公开(公告)号：NL2007536C

公开(公告)日：2013-04-08

申请号：NL2007536

申请日：2011-10-05

Applicant: ACADEMISCH ZIEKENHUIS LEIDEN LUMC ,  UNIV LEIDEN ,  ISA PHARMACEUTICALS B V ,  STICHTING TOP INST PHARMA ,  STICHTING KATHOLIEKE UNIV

Inventor： OSSENDORP FERDINAND ANTONIUS ,  MELIEF CORNELIS JOHANNES MARIA ,  KHAN SELINA ,  FILIPPOV DMITRI VIKTOROVITSJ ,  MAREL GIJSBERT ARIE

IPC: A61K39/39

CPC classification number: A61K39/39 ,  A61K47/50 ,  A61K47/62 ,  A61K47/6801 ,  A61K2039/55511 ,  A61K2039/55516 ,  C07K7/04 ,  C07K7/06

Abstract: The invention is directed to a compound according to the formula [1] wherein R1 and R2 are branched or straight groups having up to 17 atoms selected from carbon, nitrogen, oxygen and sulphur, n is 0 to and including 18, Y is sulphur or selene, X is S or 0 and R is —OH or an organic group comprising one or more peptides, one or more nucleic acids, one or more antibodies or combinations thereof. The invention is also directed to process for preparing said compound and the use of said compound as an adjuvant. The invention is also directed to a composition comprising said compound and the use of said composition, for example as a vaccine composition.

公开(公告)号：AU2011292497A1

公开(公告)日：2013-03-07

申请号：AU2011292497

申请日：2011-08-16

Applicant: STICHTING KATHOLIEKE UNIV

Inventor： JOOSTEN LEONARDUS ANTONIUS BERNARDUS ,  NETEA MIHAI GHEORGHE ,  VAN DER MEER JOHANNES WILLEM MAARTEN ,  KULLBERG BART JULIAN ,  VAN DEUREN MARCEL

IPC: G01N33/68 ,  G01N33/558

Abstract: The present invention relates to a method for diagnosing Q-fever in a subject, the method comprising the steps of: (a) obtaining a sample from said subject, (b) contacting said sample with a source of a

公开(公告)号：NL2007062C

公开(公告)日：2013-01-08

申请号：NL2007062

申请日：2011-07-07

Applicant: STICHTING KATHOLIEKE UNIV

Inventor： BERG ALBERT VICTOR

IPC: A61B3/024 ,  A61B3/032 ,  A61B3/113 ,  A61B5/055

CPC classification number: A61B3/024 ,  A61B3/0033 ,  A61B3/032 ,  A61B3/113 ,  A61B5/055

公开(公告)号：NL2005197C

公开(公告)日：2012-02-07

申请号：NL2005197

申请日：2010-08-06

Applicant: STICHTING KATHOLIEKE UNIV

Inventor： SCHOUTEN THEODORUS EVERARDUS ,  BROEK EGIDIUS LEON

IPC: G06K9/00

CPC classification number: G06K9/00785 ,  G06K9/00201 ,  G06K9/00771

公开(公告)号：AT490337T

公开(公告)日：2010-12-15

申请号：AT06700777

申请日：2006-01-09

Applicant: STICHTING KATHOLIEKE UNIV

Inventor： VAN HEERDE WAANDER

IPC: C12Q1/56

Abstract: Provided is a hemostasis assay comprising a reaction mixture comprising a blood product to be tested, a trigger molecule for inducing thrombin generation, a thrombin-specific substrate which, upon cleavage by thrombin, produces a measurable thrombin-specific signal, a trigger molecule for inducing plasmin generation, a plasmin-specific substrate which, upon cleavage by plasmin, produces a measurable plasmin-specific signal, a phospholipid-containing surface, and calcium ions. The assay allows determination of the amount of thrombin and the amount of plasmin generated in the reaction mixture in time, starting at t=0, by measuring the thrombin-specific and plasmin-specific signals.

公开(公告)号：DE602006016347D1

公开(公告)日：2010-09-30

申请号：DE602006016347

申请日：2006-05-24

Applicant: STICHTING KATHOLIEKE UNIV

Inventor： RASING THEODORUS HENRICUS MARIA ,  KIRILIOUK ANDREI IVANOVITCH ,  KIMEL ALEXEY VOLDEMAROVITSJ ,  STANCIU CLAUDIU DANIEL ,  HANSTEEN FREDRIK ,  ITOH AKIYOSHI ,  TSUKAMOTO ARATA

IPC: G11B11/10 ,  G11B11/105

公开(公告)号：AT478419T

公开(公告)日：2010-09-15

申请号：AT06757783

申请日：2006-05-24

Applicant: STICHTING KATHOLIEKE UNIV

Inventor： RASING THEODORUS HENRICUS MARIA ,  KIRILIOUK ANDREI IVANOVITCH ,  KIMEL ALEXEY VOLDEMAROVITSJ ,  STANCIU CLAUDIU DANIEL ,  HANSTEEN FREDRIK ,  ITOH AKIYOSHI ,  TSUKAMOTO ARATA

IPC: G11B11/10 ,  G11B11/105

Abstract: The invention relates to a magneto-optical switching device for switching magnetization in a medium, comprising a magnetizable medium. According to the invention, a radiation system suited for imparting angular momentum to the magnetic spin system of said magnetizable medium, so as to selectively orient the magnetization of said medium. In addition, the invention relates to a method of switching a magnetizable medium, comprising providing a magnetizable medium; providing a radiation beam of a selectively chosen angular momentum; and targeting said radiation beam to said medium so as to transfer said angular momentum to a magnetic spin system of said magnetizable medium. Accordingly, spin states in magnetic materials can be manipulated using radiation of a suitable angular momentum. An effective magnetic field is generated for orienting the magnetization of the domains and can simultaneously be used to locally heat the material.

公开(公告)号：IL188688D0

公开(公告)日：2008-08-07

申请号：IL18868808

申请日：2008-01-09

Applicant: STICHTING KATHOLIEKE UNIV

IPC: C07K20100101

公开(公告)号：CA2286304C

公开(公告)日：2007-08-07

申请号：CA2286304

申请日：1998-04-09

Applicant: STICHTING KATHOLIEKE UNIV ,  UNIV JOHNS HOPKINS

Inventor： BUSSEMAKERS MARION J G ,  ISAACS WILLIAM B

IPC: A01K67/027 ,  C12N15/12 ,  A61K31/711 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P13/08 ,  A61P35/00 ,  C07H21/04 ,  C07K14/47 ,  C07K16/18 ,  C12N1/21 ,  C12N5/10 ,  C12N5/12 ,  C12N15/09 ,  C12N15/63 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/577

Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer, therapeutic uses; and methods of preventing prostate cancer in an animal.

公开(公告)号：CA2625993A1

公开(公告)日：2007-04-19

申请号：CA2625993

申请日：2006-10-13

Applicant: STICHTING KATHOLIEKE UNIV

Inventor： BOERMAN OTTO ,  RENNEN HUUB

IPC: C07K14/54 ,  G01N33/68