Abstract:
The present disclosure relates to compounds according to Formula (I), Formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, compositions including such compounds, and methods useful for treating, preventing, and/or ameliorating a CDK4 and/or CDK6-mediated disorder, disease, or condition (e.g., cancer such as breast cancer) in a subject.
Abstract:
The present invention relates to a method for creating an individualized machine learning inference model. In accordance with the invention, the aforementioned method and a related system involve a motion capture device adapted to be worn by a user. The motion capture device is adapted to acquire measurements, which are used to compute a first estimate of one or more gait parameters. Next, a database is accessed that contains previously collected observations of gait data and the first estimate is compared to the previously collected observations of gait data. Finally, the subset of previously collected observations of gait data that is most informative for the particular user is identified and the individualized machine learning inference model can be developed using the identified subset of previously collected observations of gait data.
Abstract:
Flexible and stretchable supercapacitors are made using carbon nanostructures produced by providing a first composite structure which includes a temporary substrate and an array of carbon nanotubes arranged in a stack on a surface of the temporary substrate such that the stack of carbon nanotubes is oriented generally perpendicular to the surface of the temporary substrate, which may include silicon dioxide. The stack of carbon nanotubes is transferred from the temporary substrate to another substrate, which includes a curable polymer, thereby forming another composite structure comprising the stack of carbon nanotubes and the cured polymer. (FIG. 1 (c)).
Abstract:
The described invention provides a well plate-based perfusion culture model of endosteal-, extracellular matrix (ECM)- and endothelial- myeloma interactions and patient-specific methods for selecting treatment for and assessing drug resistance of multiple myeloma (MM). The described methods utilize an ex vivo three dimensional endosteal microenvironment effective to recapitulate spatial and temporal characteristics of a multiple myeloma cancer niche and to maintain viability of multiple myeloma cells (MMCs) obtained from a patient suffering from MM.
Abstract:
A film for the retention and controlled release of organic or inorganic molecules consists essentially of a phyllosilicate clay and a organic polyanion. The film may be a built-up layered film of alternating layers of the clay and the polyanion. Organic or inorganic molecules are absorbed into the film from solution, and released in response to changes in the film's environment. The film may be built up using layer-by- layer (LbL) methods, or deposited on a substrate from a mixture of the clay and polyanion. Articles may be coated with the film by the same methods. The film is useful for the controlled release of antibiotics in response to infections, and also retains antibiotics such that bacteria may be killed by direct contact with the film.
Abstract:
The present invention relates to surface-patterned microgels to which molecular beacon probes are immobilized. The immobilized molecular beacon probes exhibit both low non-specific background and high specific fluorescence. Also disclosed are related arrays, related detection methods, and preparation methods.
Abstract:
A method for removing dissolved contaminants from solution using a surface-activated crystalline titanium oxide product having a high adsorptive capacity and a high rate of adsorption with respect to dissolved contaminants, in particular, arsenate and arsenite. Preferably, the titanium oxide product includes crystalline anatase having primary crystallite diameters in the range of 1-30 nm. The surface- activated titanium oxide is combined with other filter media to further improve the removal of dissolved contaminants.
Abstract:
The present invention is a friction- and backlash-free flexible parallel manipulator device. The device is composed of multiple elastic fiber legs with various physical properties, a top platform, and a bottom platform. With multiple degrees of freedom, the motion of the top platform is controlled by the multiple elastic fiber legs whose lengths or curvatures between the top and bottom platforms are controlled based on the required motion of the top platform. The device can be used for nano-, micro-, or meso- manipulation.
Abstract:
An inventive sensor is used in combination with spectroscopic techniques to detect, identify and quantify ultratrace (ppt to ppb) quantities of analytes in air or water samples. The sensor preferably comprises a photonic crystal fiber having an air hole cladding with functionalized air holes. Surface-enhanced Raman spectroscopy is a preferred spectroscopic technique. In such applications, the air holes of the fiber may be functionalized by adsorbing a self-assembled monolayer on their inner surfaces, and immobilizing metallic nanoparticles to the monolayer. The invention has chemical and biomedical applications, and utility in detecting chemical and biological agents used in warfare.