公开(公告)号：KR1020120031041A

公开(公告)日：2012-03-29

申请号：KR1020120024051

申请日：2012-03-08

Applicant: 한국과학기술연구원

Inventor： 노주원 ,  이샛별 ,  윤지호 ,  정상훈 ,  이희주 ,  강경수 ,  유지혜 ,  김명수 ,  안수용 ,  김종환

IPC: A61K31/7042 ,  A61K31/704 ,  A61K36/28 ,  A61P1/16

CPC classification number: A61K36/28 ,  A61K31/222 ,  A61K31/7028

Abstract: PURPOSE: A pharmaceutical composition and a health supplement for liver function improvement containing a compound isolated from youngia denticulata as an active ingredient are provided to increase activity of detoxification enzyme of liver including Quinone reductase and Antioxidant response element. CONSTITUTION: A pharmaceutical composition and a health supplement for liver function improvement containing a compound isolated from youngia denticulata as an active ingredient comprises a compound which is represented by chemical formula 3,4, or 5 as active ingredients. The compound of chemical formula 3,4, or 5 is Youngiaside A, Youngiaside B, and Youngiaside C. A health supplement composition for liver function improvement comprises compound of the chemical formulas of 3,4, or 5. The compound of chemical formula 3, 4, or 5 detoxifies carcinogenic materials by multiplying activity of quinone reductase. The compound of chemical formula 3, 4, or 5 also detoxifies carcinogenic materials by multiplying activity of the oxygen-resistant response factor(ARE) which induces activity of 2 phase detoxifying enzyme system.

Abstract translation: 目的：提供一种药物组合物和肝脏功能改善的健康补充剂，其含有从幼牙牙齿中分离的化合物作为活性成分，以增加肝脏的解毒酶的活性，包括醌类还原酶和抗氧化剂反应元件。 构成：含有从幼齿牙齿中分离出的化合物作为活性成分的肝功能改善的药物组合物和健康补充剂包括由化学式3,4或5表示的化合物作为活性成分。 化学式3,4或5的化合物是亚氨基酸A，亚氨基二乙酸和亚油酸酯C.用于肝功能改善的健康补充剂组合物包括化学式为3,4或5的化合物。化学式3的化合物 ，4或5通过增加醌还原酶的活性来解毒致癌物质。 化学式3,4或5的化合物还通过增加诱导2相解毒酶体系活性的耐氧反应因子（ARE）的活性来对致癌物质进行解毒。

公开(公告)号：KR1020110103102A

公开(公告)日：2011-09-20

申请号：KR1020100022255

申请日：2010-03-12

Applicant: 한국과학기술연구원

Inventor： 정상훈 ,  이희주 ,  이은하 ,  김철영 ,  엄병헌 ,  노주원 ,  김경아

IPC: A61K36/899 ,  A61P27/06

Abstract: 본 발명은 오죽 추출물, 이의 분획물 또는 이로부터 분리된 하기 [화학식 1]로 기재되는 화합물을 유효성분으로 함유하는 녹내장 예방 및 치료용 조성물에 관한 것으로, 구체적으로 오죽을 유기용매로 추출하여 제조되는 추출물, 이의 분획물 및 상기 분획물에서 분리한 화합물인 루테오린 6-C-(6''-
O -트랜스-카페오일클루코사이드)[Luteolin 6-C-(6''-
O -trans-caffeoylglucoside)]을 포함하는 녹내장 예방 및 치료용 조성물에 관한 것이다. 본 발명의 조성물은 녹내장의 원인인 망막 신경 세포의 퇴화를 보호해 주는 작용을 나타냄으로써, 녹내장의 예방 또는 치료용 조성물로 유용하게 사용될 수 있다:
[화학식 1]
.

公开(公告)号：KR1020100091131A

公开(公告)日：2010-08-18

申请号：KR1020100011969

申请日：2010-02-09

Applicant: 한국과학기술연구원

Inventor： 노주원 ,  이샛별 ,  윤지호 ,  정상훈 ,  이희주 ,  강경수 ,  유지혜 ,  김명수 ,  안수용 ,  김종환

IPC: A61K36/28 ,  A61K31/222 ,  A61K31/7028 ,  A61P35/00

CPC classification number: A61K36/28 ,  A61K31/222 ,  A61K31/7028

Abstract: PURPOSE: A composition containing Youngia denticulate extract or compound isolated from the same are provided to induce activation of quinone reductase(QR) and to improve liver function. CONSTITUTION: A pharmaceutical composition for preventing cancer contains Youngia denticulate extract as an active ingredient, which is isolated using water, organic solvent or mixture solvent thereof. An organic solvent is alcohol of C1-C4, acetic acid ethyl, methylene chloride, or chloroform. The Youngia denticulate extract detoxifies carcinogen by enhancing quinone reductase activation. A pharmaceutical composition for preventing cancer contains Youngia denticulate fraction as an active ingredient. The Youngia denticulate fraction is obtained by frequently fractioning Youngia denticulate extract using n-hexane, ethyl acetate, and n-butanol. The pharmaceutical composition for preventing cancer contains a compound of chemical formula 1, 2, 3, 4, or 5 as an active ingredient.

Abstract translation: 目的：提供含有Youngia牙质提取物或从其分离的化合物的组合物以诱导醌还原酶（QR）的活化并改善肝功能。 构成：用于预防癌症的药物组合物含有作为活性成分的青ia牙提取物，其使用水，有机溶剂或其混合溶剂分离。 有机溶剂是C1-C4，乙酸乙酯，二氯甲烷或氯仿的醇。 青霉素小齿提取物通过增强醌还原酶活化来解毒致癌物质。 用于预防癌症的药物组合物含有作为活性成分的青霉素小齿状部分。 通过使用正己烷，乙酸乙酯和正丁醇频繁分选杨氏小齿提取物获得青霉素小齿级分。 用于预防癌症的药物组合物含有作为活性成分的化学式1,2,3,4或5的化合物。

公开(公告)号：KR1020080090710A

公开(公告)日：2008-10-09

申请号：KR1020070033872

申请日：2007-04-05

Applicant: 한국과학기술연구원

Inventor： 노주원 ,  김철영 ,  정상훈 ,  강경수 ,  이희주 ,  이샛별

IPC: A61K31/352 ,  A61K36/48 ,  A61P3/10

Abstract: A 5-methylsophoraflavanone B isolated from an extract of Sophora flavascens is provided to show inhibitory effect on the activity of aldose reductase causing diabetic complications and prevent obesity by inhibiting differentiation of fat cells, thereby being usefully used for preventing or treating the diabetic complications or the obesity. A pharmaceutical composition for preventing and treating diabetic complications or obesity comprises an extract of Sophora flavascens or 5-methylsophoraflavanone B isolated therefrom and represented by a formula(1) as an effective ingredient, wherein the extract of Sophora flavascens or the 5-methylsophoraflavanone B is prepared by extracting dried materials of Sophora flavascens roots with C1-4 alcohol to obtain the extract of Sophora flavascens, subjecting the extract to high speed liquid chromatography to isolate the 5-methylsophoraflavanone B and purifying the isolated 5-methylsophoraflavanone B. Further, the C1-4 alcohol is ethanol.

Abstract translation: 提供从苦参中提取物中分离出的5-甲基异佛唑酮B，以显示对糖尿病并发症的醛糖还原酶的活性的抑制作用，并通过抑制脂肪细胞的分化来预防肥胖，从而有效地用于预防或治疗糖尿病并发症或 肥胖。 用于预防和治疗糖尿病并发症或肥胖症的药物组合物包含由其分离并由式（1）代表的作为有效成分的苦参皂甙或5-甲基异佛唑酮乙酸酯B的提取物，其中苦参中的苦参提取物或5-甲基异佛唑酮B为 通过用C 1-4醇提取苦参皂甙干燥物质，得到苦参皂甙提取物，高效液相色谱法分离5-甲基异佛唑酮B，纯化分离出的5-甲基异佛唑酮B.制备C1， -4酒精是乙醇。