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    METHOD OF PHOTODYNAMIC THERAPY (PDT) FOR BLADDER CANCER
    61.
    发明申请
    METHOD OF PHOTODYNAMIC THERAPY (PDT) FOR BLADDER CANCER 审中-公开
    光动力疗法（PDT）治疗膀胱癌的方法

    公开(公告)号：WO2017103285A1

    公开(公告)日：2017-06-22

    申请号：PCT/EP2016/081809

    申请日：2016-12-19

    Applicant: PHOTOCURE ASA

    Inventor： HESTDAL, Kjetil ,  GODAL, Aslak

    IPC: A61K41/00 ,  A61P35/00

    CPC classification number: A61K41/0061

    Abstract: This invention relates to a method of photodynamic therapy (PDT) for bladder cancer and its use as an adjuvant or neoadjuvant therapy in the treatment of bladder cancer. The invention provides a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a method of photodynamic therapy for bladder cancer, wherein said composition is instilled into the bladder of a patient in need of such treatment and the inside of said bladder is exposed to blue light having a fluence rate of 1.5 to 12.5 mW/cm2

    Abstract translation: 本发明涉及用于治疗膀胱癌的膀胱癌的光动力治疗（PDT）方法及其作为佐剂或新辅助疗法的用途。 本发明提供了包含己基5-ALA酯（HAL）或其药学上可接受的盐的组合物，其用于膀胱癌的光动力治疗方法中，其中所述组合物被滴注到需要这种治疗的患者的膀胱中， 所述气囊内部暴露于通量率为1.5至12.5mW / cm 2的蓝光

    DEVICE FOR PHOTODYNAMIC TREATMENT
    62.
    发明申请
    DEVICE FOR PHOTODYNAMIC TREATMENT 审中-公开
    光电处理设备

    公开(公告)号：WO2014079972A1

    公开(公告)日：2014-05-30

    申请号：PCT/EP2013/074469

    申请日：2013-11-22

    Applicant: PHOTOCURE ASA

    Inventor： GROSETH, Morten

    IPC: A61N5/06 ,  A61M25/10 ,  A61K41/00 ,  A61B17/00

    CPC classification number: A61K41/0061 ,  A61B2018/2261 ,  A61K41/0057 ,  A61N5/0603 ,  A61N5/062 ,  A61N2005/0609 ,  A61N2005/061 ,  A61N2005/0611 ,  A61N2005/0627 ,  A61N2005/063 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/0656 ,  A61N2005/0663 ,  A61N2005/067

    Abstract: The invention relates to a device for use in the photodynamic treatment of a body cavity or hollow organ of the body such as the bladder and to the use of such a device in the photodynamic treatment of abnormalities, disorders or diseases of the internal surfaces of said body cavity or hollow organ, such as of the bladder. The device comprises: an expandable structure for insertion within the body, wherein the expandable structure is arranged to be placed within the body cavity or hollow organ such that expansion of the structure will result in mechanical distention of the body cavity or hollow organ, and wherein the expandable structure is arranged such that light emitted within the body cavity or hollow organ when it has been distended by expansion of the expandable structure will irradiate an internal surface of said body cavity or hollow organ.

    Abstract translation: 本发明涉及一种用于身体的体腔或中空器官如膀胱的光动力学治疗的装置，以及在所述光学动力学治疗所述的内表面的异常，障碍或疾病中使用这种装置的装置 体腔或中空器官，如膀胱。 该装置包括：用于插入体内的可膨胀结构，其中可扩张结构布置成放置在体腔或中空器官内，使得结构的膨胀将导致体腔或中空器官的机械膨胀，并且其中 可扩展结构被布置成使得当通过可膨胀结构的膨胀膨胀时，在体腔或中空器官中发射的光将照射所述体腔或中空器官的内表面。

    COSMETIC COMPOSITIONS
    64.
    发明申请
    COSMETIC COMPOSITIONS 审中-公开
    化妆品组合物

    公开(公告)号：WO2011107478A1

    公开(公告)日：2011-09-09

    申请号：PCT/EP2011/053036

    申请日：2011-03-01

    Applicant: PHOTOCURE ASA ,  ALABATA, Enrique ,  HELLAND, Oddveig Sellæg ,  JENTOFT, Anja J. ,  JOHNSEN, Stig Ove

    Inventor： ALABATA, Enrique ,  HELLAND, Oddveig Sellæg ,  JENTOFT, Anja J. ,  JOHNSEN, Stig Ove

    IPC: A61K8/06 ,  A61K8/37 ,  A61K8/44 ,  A61Q19/02 ,  A61Q19/08

    CPC classification number: A61K8/44 ,  A61K8/06 ,  A61K8/92 ,  A61K2800/522 ,  A61K2800/88 ,  A61Q17/04 ,  A61Q19/08

    Abstract: The present invention relates to compositions comprising a derivative of 5 - aminolevulinic acid (5-ALA), e.g. an ester of 5-ALA or a skin compatible salt thereof. Further, the invention relates to use of such compositions in methods of cosmetic or therapeutic treatment, particularly in methods of improving or otherwise enhancing the appearance of the skin. The compositions comprise 2% by weight or less of a derivative of 5-ALA, 70% by weight or more of water, 2-25% by weight of at least one liquid carrier and one or more emulsifiers. A container comprises a first compartment comprising a derivative of 5-ALA and at least one liquid carrier and a second compartment comprising water, one or more emulsifiers and optionally at least one liquid carrier. The composition is obtained by mixing the contents of the two compartments.

    Abstract translation: 本发明涉及包含5-氨基乙酰丙酸（5-ALA）衍生物的组合物，例如。 5-ALA的酯或其与皮肤相容的盐。 此外，本发明涉及这样的组合物在化妆品或治疗性治疗方法中的用途，特别是在改善或以其它方式增强皮肤外观的方法中。 组合物包含2重量％或更少的5-ALA衍生物，70重量％或更多的水，2-25重量％的至少一种液体载体和一种或多种乳化剂。 容器包括包含5-ALA衍生物和至少一种液体载体的第一隔室和包含水，一种或多种乳化剂和任选的至少一种液体载体的第二隔室。 通过混合两个隔室的内容物获得组合物。

    ENEMA PREPARATIONS AND THEIR USE
    66.
    发明申请
    ENEMA PREPARATIONS AND THEIR USE 审中-公开

    公开(公告)号：WO2010072419A3

    公开(公告)日：2010-07-01

    申请号：PCT/EP2009/009293

    申请日：2009-12-23

    Applicant: PHOTOCURE ASA ,  GODAL, Aslak ,  KLAVENESS, Jo

    Inventor： GODAL, Aslak ,  KLAVENESS, Jo

    IPC: A61K9/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/34 ,  A61K47/38 ,  A61K41/00

    Abstract: This invention relates to improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions, and in particular to improved enema preparations for use in such methods, said enema preparations comprising a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester. Such preparations may further comprise one or more viscosity enhancing agents, mucoadhesive or mucolytic agents, penetration enhancers or chelating agents. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing cancer and non-cancerous conditions in the colon and/or rectum.

    USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF
    67.
    发明申请
    USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF 审中-公开

    公开(公告)号：WO2008084241A3

    公开(公告)日：2008-07-17

    申请号：PCT/GB2008/000086

    申请日：2008-01-11

    Applicant: PHOTOCURE ASA ,  GOLDING, Louise ,  WULF, Hans, Christian ,  GODAL, Aslak ,  KLAVENESS, Jo

    Inventor： WULF, Hans, Christian ,  GODAL, Aslak ,  KLAVENESS, Jo

    IPC: A61K31/221 ,  A61K41/00 ,  A61K31/197 ,  A61P17/10 ,  A61P35/00

    Abstract: The invention provides the use of a photosensitiser which is 5- aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10 % wt (e.g. 0.5 to 8 %wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm 2 (e.g. 5 to 40 mW/cm 2 ), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).

    5-AMINOLEVULINIC ACID AND ESTERS, IN COMBINATION WITH ANOTHER PHTOSENSITIZER, AS PHOTOSENSITIZING AGENTS IN PHOTOCHEMOTHERAPY, AND THEIR USES IN TREATING WOUNDS
    68.
    发明申请
    5-AMINOLEVULINIC ACID AND ESTERS, IN COMBINATION WITH ANOTHER PHTOSENSITIZER, AS PHOTOSENSITIZING AGENTS IN PHOTOCHEMOTHERAPY, AND THEIR USES IN TREATING WOUNDS 审中-公开
    5-氨基冰片酸和酯，与另一种光敏剂，作为光敏剂在光化学治疗中的应用，以及它们用于治疗伤口的用途

    公开(公告)号：WO03011265A3

    公开(公告)日：2003-04-24

    申请号：PCT/GB0203386

    申请日：2002-07-25

    Applicant: PHOTOCURE ASA ,  KLAVENESS JO ,  HANSSON VIDAR ,  GOLDING LOUISE

    Inventor： KLAVENESS JO ,  HANSSON VIDAR

    IPC: A61K31/409 ,  A61K31/197 ,  A61K31/22 ,  A61K31/222 ,  A61K31/25 ,  A61K31/27 ,  A61K31/4406 ,  A61K41/00 ,  A61P1/04 ,  A61P9/00 ,  A61P17/02

    CPC classification number: A61K41/0061

    Abstract: The method relates to the use of a photosensitizer selected from 5-aminolevulinic acid (5-ALA) and 5-ALA derivatives, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in treating a wound. Examples of wounds which may be treated in accordance with the invention include those resulting from non-physiological processes, e.g. from surgery or from physical injury, abrasions, lacerations, and wounds arising from a thermal injury (e.g. a burn or a wound arising from any cryo-based treatment). Ulcers, e.g. leg ulcers, venous ulcers and gastric ulcers, may also be successfully treated in accordance with the methods of the invention.

    Abstract translation: 该方法涉及使用选自5-氨基乙酰丙酸（5-ALA）和5-ALA衍生物的光敏剂及其药学上可接受的盐在制备用于治疗伤口的药物中的用途。 根据本发明可以治疗的伤口的例子包括由非生理过程产生的伤口， 从手术或由于热损伤（例如由任何基于冷冻治疗引起的烧伤或伤口）引起的身体损伤，擦伤，撕裂伤和伤口。 溃疡，例如 根据本发明的方法也可以成功治疗腿部溃疡，静脉溃疡和胃溃疡。

    METHOD
    69.
    发明申请
    METHOD 审中-公开
    5-氨基酸和酯，与其他光敏剂组合使用，作为光致变色剂中的光敏剂，以及它们在治疗伤口中的用途

    公开(公告)号：WO2003011265A2

    公开(公告)日：2003-02-13

    申请号：PCT/GB2002/003386

    申请日：2002-07-25

    Applicant: PHOTOCURE ASA ,  GOLDING, Louise ,  KLAVENESS, Jo ,  HANSSON, Vidar

    Inventor： KLAVENESS, Jo ,  HANSSON, Vidar

    IPC: A61K31/00

    CPC classification number: A61K41/0061

    Abstract: The method relates to the use of a photosensitizer selected from 5-aminolevulinic acid (5-ALA) and 5-ALA derivatives, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in treating a wound. Examples of wounds which may be treated in accordance with the invention include those resulting from non-physiological processes, e.g. from surgery or from physical injury, abrasions, lacerations, and wounds arising from a thermal injury (e.g. a burn or a wound arising from any cryo-based treatment). Ulcers, e.g. leg ulcers, venous ulcers and gastric ulcers, may also be successfully treated in accordance with the methods of the invention.

    Abstract translation: 该方法涉及在制备用于治疗伤口的药物中使用选自5-氨基乙酰丙酸（5-ALA）和5-ALA衍生物的光敏剂及其药学上可接受的盐。 根据本发明可以治疗的伤口的实例包括由非生理过程产生的伤口。 来自手术或来自身体伤害，擦伤，撕裂和由热损伤引起的伤口（例如，由任何基于冷冻的治疗产生的烧伤或伤口）。 溃疡，例如 还可以根据本发明的方法成功治疗腿部溃疡，静脉溃疡和胃溃疡。

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