C10L2200/0469 ,  C10L2270/026 ,  C10L2270/04 ,  C10L2290/26 ,  C12P7/649 ,  Y02E50/13 ,  Y02P30/20

Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.

Abstract translation: 本发明提供生物油及其方法和用途。 生物油优选通过使用含纤维素原料作为主要碳源的一种或多种微生物的异养发酵产生。 本发明还提供了使用生物油制备基于脂质的生物燃料和食品，营养和药物产品的方法。

公开(公告)号：WO2009029793A1

公开(公告)日：2009-03-05

申请号：PCT/US2008/074790

申请日：2008-08-29

Applicant: MARTEK BIOSCIENCES CORPORATION ,  SENANAYAKE, Janaka, Namal, S., P. ,  AHMED, Naseer ,  FICHTALI, Jaouad

Inventor： SENANAYAKE, Janaka, Namal, S., P. ,  AHMED, Naseer ,  FICHTALI, Jaouad

IPC: A23D9/013

CPC classification number: A61K47/44 ,  A21D2/165 ,  A23D7/001 ,  A23D7/003 ,  A23D7/0053 ,  A23D7/0056 ,  A23D9/00 ,  A23D9/007 ,  A23K20/158 ,  A23L33/30 ,  C11B1/025 ,  C11B1/10 ,  C11B5/00

Abstract: The present invention provides a solid fat composition that includes an oil having saturated fat and an oil having at least one long chain polyunsaturated fatty acid. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low to no presence of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions.

Abstract translation: 本发明提供一种固体脂肪组合物，其包含具有饱和脂肪的油和具有至少一种长链多不饱和脂肪酸的油。 特别地，固体脂肪组合物可以具有高水平的长链多不饱和脂肪酸，并且低至无乳化剂存在。 在优选的实施方案中，多不饱和的油是未连续的微生物油。 本发明还涉及制备这种组合物的方法以及包含所述组合物的食品，营养和药物产品。

公开(公告)号：WO2008157629A1

公开(公告)日：2008-12-24

申请号：PCT/US2008/067383

申请日：2008-06-18

Applicant: MARTEK BIOSCIENCES CORPORATION ,  WILLS, Todd ,  CONNOLLY, Brian, J. ,  SUBRAMANIAN, Srinivasan

Inventor： WILLS, Todd ,  CONNOLLY, Brian, J. ,  SUBRAMANIAN, Srinivasan

IPC: A23L1/00

CPC classification number: A61K9/5052 ,  A23L2/38 ,  A23L2/52 ,  A23L7/122 ,  A23L27/215 ,  A23L27/72 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23L33/18 ,  A23L33/40 ,  A61K8/11 ,  A61K9/1075 ,  A61K9/4891 ,  A61K9/5015 ,  A61K9/5073 ,  A61K2800/412 ,  A61Q19/00

Abstract: Products comprising core materials, such as polyunsaturated fatty acids, encapsulated by an encapsulant formed from hydrolyzed protein having a degree of protein hydrolysis of between about 1% and about 15%, and from caramelization products, are disclosed. Methods of making the same and of making the encapsulant are also provided.

Abstract translation: 公开了包含由具有约1％至约15％的蛋白质水解度的水解蛋白质形成的密封剂包封的核心材料（例如多不饱和脂肪酸）和焦糖化产品的产品。 还提供了制造该密封剂的方法和制造密封剂。

公开(公告)号：WO2008027991A2

公开(公告)日：2008-03-06

申请号：PCT/US2007/077150

申请日：2007-08-29

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ARTERBURN, Linda ,  BARCLAY, William ,  FLATT, James ,  VAN ELSWYK, Mary ,  ZELLER, Samuel G.

Inventor： ARTERBURN, Linda ,  BARCLAY, William ,  FLATT, James ,  VAN ELSWYK, Mary ,  ZELLER, Samuel G.

IPC: A23L1/29 ,  A23L1/30 ,  A61K31/02 ,  A61K31/66

CPC classification number: A23L1/296 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/187 ,  A23V2250/1868 ,  A23V2250/1882

Abstract: Infant formula compositions containing docosapentaenoic acid n-6 ("DPA(n-6)") and other polyunsaturated fatty acids and methods for their preparation and use are provided.

Abstract translation: 提供含有二十二碳五烯酸n-6（“DPA（n-6）”）和其他多不饱和脂肪酸的婴儿配方组合物及其制备和使用方法。

公开(公告)号：WO2008003064A2

公开(公告)日：2008-01-03

申请号：PCT/US2007/072405

申请日：2007-06-28

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ABRIL, Jesus, Ruben

Inventor： ABRIL, Jesus, Ruben

IPC: A23D7/005 ,  A23L1/22 ,  A23L1/236 ,  A23L1/27 ,  A23L1/30 ,  A23L1/302 ,  C11B5/00

CPC classification number: A23D9/007 ,  A23L27/32 ,  A23L33/12 ,  A23V2002/00 ,  C11B5/0007 ,  C11B5/0042 ,  A23V2200/10 ,  A23V2250/24 ,  A23V2250/1882 ,  A23V2250/2484

Abstract: Sweetened oil compositions, and methods for their preparation, comprising long chain polyunsaturated fatty acids are provided. The oil compositions are sweetened with a high- intensity sweetener, and preferably a peptide based sweetener. Particularly, omega-3 long chain polyunsaturated fatty acids, omega-6 long chain polyunsaturated fatty acids, and mixtures thereof are utilized in the compositions and methods.

Abstract translation: 提供甜味油组合物及其制备方法，其包含长链多不饱和脂肪酸。 油组合物用高强度甜味剂，优选基于肽的甜味剂加甜。 特别地，在组合物和方法中使用ω-3长链多不饱和脂肪酸，ω-6长链多不饱和脂肪酸及其混合物。

公开(公告)号：WO2007008586A3

公开(公告)日：2007-01-18

申请号：PCT/US2006/026331

申请日：2006-07-07

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ELLIS, Lorie, A.

Inventor： ELLIS, Lorie, A.

IPC: A61K31/20

Abstract: Disclosed are compositions and methods for treating or preventing dementia and pre-dementia-related conditions and/or symptoms or characteristics of such conditions.

公开(公告)号：WO2006047445A2

公开(公告)日：2006-05-04

申请号：PCT/US2005/038252

申请日：2005-10-21

Applicant: MARTEK BIOSCIENCES CORPORATION ,  FICHTALI, Jaouad ,  SUNDARARAJAN, Anand

Inventor： FICHTALI, Jaouad ,  SUNDARARAJAN, Anand

IPC: C11B1/00

CPC classification number: C12N1/14 ,  A23L33/12 ,  A61K36/00 ,  A61K36/062 ,  C11B1/02 ,  C11B1/10 ,  C12N1/005 ,  C12N1/12

Abstract: The present invention relates to a process for preparing a biomass, such as from a microbial fermentation, for an extraction process to separate desired chemicals, nutritional products, bioactive components, proteins, carbohydrates, and lipids, from the biomass. Particularly preferred substances to extract include docosahexaenoic acid, docosapentaenoic acid, and arachidonic acid. The present invention also includes extracting the prepared biomass. Biomasses to be treated in accordance with the methods of the invention include plant, animal, and microbial biomass, particularly a microorganism such as Crypthecodinium cohnii and a fungus such as Mortierella alpina.

Abstract translation: 本发明涉及从微生物发酵制备生物质的方法，用于从生物质中分离所需化学品，营养产品，生物活性成分，蛋白质，碳水化合物和脂质的提取方法。 特别优选的提取物质包括二十二碳六烯酸，二十二碳五烯酸和花生四烯酸。 本发明还包括提取制备的生物质。 根据本发明的方法处理的生物质包括植物，动物和微生物生物质，特别是微生物如隐孢子虫（Crypthecodinium cohnii）和真菌如高山被孢霉（Mortierella alpina）。

公开(公告)号：WO2004028470A2

公开(公告)日：2004-04-08

申请号：PCT/US2003/030484

申请日：2003-09-29

Applicant: MARTEK BIOSCIENCES CORPORATION ,  ARTERBURN, Linda, M ,  HOFFMAN, James, P ,  OKEN, Harry, A ,  VAN ELSWYK, Mary

Inventor： ARTERBURN, Linda, M ,  HOFFMAN, James, P ,  OKEN, Harry, A ,  VAN ELSWYK, Mary

IPC: A61K

CPC classification number: A61K45/06 ,  A61K31/202 ,  A61K31/232 ,  A61K31/60 ,  A61K2300/00

Abstract: This invention is directed to methods and compositions which impede the development and progression of diseases associated with subclinical inflammation. Subclinical inflammation is commonly associated with atherosclerotic cardiovascular disease, coronary disease or cerebrovascular disease. The methods and compositions of the invention are also particularly suited to providing therapy for subclinical inflammation in diabetic and prediabetic patients. Methods of the invention comprise administration of DHA alone and in combination with antiplatelet drugs.

Abstract translation: 本发明涉及阻止亚临床炎症相关疾病发展和进展的方法和组合物。 亚临床炎症通常与动脉粥样硬化性心血管疾病，冠状动脉疾病或脑血管疾病有关。 本发明的方法和组合物还特别适用于为糖尿病和前驱糖尿病患者提供亚临床炎症的治疗。 本发明的方法包括单独给药DHA和与抗血小板药物联合给药。

公开(公告)号：WO2003097798A3

公开(公告)日：2003-11-27

申请号：PCT/US2003/015229

申请日：2003-05-14

Applicant: MARTEK BIOSCIENCES CORPORATION

Inventor： WEAVER, Craig, A. ,  METZ, James, G. ,  KUNER, Jerry, M. ,  OVERTON, Frank, H., Jr.

IPC: C12P1/04

Abstract: Described herein is a novel three domain gene from Schizochytrium , denoted carotene synthase, that encodes a protein with three different enzymatic activities; phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.