公开(公告)号：WO2002081625A2

公开(公告)日：2002-10-17

申请号：PCT/US2002/010366

申请日：2002-04-03

Applicant: CURAGEN CORPORATION ,  PADIGARU, Muralidhara ,  SHENOY, Suresh, G. ,  KEKUDA, Ramesh ,  RASTELLI, Luca ,  MEZES, Peter, D. ,  SMITHSON, Glennda ,  GUO, Xiaojia ,  GERLACH, Valerie ,  CASMAN, Stacie, J. ,  BOLDOG, Ferenc, L. ,  LI, Li ,  ZERHUSEN, Bryan, D. ,  TCHERNEV, Velizar, T. ,  GANGOLLI, Esha, A. ,  VERNET, Corine, A., M. ,  SPYTEK, Kimberly, A. ,  MALYANKAR, Uriel, M. ,  PATTURAJAN, Meera ,  MILLER, Charles, E. ,  TAUPIER, Raymond, J., Jr. ,  HEYES, Melvyn, P. ,  JU, Jingfang ,  PEYMAN, John, A. ,  CATTERTON, Elina ,  MACDOUGALL, John, R. ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MAZUR, Ann

Inventor： PADIGARU, Muralidhara ,  SHENOY, Suresh, G. ,  KEKUDA, Ramesh ,  RASTELLI, Luca ,  MEZES, Peter, D. ,  SMITHSON, Glennda ,  GUO, Xiaojia ,  GERLACH, Valerie ,  CASMAN, Stacie, J. ,  BOLDOG, Ferenc, L. ,  LI, Li ,  ZERHUSEN, Bryan, D. ,  TCHERNEV, Velizar, T. ,  GANGOLLI, Esha, A. ,  VERNET, Corine, A., M. ,  SPYTEK, Kimberly, A. ,  MALYANKAR, Uriel, M. ,  PATTURAJAN, Meera ,  MILLER, Charles, E. ,  TAUPIER, Raymond, J., Jr. ,  HEYES, Melvyn, P. ,  JU, Jingfang ,  PEYMAN, John, A. ,  CATTERTON, Elina ,  MACDOUGALL, John, R. ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MAZUR, Ann

IPC: C12N

CPC classification number: C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/5421 ,  C07K14/705 ,  C07K14/82 ,  C12N9/1051 ,  C12N9/1211 ,  C12N15/1135 ,  C12N15/1137 ,  C12N15/1138 ,  C12Y204/0115

Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.

Abstract translation: 本文公开了编码多肽的核酸序列。 还公开了免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及这些新型人核酸，多肽或抗体或其片段中的任何一种的病症的治疗，诊断和研究方法。

公开(公告)号：WO2002081498A2

公开(公告)日：2002-10-17

申请号：PCT/US2002/010780

申请日：2002-04-03

Applicant: CURAGEN CORPORATION ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  MILLER, Charles, E. ,  MALYANKAR, Uriel, M. ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  LIU, Xiaohong ,  GUSEV, Vladimir, Y. ,  LI, Li ,  VERNET, Corine, A.M. ,  ZERHUSEN, Bryan, D. ,  GORMAN, Linda ,  SHENOY, Suresh, G. ,  PENA, Carol, E., A. ,  SMITHSON, Glennda ,  BURGESS, Catherine, E. ,  GERLACH, Valerie ,  PADIGARU, Muralidhara ,  SHIMKETS, Richard, A. ,  GANGOLLI, Esha, A. ,  TAUPIER, Raymond, J., Jr. ,  CASMAN, Stacie, J. ,  JI, Weizhen ,  ANDERSON, David, W. ,  LEITE, Mario, W. ,  RASTELLI, Luca ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MACDOUGALL, John, R. ,  ROTHENBERG, Mark, E. ,  MAZUR, Ann ,  MILLET, Isabelle ,  PEYMAN, John, A. ,  ELLERMAN, Karen

Inventor： GUO, Xiaojia ,  KEKUDA, Ramesh ,  MILLER, Charles, E. ,  MALYANKAR, Uriel, M. ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  LIU, Xiaohong ,  GUSEV, Vladimir, Y. ,  LI, Li ,  VERNET, Corine, A.M. ,  ZERHUSEN, Bryan, D. ,  GORMAN, Linda ,  SHENOY, Suresh, G. ,  PENA, Carol, E., A. ,  SMITHSON, Glennda ,  BURGESS, Catherine, E. ,  GERLACH, Valerie ,  PADIGARU, Muralidhara ,  SHIMKETS, Richard, A. ,  GANGOLLI, Esha, A. ,  TAUPIER, Raymond, J., Jr. ,  CASMAN, Stacie, J. ,  JI, Weizhen ,  ANDERSON, David, W. ,  LEITE, Mario, W. ,  RASTELLI, Luca ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MACDOUGALL, John, R. ,  ROTHENBERG, Mark, E. ,  MAZUR, Ann ,  MILLET, Isabelle ,  PEYMAN, John, A. ,  ELLERMAN, Karen

IPC: C07K

CPC classification number: C12N15/113 ,  C07K14/47 ,  C07K14/5421 ,  C07K14/705 ,  C07K14/82 ,  C12N9/1051 ,  C12N9/1211 ,  C12N15/1135 ,  C12N15/1137 ,  C12N15/1138 ,  C12Y204/0115

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

Abstract translation: 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。

公开(公告)号：WO2002068652A3

公开(公告)日：2002-09-06

申请号：PCT/US2002/005910

申请日：2002-02-26

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BALLINGER, Robert, A. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  ELLERMAN, Karen, E. ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GILBERT, Jennifer, A. ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  KEKUDA, Ramesh ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BALLINGER, Robert, A. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  ELLERMAN, Karen, E. ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GILBERT, Jennifer, A. ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  KEKUDA, Ramesh ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2013066764A2

公开(公告)日：2013-05-10

申请号：PCT/US2012/062218

申请日：2012-10-26

Applicant: MERCK SHARP & DOHME CORP. ,  LOBODA, Andrey ,  NEBOZHYN, Michael ,  PODTELEZHNIKOV, Alexei ,  STONE, David, J. ,  TANIS, Keith ,  RAY, William, J.

Inventor： LOBODA, Andrey ,  NEBOZHYN, Michael ,  PODTELEZHNIKOV, Alexei ,  STONE, David, J. ,  TANIS, Keith ,  RAY, William, J.

IPC: A01K67/027

CPC classification number: C12Q1/6883 ,  A01K67/0275 ,  C12Q2600/158 ,  G01N33/6896

Abstract: Methods, biomarkers, and expression signatures are disclosed for assessing the disease progression of Alzheimer's disease (AD). In one embodiment, BioAge (biological age), NdStress (neurodegenerative stress), Alz (Alzheimer), and Inflame (inflammation) are used as biomarkers of AD progression. In another aspect, the invention comprises a gene signature for evaluating disease progression. In still another embodiment, methods for evaluating disease progression are provided. In yet another embodiment, the invention can be used to identify animal models for use in the development and evaluation of therapeutics for the treatment of AD.

Abstract translation: 公开了评估阿尔茨海默氏病（AD）疾病进展的方法，生物标志物和表达特征。 在一个实施方案中，使用BioAge（生物学年龄），NdStress（神经变性应激），Alz（阿尔茨海默）和Inflame（炎症））作为AD进展的生物标志物。 另一方面，本发明包括用于评估疾病进展的基因特征。 在另一个实施方案中，提供了评估疾病进展的方法。 在另一个实施方案中，本发明可用于鉴定用于开发和评估治疗AD的动物模型。

公开(公告)号：WO2009011778A1

公开(公告)日：2009-01-22

申请号：PCT/US2008/008440

申请日：2008-07-09

Applicant: MERCK & CO., INC. ,  MAJERCAK, John, M. ,  RAY, William, J. ,  STONE, David, J.

Inventor： MAJERCAK, John, M. ,  RAY, William, J. ,  STONE, David, J.

IPC: G01N33/567 ,  C07H21/04

CPC classification number: G01N33/5032 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/2828

Abstract: Methods for identifying modulators of LRRTM1, LRRTM2 and LRRTM4 are described. The methods are particularly useful for identifying analytes that stimulate LRRTM1or LRRTM2 activity or inhibit LRRTM4 activity such that they antagonize processing of amyloid precursor protein (APP) to Aβ peptide (Aβ). Such methods can be used to identify analyties for treating Alzheimer disease.

Abstract translation: 描述了用于鉴定LRRTM1，LRRTM2和LRRTM4的调节剂的方法。 该方法特别可用于鉴定刺激LRRTM1或LRRTM2活性或抑制LRRTM4活性的分析物，使得它们拮抗淀粉样蛋白前体蛋白（APP）对Aβ肽（Aß）的加工。 这些方法可用于鉴定治疗阿尔茨海默病的分析。

公开(公告)号：WO2004000997A3

公开(公告)日：2007-08-16

申请号：PCT/US0317512

申请日：2003-06-04

Applicant: CURAGEN CORP ,  ANDERSON DAVID W ,  BOLDOG FERENC L ,  BURGESS CATHERINE E ,  CASMAN STACIE J ,  EDINGER SHLOMIT R ,  EISEN ANDREW ,  ELLERMAN KAREN ,  GERLACH VALERIE L ,  GORMAN LINDA ,  GUO XIAOJIA ,  GUSEV VLADIMIR Y ,  JI WEIZHEN ,  LI LI ,  MACDOUGALL JOHN R ,  MALYANKAR URIEL M ,  MILLET ISABELLE ,  ORT TATIANA ,  PADIGARU MURALIDHARA ,  PRAYAGA SUDHIRDAS K ,  PATTURAJAN MEERA ,  PENA CAROL E A ,  PEYMAN JOHN A ,  RIEGER DANIEL K ,  ROTHENBERG MARK E ,  SCIORE PAUL ,  SHENOY SURESH G ,  SMITHSON GLENNDA ,  SPYTEK KIMBERLY A ,  STONE DAVID J ,  TAUPIER RAYMOND J JR ,  TCHERNEV VELIZAR T ,  VERNET CORINE A M ,  VOSS EDWARD Z ,  ZERHUSEN BRYAN D ,  ZHONG MEI

Inventor： ANDERSON DAVID W ,  BOLDOG FERENC L ,  BURGESS CATHERINE E ,  CASMAN STACIE J ,  EDINGER SHLOMIT R ,  EISEN ANDREW ,  ELLERMAN KAREN ,  GERLACH VALERIE L ,  GORMAN LINDA ,  GUO XIAOJIA ,  GUSEV VLADIMIR Y ,  JI WEIZHEN ,  LI LI ,  MACDOUGALL JOHN R ,  MALYANKAR URIEL M ,  MILLET ISABELLE ,  ORT TATIANA ,  PADIGARU MURALIDHARA ,  PRAYAGA SUDHIRDAS K ,  PATTURAJAN MEERA ,  PENA CAROL E A ,  PEYMAN JOHN A ,  RIEGER DANIEL K ,  ROTHENBERG MARK E ,  SCIORE PAUL ,  SHENOY SURESH G ,  SMITHSON GLENNDA ,  SPYTEK KIMBERLY A ,  STONE DAVID J ,  TAUPIER RAYMOND J JR ,  TCHERNEV VELIZAR T ,  VERNET CORINE A M ,  VOSS EDWARD Z ,  ZERHUSEN BRYAN D ,  ZHONG MEI

IPC: A61K38/17 ,  A61K39/395 ,  C07H21/02 ,  C07H21/04 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/00 ,  C07K16/18 ,  C12N20060101 ,  C12N1/00 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/00 ,  G01N33/53

CPC classification number: C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2006138363A2

公开(公告)日：2006-12-28

申请号：PCT/US2006/023144

申请日：2006-06-14

Applicant: MERCK & CO., INC. ,  MAJERCAK, John, M. ,  RAY, William, J. ,  STONE, David, J.

Inventor： MAJERCAK, John, M. ,  RAY, William, J. ,  STONE, David, J.

IPC: G01N33/53

CPC classification number: G01N33/5038 ,  G01N33/5023 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2500/02 ,  G01N2800/2821

Abstract: Methods for identifying modulators of KEAH6 are described. The methods are particularly useful for identifying analytes that antagonize KEAH6's effect on processing of amyloid precursor protein to Aβ peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.

Abstract translation: 描述了用于鉴定KEAH6调节剂的方法。 该方法特别适用于鉴定拮抗KEAH6对淀粉样前体蛋白加工成Aβ肽的作用的分析物，因此可用于鉴定可用于治疗阿尔茨海默病的分析物。

公开(公告)号：WO2004088274A2

公开(公告)日：2004-10-14

申请号：PCT/US2004/009042

申请日：2004-03-26

Applicant: CURAGEN CORPORATION ,  GUNTHER, Erik ,  STONE, David, J. ,  GERWIEN, Robert, W.

Inventor： GUNTHER, Erik ,  STONE, David, J. ,  GERWIEN, Robert, W.

IPC: G01N

CPC classification number: G01N33/5008 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N33/5058 ,  G01N33/94 ,  G01N33/9486

Abstract: Disclosed are methods of identifying psychoactive agents, e.g. , anti-depressant, anti-psychotic or opioid compound, using differential gene expression.

Abstract translation: 公开了使用差异基因表达鉴定精神活性剂，例如抗抑郁药，抗精神病药或阿片样物质的方法。

公开(公告)号：WO2004061073A2

公开(公告)日：2004-07-22

申请号：PCT/US2002/024498

申请日：2002-08-02

Applicant: CURAGEN CORPORATION ,  GORMAN, Linda ,  ZERHUSEN, Bryan, D. ,  EDINGER, Shlomit, R. ,  PADIGARU, Muralidhara ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  ZHONG, Mei ,  PATTURAJAN, Meera ,  MILLER, Charles, E. ,  JI, Weizhen ,  PENA, Carol, E., A. ,  BURGESS, Catherine, E. ,  SCIORE, Paul ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  CASMAN, Stacie, J. ,  ROTHENBERG, Mark, E. ,  MALYANKAR, Uriel, M. ,  BOLDOG, Ferenc, L.

Inventor： GORMAN, Linda ,  ZERHUSEN, Bryan, D. ,  EDINGER, Shlomit, R. ,  PADIGARU, Muralidhara ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  ZHONG, Mei ,  PATTURAJAN, Meera ,  MILLER, Charles, E. ,  JI, Weizhen ,  PENA, Carol, E., A. ,  BURGESS, Catherine, E. ,  SCIORE, Paul ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  CASMAN, Stacie, J. ,  ROTHENBERG, Mark, E. ,  MALYANKAR, Uriel, M. ,  BOLDOG, Ferenc, L.

IPC: C12N

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法也包括在内。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2004000997A2

公开(公告)日：2003-12-31

申请号：PCT/US2003/017512

申请日：2003-06-04

Applicant: CURAGEN CORPORATION ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PRAYAGA, Sudhirdas, K. ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SCIORE, Paul ,  SHENOY, Suresh, G. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

Inventor： ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PRAYAGA, Sudhirdas, K. ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SCIORE, Paul ,  SHENOY, Suresh, G. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

IPC: C12N

CPC classification number: C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.