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61.发明授权엘라스테아제 저해 효과를 갖는 3,5-디히드록시벤조산유도체 화합물과 그 제조방법 및 이를 함유하는 항노화화장료 조성물 有权,5-라스테아제저해효과를갖갖갖는,5- ,5- 3 3 3 3 3 3 3 3 3 3 3 3
公开(公告)号：KR100726280B1
公开(公告)日：2007-06-11
申请号：KR1020060035603
申请日：2006-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C233/65 , C07C235/64
Abstract: Provided is a 3,5-dihydroxybenzoic acid derivative, which shows an elastase inhibitory effect and an excellent effect of scavenging free radicals generated by UV irradiation, has an excellent anti-aging effect, and is useful for an anti-aging cosmetic composition. The 3,5-dihydroxybenzoic acid derivative is a compound represented by a formula 1, substituted with hydroxyl groups at 3,5-position thereof and the amide group being substituted with a bulky substituent. The 3,5-dihydroxybenzoic acid derivative is obtained by the method comprising the steps of: (A) reacting 3,5-dihydroxybenzoic acid with acetic anhydride to form 3,5-diacetyloxybenzoic acid; (B) forming an amide compound from the 3,5-diacetyloxybenzoic acid by using ethyl chloroformate and an oleophilic group; and (C) hydrolyzing the acetyl group of the amide compound to provide a 3,5-dihydroxybenzoic acid derivative.
Abstract translation: 本发明提供一种3,5-二羟基苯甲酸衍生物，其显示出弹性蛋白酶抑制作用，并且通过UV照射产生的清除自由基的优异效果，具有优异的抗老化作用，并且可用于抗老化化妆品组合物。 3,5-二羟基苯甲酸衍生物是由式3表示的化合物，其3,5-位被羟基取代且酰胺基被大体积取代基取代。 3,5-二羟基苯甲酸衍生物通过包括以下步骤的方法获得：（A）使3,5-二羟基苯甲酸与乙酸酐反应形成3,5-二乙酰氧基苯甲酸; （B）通过使用氯甲酸乙酯和亲油基团由3,5-二乙酰氧基苯甲酸形成酰胺化合物; 和（C）水解酰胺化合物的乙酰基得到3,5-二羟基苯甲酸衍生物。
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公开(公告)号：KR1020070039668A
公开(公告)日：2007-04-13
申请号：KR1020050094794
申请日：2005-10-10
Applicant: (주)아모레퍼시픽
CPC classification number: C01B33/18 , A61K8/0279 , A61K8/25 , A61Q19/007 , C01P2004/61 , C01P2006/12 , C01P2006/16
Abstract: 본 발명은 펜타에리스리톨 유도체가 포집된 메조포러스 다공성 실리카 복합 분체 및 그 제조방법에 관한 것으로서, 보다 상세하게는 높은 흡유량을 가진 다공성 실리카에 피부 각질층의 수분 유지 능력을 향상시키고, 특히 건조환경에서도 높은 보습력을 보이는 펜타에리스리톨 유도체가 포집된 메조포러스 다공성 실리카 복합 분체 및 그 제조방법에 관한 것이다.
펜타에리스리톨 유도체, 수분유지능력, 보습력, 다공성 실리카-
公开(公告)号：KR1020070013482A
公开(公告)日：2007-01-31
申请号：KR1020050067815
申请日：2005-07-26
Applicant: (주)아모레퍼시픽
IPC: C07D317/64
Abstract: Sesamol derivatives and a process for preparing the same compounds are provided to improve anti-oxidizing activity and stability of sesamol, recover the skin damaged by reactive oxygen species, prevent aging of biological membranes, and inhibit production of peroxides of unsaturated fatty acid and its derivatives. The sesamol derivatives represented by the formula(1) are provided, wherein the sesamol derivatives are prepared by reacting sesamol with adamantanol in an equivalence ratio of 1:1.0~1.3 under acid condition, and recrystallizing the resulting product in polar solvent; the acid is hydrochloric acid, nitric acid, sulfuric acid, p-toluenesulfonic acid, benzene sulfonic acid, acetic acid, trichloroacetic acid or trifluoroacetic acid; the solvent used in the reaction is dichloromethane, tetrahydrofuran, ethyl acetate, acetonitrile, chloroform, ethyl ether, trichloro ethylene, benzene or toluene; and the polar solvent is methanol, ethanol, isopropanol, acetone, acetonitrile or water.
Abstract translation: 提供了芝麻酚衍生物和制备相同化合物的方法，以提高芝麻素的抗氧化活性和稳定性，回收活性氧损伤的皮肤，防止生物膜老化，抑制不饱和脂肪酸及其衍生物过氧化物的产生 。 提供由式（1）表示的芝麻酚衍生物，其中芝麻酚衍生物通过在酸性条件下使芝麻酚与当量比为1：1.0〜1.3的金刚烷醇反应制备，并将所得产物在极性溶剂中重结晶; 酸是盐酸，硝酸，硫酸，对甲苯磺酸，苯磺酸，乙酸，三氯乙酸或三氟乙酸; 反应中使用的溶剂是二氯甲烷，四氢呋喃，乙酸乙酯，乙腈，氯仿，乙醚，三氯乙烯，苯或甲苯; 极性溶剂为甲醇，乙醇，异丙醇，丙酮，乙腈或水。
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公开(公告)号：KR100643514B1
公开(公告)日：2006-11-23
申请号：KR1020050041060
申请日：2005-05-17
Applicant: (주)아모레퍼시픽
IPC: C07C233/64 , A61K8/368
Abstract: Provided are a hydroxybenzoic acid amide compound which suppresses the generation of melanin, its preparation method, and a whitening cosmetic composition containing the compound. The hydroxybenzoic acid amide compound is represented by the formula 1, wherein R1 and R2 are H or OH. The method comprises the steps of dissolving hydroxybenzoic acid in a solvent, adding a catalyst and a base drop by drop, and reacting it with acetic anhydride to prepare an acetylated compound represented by the formula II; dissolving the acetylated compound of the formula II in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare an amide compound represented by the formula III; and reacting the amine compound of the formula III with a base to hydrolyze it (See the reaction scheme 1), wherein R3 and R4 is H or an acetoxy group.
Abstract translation: 本发明提供抑制黑色素生成的羟基苯甲酸酰胺化合物及其制备方法和含有该化合物的美白化妆品组合物。 羟基苯甲酸酰胺化合物由式1表示，其中R 1和R 2是H或OH。 该方法包括以下步骤：将羟基苯甲酸溶解在溶剂中，逐滴加入催化剂和碱，并使其与乙酸酐反应以制备式II表示的乙酰化化合物; 将式II的乙酰化的化合物溶解在溶剂中并加入碱，氯甲酸乙酯和金刚烷胺以制备式III表示的酰胺化合物; 和使式III的胺化合物与碱反应以水解（参见反应方案1），其中R 3和R 4是H或乙酰氧基。
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公开(公告)号：KR100636737B1
公开(公告)日：2006-10-20
申请号：KR1020050032607
申请日：2005-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C225/20
Abstract: Provided are a gallic acid adamantamine amide compound which inhibits the generation of melanin, a method for preparing the compound, and a cosmetic composition containing the compound. The gallic acid adamantamine amide compound is represented by the formula 1. The method comprises the steps of dissolving gallic acid in a solvent, adding a catalyst and a base to the solution drop by drop, and reacting it with acetic anhydride to prepare the acetylated compound represented by the formula II (See the reaction scheme 1); dissolving the acetylated compound in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare the amide compound represented by the formula III; and reacting the obtained amide compound with a base to hydrolyze it, thereby preparing the gallic acid adamantamine amide compound represented by the formula 1. Preferably the catalyst is dimethyl aminopyridine; and the base is triethylamine.
Abstract translation: 本发明提供抑制黑色素生成的没食子酸金刚胺酰胺化合物，其制备方法以及含有该化合物的化妆品组合物。 没食子酸金刚烷胺酰胺化合物由式1表示。该方法包括以下步骤：将没食子酸溶解在溶剂中，逐滴向溶液中加入催化剂和碱，并使其与乙酸酐反应以制备乙酰化的化合物 由式II表示（参见反应方案1）; 将乙酰化的化合物溶解在溶剂中，加入碱，氯甲酸乙酯和金刚烷胺制备式III所示的酰胺化合物; 并使所得酰胺化合物与碱反应以将其水解，从而制备式1代表的没食子酸金刚烷胺酰胺化合物。优选该催化剂是二甲基氨基吡啶; 碱是三乙胺。
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Patent Agency Ranking
公开(公告)号：KR1020060104054A
公开(公告)日：2006-10-09
申请号：KR1020050025883
申请日：2005-03-29
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 미숙성 감귤 추출물을 유효성분으로 함유하는 미백용 피부 화장료 조성물에 관한 것으로서, 더욱 상세하게는 미숙성 온주밀감 추출물을 단독으로 사용하거나 여기에 진지향 추출물, 팔삭 추출물 등 온주밀감 이외의 감귤 추출물을 혼합하여 함유함으로써 피부에 대한 부작용 없이 안전하게 사용할 수 있을 뿐만 아니라 멜라닌 생성을 억제하여 색소 침착을 저해하는 효과가 뛰어나 기미 또는 주근깨 개선 및 피부 미백 효과가 우수한 미백용 피부 화장료 조성물에 관한 것이다.
감귤, 미숙성 온주밀감, 온주밀감, 진지향, 팔삭, 미백, 화장료 조성물-
公开(公告)号：KR100629712B1
公开(公告)日：2006-09-29
申请号：KR1020040020401
申请日：2004-03-25
Applicant: (주)아모레퍼시픽
IPC: C07C239/14
Abstract: 본 발명은 하기 화학식 1로 표시되는 히드록삼산(Hydroxamic acid) 유도체 및 그 제조방법에 관한 것이다:
[화학식 1]
상기 식 중에서, R
1 및 R
2 는 수소, C
1-10 의 알킬 또는 C
3-6 의 알킬 고리이고;
R
3 는 CONH, NHCO, CONR
5 , 또는 NR
5 CO 이며, 이때, R
5 는 수소 또는 C
1-10 의 알킬이고; 및
R
4 는 -(CH)n- 이며, n = 0, 1이다.
또한 본 발명은 상기 화학식 1의 히드록삼산 유도체를 유효성분으로 함유하는 피부노화 방지용 피부 외용제 조성물에 관한 것이다.
레티노이드 * 레티노익산 수용체 * 히드록삼산 유도체 * 항노화 * 콜라겐 * 엘라스틴 * 콜라게나아제 발현억제 * 엘라스테이즈 발현억제 * 탄력 개선 * 피부 외용제-
公开(公告)号：KR1020060067294A
公开(公告)日：2006-06-20
申请号：KR1020040105553
申请日：2004-12-14
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/0279 , A61K8/66 , A61K8/736 , A61K2800/57 , A61Q19/00
Abstract: 본 발명은 키토산-리파아제 접합체가 포집된 메조포러스 실리카 복합 분체에 관한 것으로서, 보다 상세하게는 피지를 다량 흡수하며 키토산-리파아제 접합체가 더욱 안정화된 키토산-리파아제 접합체가 포집된 메조포러스 실리카 복합 분체에 관한 것이다. 본 발명에 의한 키토산-리파아제 접합체가 포집된 메조포러스 실리카 복합 분체는 피지를 분해할 수 있을 뿐만 아니라 분해된 산출물인 지방산에 흡착하여 자극원인을 제거할 수 있다.
리파아제, 키토산, 효소안정화, 메조포러스 실리카-
69.发明公开토코마이드, 콜레스테롤 및 리놀레익산을 최적비로 혼합한유사각질지질복합체 및 이를 함유하는 화장료 조성물 无效碳酸钙，胆固醇和亚油酸在最佳比例和含有它们的化妆品组合物的PSEUDO-STRATUM CORIEUM LIPID COMPLEX
公开(公告)号：KR1020040038133A
公开(公告)日：2004-05-08
申请号：KR1020020067009
申请日：2002-10-31
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: Provided are a pseudo-stratum corneum lipid complex of tocomide, cholesterol and linoleic acid in the optimum ratio and a cosmetic composition containing the same. The cosmetic composition contains insoluble natural ceramide and a large amount of moisture to show excellent moisturizing effect on the skin. CONSTITUTION: A pseudo-stratum corneum lipid complex of tocomide, cholesterol and linoleic acid in the optimum ratio of 4-6:0.5-1.5:3-5 has excellent moisturizing effect on the skin. The pseudo-stratum corneum lipid complex is composed of 20-70 wt.% of tocomide, 0.01-20 wt.% of cholesterol and 20-70 wt.% of linoleic acid, based on the total weight of the complex. A cosmetic composition is characterized by containing 0.01-40 wt.% of the pseudo-stratum corneum lipid complex.
Abstract translation: 目的：提供最佳比例的toocide，胆固醇和亚油酸的假角质层脂质复合物和含有它们的化妆品组合物。 化妆品组合物含有不溶性天然神经酰胺和大量的水分以对皮肤显示优异的保湿作用。 构成：皮质，胆固醇和亚油酸的假角质层脂质复合物的最佳比例为4-6：0.5-1.5：3-5，对皮肤有很好的保湿作用。 基于复合物的总重量，假角质层脂质复合物由20-70重量％的tocomide，0.01-20重量％的胆固醇和20-70重量％的亚油酸组成。 化妆品组合物的特征在于含有0.01-40重量％的假角质层脂质复合物。
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