公开(公告)号：US11851459B2

公开(公告)日：2023-12-26

申请号：US17044602

申请日：2019-04-04

Applicant: University of Saskatchewan

Inventor： Troy Harkness ,  Terra Gayle Arnason

IPC: C07K14/47 ,  A61P35/00 ,  A61K38/00 ,  A61K45/06

CPC classification number: C07K14/4705 ,  A61P35/00 ,  A61K38/00 ,  A61K45/06

Abstract: Methods and uses of activators of the APC complex for treating cancer in a subject, inhibiting the growth of a cancer cell, increasing sensitivity to a cancer treatment in a cancer cell or a subject and/or reducing resistance to a cancer treatment in a cancer cell or a subject.

公开(公告)号：US20230218734A1

公开(公告)日：2023-07-13

申请号：US17996688

申请日：2021-04-19

Applicant: University of Saskatchewan ,  The University of British Columbia

Inventor： Antonio Facciuolo ,  Philip Griebel ,  Volker Gerdts ,  Andrew Potter ,  Neil Rawlyk ,  Jeffrey Chen ,  Elodie Pastural ,  Manjeet Bains ,  Michael Trimble ,  Amy Lee ,  Robert Hancock

IPC: A61K39/04 ,  A61K39/39 ,  A61P31/04 ,  G01N33/569

CPC classification number: A61K39/04 ,  A61K39/39 ,  A61P31/04 ,  G01N33/5695 ,  A61K2039/55566

Abstract: Mycobacterial antigens, such as MAP and M. bovis antigens, are described. The antigens can be used in subunit compositions to elicit immune responses in order to prevent and/or control mycobacterial infections, as well as in diagnostics in order to detect mammals infected with mycobacteria.

公开(公告)号：US20230161057A1

公开(公告)日：2023-05-25

申请号：US17908722

申请日：2021-03-04

Applicant: University of Saskatchewan

Inventor： Timothy Lewis Kelly ,  Yunlong Li ,  Richard Pettipas

IPC: G01T1/24 ,  C09D11/52 ,  C09D11/037 ,  C09D11/033 ,  C09D11/106

CPC classification number: G01T1/24 ,  C09D11/52 ,  C09D11/037 ,  C09D11/033 ,  C09D11/106

Abstract: A direct conversion x-ray detection apparatus having a planar x-ray detection layer having a detection layer upper surface and a detection layer lower surface, the planar x-ray detection layer including a lead halide perovskite material; a top electrode layer above the detection layer upper surface; a bottom electrode layer below the detection layer lower surface and in conductive communication with the top electrode layer through the x-ray detection layer to apply a bias voltage across the x-ray detection layer; and a blocking layer between the x-ray detection layer and the top electrode layer to inhibit a dark current, the blocking layer including a polymer selected from the group comprising polyacrylates, polyimides, polyamides, polysulfones, polystyrenes, and polycarbonates.

公开(公告)号：US11427886B2

公开(公告)日：2022-08-30

申请号：US15568245

申请日：2016-04-21

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Stephen Foley ,  Hiwa Salimi ,  Loghman Moradi

IPC: C22B11/00 ,  C22B3/16 ,  C22B3/26 ,  C22B3/06 ,  C22B3/44 ,  C07C335/26 ,  C07D207/06 ,  C07D211/16 ,  C07D295/215 ,  C22B1/00 ,  C25C1/20 ,  C25C7/06

Abstract: The present application relates to methods for the simultaneous leaching and extraction of precious metals. For example, the present application relates to methods of leaching and extracting gold and/or palladium from a substance comprising gold and/or palladium such as a gold- and/or palladium-containing ore in one step using a compound of Formula I:(I).

公开(公告)号：US20220024904A1

公开(公告)日：2022-01-27

申请号：US17368272

申请日：2021-07-06

Applicant: Research Foundation of the City University of New York ,  University of Saskatchewan

Inventor： Brian Zeglis ,  Guillaume Dewaele-Le Roi ,  Eric W. Price ,  Elaheh Khozeimeh Sarbisheh

IPC: C07D413/10 ,  A61K49/00 ,  A61K51/10 ,  A61K51/04 ,  A61K47/68 ,  A61K47/54

Abstract: A label that permits rebridging of disulfide linkages in antibodies or proteins. The label has a general formula given by wherein R1 is methyl, ethyl or propyl and R2 is a metal chelator, a fluorophore or a click-chemistry synthon.

公开(公告)号：US20210236667A1

公开(公告)日：2021-08-05

申请号：US17163145

申请日：2021-01-29

Applicant: University of Saskatchewan

Inventor： Humphrey Fonge ,  Clarence Ronald Geyer ,  Siddesh Vrushabendra swamy Hartimath

IPC: A61K51/10 ,  C07K16/28 ,  C07K16/32 ,  A61K47/68 ,  A61K47/60 ,  A61K47/64 ,  A61P35/00

Abstract: The disclosure provides radiolabeled and/or cytotoxin labelled antibodies and methods and uses of these antibodies. In one embodiment, provided is a cytotoxic agent comprising an antibody that specifically binds a target disease cell surface receptor, a cytotoxin, and a radiolabel, wherein the cytotoxin is linked directly or indirectly to the antibody, and wherein the radiolabel comprises a radionuclide and optionally a scaffold, wherein the scaffold is directly or indirectly coupled to the antibody. Also provided are methods of preparing the cytotoxic agent and methods of treating disease using the cytotoxic agent.

公开(公告)号：US20210213384A1

公开(公告)日：2021-07-15

申请号：US16757193

申请日：2018-10-19

Applicant: University of Saskatchewan

Inventor： Saeed Ghanbari ,  Catherine Hui Niu ,  Rlee George Prokopishyn

IPC: B01D53/26 ,  B01D53/047 ,  B01D53/04 ,  B01D53/28 ,  C10L3/10

Abstract: Systems and methods of separating components of a multi-component gas mixture are described herein. The systems include one or more packed bed columns packed with a biosorbent material. Upon passing the multi-component gas mixture through the packed bed column, substantially all of a polar component of the multi-component gas mixture is adsorbed by the biosorbent material and a non-polar component of the multi-component gas mixture is not substantially adsorbed by the biosorbent material.

公开(公告)号：US20210052752A1

公开(公告)日：2021-02-25

申请号：US16756872

申请日：2018-10-19

Applicant: Daniel Tesolin ,  University of Saskatchewan

Inventor： Christopher Phenix ,  Daniel Tesolin ,  Morshed Chowdhury ,  Shusheng Wang

IPC: A61K51/04 ,  C07D401/12

Abstract: The present application relates to conduritol aziridines of Formula (I), and uses thereof, for example, of 18F-labelled derivatives thereof in positron-emission tomography (PET) imaging of β-glucocerebrosidase activity.

公开(公告)号：US10784583B2

公开(公告)日：2020-09-22

申请号：US15105294

申请日：2014-12-19

Applicant: University of Saskatchewan

Inventor： Mohammadreza Tayfeh Aligodarz ,  David Klymyshyn ,  Atabak Rashidian ,  Xun Liu

IPC: H01Q9/04 ,  H01Q21/06 ,  H01Q21/00 ,  H01Q1/50 ,  H01P5/12

Abstract: Arrays of low permittivity Polymer-based Resonator Antenna elements with different configurations. Individual array elements can be fabricated with complicated geometries; these elements can be assembled into complicated patterns as a single monolithic fabricated structure using narrow wall connecting structures, which removes the requirement to position and assemble the array elements. Monolithic array structures can be assembled as sub-arrays in larger array structures. Elements, sub-arrays, and arrays can also be formed by inserting dielectric materials into cavities defining their lateral geometries, and fabricated in polymer templates. The polymer templates can be removed or retained to function as part of the antenna. Effective excitation is achieved by one of a number of coupling methods, including standing metal strip feeding on the vertical sides of the elements, feeding by tall metal transmission lines in contact or in close proximity to the vertical sides of the elements, modified microstrip feeding, or aperture feeding by using a slot in the metal plane underneath the elements. The wideband array feeds are realized by optimized transmission line distribution networks which include wideband matching sections.

公开(公告)号：US20200062782A1

公开(公告)日：2020-02-27

申请号：US16328250

申请日：2017-09-08

Applicant: University of Saskatchewan

Inventor： Joseph KAKISH ,  Edward KROL ,  Jeremy LEE ,  Kevin ALLEN

IPC: C07D519/00 ,  A61K51/04 ,  C07D473/12

Abstract: Bifunctional molecules having first and second alpha-synuclein binding agents coupled by a linker are disclosed. The bifunctional molecules have potential utility in the diagnosis, treatment and/or prophylaxis of disorders in which alpha-synuclein is implicated, including Parkinson's disease. Methods of making and using the bifunctional molecules are disclosed.