公开(公告)号：US11939290B2

公开(公告)日：2024-03-26

申请号：US17270334

申请日：2019-08-22

Applicant: TOKUSHIMA UNIVERSITY ,  AICHI STEEL CORPORATION

Inventor： Kosuke Namba ,  Motofumi Suzuki ,  Akane Mera

IPC: C07D207/16 ,  A01N43/36 ,  A01N59/16 ,  C05C11/00 ,  C07F15/02

CPC classification number: C07D207/16 ,  A01N43/36 ,  A01N59/16 ,  C05C11/00 ,  C07F15/02

Abstract: The present invention is a heterocycle-containing amino acid compound represented by a general formula (1):




wherein R1 and R2 are identical with or different from each other, and each represent a hydrogen atom or a carboxy-protecting group;
R3 represents a carboxyl group or a hydroxyl group; and
n is 1 or 2,
or a salt thereof.

公开(公告)号：US20240074417A1

公开(公告)日：2024-03-07

申请号：US18261759

申请日：2021-03-04

Applicant: JTEKT CORPORATION ,  Tokushima University

Inventor： Nozomu MIURA ,  Yasuhiro MURATA ,  Shigekazu KAWAI ,  Takahito WATANABE ,  Taro MITO

IPC: A01K67/033

CPC classification number: A01K67/0339

Abstract: Provided is a breeding apparatus that can facilitate disposition and collection of a spawning bed. A breeding apparatus includes a breeding area forming member that forms breeding areas for organisms and is open at least at the bottoms of the breeding areas, and a spawning bed sheet that forms the bottom surfaces of the breeding areas, has a belt shape, and is provided so as to be movable in a longitudinal direction of the belt shape relative to the breeding area forming member.

公开(公告)号：US20230137078A1

公开(公告)日：2023-05-04

申请号：US17905238

申请日：2020-12-10

Applicant: AICHI STEEL CORPORATION ,  TOKUSHIMA UNIVERSITY

Inventor： Akane MERA ,  Motofumi SUZUKI ,  Kensuke HOSODA ,  Kosuke NAMBA

IPC: A01N43/36 ,  C07D207/273 ,  A01P21/00 ,  C07F15/02 ,  C05C11/00

Abstract: A lactam compound and a salt thereof, represented by general formulae (1) and (2): In the formulae, R1 and R2 may be the same or different, and each represent a hydrogen atom, a protective group of a carboxyl group or a cation, and X− is a halogen ion, an organic acid ion, or an inorganic acid ion.

公开(公告)号：US20220098256A1

公开(公告)日：2022-03-31

申请号：US17297986

申请日：2019-11-28

Applicant: TOKUSHIMA UNIVERSITY ,  ONCOTHERAPY SCIENCE, INC.

Inventor： TOYOMASA KATAGIRI ,  TETSURO YOSHIMARU ,  AKIRA OTAKA ,  TAKASHI MIYAMOTO ,  YASUHIDE OKAMOTO

IPC: C07K14/47 ,  A61P35/00

Abstract: The present invention provides peptides containing the BIG3 polypeptide-binding site in a PHB2 polypeptide, which inhibit the binding between a PHB2 polypeptide and a BIG3 polypeptide, and pharmaceutical compositions containing the peptide. The peptides of the present invention have the ability to bind not to PHB2, whose expression is found in organs throughout the human body, but to BIG3, which is a protein highly expressed specifically in particularly estrogen receptor-positive cancer, and have excellent growth suppressive effects on BIG3-positive cancer cells. Accordingly, the peptides of the present invention are useful as therapeutic agents for breast cancer which can avoid expression of side effects.

公开(公告)号：US20220025051A1

公开(公告)日：2022-01-27

申请号：US17311148

申请日：2019-12-06

Applicant: ONO PHARMACEUTICAL CO., LTD. ,  TOKUSHIMA UNIVERSITY

Inventor： Taku OKAZAKI ,  Daisuke SUGIURA ,  Takeo MAEDA ,  Shiro SHIBAYAMA

IPC: C07K16/28 ,  A61P37/06

Abstract: An immunosuppressive agent containing a substance that is selected from anti-CD80 antibodies and anti-PD-L1 antibodies and that promotes binding between PD-L1 and PD-1.

公开(公告)号：US20210338809A1

公开(公告)日：2021-11-04

申请号：US17270561

申请日：2019-08-20

Applicant: Tokushima University

Inventor： Hiroshi Kido ,  Etsuhisa Takahashi ,  Takashi Kimoto ,  Satoko Sakai

IPC: A61K39/35 ,  A61K39/39 ,  A61P37/08

Abstract: An object of the present invention is to provide an allergen vaccine for treatment or prevention of an allergic disease, while reducing the risk of developing an immediate type allergy including anaphylaxis. The present inventors have found that (1) oral inoculation of a composition comprising a particular antigen (allergen) and SF10 into subjects having allergic diseases can suppress the development of an immediate type allergy caused by sensitization with the antigen, and (2) oral inoculation of a composition comprising a particular antigen (allergen) and SF10 into subjects not having allergic diseases can inhibit establishment of sensitization to the antigen, and have completed the present invention.

公开(公告)号：US11124881B2

公开(公告)日：2021-09-21

申请号：US17272765

申请日：2020-06-04

Applicant: CHEMICAL DENSHI CO., LTD. ,  Tokushima University

Inventor： Shoichi Yamada ,  Toshio Hyuga ,  Hisao Nemoto

IPC: C23F11/12 ,  C07D319/06 ,  C23F11/16 ,  C07C327/22 ,  C07D317/20

Abstract: The objective of the present invention is to provide a hydrophilic metal surface treatment agent by which a water-repellent property can be given to a metal surface with suppressing a corrosion and a discolorment of the metal, a method for treating a surface of a metal by using the hydrophilic metal surface treatment agent, a synthetic intermediate compound of a branched glycerol derivative as an active ingredient of the hydrophilic metal surface treatment agent, and a method for efficiently producing the synthetic intermediate compound. The hydrophilic metal surface treatment agent of the present invention is characterized in comprising the branched glycerol derivative represented by the following formula (I) as an active ingredient. wherein R1 is a hydrocarbon group having a carbon number of 10 or more and 30 or less, X is S or a carbonyl group, Y is an n+1 valent linker group, n is an integer of 1 or more and 5 or less.

公开(公告)号：US11091517B2

公开(公告)日：2021-08-17

申请号：US16631141

申请日：2018-07-18

Applicant: TOKUSHIMA UNIVERSITY ,  ONCOTHERAPY SCIENCE, INC.

Inventor： Toyomasa Katagiri ,  Tetsuro Yoshimaru ,  Takashi Miyamoto ,  Yasuhide Okamoto

IPC: C07K7/08 ,  A61K47/65 ,  A61P35/00 ,  A61K38/00

Abstract: The present invention provides peptides having a structure in which portions of a dominant-negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 are replaced by at least two stapling structures. The peptides of the present invention have excellent cell growth inhibiting activity. The cell growth inhibiting activity lasts longer, compared to a single-stapled peptide. Therefore, the peptides of the present invention have a feature suitable for clinical applications in cancer therapy.

公开(公告)号：US20210030823A1

公开(公告)日：2021-02-04

申请号：US16964142

申请日：2019-01-25

Applicant: TOKUSHIMA UNIVERSITY ,  JICHI MEDICAL UNIVERSITY ,  GENE THERAPY RESEARCH INSTITUTION CO., LTD.

Inventor： Kohji ITOH ,  Daisuke TSUJI ,  Shinichi MURAMATSU ,  Katsuhito ASAI

IPC: A61K35/76 ,  C12N7/00 ,  A61P25/28

Abstract: According to a conventional method for treatment of Sandhoff disease and Tay-Sachs disease comprising administering a modified β-subunit to a patient in the form of a protein, it is necessary that administration be performed frequently. This invention relates to a recombinant adeno-associated virus virion comprising: capsomere comprising a protein capable of forming a virus virion; and a polynucleotide packaged in the capsomere comprising a promoter sequence and nucleotide sequences operably linked to the promoter sequence encoding a first amino acid sequence derived from the amino acid sequence of the β-subunit of wild-type human β-hexosaminidase composed of amino acids 55 to 556 in the sequence as shown in SEQ ID NO: 28 by substitution of amino acids 312 to 318 with glycine, serine, glutamic acid, proline, serine, glycine, and threonine in that order and a second amino acid sequence, which is an amino acid sequence of a signal peptide linked to the N terminus of the first amino acid.

公开(公告)号：US10371630B2

公开(公告)日：2019-08-06

申请号：US14909424

申请日：2014-07-18

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Nobukazu Ikeda ,  Michio Yamaji

IPC: G01N21/31 ,  G01N21/33 ,  G01N21/59 ,  G01N21/84 ,  G01N21/85

Abstract: An inline concentration meter includes a light source unit emitting mixed light containing at least two wavelengths with a phase difference, a detecting unit including a light incident part for entering the mixed light emitted from the light source unit into a fluid passage of a detector body and at least two light detection parts receiving the mixed light passed through the fluid passage, a computing processor unit conducting frequency analyzes of detection signals of the mixed light output from the respective light detection parts and computing variations of intensities of the detection signals corresponding to absorbances in at least two frequency ranges to compute a concentration of fluid in the fluid passage based on the variations of the intensities of the detection signals, and a recording/displaying unit recording and displaying a value of the fluid concentration computed at the computing processor unit.