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公开(公告)号：KR101806524B1
公开(公告)日：2017-12-07
申请号：KR1020160143466
申请日：2016-10-31
Applicant: (주)아모레퍼시픽
CPC classification number: A45D40/24 , A45D34/041 , A45D2200/052 , A45D2200/058 , A45D2200/1009 , B65D35/22 , B65D35/36 , B65D81/32 , A45D34/00 , A45D34/04 , A45D2034/002 , B65D35/242 , B65D81/3261
Abstract: 본발명은화장품용기에관한것이다. 본발명의일 실시예에따르면, 서로다른밀도를갖고, 서로혼합된상태에서밀도차에의해원래의상태로분리되는제1 용액과제2 용액을하나의저장공간에수용하는본체; 상기본체의일측에제공되고, 상기제1 용액또는상기제1 용액과상기제2 용액이혼합된혼합액을도포할수 있는제1 어플리케이터; 상기본체의타측에제공되고, 상기제2 용액을도포할수 있는제2 어플리케이터; 및상기본체의내측에제공되고, 상기제1 용액이상기제2 어플리케이터측으로이동되는것을차단하고, 상기제2 용액은통과시킬수 있는선택적투과막을포함하는화장품용기가제공될수 있다.
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公开(公告)号：KR101776073B1
公开(公告)日：2017-09-19
申请号：KR1020100104608
申请日：2010-10-26
Applicant: (주)아모레퍼시픽
Abstract: 본발명은파이토크롬을유효성분으로함유하는메이크업화장료조성물에관한것으로, 보다상세하게는파이토크롬을유효성분으로함유하여외관색상이선명하고자연스러운메이크업이가능하고, 오메가 3,6,9 오일을더 함유하면보습지속효과를향상시킬수 있는메이크업화장료조성물에관한것이다.
Abstract translation: 本发明涉及含有光敏色素作为活性成分的化妆用化妆品组合物，更具体地涉及含有光敏色素作为活性成分的化妆用化妆品组合物， 本发明涉及可以改善保湿效果的化妆用化妆品组合物。
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公开(公告)号：KR1020170094526A
公开(公告)日：2017-08-18
申请号：KR1020170098819
申请日：2017-08-04
Applicant: (주)아모레퍼시픽
IPC: A61K8/60 , C12N15/113 , A61Q19/02
CPC classification number: A61K8/606 , A61Q19/02 , C12N15/1137 , C12N2310/141 , C12N2310/322
Abstract: 본발명의서열번호 1의 miRNA는 has-miR-1248의모방체로서, has-miR-1248의발현에대한촉진제로사용되어색소형성유전자인티로시나아제, 티로시나아제관련단백질 1, 멜란-A의발현을억제하여피부미백효과를제공할수 있으며, 서열번호 2의 miRNA는상기서열번호 1의 miRNA에대한안티센스핵산분자로서 has-miR-1248의발현에대한억제제로사용되어색소형성유전자인티로시나아제, 티로시나아제관련단백질 1, 멜란-A의발현을촉진시켜백모방지또는흑모생성효능을제공할수 있다. 또한, 본발명의서열번호 1의 miRNA는 has-miR-1248의발현에대한촉진제로사용되어진피세포재생조절유전자인트로포미오신 3과아그레칸의발현을억제하여우수한진피세포재생효과를제공할수 있다.
Abstract translation: 如SEQ ID NO的miRNA的模拟物：本发明具有-MIR-1248的1，已-MIR-1248使用的启动子用于基因表达在色素沉着合成方案激酶，酪氨酸酶相关蛋白1，-A的甘美兰 并且SEQ ID NO：1的miRNA用作针对作为SEQ ID NO：1的miRNA的反义核酸分子的has-miR-1248的表达的抑制剂， 有可能促进黑素-A，酪氨酸酶相关蛋白1和黑素-A的表达，由此提供抗白化或黑发的效果。 此外，本发明的SEQ ID NO：1的miRNA可以用作has-miR-1248表达的启动子，从而抑制内引霉素-3调控基因的表达， 。
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公开(公告)号：KR101716325B1
公开(公告)日：2017-03-15
申请号：KR1020110017894
申请日：2011-02-28
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: 열차단지수의생성방법은, 열차단물질이도포된제1 영역및 상기열 차단물질이도포되지않은제2 영역에각각열을가하는단계; 상기제1 영역및 제2 영역각각의포화온도를측정하는단계; 상기제1 영역에가해진열에대응되는에너지를상기제1 영역의포화온도로나누어제1 에너지를산출하는단계; 상기제2 영역에가해진열에대응되는에너지를상기제2 영역의포화온도로나누어제2 에너지를산출하는단계; 및상기제1 에너지를상기제2 에너지로나누거나, 또는상기제1 에너지및 상기제2 에너지의차를상기제1 에너지로나누어상기열 차단물질의열 차단지수를산출하는단계를포함할수 있다.
Abstract translation: 本发明涉及一种计算热保护因子的方法，其中该方法包括以下步骤：将热量施加到涂覆有热保护材料的第一区域和未涂覆有热保护材料的第二区域; 测量第一区域和第二区域的各自的饱和温度; 通过将对应于第一区域的热量的能量除以第一区域的饱和温度来计算第一能量; 通过将对应于第二区域的热量的能量除以第二区域的饱和温度来计算第二能量; 以及通过将第一能量除以第二能量或将第一能量与第二能量之间的差除以第一能量来计算热保护材料的热保护因子。
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公开(公告)号：KR1020160015745A
公开(公告)日：2016-02-15
申请号：KR1020140098395
申请日：2014-07-31
Applicant: (주)아모레퍼시픽
Abstract: 본발명은케모카인, 특히 ITAC(interferon-inducible T-cell alpha chemoattractant; 인터페론유도성 T 세포알파화학주성인자)를함유함으로써멜라닌형성세포에서멜라닌색소생성관련인자의유전자발현을감소시켜피부미백효과를가져올수 있는조성물에관한것이다.
Abstract translation: 本发明涉及包含趋化因子，特别是干扰素诱导型T细胞α化学引诱物（ITAC）的组合物。 此外，本发明的组合物降低与黑素细胞中黑色素的生成相关因素的遗传表达，从而显示出皮肤美白效果，其中ITAC的含量相对于总量为0.0001-0.955重量％ 组合物的重量。
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Patent Agency Ranking
公开(公告)号：KR1020140055401A
公开(公告)日：2014-05-09
申请号：KR1020120122155
申请日：2012-10-31
Abstract: The present invention relates to a method for screening skin whitening substances, and more specifically, to a method for screening skin whitening substances comprising a step of treating a test substance on a melanin-producing cell; and a step of checking relative expression level of one or more proteins selected from a group consisting of tyrosinase, integrin alpha 6, and MITF in a cell treated with the test substance of the step.
Abstract translation: 本发明涉及一种用于筛选皮肤美白物质的方法，更具体地，涉及一种用于筛选皮肤美白物质的方法，包括在黑色素产生细胞上处理测试物质的步骤; 以及在用该步骤的测试物质处理的细胞中检查选自由酪氨酸酶，整联蛋白α6和MITF组成的组中的一种或多种蛋白质的相对表达水平的步骤。
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公开(公告)号：KR1020130131628A
公开(公告)日：2013-12-04
申请号：KR1020120055319
申请日：2012-05-24
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/4926 , A61K9/0014 , A61K31/445 , A61Q19/02
Abstract: The present invention relates to a composition for skin whitening, wherein the composition contains Plumarol as an active ingredient. The composition for skin whitening according to the present invention suppresses the protein expression of tyrosinase, which is a melanogenic enzyme, and inhibits melanogenesis, by containing Plumarol as an active ingredient, thereby exhibiting a whitening effect. [Reference numerals] (AA) Comparative example 1;(BB) Example 1;(CC) Example 2
Abstract translation: 本发明涉及一种用于皮肤美白的组合物，其中该组合物含有Plumarol作为活性成分。 根据本发明的皮肤美白组合物通过含有Plumarol作为活性成分抑制作为黑素生成酶的酪氨酸酶的蛋白质表达并抑制黑素生成，从而表现出美白效果。 （AA）比较例1（BB）实施例1（CC）实施例2
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公开(公告)号：KR1020130128907A
公开(公告)日：2013-11-27
申请号：KR1020120053095
申请日：2012-05-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/133 , A23L29/035 , A23L29/045 , A23V2200/318 , A61K8/41 , A61Q19/02
Abstract: The present invention relates to a whitening composition which suppresses or prevents melanogenesis and, particularly, to a composition containing valiolamine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 本发明涉及抑制或预防黑素生成的增白组合物，特别涉及包含化学式1的缬草烯胺衍生物或其药学上可接受的盐作为活性成分的组合物。
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公开(公告)号：KR1020130001123A
公开(公告)日：2013-01-03
申请号：KR1020120061988
申请日：2012-06-11
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K8/00 , A61Q19/02 , A61Q7/00
CPC classification number: C12N15/1137 , A61K8/606 , A61K31/7105 , A61K2800/78 , A61K2800/782 , A61Q5/10 , C12N15/113 , C12N2310/113 , C12N2310/141 , G01N33/5023
Abstract: PURPOSE: A composition containing miRNA or an antisense molecule of the miRNA is provided to regulate tyrosinase mRNA expression and pigmentation and to enhance skin whitening effect. CONSTITUTION: A composition for regulating pigmentation and expression of a pigmentation-related gene contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected among sequences of sequence number 1 and is also selected among oligonucleotide molecules containing 22 continuous bases with CCCUGAG. The pigmentation-related gene is tyrosinase mRNA. The composition is a cosmetic or pharmaceutical composition for skin whitening. A composition for regulating pigmentation and expression of a pigmentation-related gene contains a base sequence which is complementary to miRNA of sequence number and an antisense nucleic acid molecule of sequence number 2, which is hybridizable with the miRNA. [Reference numerals] (AA) Relative mRNA expression of TYR/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) MiR-125b derivatives
Abstract translation: 目的：提供含有miRNA或miRNA的反义分子的组合物，以调节酪氨酸酶mRNA表达和色素沉着，并增强皮肤美白效果。 构成：用于调节色素沉着相关基因的色素沉着和表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的序列，也选自含有CCCUGAG的22个连续碱基的寡核苷酸分子。 色素沉着相关基因是酪氨酸酶mRNA。 该组合物是用于皮肤美白的化妆品或药物组合物。 用于调节色素沉着相关基因的色素沉着和表达的组合物含有与序列号的miRNA互补的碱基序列和与miRNA杂交的序列号2的反义核酸分子。 （AA）相对mRNA表达TYR / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）MiR-125b衍生物
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公开(公告)号：KR1020120139430A
公开(公告)日：2012-12-27
申请号：KR1020110059227
申请日：2011-06-17
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K31/7088 , A61Q19/00 , A61Q7/00
Abstract: PURPOSE: A composition containing miRNA for controlling pigmentation gene expression is provided to suppress tyrosinase, tyrosinase-related proteins, and melan-A expression. CONSTITUTION: A composition for controlling pigmentation gene expression contains miRNA containing a base of sequence number 1 as an active ingredient. The miRNA has continuous 27 bases containing ccuucuu of sequence number 1 and a base which suppresses pigmentation gene expression. The pigmentation gene is tyrosinase, tyrosinase-related protein 1, or melan-A gene. The miRNA targets 909-915th nucleic acids of melan A mRNA 3'-UTR. The composition is a cosmetic or pharmaceutical composition for skin whitening. A composition for controlling pigmentation gene expression contains a complementary base with miRNA of sequence number 1. [Reference numerals] (AA) Relative TYR/GAPDH mRNA expression level; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有miRNA用于控制色素沉着基因表达的组合物，以抑制酪氨酸酶，酪氨酸酶相关蛋白和黑色素A表达。 构成：用于控制色素沉着基因表达的组合物含有含有序列号1的碱基作为活性成分的miRNA。 miRNA具有连续的27个碱基，其含有序列号1的碱基和抑制色素沉着基因表达的碱基。 色素沉着基因是酪氨酸酶，酪氨酸酶相关蛋白1或黑色素A基因。 miRNA靶向黑色A mRNA 3'-UTR的第909-915个核酸。 该组合物是用于皮肤美白的化妆品或药物组合物。 用于控制色素沉着基因表达的组合物含有与序列号1的miRNA的互补碱基。[参考数字]（AA）相对TYR / GAPDH mRNA表达水平; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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