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    DETECTION OF GLUCOSE IN SOLUTIONS ALSO CONTAINING AN ALPHA-HYDROXY ACID OR A BETA-DIKETONE
    62.
    发明申请
    DETECTION OF GLUCOSE IN SOLUTIONS ALSO CONTAINING AN ALPHA-HYDROXY ACID OR A BETA-DIKETONE 审中-公开
    在含有ALPHA-羟基酸或BETA-DIKETONE的溶液中检测葡萄糖

    公开(公告)号：WO2003078424A1

    公开(公告)日：2003-09-25

    申请号：PCT/US2003/007938

    申请日：2003-03-14

    Applicant: SENSORS FOR MEDICINE AND SCIENCE, INC.

    Inventor： DANILOFF, George, Y. ,  KALIVRETENOS, Aristotle, G. ,  NIKOLAITCHIK, Alexandre, V.

    IPC: C07D417/00

    CPC classification number: G01N33/533 ,  C07F5/025 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  Y10T436/144444

    Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.

    Abstract translation: 用于确定样品中葡萄糖的存在或浓度的组合物和方法，其还可以含有α-羟基酸或β-二酮。 该方法使用具有至少两个用于葡萄糖的识别元件的化合物取向，使得化合物和葡萄糖之间的相互作用比化合物和α-羟基酸或β-二酮之间的相互作用更稳定，使得存在 α-羟基酸或β-二酮基本不干扰所述测定。

    IMPLANTABLE DEVICE FOR DETECTING AN ANALYTE IN VIVO
    63.
    发明申请
    IMPLANTABLE DEVICE FOR DETECTING AN ANALYTE IN VIVO 审中-公开

    公开(公告)号：WO2007011691A3

    公开(公告)日：2007-01-25

    申请号：PCT/US2006/027301

    申请日：2006-07-18

    Applicant: SENSORS FOR MEDICINE AND SCIENCE, INC. ,  MERICAL, Kandace, Marie ,  COLVIN, Arthur, E. ,  MORTELLARO, Mark, Alan

    Inventor： MERICAL, Kandace, Marie ,  COLVIN, Arthur, E. ,  MORTELLARO, Mark, Alan

    IPC: A61B5/00 ,  G01N21/64 ,  G01N21/77

    Abstract: The present application relates to an implantable device for detecting the presence or concentration of an analyte, e.g. glucose, in an aqueous environment in vivo. The device includes a superoxide resistant indicator macromolecule that comprises a copolymer of : (a) one or more indicator component monomers which individually are not sufficiently water soluble to permit their use in an aqueous environment for detecting said analyte, e.g. N- (o-boronobenzyl) aminomethylanthracene derivatives : (b) one or more hydrophilic monomers, e.g. MAPTAC; (c) one or more catalytic antioxidant monomers, especially superoxide dismutase mimics (SODm) , such that the macromolecule is capable of detecting the analyte in an aqueous environment, especially via fluorescence. The presence of the catalytic antioxidant reduces or prevents oxidative damage to the macromolecule .

    SYSTEMS AND METHODS FOR EXTENDING THE USEFUL LIFE OF OPTICAL SENSORS
    66.
    发明申请
    SYSTEMS AND METHODS FOR EXTENDING THE USEFUL LIFE OF OPTICAL SENSORS 审中-公开
    扩展光传感器有效寿命的系统和方法

    公开(公告)号：WO2005106435A1

    公开(公告)日：2005-11-10

    申请号：PCT/US2005/014101

    申请日：2005-04-25

    Applicant: SENSORS FOR MEDICINE AND SCIENCE, INC. ,  COLVIN, Arthur, Earl, Jr. ,  LESHO, Jeffery, C. ,  LORENZ, Carrie, R.

    Inventor： COLVIN, Arthur, Earl, Jr. ,  LESHO, Jeffery, C. ,  LORENZ, Carrie, R.

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B2560/0209

    Abstract: The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.

    Abstract translation: 本发明提供了一种增加光学传感器寿命的方法。 一方面，该方法包括配置光学传感器的步骤，使得传感器的辐射源的占空比在传感器周期性地获得关于分析物的数据的连续时间量的时间内小于100％。 通过根据上述发明方法操作传感器，在需要传感器提供关于物质的存在或浓度的数据的整个连续时间段期间，光学传感器的指示剂分子不被激发。 因此，该方法增加指示剂分子的寿命。

    NON-COVALENT IMMOBILIZATION OF INDICATOR MOLECULES
    67.
    发明申请
    NON-COVALENT IMMOBILIZATION OF INDICATOR MOLECULES 审中-公开
    指示剂分子的非共价固定

    公开(公告)号：WO2005100981A1

    公开(公告)日：2005-10-27

    申请号：PCT/US2005/011654

    申请日：2005-04-07

    Applicant: SENSORS FOR MEDICINE AND SCIENCE, INC. ,  COLVIN, JR., Arthur, E. ,  LORENZ, Carrie, R.

    Inventor： COLVIN, JR., Arthur, E. ,  LORENZ, Carrie, R.

    IPC: G01N31/22

    CPC classification number: G01N31/22 ,  A61B5/0071 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14735

    Abstract: The invention relates to immobilization methods, in particular for immobilizing indicator molecules on supports such as sensors and to sensors having those molecules immobilized to their surface. Non-covalent immobilization of macromolecular indicator molecules on those supports via mechanical interlacing interpenetrating networks with polymers at the surface of a support and via ionic bonding via charged moieties of indicator molecules and ionic groups on the surface of the support are disclosed.

    Abstract translation: 本发明涉及固定化方法，特别是用于将指示剂分子固定在诸如传感器的载体上，以及将具有固定在其表面上的那些分子的传感器。 公开了通过机械交织互穿网络将非分子指示剂分子固定在载体表面上的聚合物，并且通过载体表面上的指示剂分子和离子基团的带电部分经由离子键合将大分子指示剂分子非共价固定。

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