Abstract:
본 발명은 이고들빼기( Youngia denticulata ) 추출물, 이의 분획물 또는 이로부터 분리한 화합물인 클로로제닉엑시드(Chlorogenic acid), 3,5-다이-오-카페오일퀴닉엑시드(3,5-Di-O-caffeoylquinic acid), 영지아사이드 A(Youngiaside A), 영지아사이드 B(Youngiaside B), 영지아사이드 C(Youngiaside C)로 구성되는 군으로부터 선택되는 하나 이상의 화합물을 유효성분으로 함유하는 암 예방용 약학적 조성물 또는 간 기능 개선용 약학적 조성물에 관한 것으로, 본 발명에 따른 이고들빼기 추출물, 이의 분획물 또는 이로부터 분리된 화합물은 암 예방 지표효소인 퀴논 리덕타아제(Quinone reductase, QR)와 항산화 반응인자인 항산화반응인자(Antioxidant response element, ARE)를 비롯한 간의 해독효소의 활성을 증진시키고, 세포 독성이 없을 뿐만 아니라, 에탄올과 아세트아미노펜에 의해 유도되는 간손상으로부터 간을 보호하므로, 본 발명에 따른 조성물은 암 예방 또는 간 기능 개선을 위한 의약품, 건강기능식품에 유용하게 사용될 수 있다.
Abstract:
The present invention relates to an antibacterial composition containing a natural extract. The antibacterial composition of the present invention includes a Cirsium sp. plant extract as an active ingredient. A Cirsium sp. plant is selected from a group consisting of Cirsium pendulum, Cirsium japonicum, Cirsium vulgare, Cirsium canum, Cirsium pyrenaicum, and Cirsium arizonicum. [Reference numerals] (AA) Control group;(BB) Treatment group of Circii Radix extract
Abstract:
The present invention relates to an antimicrobial composition including natural extracts, and more specifically, to an antimicrobial composition including Staphylea sp. plant extracts as an active ingredient. The Staphylea sp. plant is Staphylea bumalda. [Reference numerals] (AA) Control group;(BB) Pepper tree extract
Abstract:
본 발명의 포도근, 검은재나무 및 꽃싸리로 이루어지는 군으로부터 선택되는 어느 하나 이상의 추출물을 유효성분으로 함유하는 항균용 조성물은 부패 악취 유발 세균, 식품 부패의 원인균, 식중독의 원인균, 여드름의 원인균, 피부질환 세균 또는 구강질환 원인균에 대하여 항균활성을 가지고 있어, 식품의 부패를 막고 식중독을 예방하며, 피부 표면을 세정 및 정균·살균하고, 구강 내 질환 및 충치를 예방하는 항균용 조성물로서, 피부 외용제, 화장료 조성물 및 구강용 조성물로 유용하게 사용될 수 있다.
Abstract:
PURPOSE: A pharmaceutical composition and a health supplement for liver function improvement containing a compound isolated from youngia denticulata as an active ingredient are provided to increase activity of detoxification enzyme of liver including Quinone reductase and Antioxidant response element. CONSTITUTION: A pharmaceutical composition and a health supplement for liver function improvement containing a compound isolated from youngia denticulata as an active ingredient comprises a compound which is represented by chemical formula 3,4, or 5 as active ingredients. The compound of chemical formula 3,4, or 5 is Youngiaside A, Youngiaside B, and Youngiaside C. A health supplement composition for liver function improvement comprises compound of the chemical formulas of 3,4, or 5. The compound of chemical formula 3, 4, or 5 detoxifies carcinogenic materials by multiplying activity of quinone reductase. The compound of chemical formula 3, 4, or 5 also detoxifies carcinogenic materials by multiplying activity of the oxygen-resistant response factor(ARE) which induces activity of 2 phase detoxifying enzyme system.
Abstract:
PURPOSE: A composition containing Youngia denticulate extract or compound isolated from the same are provided to induce activation of quinone reductase(QR) and to improve liver function. CONSTITUTION: A pharmaceutical composition for preventing cancer contains Youngia denticulate extract as an active ingredient, which is isolated using water, organic solvent or mixture solvent thereof. An organic solvent is alcohol of C1-C4, acetic acid ethyl, methylene chloride, or chloroform. The Youngia denticulate extract detoxifies carcinogen by enhancing quinone reductase activation. A pharmaceutical composition for preventing cancer contains Youngia denticulate fraction as an active ingredient. The Youngia denticulate fraction is obtained by frequently fractioning Youngia denticulate extract using n-hexane, ethyl acetate, and n-butanol. The pharmaceutical composition for preventing cancer contains a compound of chemical formula 1, 2, 3, 4, or 5 as an active ingredient.