公开(公告)号：US20170199196A1

公开(公告)日：2017-07-13

申请号：US15444679

申请日：2017-02-28

Applicant: STICHTING VU-VUMC

Inventor： Linda Janna Willemien Bosch ,  Meike De Wit ,  Beatriz Pinto Pinto Morais De Carvalho ,  Remond Johannes Adriaan Fijneman ,  Gerrit Albert Meijer ,  Cornelia Ramona Jimenez ,  Sander Rogier Piersma ,  Viet Thang Pham ,  Gideon Oudgenoeg

IPC: G01N33/574

CPC classification number: G01N33/57419 ,  G01N33/6848 ,  G01N2500/10 ,  G01N2570/00 ,  G01N2800/7028

Abstract: The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.

公开(公告)号：US20140271463A1

公开(公告)日：2014-09-18

申请号：US14207396

申请日：2014-03-12

Applicant: Stichting VU-VUmc

Inventor： Marta DEL CAMPO MILAN ,  Cornelia Ramona Jimenez ,  Chrlott Elisabeth Teunissen

IPC: C07K16/28 ,  A61K51/10 ,  G01N33/569

CPC classification number: C07K16/28 ,  A61K51/1018 ,  A61K51/1027 ,  C07K14/4711 ,  G01N33/56966 ,  G01N33/6896 ,  G01N2800/2821 ,  G01N2800/50

Abstract: The disclosure relates to the use of altered BRI2 levels as a biomarker for the risk of developing Alzheimer's disease. Novel treatments based on altered BRI2 levels and anti-BRI2 antibodies are also provided.

Abstract translation: 本公开涉及使用改变的BRI2水平作为发展阿尔茨海默病的风险的生物标志物。 还提供了基于改变的BRI2水平和抗BRI2抗体的新型治疗。