公开(公告)号：WO2015020523A1

公开(公告)日：2015-02-12

申请号：PCT/NL2014/050550

申请日：2014-08-05

Applicant: STICHTING VU-VUMC ,  RUHR-UNIVERSITÄT BOCHUM ,  UNIVERSITÄT DUISBURG-ESSEN

Inventor： CHIASSERINI, Davide ,  TEUNISSEN, Charlotte Elisabeth ,  JIMENEZ, Cornelia Ramona ,  MÜLLER, Thorsten ,  MARCUS, Katrin ,  MEYER, Helmut Erich ,  WILTFANG, Jens

IPC: G01N33/68

CPC classification number: G01N33/6896

Abstract: The present invention relates to methods and kits for classifying an individual as being at risk of developing Alzheimer's disease, in particular Alzheimer's disease type-dementia.

Abstract translation: 本发明涉及将个体分类为处于发展阿尔茨海默氏病，特别是阿尔茨海默氏病型痴呆风险的方法和试剂盒。

公开(公告)号：WO2014195477A1

公开(公告)日：2014-12-11

申请号：PCT/EP2014/061874

申请日：2014-06-06

Applicant: STICHTING VU-VUMC ,  FOM-NIKHEF

Inventor： BULTEN, Henk Jan ,  VAN DEN BRAND, Johannes Franciscus Josephina

IPC: H04W72/04

CPC classification number: H04W72/005 ,  H04B7/2656 ,  H04W52/0216 ,  H04W72/0446 ,  H04W72/048 ,  H04W84/18 ,  Y02D70/00 ,  Y02D70/144 ,  Y02D70/162 ,  Y02D70/164 ,  Y02D70/22 ,  Y02D70/449

Abstract: A method for managing communication in a wireless mesh network comprising a plurality of wireless nodes and a wireless node for use in such network are described, wherein said method may comprise: providing a time slot schedule (frame), preferably a TDMA time slot schedule (frame), comprising one or more time slots, including a transmission time slot enabling a node to transmit a broadcast message, a reception time slot enabling a node to receive a broadcast message from one or more other nodes; and/or a sleep time slot for configuring said node in an idle state; and, assigning said time slots to nodes in said network on the basis of the position of said nodes in said network.

Abstract translation: 描述了一种用于管理无线网状网络中的通信的方法，该无线网状网络包括用于这种网络的多个无线节点和无线节点，其中所述方法可以包括：提供时隙调度（帧），优选地，TDMA时隙调度（ 帧），包括一个或多个时隙，包括使得节点能够发送广播消息的传输时隙;使得节点能够从一个或多个其他节点接收广播消息的接收时隙; 和/或用于将所述节点配置为空闲状态的休眠时隙; 并且基于所述网络中的所述节点的位置，将所述时隙分配给所述网络中的节点。

公开(公告)号：WO2014118197A1

公开(公告)日：2014-08-07

申请号：PCT/EP2014/051659

申请日：2014-01-28

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  STICHTING VU-VUMC

Inventor： SLOBBE, Paul ,  POOT, Alex Johannes ,  VAN DONGEN, Augustinus Antonius Maria Silvester ,  NIESSEN, Heiko ,  WINDHORST, Albert Dirk

IPC: C07D405/12 ,  A61K51/04

CPC classification number: C07D405/12 ,  A61K51/0459 ,  C07B2200/05

Abstract: Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18 F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18 F-iabeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).

Abstract translation: 描述了用于正电子发射断层扫描（PET）或单光子发射计算机断层摄影（SPECT）成像的新型放射性示踪剂。 具体地说，本发明涉及适用于成像表皮生长因子受体（EGFR，erbB1）和人表皮生长因子受体2（Her2，erbB2）的PET或SPECT示踪剂的18F-标记的阿片碱，用于其合成中的前体化合物 ，依据EGFR（erbB1）和Her2（erbB2）的突变状态制备18F-标记的阿伐替尼的方法，以及其在体内诊断，肿瘤成像或患者分层中的应用。

公开(公告)号：WO2013124740A3

公开(公告)日：2014-01-09

申请号：PCT/IB2013000670

申请日：2013-02-25

Applicant: STICHTING VU VUMC ,  STICHTING NL KANKER INST

Inventor： JIMENEZ CORNELIA RAMONA ,  WARMOES MARC OMER ,  PHAM THANG VIET ,  ROTTENBERG SVEN

IPC: G01N33/574

CPC classification number: G01N33/57415 ,  G01N33/57484 ,  G01N2800/52

Abstract: BRCA-deficiency signatures comprising differentially regulated proteins present in BRCA1-deficient tumors, and BRCA-deficiency signatures comprising nucleic acids isolated from BRCA1-deficient tumors, as well as methods of using the same, are disclosed.

Abstract translation: 公开了包含BRCA1缺陷型肿瘤中存在的差异调节蛋白质的BRCA缺陷特征以及包含从BRCA1缺陷型肿瘤分离的核酸的BRCA缺陷型特征，以及使用该BRCA缺陷型鉴定的方法。

公开(公告)号：WO2013187761A1

公开(公告)日：2013-12-19

申请号：PCT/NL2013/050415

申请日：2013-06-12

Applicant: STICHTING VU-VUMC

Inventor： HEUS, Ferry Adam Henricus ,  KOOL, Jeroen

IPC: G01N30/84 ,  B01D15/08 ,  B01D15/24

CPC classification number: G01N30/84 ,  B01D15/24 ,  G01N30/30 ,  G01N30/80 ,  G01N2030/025 ,  G01N2030/065 ,  G01N2030/8435

Abstract: The invention is directed to a process to separate compounds starting from a mixture of two or more compounds by performing the following steps:(a) passing a portion of a gaseous mixture of a carrier gas and the mixture of compounds through a GC column wherein two or more compounds of the mixture are discharged at a different time from the column. In a step (b) a fluid is added to the gaseous flow to obtain a flow comprising of the fluid as a gas, the carrier gas and the compounds. In a step (c) the flow of step (b) is cooled to obtain a flow comprising a gaseous phase comprising the carrier gas and a liquid phase comprising the condensed fluid and the compounds. In a step(d) the one or more liquid fractions from the flow of step (c)are isolated.

Abstract translation: 本发明涉及从两种或更多种化合物的混合物开始分离化合物的方法，其通过以下步骤：（a）将载气和混合物的气体混合物的一部分通过GC柱，其中两个 或更多的混合物的化合物在与该柱不同的时间排出。 在步骤（b）中，将流体添加到气流中以获得包含作为气体的流体，载气和化合物的流动。 在步骤（c）中，将步骤（b）的流程冷却以获得包括包含载气的气相和包含冷凝流体和化合物的液相的流。 在步骤（d）中，分离来自步骤（c）的流程的一种或多种液体馏分。

公开(公告)号：WO2013176549A1

公开(公告)日：2013-11-28

申请号：PCT/NL2013/050378

申请日：2013-05-24

Applicant: STICHTING VU-VUMC

Inventor： PETERMAN, Erwin ,  MANGEOL, Pierre

IPC: G02B21/22 ,  G02B21/36

CPC classification number: G02B21/22 ,  G02B21/365

Abstract: The present invention relates to an optical apparatus (202) comprising a sample support (219) and imaging means (2119) arranged, when said optical apparatus (202) is in use, to receive a first beam (2115) emanating from the sample support (219) under a first angle (2127) with respect to a reference axis (2131)wherein the optical apparatus (202) further comprises a reflector (217) and in that the imaging means (2119) are arranged to receive at least a second beam (2113, 211) emanating from the sample support (219) under a second angle (2129) with respect to the reference axis (2131),the second angle (2129) being different from the first angle (2127), the second beam (2113, 211) when passing from the sample support (219) to the imaging means (2119) being reflected by the reflector (217).

Abstract translation: 本发明涉及一种光学设备（202），包括样本支撑件（219）和成像装置（2119），当所述光学设备（202）在使用中时，所述成像装置（2119）被布置成接收从样品支架 （2131），其中所述光学设备（202）还包括反射器（217），并且所述成像装置（2119）被布置成接收至少第二个 从所述样品支撑件（219）以相对于所述参考轴线（2131）的第二角度（2129）发出的所述第一角度（2113,211），所述第二角度（2129）不同于所述第一角度（2127），所述第二光束 （2113,211）当从样品支撑件（219）通过被反射器（217）反射的成像装置（2119）时。

公开(公告)号：WO2013070079A2

公开(公告)日：2013-05-16

申请号：PCT/NL2012/050793

申请日：2012-11-09

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK, ,  STICHTING VU-VUMC

Inventor： REIJERKERK, Arie ,  DE VRIES, Helga Eveline

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  C12Q2600/178

Abstract: The blood-brain barrier (BBB) separates the blood and the central nervous system (CNS). Here it is disclosed that blood-brain barrier function can be increased with particular nucleic acid sequences, in particular in patients suffering from or diagnosed with Multiple Sclerosis. The use of compounds comprising such nucleic acid sequences for increasing blood-brain barrier function is described.

Abstract translation: 血脑屏障（BBB）分离血液和中枢神经系统（CNS）。 这里公开了可以用特定的核酸序列增加血脑屏障功能，特别是患有或诊断患有多发性硬化症的患者。 描述了包含这种核酸序列的化合物用于增加血脑屏障功能的用途。

公开(公告)号：WO2012008839A3

公开(公告)日：2012-03-01

申请号：PCT/NL2011050518

申请日：2011-07-15

Applicant: STICHTING VU VUMC ,  WUERDINGER THOMAS ,  NILSSON ROLF JONAS

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

Abstract translation: 本发明涉及一种分析患者血液样本中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的未核化血细胞提取核酸，以提供无核细胞提取的 核酸级分，以及b）分析所述无核细胞提取的核酸级分是否存在疾病标志物，其中所述疾病标志物是所述受试者的细胞基因中的疾病特异性突变，或其中所述疾病标记 是所述受试者的细胞的基因的疾病特异性表达谱。

公开(公告)号：EP3005808A1

公开(公告)日：2016-04-13

申请号：EP14729299.9

申请日：2014-06-06

Applicant: Stichting VU-VUmc ,  FOM-Nikhef

Inventor： BULTEN, Henk Jan ,  VAN DEN BRAND, Johannes Franciscus Josephina

IPC: H04W72/04

CPC classification number: H04W72/005 ,  H04B7/2656 ,  H04W52/0216 ,  H04W72/0446 ,  H04W72/048 ,  H04W84/18 ,  Y02D70/00 ,  Y02D70/144 ,  Y02D70/162 ,  Y02D70/164 ,  Y02D70/22 ,  Y02D70/449

Abstract: A method for managing communication in a wireless mesh network comprising a plurality of wireless nodes and a wireless node for use in such network are described, wherein said method may comprise: providing a time slot schedule (frame), preferably a TDMA time slot schedule (frame), comprising one or more time slots, including a transmission time slot enabling a node to transmit a broadcast message, a reception time slot enabling a node to receive a broadcast message from one or more other nodes; and/or a sleep time slot for configuring said node in an idle state; and, assigning said time slots to nodes in said network on the basis of the position of said nodes in said network.

公开(公告)号：EP2779915A2

公开(公告)日：2014-09-24

申请号：EP12824824.2

申请日：2012-11-16

Applicant: Stichting VU-VUmc

Inventor： VAN LOENEN, Rianne, Irene ,  PAALMAN, Micha, Ilan ,  VEENHOF, Alexander, Arnold, Frederik, Adriaan

IPC: A61B17/04

CPC classification number: A61B17/0469 ,  A61B2017/047 ,  A61B2017/0472 ,  F04C2270/0421

Abstract: A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.

Abstract translation: 缝合装置技术领域本发明涉及一种缝合装置，其包括针操作装置和细长壳体，其中针操作装置能够相对于壳体在至少插入位置和针转移位置之间沿纵向方向移动，其中针操作 装置包括：细长操作元件，其布置或布置为从所述外壳的远端延伸到所述外壳的近端或在所述外壳的近端附近; 持针器，所述持针器连接在所述操作元件的远端处以夹持两个或更多个针，使得所述针的所述自由端指向所述缝线装置的近侧方向; 以及针保护装置，其中针保持器相对于针保护装置至少部分可移动地在至少保护位置和保护位置之间，在所述保护位置中，由针保持装置保持至少由针保持器保持的针的自由端部，以及 其中所述针的自由端未被所述针保护装置遮蔽的非保护位置，其中所述外壳包括布置在所述外壳的远端处的针接收装置，以当所述针操作装置接收所述针的所述自由端时 从插入位置移动到针转移位置，并且其中至少在针操作装置的插入位置中，持针器和针保护装置在纵向方向上与壳体间隔开以接收待缝合在其之间的组织 。