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    Use of aminolevulinic acid and derivative thereof
    2.
    发明专利
    Use of aminolevulinic acid and derivative thereof 有权
    氨基酸及其衍生物的使用

    公开(公告)号：JP2014094963A

    公开(公告)日：2014-05-22

    申请号：JP2014009382

    申请日：2014-01-22

    Applicant: Photocure Asa ,  フォトキュア エイエスエイ

    Inventor： HANS CHRISTIAN WULF ,  ASLAK GODAL ,  JO KLAVENESS

    IPC: A61K31/22 ,  A61P31/12

    CPC classification number: A61K41/0061 ,  A61K31/221 ,  A61N5/062

    Abstract: PROBLEM TO BE SOLVED: To provide hexyl ester of 5-aminolevulinic acid (5-ALA) or a pharmaceutically acceptable salt thereof and use thereof, in the manufacture of a composition for use in a method of photodynamic therapy (PDT) on an animal to treat the viral infection of lining of the vagina, uterine cervix, and uterus.SOLUTION: The PDT comprises the steps of: (a) administering to an animal a composition; and (b) photoactivating the hexyl ester of 5-ALA. Further, the PDT uses (i): the composition comprises the hexyl ester of 5-ALA in a concentration of 0.5 to 6 wt.% in combination with (iii): the photoactivation is carried out with a light source having a fluence rate of 5 to 40 mW/cm, thereby preventing or reducing side-effect of the PDT.

    Abstract translation: 要解决的问题：提供5-氨基乙酰丙酸（5-ALA）的己基酯或其药学上可接受的盐及其用途，在制备用于动物的光动力疗法（PDT）的方法中使用的组合物 治疗阴道，子宫颈和子宫内膜的病毒感染。解决方案：PDT包括以下步骤：（a）向动物施用组合物; 和（b）光活化5-ALA的己酯。 此外，PDT使用（i）：组合物包含浓度为0.5至6重量％的5-ALA的己基酯与（iii）的组合：光活化用光通量为 5至40mW / cm，从而防止或减少PDT的副作用。

    Semi-solid compositions and pharmaceutical products
    5.
    发明授权
    Semi-solid compositions and pharmaceutical products 有权
    半固体组合物和药物产品

    公开(公告)号：US09326964B2

    公开(公告)日：2016-05-03

    申请号：US14707639

    申请日：2015-05-08

    Applicant: PHOTOCURE ASA

    Inventor： Gry Stensrud

    IPC: A61K31/195 ,  A61K31/221 ,  A61K9/00 ,  A61K9/06 ,  A61K41/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26

    CPC classification number: A61K31/221 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/195 ,  A61K41/0061 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26

    Abstract: This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.

    Abstract translation: 本发明涉及用于癌症的光动力学治疗（PDT），女性生殖系统，肛门和阴茎中的癌前病症和非癌症状态的半固体组合物和半固体药物产品，优选用于 在子宫内膜，子宫颈，外阴，阴道，肛门和阴茎发育异常和子宫，子宫颈，外阴，阴道，肛门和阴茎的HPV感染的PDT中。 半固体组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。 本发明还涉及在雌性生殖系统，肛门和阴茎中的癌症的PDT，癌前病症和非癌症病症的方法，其中使用所述半固体组合物和药物产品。

    IRRADIATION DEVICE
    6.
    发明申请
    IRRADIATION DEVICE 有权
    辐射装置

    公开(公告)号：US20160045757A1

    公开(公告)日：2016-02-18

    申请号：US14783240

    申请日：2014-04-09

    Applicant: PHOTOCURE ASA

    Inventor： Morten GROSETH

    IPC: A61N5/06 ,  A61K41/00

    CPC classification number: A61N5/062 ,  A61K41/0061 ,  A61N5/0603 ,  A61N2005/0605 ,  A61N2005/0607 ,  A61N2005/0608 ,  A61N2005/0611 ,  A61N2005/0632 ,  A61N2005/0645 ,  A61N2005/0651 ,  A61N2005/0652

    Abstract: An irradiation device for insertion into an orifice of the body to provide photodynamic therapy comprises: a housing moulded from a resilient material and adapted to be fully inserted and secured in the orifice, the housing enclosing an LED lamp system 22 and a power source 41 for powering the LED lamp system 22; wherein the device is independently operational while located in the orifice; characterised in that: the housing comprises a first housing part 2 for holding the power source 41 and a second housing part 4 for holding the LED lamp system 22, the first and second housing parts 2, 4 being separable and being preferably formed separately from the LED lamp system 22; and in that the first housing part 2 consists of a chamber 6 for holding the power source 41 and an opening 26 into the chamber 6 is provided through a resilient opening part 8, wherein the chamber 6 is closed when the first housing part 2 is joined to the second housing part 4.

    Abstract translation: 一种用于插入身体的孔中以提供光动力疗法的照射装置包括：由弹性材料模制的并适于完全插入并固定在孔中的壳体，壳体包围LED灯系统22和用于 为LED灯系统22供电; 其中所述装置在位于所述孔中时独立地操作; 其特征在于：壳体包括用于保持电源41的第一壳体部分2和用于保持LED灯泡系统22的第二壳体部分4，第一和第二壳体部分2,4可分离并优选地与 LED灯系统22; 并且第一壳体部分2包括用于保持动力源41的腔室6和通过弹性开口部分8设置在腔室6中的开口26，其中当第一壳体部分2接合时腔室6关闭 到第二壳体部分4。

    USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF
    7.
    发明申请
    USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF 审中-公开

    公开(公告)号：US20160030565A1

    公开(公告)日：2016-02-04

    申请号：US14873566

    申请日：2015-10-02

    Applicant: Photocure ASA

    Inventor： Hans Christian Wulf ,  Aslak Godal ,  Jo Klaveness ,  Per Harald Fuglerud

    IPC: A61K41/00 ,  A61N5/06 ,  A61K31/221

    CPC classification number: A61K41/0061 ,  A61K31/221 ,  A61N5/0616 ,  A61N5/062 ,  A61N2005/0652 ,  A61N2005/0662 ,  A61N2005/0663

    Abstract: The invention provides the use of a photosensitiser which is a derivative (e.g. an ester) of 5-aminolevulinic acid (5-ALA), or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side effects of PDT are prevented or reduced by using (ii) or (iv) in combination with (i) and/or (ii).

    Method of photodynamic therapy (PDT) for bladder cancer
    9.
    发明授权
    Method of photodynamic therapy (PDT) for bladder cancer 有权

    公开(公告)号：US11235168B2

    公开(公告)日：2022-02-01

    申请号：US16063142

    申请日：2016-12-19

    Applicant: PHOTOCURE ASA

    Inventor： Kjetil Hestdal ,  Aslak Godal

    IPC: A61N5/06 ,  A61K41/00 ,  A61B1/307

    Abstract: This invention relates to a method of photodynamic therapy (PDT) for bladder cancer and its use as an adjuvant or neoadjuvant therapy in the treatment of bladder cancer. The invention provides a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a method of photodynamic therapy for bladder cancer, wherein said composition is instilled into the bladder of a patient in need of such treatment and the inside of said bladder is exposed to blue light having a fluence rate of 1.5 to 12.5 mW/cm2.

    METHOD FOR PREPARING A LIQUID PHARMACEUTICAL COMPOSITION AND DEVICE FOR USE IN SUCH METHOD
    10.
    发明申请
    METHOD FOR PREPARING A LIQUID PHARMACEUTICAL COMPOSITION AND DEVICE FOR USE IN SUCH METHOD 有权

    公开(公告)号：US20210145969A1

    公开(公告)日：2021-05-20

    申请号：US16623540

    申请日：2018-06-21

    Applicant: PHOTOCURE ASA

    Inventor： Tore Gjørsvik

    IPC: A61K41/00 ,  A61M5/14

    Abstract: The invention relates to a dissolution chamber (10) for use with a catheter for dissolving and preparing an aqueous solution of a water-soluble photosensitizing agent for installation into the bladder, e.g. for use in photodynamic diagnosis (PDD) or photodynamic therapy (PDT) of bladder cancer and to a method for preparing a liquid pharmaceutical preparation for delivery into a patient's bladder which includes the use of said dissolution chamber (10).

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