公开(公告)号：KR100813008B1

公开(公告)日：2008-03-13

申请号：KR1020060123331

申请日：2006-12-06

Applicant: 한국전자통신연구원

Inventor： 정호열 ,  김민호 ,  정명근 ,  김보라 ,  박선희 ,  박수준

IPC: G01N33/48

CPC classification number: G06F19/24 ,  G06F19/20 ,  G06F19/26 ,  G06F19/18

Abstract: An apparatus and a method for predicting a gene module are provided to predict the gene module(a group of genes) controlled by the same transcription factor group and performing the same function in a cell from gene expression data and transcription factor binding information. An apparatus for predicting a gene module(103) comprises: a gene expression similarity matrix generation means(104) which generates a gene expression similarity matrix using gene expression date from the outside gene expression data; a gene expression similarity graph generation means(105) which generates a gene expression similarity graph using the gene expression similarity matrix generated from the gene expression similarity matrix generation means; a crowd portion graph generation means(106) which applies a crowd portion graph algorithm to the gene expression similarity graph to generate a crowd portion graph; and a significant gene module generation means(107) which extracts the transcription factor binding information from the outside transcription factor binding database using the crowd portion graph to generate a significant gene module, wherein the crowd portion graph generation means generates the crowd portion graph accepting the replication of the gene.

Abstract translation: 提供一种用于预测基因模块的装置和方法，以预测由相同转录因子组控制的基因模块（一组基因），并从基因表达数据和转录因子结合信息在细胞中起相同的功能。 一种用于预测基因模块（103）的装置，包括：使用基因表达日期从外部基因表达数据生成基因表达相似性矩阵的基因表达相似性矩阵生成装置（104） 使用从基因表达相似矩阵生成单元生成的基因表达相似性矩阵生成基因表达相似图的基因表达相似图生成单元（105） 人群部分图生成装置，将群体部分图算法应用于基因表达相似图，生成人群部分图; 以及使用人群部分图从外部转录因子结合数据库中提取转录因子结合信息以产生重要基因模块的显着基因模块产生装置（107），其中，群体部分图生成装置生成接受 基因的复制。