公开(公告)号：GB2378512A

公开(公告)日：2003-02-12

申请号：GB0200348

申请日：2000-07-11

Applicant: MOLECULAR DYNAMICS INC ,  PEPONNET CHRISTINE

Inventor： MANSFIELD ELAINE S ,  BASHKIN JOHN S ,  KAUTZER CURTIS R ,  PEPONNET CHRISTINE

IPC: B01J19/00 ,  C12M1/00 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447

Abstract: The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresis. Once all samples are loaded into the capillaries, continuous electrophoresis and detection is used to separate and detect target compounds within the sample. The interval between injections is matched to the target compound migration rate to be sufficient to allow the target compounds to be detectably separated when the compounds reach the detector.

公开(公告)号：AU5928900A

公开(公告)日：2001-01-30

申请号：AU5928900

申请日：2000-07-11

Applicant: MOLECULAR DYNAMICS INC ,  PEPONNET CHRISTINE

Inventor： PEPONNET CHRISTINE ,  MANSFIELD ELAINE S ,  BASHKIN JOHN S ,  KAUTZER CURTIS R

IPC: B01J19/00 ,  C12M1/00 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447

公开(公告)号：CA2378170A1

公开(公告)日：2001-01-18

申请号：CA2378170

申请日：2000-07-11

Applicant: PEPONNET CHRISTINE ,  MOLECULAR DYNAMICS INC

Inventor： PEPONNET CHRISTINE ,  BASHKIN JOHN S ,  KAUTZER CURTIS R ,  MANSFIELD ELAINE S

IPC: B01J19/00 ,  C12M1/00 ,  C12Q1/68 ,  C40B60/14 ,  G01N27/447

Abstract: The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresi s. Once all samples are loaded into the capillaries, continuous electrophoresis and detection is used to separate and detect target compounds within the sample. The interval between injections is matched to the target compound migration rate to be sufficient to allow the target compounds to be detectab ly separated when the compounds reach the detector.

公开(公告)号：EP1194770A1

公开(公告)日：2002-04-10

申请号：EP00945324.2

申请日：2000-07-11

Applicant: MOLECULAR DYNAMICS, INC. ,  Peponnet, Christine

Inventor： PEPONNET, Christine ,  MANSFIELD, Elaine, S. ,  BASHKIN, John, S. ,  KAUTZER, Curtis, R.

IPC: G01N27/447

CPC classification number: G01N27/44743 ,  B01J2219/00315 ,  B01J2219/00587 ,  B01J2219/00707 ,  C40B60/14 ,  G01N27/44782

Abstract: The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresis. Once all samples are loaded into the capillaries, continuous electrophoresis and detection is used to separate and detect target compounds within the sample. The interval between injections is matched to the target compound migration rate to be sufficient to allow the target compounds to be detectably separated when the compounds reach the detector.

公开(公告)号：WO0168913A3

公开(公告)日：2002-10-31

申请号：PCT/IB0100465

申请日：2001-03-13

Applicant: GENSET SA ,  PEPONNET CHRISTINE ,  SUDOR JAN

Inventor： PEPONNET CHRISTINE ,  SUDOR JAN

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6869 ,  C12Q2600/156

Abstract: The present invention provides novel nucleic acid detection methods based on nucleic acid template-directed primer extension assays. Also provided are kits and genetic analysis methods. Included are microsequencing methods comprising detecting an incorporated nucleotide by measuring direct fluorescence intensity, fluorescence-based nucleic acid detection methods using oligonucleotide primers hybridizing to both complementary strands of a nucleic acid sample, and methods for decreasing background signal in nucleic acid template-directed primer extension assays.

Abstract translation: 本发明提供了基于核酸模板定向引物延伸测定的新型核酸检测方法。 还提供了试剂盒和遗传分析方法。 包括微测序方法，其包括通过测量直接荧光强度检测并入的核苷酸，使用与核酸样品的两条互补链杂交的寡核苷酸引物的基于荧光的核酸检测方法，以及用于降低核酸模板定向引物延伸中的背景信号的方法 试验。

公开(公告)号：WO2010128221A1

公开(公告)日：2010-11-11

申请号：PCT/FR2010/000344

申请日：2010-05-05

Applicant: ECHOSENS ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  COSNIER, Marie-Line ,  CAILLAT, Patrice ,  CUBIZOLLES, Myriam-Laure ,  FAIVRE, Magalie ,  PELTIE, Philippe ,  PEPONNET, Christine ,  POUTEAU, Patrick ,  VAUCHIER, Claude ,  TALINI, Luc

Inventor： COSNIER, Marie-Line ,  CAILLAT, Patrice ,  CUBIZOLLES, Myriam-Laure ,  FAIVRE, Magalie ,  PELTIE, Philippe ,  PEPONNET, Christine ,  POUTEAU, Patrick ,  VAUCHIER, Claude ,  TALINI, Luc

IPC: C12Q1/52 ,  C12Q1/56 ,  G01N33/86 ,  G01N21/64 ,  G01N33/49

CPC classification number: G01N33/86 ,  C12Q1/52 ,  C12Q1/56 ,  G01N21/6428 ,  G01N33/4905 ,  G01N2800/085

Abstract: Dispositif consommable (P) pour effectuer automatiquement des analyses sanguines, comportant une pluralité de chambres fluidiques (C1 - C6) susceptibles de recevoir un échantillon de sang total ô analyser et dont au moins certaines ont au moins une paroi transparente, caractérisé en ce qu'il comprend au moins trois chambres (C5, C6) ou groupes de chambres fluidiques (C1, C2) contenant chacune un réactif ou un ensemble de réactifs aptes ô permettre, respectivement : le dosage d'une ou deux transaminases, le comptage des thrombocytes et la détermination du temps de coagulation du sang. Appareil coopérant avec ledit dispositif consommable pour effectuer automatiquement des analyses sanguines

Abstract translation: 本发明涉及一种用于自动执行血液检查的一次性装置（P），包括能够接收待分析的全血样本的多个流体室（C1-C6），其中至少一些具有至少一个透明壁， 其特征在于，所述装置包括至少三个室（C5，C6）或一组流体室（C1，C2），每个腔室包含试剂或一组试剂，用于分别：测定一种或两种转氨酶，计数血小板和测定血液 凝血时间。 本发明还涉及与所述一次性装置相互作用的装置，用于自动执行血液测试。

公开(公告)号：WO2009071775A1

公开(公告)日：2009-06-11

申请号：PCT/FR2008001341

申请日：2008-09-26

Applicant: COMMISSARIAT ENERGIE ATOMIQUE ,  ROSTAING HERVE ,  PEPONNET CHRISTINE ,  POUTEAU PATRICK ,  SOLLIER ELODIE

Inventor： ROSTAING HERVE ,  PEPONNET CHRISTINE ,  POUTEAU PATRICK ,  SOLLIER ELODIE

IPC: A61B5/151

CPC classification number: G01N33/491 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150419 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15142

Abstract: The invention relates to a capillary blood sampling device, incorporating a filter and, downstream of the same, an absorbent material for separating a blood plasma phase from a cellular phase, characterised in that the filter comprises successively: a pre-filter (6) for distributing the blood on the surface of a first membrane (2) with pores of size 0.1 µm to 5 µm, said membrane being provided with an agglomeration agent and said first membrane (2).

Abstract translation: 本发明涉及一种毛细管血液采样装置，其包括过滤器，并且在其下游具有用于从血液相分离血浆相的吸收材料，其特征在于，所述过滤器依次包括：预过滤器（6），用于 在具有0.1μm至5μm的孔的第一膜（2）的表面上分配血液，所述膜具有附聚剂和所述第一膜（2）。

公开(公告)号：WO02060584A3

公开(公告)日：2003-02-13

申请号：PCT/IB0201048

申请日：2002-01-22

Applicant: GENSET SA ,  FOUILLET YVES ,  VAUCHIER CLAUDE ,  CLERC JEAN-FREDERIC ,  PEPONNET CHRISTINE ,  CHARLES RAYMOND ,  SARRUT NICOLAS ,  CLAUSTRE PATRICIA ,  COMMISSARIAT ENERGIE ATOMIQUE

Inventor： FOUILLET YVES ,  VAUCHIER CLAUDE ,  CLERC JEAN-FREDERIC ,  PEPONNET CHRISTINE ,  CHARLES RAYMOND ,  SARRUT NICOLAS ,  CLAUSTRE PATRICIA

IPC: G01N33/50 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L7/02 ,  B81B1/00 ,  B81C1/00 ,  C12M1/00 ,  C12M1/22 ,  C12M1/34 ,  C12M1/38 ,  C12N15/09 ,  C12P19/34 ,  C12Q1/68 ,  G01N1/28 ,  G01N35/02 ,  G01N35/08 ,  G01N37/00

CPC classification number: G01N35/08 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502784 ,  B01L7/02 ,  B01L7/52 ,  B01L7/525 ,  B01L7/5255 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0845 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1838 ,  B01L2300/1883 ,  B01L2400/0415 ,  B01L2400/0487 ,  F28F2260/02

Abstract: Devices and methods for carrying out a chemical or biochemical protocol are disclosed. In one embodiment, the chemical or biochemical protocol is performed by cycling at least one thermal transfer member between at least two temperatures while liquid samples on which the chemical or biochemical protocol is to be performed are continuously moving through at least one temperature regulated zone upon which the at least one thermal transfer member acts. In some embodiments, the device comprises a sample transport member that comprises liquid samples in sample receiving regions. The sample transport member moves the samples continuously through a temperature regulated zone which cycles between at least two temperatures while the liquid samples are moving through a temperature regulated zone on which at least one thermal transfer member acts. In some embodiments, the sample receiving regions comprise wells, hydrophillic films or hydrophillic filaments.

Abstract translation: 公开了用于执行化学或生物化学方案的装置和方法。 在一个实施方案中，通过在至少两个温度之间循环至少一个热传递构件来执行化学或生物化学方案，而在其上执行化学或生物化学方案的液体样品连续移动通过至少一个温度调节区， 所述至少一个热转印构件起作用。 在一些实施例中，该装置包括样品输送构件，其在样品接收区域中包含液体样品。 样品输送构件将样品连续移动通过在至少两个温度之间循环的温度调节区，同时液体样品移动通过至少一个热转印构件作用的温度调节区。 在一些实施方案中，样品接收区域包括孔，亲水膜或亲水长丝。

公开(公告)号：WO2002060584A2

公开(公告)日：2002-08-08

申请号：PCT/IB2002/001048

申请日：2002-01-22

Applicant: GENSET ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ,  FOUILLET, Yves ,  VAUCHIER, Claude ,  CLERC, Jean-Frederic ,  PEPONNET, Christine ,  CHARLES, Raymond ,  SARRUT, Nicolas ,  CLAUSTRE, Patricia

Inventor： FOUILLET, Yves ,  VAUCHIER, Claude ,  CLERC, Jean-Frederic ,  PEPONNET, Christine ,  CHARLES, Raymond ,  SARRUT, Nicolas ,  CLAUSTRE, Patricia

IPC: B01L7/00

CPC classification number: G01N35/08 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502784 ,  B01L7/02 ,  B01L7/52 ,  B01L7/525 ,  B01L7/5255 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0845 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1838 ,  B01L2300/1883 ,  B01L2400/0415 ,  B01L2400/0487 ,  F28F2260/02

Abstract: Devices and methods for carrying out a chemical or biochemical protocol are disclosed. In one embodiment, the chemical or biochemical protocol is performed by cycling at least one thermal transfer member between at least two temperatures while liquid samples on which the chemical or biochemical protocol is to be performed are continuously moving through at least one temperature regulated zone upon which the at least one thermal transfer member acts. In some embodiments, the device comprises a sample transport member that comprises liquid samples in sample receiving regions. The sample transport member moves the samples continuously through a temperature regulated zone which cycles between at least two temperatures while the liquid samples are moving through a temperature regulated zone on which at least one thermal transfer member acts. In some embodiments, the sample receiving regions comprise wells, hydrophillic films or hydrophillic filaments.

Abstract translation: 公开了用于执行化学或生物化学方案的装置和方法。 在一个实施方案中，通过在至少两个温度之间循环至少一个热传递构件来执行化学或生物化学方案，而在其上执行化学或生物化学方案的液体样品连续移动通过至少一个温度调节区， 所述至少一个热转印构件起作用。 在一些实施例中，该装置包括样品输送构件，其在样品接收区域中包含液体样品。 样品输送构件将样品连续移动通过在至少两个温度之间循环的温度调节区，同时液体样品移动通过至少一个热转印构件作用的温度调节区。 在一些实施方案中，样品接收区域包括孔，亲水膜或亲水长丝。

公开(公告)号：WO1996013609A1

公开(公告)日：1996-05-09

申请号：PCT/FR1995001422

申请日：1995-10-27

Applicant: GENSET ,  PEPONNET, Christine

Inventor： GENSET

IPC: C12Q01/68

CPC classification number: C12Q1/6837 ,  C12Q1/6846 ,  C12Q2565/537 ,  C12Q2525/197

Abstract: A solid-phase nucleic acid amplification method using a primer immobilised on a functionalised heat-resistant solid support, wherein said primer is immobilised on the solid support via a linking arm consisting of a polyfunctional molecule which forms a covalent bond between the solid support and a first functional group of said polyfunctional molecule, and between the 5' end of said primer and a second functional group of said polyfunctional molecule.

Abstract translation: 一种使用固定在官能化耐热固体支持物上的引物的固相核酸扩增方法，其中所述引物通过连接臂固定在固体支持物上，所述连接臂由在固体支持物和固体支持物之间形成共价键的多官能分子组成 所述多官能分子的第一官能团和所述引物的5'末端和所述多官能分子的第二官能团之间。