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    Specific method for detecting prostate cancer based on pca3 gene and kit for performing the same
    1.
    发明专利
    Specific method for detecting prostate cancer based on pca3 gene and kit for performing the same 审中-公开
    用于检测基于PCA3基因的前列腺癌的特异性方法和用于实施其的试剂盒

    公开(公告)号：JP2011172574A

    公开(公告)日：2011-09-08

    申请号：JP2011059978

    申请日：2011-03-18

    Applicant: Stichting Katholieke Univ Univ Medical Centre Nijmegen ,  スティヘイティング カソリケ ユニフェルシテイト、ユニバーシティ メディカル センター ナイメーヘン

    Inventor： SCHALKEN JACK A ,  VERHAEGH GERALD ,  HESSELS DAPHNE ,  SMIT FRANK

    IPC: C12Q1/68 ,  C12N15/09

    CPC classification number: C12Q1/6886 ,  C12Q2600/158

    Abstract: PROBLEM TO BE SOLVED: To provide a method for diagnosing prostate cancer of a patient by detecting a PCA3 sequence, for example, a PCA3 RNA in a sample from the patient to be or not to be specifically associated with prostate cancer, and an in vitro method for detecting kidney cells or bladder cells from a non-prostate sample derived from the urinary tract.
    SOLUTION: The method for detecting the presence of kidney cells or bladder cells in the sample includes isolating the RNA from the non-prostate sample derived from the objective organism, amplifying PCA3 nucleic acid contained in the RNA using a primer and detecting the amplified nucleic acid including intron 3 of PCA3 or a complimentary chain thereof in the collected amplified product.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种通过检测PCA3序列来诊断患者的前列腺癌的方法，例如来自患者的样品中的PCA3 RNA将与前列腺癌特异性相关，以及 用于从源自泌尿道的非前列腺样品检测肾细胞或膀胱细胞的体外方法。 解决方案：用于检测样品中肾细胞或膀胱细胞存在的方法包括从来自目标生物体的非前列腺样品中分离RNA，使用引物扩增RNA中所含的PCA3核酸，并检测 在收集的扩增产物中扩增的核酸包括PCA3的内含子3或其互补链。 版权所有（C）2011，JPO＆INPIT

    AUTOMATED SYSTEM FOR TRAINING ORAL LANGUAGE PROFICIENCY
    7.
    发明申请
    AUTOMATED SYSTEM FOR TRAINING ORAL LANGUAGE PROFICIENCY 审中-公开
    用于培训口语语言专业的自动化系统

    公开(公告)号：WO2013172707A3

    公开(公告)日：2014-01-16

    申请号：PCT/NL2013050356

    申请日：2013-05-14

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： STRIK WILHELMUS ALBERTUS JOHANNES ,  CUCCHIARINI CATIA

    IPC: G09B5/04

    CPC classification number: G09B5/04 ,  G09B19/06

    Abstract: The present invention is in the field of automated systems and methods for improving of oral language proficiency. As a result of increasing internationalization there is a growing demand from education and business community for people who speak foreign languages well. An intelligible pronunciation is regarded as important for e.g. successful inter- action and social acceptance. However, an important problem is that oral proficiency training requires so much time, feedback and practice, that very often it cannot be sufficiently provided in traditional language classes. Thereto an automated system is provided.

    Abstract translation: 本发明涉及用于提高口语能力的自动化系统和方法领域。 由于国际化日益加强，教育和商业界对外语人士的需求日益增加。 一个可理解的发音被认为是重要的。 成功的相互作用和社会接受。 然而，一个重要的问题是口语能力培训需要很多时间，反馈和实践，这在传统的语言课程中往往不能充分提供。 提供了一个自动化系统。

    BLOOD COAGULATION STATUS MEASUREMENT IN SALIVA
    9.
    发明申请
    BLOOD COAGULATION STATUS MEASUREMENT IN SALIVA 审中-公开
    唾液中的血液凝固状况测量

    公开(公告)号：WO2011049442A3

    公开(公告)日：2011-06-30

    申请号：PCT/NL2010050693

    申请日：2010-10-19

    Applicant: STICHTING KATHOLIEKE UNIV ,  LOOF ARNOUD HARMEN ,  VAN HEERDE WAANDER LAURENS

    Inventor： LOOF ARNOUD HARMEN ,  VAN HEERDE WAANDER LAURENS

    IPC: G01N33/86

    CPC classification number: G01N33/86 ,  G01N33/6848

    Abstract: The present invention is concerned with a method for measuring blood coagulation status in a saliva sample from a subject by measuring the concentration of various proteins which have been demonstrated to correlate with the international normalized ratio in said saliva. The invention further relates to a non-invasive device for performing said method, as well as a kit suitable for performing said method.

    Abstract translation: 本发明涉及通过测量已证明与所述唾液中的国际标准化比率相关的各种蛋白质的浓度来测量来自受试者的唾液样品中的凝血状态的方法。 本发明还涉及用于执行所述方法的非侵入式装置，以及适用于执行所述方法的套件。

    METHOD FOR OBTAINING HOLLOW PARTICLES
    10.
    发明申请
    METHOD FOR OBTAINING HOLLOW PARTICLES 审中-公开
    获得中空颗粒的方法

    公开(公告)号：WO2007064191A8

    公开(公告)日：2007-09-27

    申请号：PCT/NL2005000828

    申请日：2005-12-02

    Applicant: STICHTING KATHOLIEKE UNIV ,  DAAMEN WILHELMINA FRANCISCA ,  GEUTJES PETRUS JOHANNES ,  VAN KUPPEVELT ANTONIUS HENRICU

    Inventor： DAAMEN WILHELMINA FRANCISCA ,  GEUTJES PETRUS JOHANNES ,  VAN KUPPEVELT ANTONIUS HENRICU

    IPC: A61K9/16

    CPC classification number: A61K9/1652 ,  A61K9/1658 ,  Y10T428/2984

    Abstract: Described is a method for obtaining hollow particles, having a particle wall and a particle lumen, the particle having dimensions of between 1 nm and 100 µm, from a mixture comprising a liquid medium comprising at least one colloid or solute, the method comprising freezing said mixture and lyophilising the obtained frozen mixture, characterised in that a volume of at least 0.1 µl of the mixture is subjected to a freezing step comprising: (a) (1) quench freezing the mixture resulting in a quench frozen mixture, and (2) incubating said quench frozen mixture at a temperature above the quench freezing temperature and below the melting point of the liquid medium, or b) (1) reducing the temperature of the mixture at a rate of 1 to 100 °C/minute to below the freezing temperature of the mixture and (2) incubating said frozen mixture at a temperature above the temperature of the mixture and below the melting point of the liquid medium. Further, hollow particles obtainable by the said method, compositions comprising said hollow particles and uses thereof are described.

    Abstract translation: 描述了一种从包含至少一种胶体或溶质的液体介质的混合物中获得具有颗粒壁和颗粒内腔，尺寸为1nm至100μm的颗粒的中空颗粒的方法，所述方法包括将所述 混合物并冻干所得的冷冻混合物，其特征在于至少0.1μl混合物的体积进行冷冻步骤，包括：（a）（1）骤冷冷冻混合物，得到骤冷的混合物，和（2） 在高于猝灭冷冻温度并低于液体培养基的熔点的温度下孵育所述骤冷冷冻混合物，或b）（1）以1至100℃/分钟的速率将混合物的温度降低至低于冰点 混合物的温度和（2）在高于混合物温度并低于液体介质的熔点的温度下孵育所述冷冻混合物。 此外，描述了可通过所述方法获得的中空颗粒，包含所述中空颗粒的组合物及其用途。

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