公开(公告)号：TWI477278B

公开(公告)日：2015-03-21

申请号：TW099140959

申请日：2010-11-26

Applicant: 大曹股份有限公司 ,  DAISO CO., LTD. ,  公立大學法人大阪市立大學 ,  OSAKA CITY UNIVERSITY ,  公立大學法人大阪府立大學 ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION ,  京都府公立大學法人 ,  KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION ,  國立大學法人奈良先端科學技術大學院大學 ,  NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： 鈴木利雄 ,  SUZUKI, TOSHIO ,  植田秀昭 ,  UEDA, HIDEAKI ,  長崎健 ,  NAGASAKI, TAKESHI ,  切畑光統 ,  KIRIHATA, MITSUNORI ,  沼田宗典 ,  NUMATA, MUNENORI ,  池田篤志 ,  IKEDA, ATSUSHI

IPC: A61K33/22 ,  A61K31/716 ,  A61N5/10

CPC classification number: C01B31/0273 ,  B22F1/0062 ,  B22F1/0074 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C07F5/027 ,  C08B37/0057 ,  C08K3/02 ,  C08K3/041 ,  C08K3/045 ,  C08K3/06 ,  C08K3/08 ,  Y10S977/734 ,  Y10S977/742 ,  C08L5/00

公开(公告)号：US20190198870A1

公开(公告)日：2019-06-27

申请号：US16327015

申请日：2017-08-21

Applicant: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Satoru WATANO ,  Hideya NAKAMURA

IPC: H01M4/40 ,  H01M10/0525 ,  H01M10/054 ,  H01M10/0562 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/587

CPC classification number: H01M4/405 ,  H01M4/36 ,  H01M4/40 ,  H01M4/48 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/58 ,  H01M4/587 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/054 ,  H01M10/0562 ,  H01M2004/028 ,  Y02E60/122 ,  Y02T10/7011

Abstract: A composite positive electrode active material for an all-solid-state secondary battery containing particles of a positive electrode active material and a sulfide-based solid electrolyte layer coating surfaces of the particles, wherein the composite positive electrode active material has an average roundness that is 1.3 times or more of that of a positive electrode active material at an inner core of the composite positive electrode active material.

公开(公告)号：US20190041337A1

公开(公告)日：2019-02-07

申请号：US16076637

申请日：2017-02-09

Applicant: SEKISUI CHEMICAL CO., LTD. ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Yoshinori Akagi ,  Nobuhiko Inui ,  Kazuhiko Imamura ,  Takamasa Kouno ,  Shigeru Nomura ,  Tatsuro Endo

IPC: G01N21/77 ,  G01N33/579

Abstract: Provided is an implement for inspection capable of measuring the concentration of a test substance with high accuracy. The implement for inspection according to the present invention is an implement for inspection used for measuring the concentration of a test substance that includes a compound for reacting with a test substance to form a granular substance or a compound which is for being bound to the test substance and is a granular substance, and a wall portion having a periodic structure on its surface.

公开(公告)号：US10137097B2

公开(公告)日：2018-11-27

申请号：US15574651

申请日：2016-06-08

Applicant: Osaka Prefecture University Public Corporation

Inventor： Hidemitsu Nakajima

IPC: A61K31/16 ,  A61K31/10 ,  A61P25/28 ,  A61P25/16 ,  A61K31/164 ,  C07C323/57

Abstract: [Problem] Provided is a non-peptide compound which can be used as a GAPDH aggregation inhibitor. [Solution] Provided is a GAPDH aggregation inhibitor including as an active ingredient a compound represented by the chemical formula 1 wherein R1, R2, and R3 are each independently a hydrogen atom, a halogen atom, or an aliphatic hydrocarbon group having a carbon number of from 1 to 10, a polysulfurized derivative thereof, or a pharmaceutically acceptable salt thereof. The present compound has a GAPDH aggregation inhibitory activity to suppress intracerebral aggregation of various proteins involved in cerebral neurodegenerative diseases, thereby contributing to improvement in various brain neurological diseases associated with aggregation of these proteins such as Alzheimer's disease, Parkinson's disease, and cerebral infarction, and prevention of advanced seriousness of these diseases.

公开(公告)号：US10125406B2

公开(公告)日：2018-11-13

申请号：US15108406

申请日：2014-12-28

Applicant: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Yasuhiro Konishi ,  Norizo Saito ,  Masao Kishida

IPC: C12N1/16 ,  C22B3/18 ,  C12R1/645 ,  C12R1/865 ,  C22B11/00 ,  C22B3/00 ,  C12P3/00

Abstract: The present application provides a method to recover noble metal ions by reduction with using yeast. In the method, a liquid containing noble metal ions is provided. An electron donor and yeast are added into the liquid to bring the yeast in contact with the noble metal ions to reduce the noble metal ions. The noble metal can be accumulated in a fungus body of the yeast. The electron donor can be an organic acid, a salt thereof, an alcohol and hydrogen gas.

公开(公告)号：US20180214528A1

公开(公告)日：2018-08-02

申请号：US15881452

申请日：2018-01-26

Applicant: TOAGOSEI CO., LTD. ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Ikuhiko NAKASE ,  Kosuke NOGUCHI ,  Nahoko BAILEYKOBAYASHI ,  Tetsuhiko YOSHIDA

IPC: A61K39/00 ,  A61K9/127

CPC classification number: A61K39/0011 ,  A61K9/127 ,  A61K35/36 ,  A61K35/54

Abstract: The pharmaceutical composition for inhibiting expression of CD47 in tumor cells provided by the present invention contains: exosomes produced by cultured tumor cells in an amount effective for inhibiting expression of the CD47; and a pharmaceutically acceptable carrier.

公开(公告)号：US09903861B2

公开(公告)日：2018-02-27

申请号：US14894452

申请日：2014-05-30

Applicant: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Takuya Iida ,  Shiho Tokonami

IPC: G01N21/21 ,  G01N33/543 ,  G01N21/552 ,  G01N21/65 ,  G01N33/53 ,  G01N33/553 ,  C12Q1/68

CPC classification number: G01N33/54346 ,  C12Q1/6834 ,  C12Q2563/155 ,  C12Q2565/628 ,  G01N21/21 ,  G01N21/554 ,  G01N21/658 ,  G01N33/5308 ,  G01N33/553 ,  G01N2201/061 ,  G01N2201/0683

Abstract: A detection device detects an analyte that may be contained in a specimen. The detection device includes a plurality of gold nanoparticles, an optical trapping light source, an illumination light source, an objective lens, an image pick-up device, and a computation unit. The plurality of gold nanoparticles are each modified with a probe DNA allowing the analyte to specifically adhere thereto. The optical trapping light source emits polarized light for assembling the plurality of gold nanoparticles together. The objective lens focuses and introduces the polarized light into a liquid containing a specimen and the plurality of gold nanoparticles. The image pick-up device receives light from the liquid. The computation unit detects an analyte based on a signal received from the image pick-up device.

公开(公告)号：US20170333987A1

公开(公告)日：2017-11-23

申请号：US15657300

申请日：2017-07-24

Applicant: DAIHEN CORPORATION ,  TECHNOLOGY RESEARCH INSTITUTE OF OSAKA PREFECTURE

Inventor： Ryusuke TSUBOTA ,  Junichi TANAKA ,  Yohei OKA ,  Takayuki NAKAMOTO ,  Takahiro SUGAHARA ,  Mamoru TAKEMURA ,  Sohei UCHIDA

IPC: B22F1/00 ,  C22C9/06 ,  C22C9/10 ,  B22F3/105 ,  B22F3/24 ,  C22C9/00 ,  C22C1/04 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

Abstract: A metal powder contains not less than 0.10 mass % and not more than 1.00 mass % of at least one of chromium and silicon, and a balance of copper. The total content of the chromium and the silicon is not more than 1.00 mass %. In accordance with an additive manufacturing method for this metal powder, an additively-manufactured article made from a copper alloy is provided. The additively-manufactured article has both an adequate mechanical strength and an adequate electrical conductivity.

公开(公告)号：US09800106B2

公开(公告)日：2017-10-24

申请号：US15122476

申请日：2015-03-04

Applicant: DAIKIN INDUSTRIES, LTD. ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Toshinari Kondou ,  Masayuki Sanada ,  Shigeo Morimoto ,  Yukinori Inoue

IPC: H02K21/12 ,  H02K1/27 ,  H02K1/02

CPC classification number: H02K1/276 ,  H02K1/02 ,  H02K2213/03

Abstract: Satisfactory magnet torque is achieved while avoiding a reduction in the reluctance torque generated. The rotor core is provided with a plurality of magnet slots arranged in the circumferential direction of the rotor core and a gap formed of base holes and a projecting hole. The base holes extend from both ends in the circumferential direction of each magnet slot to the outer side of the rotor core. The projecting hole projects in the circumferential direction of the rotor core from at least one of peripheral portions, opposed to each other, of the base holes provided at both of the ends of the magnet slot, when viewed in an axial direction. The projecting hole is located closer to the magnet slot than to an outer peripheral side end of the base hole.

公开(公告)号：US20170246304A1

公开(公告)日：2017-08-31

申请号：US15585228

申请日：2017-05-03

Applicant: TOAGOSEI CO., LTD ,  OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Ikuhiko Nakase ,  Tetsuhiko Yoshida ,  Nahoko Baileykobayashi

IPC: A61K47/46 ,  A61K38/18

CPC classification number: A61K47/46 ,  A61K9/5063 ,  A61K38/1808

Abstract: Provided is a novel material used to introduce an exogenous substance into cells. Also provided is a method for introducing an exogenous substance into target cells using this material. The present invention provides an exosome that is used to introduce an exogenous substance into target cells, wherein the exosome contains one type or two or more types of an exogenous substance and a substance that induces macropinocytosis in the target cells. The present invention also provides a composition containing the exosome and a method for introducing an exogenous substance into cells using this exosome.