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    FIBER ENDOSCOPE
    62.
    发明申请
    FIBER ENDOSCOPE 有权

    公开(公告)号：US20210022590A1

    公开(公告)日：2021-01-28

    申请号：US17042488

    申请日：2019-03-28

    Applicant: Stichting VU

    Inventor： Fabio FEROLDI ,  Johannes Fitzgerald DE BOER

    IPC: A61B1/00 ,  G02B6/28

    Abstract: A fibre endoscope system (100) comprises a catheter (10) with a probe head (10a) for entering into a body cavity (C) adjacent or near a sample region (S). A source fiber (11) has a first fiber ending (11a) and a signal fiber (12) has a second fiber ending (12a) both remote from the probe head (10a) but separate. A sampling fiber (13) has a third fiber ending (13a) disposed at the probe head (10a). A fiber coupler (15) is configured to optically couple at least the source fiber (11) to the sampling fiber (13), and the sampling fiber (13) to the signal fiber (12). A sampling fiber length (L13) of the sampling fiber (13) between a fiber coupler (15) and the third fiber ending (13a) is shorter than a source fiber length (L11) of the source fiber (11) between the fiber coupler (15) and the first fiber ending (11a).

    METHOD OF DETERMINING BRAIN ACTIVITY
    63.
    发明申请
    METHOD OF DETERMINING BRAIN ACTIVITY 有权

    公开(公告)号：US20210000367A1

    公开(公告)日：2021-01-07

    申请号：US16981065

    申请日：2019-03-18

    Applicant: Stichting VU

    Inventor： Klaus LINKENKAER-HANSEN ,  Richard Edward HARDSTONE

    IPC: A61B5/04 ,  A61B5/0476 ,  A61B5/00

    Abstract: A first aspect provides, in a device for processing biomedical data obtained from a body, a method of determining brain activity. The method comprises obtaining neuron oscillation signal data of a first part of a brain over a period of time. The oscillation signal data is apportioned in timeslots within the period and per time slot, based on the oscillation data for the timeslot, an amplitude value and variation value representing data values in the timeslot are obtained. A correlation value is determined between the amplitude values and the corresponding variation values over at least a substantial part of the first time period; and the correlation value is provided as an output. The correlation value may optionally be used for estimating a ratio between excitation and inhibition activity of the brain under scrutiny.

    METHOD AND SYSTEM FOR OPTICAL FORCE MEASUREMENT
    64.
    发明申请
    METHOD AND SYSTEM FOR OPTICAL FORCE MEASUREMENT 审中-公开

    公开(公告)号：US20200370974A1

    公开(公告)日：2020-11-26

    申请号：US16764275

    申请日：2018-11-19

    Applicant: STICHTING VU

    Inventor： Graeme Alan KING ,  Andreas Sebastian BIEBRICHER ,  Iddo HELLER ,  Erwin Johannes Gerard PETERMAN ,  Gijs Jan Lodewijk WUITE

    IPC: G01L1/24 ,  G01N15/14 ,  G02B21/00 ,  G02B21/06

    Abstract: One aspect of this disclosure relates to a computer-implemented method for determining a force acting on at least part of a structure, for example a biological structure, such as a DNA molecule. The method comprises controlling a light-sensitive system, e.g. of a microscope, to determine light information based on light from the structure. The light is incident on at least a part of the light sensitive system. The light-sensitive system may be said to capture the light from the structure. The at least part of the structure comprises one or more optically active entities, such as DNA intercalator molecules and donor/acceptor fluorophores. At least one of (i) an optical activity of the entities and (ii) a quantity of the entities depends on the force acting on the at least part of the structure. Furthermore, the light information defines a light property value associated with said at least part of the structure. The method further comprises determining the force acting on the at least part of the structure on the basis of said light property value and a reference light property value.

    Suture device
    65.
    发明授权
    Suture device 有权

    公开(公告)号：US10058324B2

    公开(公告)日：2018-08-28

    申请号：US14358136

    申请日：2012-11-16

    Applicant: Stichting VU-VUMC

    Inventor： Rianne Irene Van Loenen ,  Micha Ilan Paalman ,  Alexander Arnold Frederik Adriaan Veenhof

    IPC: A61B17/04 ,  A61B17/12

    CPC classification number: A61B17/0469 ,  A61B2017/047 ,  A61B2017/0472 ,  F04C2270/0421

    Abstract: A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.

    RADIOLABELED QUINAZOLINE DERIVATIVES
    68.
    发明申请
    RADIOLABELED QUINAZOLINE DERIVATIVES 审中-公开
    放射性喹唑啉衍生物

    公开(公告)号：US20150368230A1

    公开(公告)日：2015-12-24

    申请号：US14765042

    申请日：2014-01-28

    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  STICHTING VU-VUMC

    Inventor： Paul SLOBBE ,  Alex Johannes POOT ,  Augustinus Antonius Maria Silvester VAN DONGEN ,  Heiko NIESSEN ,  Albert Dirk WINDHORST

    IPC: C07D405/12 ,  A61K51/04

    CPC classification number: C07D405/12 ,  A61K51/0459 ,  C07B2200/05

    Abstract: Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18F-labeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).

    Abstract translation: 描述了用于正电子发射断层扫描（PET）或单光子发射计算机断层摄影（SPECT）成像的新型放射性示踪剂。 具体地说，本发明涉及适用于成像表皮生长因子受体（EGFR，erbB1）和人表皮生长因子受体2（Her2，erbB2）的PET或SPECT示踪剂的18F-标记的阿片碱，用于其合成中的前体化合物 ，用于制备18F标记的阿伐替尼的方法，以及其在体内诊断，肿瘤成像或患者分层中的用途，其基于EGFR（erbB1）和Her2（erbB2）的突变状态。

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