公开(公告)号：AU5928900A

公开(公告)日：2001-01-30

申请号：AU5928900

申请日：2000-07-11

Applicant: MOLECULAR DYNAMICS INC ,  PEPONNET CHRISTINE

Inventor： PEPONNET CHRISTINE ,  MANSFIELD ELAINE S ,  BASHKIN JOHN S ,  KAUTZER CURTIS R

IPC: B01J19/00 ,  C12M1/00 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447

公开(公告)号：CA2378170A1

公开(公告)日：2001-01-18

申请号：CA2378170

申请日：2000-07-11

Applicant: PEPONNET CHRISTINE ,  MOLECULAR DYNAMICS INC

Inventor： PEPONNET CHRISTINE ,  BASHKIN JOHN S ,  KAUTZER CURTIS R ,  MANSFIELD ELAINE S

IPC: B01J19/00 ,  C12M1/00 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447

Abstract: The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresi s. Once all samples are loaded into the capillaries, continuous electrophoresis and detection is used to separate and detect target compounds within the sample. The interval between injections is matched to the target compound migration rate to be sufficient to allow the target compounds to be detectab ly separated when the compounds reach the detector.

公开(公告)号：GB2378512A

公开(公告)日：2003-02-12

申请号：GB0200348

申请日：2000-07-11

Applicant: MOLECULAR DYNAMICS INC ,  PEPONNET CHRISTINE

Inventor： MANSFIELD ELAINE S ,  BASHKIN JOHN S ,  KAUTZER CURTIS R ,  PEPONNET CHRISTINE

IPC: B01J19/00 ,  C12M1/00 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447

Abstract: The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresis. Once all samples are loaded into the capillaries, continuous electrophoresis and detection is used to separate and detect target compounds within the sample. The interval between injections is matched to the target compound migration rate to be sufficient to allow the target compounds to be detectably separated when the compounds reach the detector.

公开(公告)号：GB2360284B

公开(公告)日：2002-02-27

申请号：GB0024263

申请日：2000-10-04

Applicant: MOLECULAR DYNAMICS INC ,  ANNOMAX INC ,  AEOMICA INC

Inventor： PENN SHARRON GAYNOR ,  RANK DAVID R ,  CHEN WENSHENG ,  HANZEL DAVID KAGEN

IPC: A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N15/10 ,  C12Q1/68 ,  G06F19/20 ,  G06F19/22 ,  C07H21/00

Abstract: A spatially addressable set of such probes is provided for measuring gene expression in a sample derived from human heart, the probes comprising any one of the nucleotide sequences set out in SEQ ID NOS: 1-5202 or 5203-10283 or a complementary sequence. The set may comprise 50-20,000 probes of average length 200-500 bp and may be addressably disposed upon a substrate. At least 50% of the probes lack prokaryotic and bacteriophage vector sequence and at least 50% lack homopolymeric stretches of A or T. Each of the probes may be amplifiable using at least one common primer. Also claimed are said nucleotide sequences and peptides encoded thereby.

公开(公告)号：AU3275901A

公开(公告)日：2001-08-14

申请号：AU3275901

申请日：2001-01-30

Applicant: MOLECULAR DYNAMICS INC

Inventor： PENN SHARRON G ,  HANZEL DAVID K ,  CHEN WENSHENG ,  RANK DAVID R

IPC: A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N15/10 ,  C12N15/66 ,  C12Q1/68 ,  G16B45/00 ,  G06F19/00

Abstract: Abstract Methods and apparatus for predicting, confirming and displaying functional regions from genomic sequence data are presented. The methods and apparatus are particularly useful for predicting coding regions within genomic sequence data, confirming the expression thereof experimentally, and relating and displaying the expression data in meaningful relationship to the genomic sequence. The methods and apparatus of the present invention thus present powerful tools for novel gene discovery.

公开(公告)号：AU3088001A

公开(公告)日：2001-08-14

申请号：AU3088001

申请日：2001-01-30

Applicant: MOLECULAR DYNAMICS INC

Inventor： PENN SHARRON G ,  HANZEL DAVID K ,  CHEN WENSHENG ,  RANK DAVID R

IPC: A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N15/10 ,  C12N15/66 ,  C12Q1/68 ,  G16B45/00

Abstract: Abstract Methods and apparatus for predicting, confirming and displaying functional regions from genomic sequence data are presented. The methods and apparatus are particularly useful for predicting coding regions within genomic sequence data, confirming the expression thereof experimentally, and relating and displaying the expression data in meaningful relationship to the genomic sequence. The methods and apparatus of the present invention thus present powerful tools for novel gene discovery.

公开(公告)号：CA2380794A1

公开(公告)日：2001-02-08

申请号：CA2380794

申请日：2000-08-02

Applicant: MOLECULAR DYNAMICS INC

Inventor： HADD ANDY ,  JOVANOVICH STEVAN

IPC: C12N15/09 ,  B01D57/02 ,  B01J4/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  B01L99/00 ,  B03C5/00 ,  C12M1/00 ,  C12M1/34 ,  C12M1/38 ,  C12Q1/68 ,  C40B40/02 ,  C40B40/06 ,  C40B50/06 ,  C40B60/04 ,  C40B60/14 ,  G01N1/00 ,  G01N27/447 ,  G01N31/20 ,  G01N33/50 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N37/00

Abstract: Methods for preparing nanoscale reactions using nucleic acids are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surfac e of the reaction chamber, typically a capillary. Excess nucleic acid is remov ed and the reaction is performed directly within the capillary. Alternatively, the saturably bound nucleic acid is eluted, dispensing a metered amount of nucleic acid for subsequent reaction in a separate chamber. Devices for effecting the methods of the invention and a system designed advantageously to utilize the methods for high throughput nucleic acid sequencing reactions ar e also provided.

公开(公告)号：CA2350139A1

公开(公告)日：2000-05-25

申请号：CA2350139

申请日：1999-11-12

Applicant: MOLECULAR DYNAMICS INC

Inventor： MEADE THOMAS J ,  YU CHANGJUN

IPC: C12N15/09 ,  C07H19/06 ,  C07H21/04 ,  C07H21/00 ,  C07H23/00 ,  C07H19/16

Abstract: The invention is directed to novel methods of making nucleosides modified wi th signalling moieties and polydentate ligands, particularly for use in chelati ng transition metal complexes to form signalling moieties such as electron transfer moieties and fluorophores.

公开(公告)号：AU5605894A

公开(公告)日：1994-06-08

申请号：AU5605894

申请日：1993-11-12

Applicant: MOLECULAR DYNAMICS INC

Inventor： SCHLESINGER DAVID

IPC: A23L3/3463 ,  A23L3/3526 ,  A61K8/64 ,  A61K38/02 ,  A61K47/48 ,  A61Q15/00 ,  C07K7/02 ,  C07K14/00 ,  A61K37/00

公开(公告)号：EP2679377B1

公开(公告)日：2016-12-28

申请号：EP13186032.2

申请日：2012-04-19

Applicant: Coretech System Co., Ltd. ,  Molecular Dynamics Technology Co., Ltd.

Inventor： Tseng, Huan Chang ,  Chang, Rong Yeu ,  Hsu, Chia Hsiang

IPC: B29C45/76 ,  B29C45/00 ,  B29K105/06 ,  B29K105/18 ,  G06F17/50

CPC classification number: B29C45/0005 ,  B29C45/7693 ,  B29K2105/06 ,  G06F17/5009