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公开(公告)号：HRP20151389T1
公开(公告)日：2016-01-15
申请号：HRP20151389
申请日：2015-12-17
Applicant: ABBVIE BAHAMAS LTD
Inventor： DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHEL V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , GAO YI , LIU DACHUN , PRATT JOHN K , ROCKWAY TODD W , MARING CLARENCE J , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , TUFANO MICHAEL D , BETEBENNER DAVID A , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBEL H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , CARROLL WILLIAM A
IPC: A61K31/454 , A61P31/14
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公开(公告)号：PH12015500289A1
公开(公告)日：2015-09-07
申请号：PH12015500289
申请日：2015-02-09
Applicant: ABBVIE BAHAMAS LTD
Inventor： RANDOLPH JOHN T , DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , SOLTWEDEL TODD N , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , ROLF WAGNER , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , DACHUN LIU , PRATT JOHN K , LAVIN MICHAEL J , KATHY SARRIS , WOLLER KEVIN R , WAGAW SEHLE H , CALIFANO JEAN C , WENKE LI
IPC: A61K31/401 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/4439 , A61K45/00 , A61P31/14 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：CR20150238A
公开(公告)日：2015-07-01
申请号：CR20150238
申请日：2015-05-08
Applicant: ABBVIE BAHAMAS LTD
Inventor： WAGNER ROLF , TUFANO MICHAEL D , STEWART KENT D , ROCKWAY TODD W , RANDOLPH JOHN T , PRATT JOHN K , MOTTER CHRISTOPHER E , MARING CLARENCE J , LONGENECKER KENTON L , LIU YAYA , LIU DACHUN , KRUEGER ALLAN C , KATI WARREN M , HUTCHINSON DOUGLAS K , HUANG PEGGY P , FLENTGE CHARLES A , DONNER PAMELA L , DEGOEY DAVID A , BETEBENNER DAVID A , BARNES DAVID M , CHEN SHUANG , FRANCZYK II THADDEUS S , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , HENRY RODGER F , KOTECKI BRIAN J , LOU XIAOCHUN , SARRIS KATHY , ZHANG GEOFF G Z
IPC: C07D239/22 , A61K31/513 , A61P31/12 , C07D239/54 , C07D401/10 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10
Abstract: Esta invención se relaciona con: (a) compuestos y sales de los mismos que, entre otros, inhiben el HCV; (b) intermediarios de utilidad para la preparación de dichos compuestos y sales; (c) composiciones que comprenden dichos compuestos y sales; (d) métodos para preparar dichos intermediarios
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公开(公告)号：SI2368882T1
公开(公告)日：2015-02-27
申请号：SI200831329
申请日：2008-09-17
Applicant: ABBVIE BAHAMAS LTD
Inventor： FLENTGE CHARLES A , HUTCHINSON DOUGLAS K , BETEBENNER DAVID A , DEGOEY DAVID A , DONNER PAMELA L , KATI WARREN M , KRUEGER ALLAN C , LIU DACHUN , LIU YAYA , LONGENECKER KENTON L , MARING CLARENCE J , MOTTER CHRISTOPHER E , PRATT JOHN K , RANDOLPH JOHN T , ROCKWAY TODD W , STEWART KENT D , WAGNER ROLF , BARNES DAVID M , CHEN SHUANG , FRANCZYK II THADDEUS S , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , KOTECKI BRIAN J , LOU XIAOCHUN , ZHANG GEOFF G Z
IPC: C07D239/00 , A61K31/00 , A61P31/00 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D413/00 , C07D417/00
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公开(公告)号：UY34983A
公开(公告)日：2014-01-31
申请号：UY34983
申请日：2013-08-21
Applicant: ABBVIE BAHAMAS LTD
Inventor： DEGOEY DAVID A , WOLLER KEVIN R , NELSON LISSA T , PATEL SACHIN V , KEDDY RYAN G , JINKERSON TAMMIE K , DACHUN LIU , PRATT JOHN K , CALIFANO JEAN C , HUTCHINS CHARLES W , RANDOLPH JOHN T , KATI WARREN M , BETEBENNER DAVID A , DONNER PAMELA L , KRUEGER ALLAN C , MOTTER CHRISTOPHER E , MATULENKO MARK A , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , ROLF WAGNER , MARING CLARENCE J , TUFANO MICHAEL D , ROCKWAY TODD W , KATHY SARRIS , WAGAW SEBLE H , CASPI DANIEL D , BELLIZZI MARY E , PILOT-MATIAS TAMI , PREETHI KRISHNAN , MISTRY NEETA C , WENKE LI
IPC: A61P31/14 , A61K31/4025 , A61K31/4184 , C07D207/08 , C07D207/10 , C07D211/08 , C07D263/56 , C07D277/82 , C07D307/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/08
Abstract: Compuestos eficaces para inhibir la replicación del virus de la hepatitis C (?HCV?). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que compre nden a dichos compuestos y con métodos de uso de dichos para tratar una infección por HCV
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Patent Agency Ranking
公开(公告)号：ES2414934T9
公开(公告)日：2013-11-28
申请号：ES11160830
申请日：2010-06-10
Applicant: ABBVIE INC. , ABBVIE BAHAMAS LTD
Inventor： RANDOLPH JOHN T , DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER CHARLES A , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , LIU DACHUN , PRATT JOHN K , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , YI GAO
IPC: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/4439 , A61P31/14 , C07D401/14 , C07D417/14
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公开(公告)号：CA2849420A1
公开(公告)日：2009-03-26
申请号：CA2849420
申请日：2008-09-17
Applicant: ABBVIE BAHAMAS LTD
Inventor： FLENTGE CHARLES A , HUTCHINSON DOUGLAS K , BETEBENNER DAVID A , DEGOEY DAVID A , DONNER PAMELA L , KATI WARREN M , KRUEGER ALLAN C , LIU DACHUN , LIU YAYA , LONGENECKER KENTON L , MARING CLARENCE J , MOTTER CHRISTOPHER E , PRATT JOHN K , RANDOLPH JOHN T , ROCKWAY TODD W , STEWART KENT D , WAGNER ROLF , BARNES DAVID M , CHEN SHUANG , FRANCZYK THADDEUS S II , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , KOTECKI BRIAN J , LOU XIAOCHUN , ZHANG GEOFF G Z
IPC: A61K31/505 , A61K31/7056 , A61P31/14
Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号：ECSP17064986A
公开(公告)日：2017-10-31
申请号：ECPI201764986
申请日：2017-09-29
Applicant: ABBVIE BAHAMAS LTD
Inventor： FLENTGE CHARLES A , MARING CLARENCE J , WAGNER ROLF , WOLLER KEVIN R , PRATT JOHN K , MOTTER CHRISTOPHER E , BETEBENNER DAVID A , SARRIS KATHY , PATEL SACHIN V , HUTCHINS CHARLES W , CALIFANO JEAN C , HUTCHINSON DOUGLAS K , DEGOEY DAVID , LIU DACHUN , GAO YI , CASPI DANIEL , BELLIZZI MARY , RANDOLPH JOHN T , LI WENKE , WAGAW SEBIE H , TUFANO MICHAEL D , KEDDY RYAN G , KRUEGER ALLAN C , ROCKWAY TODD W , JINKERSON TAMMIE K , MATULENKO MARK A , NELSON LISSA T , DONNER PAMELA L , KATI WARREN M
IPC: C07D403/14
Abstract: Compuestos eficaces para inhibir la replicación del virus de la hepatitis C (“HCV”). Esta invención también se relaciona con procesos de elaboración de tales compuestos, con composiciones que comprenden a dichos compuestos y con métodos de uso de dichos compuestos para tratar una infección por HCV.
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公开(公告)号：NZ715562A
公开(公告)日：2017-09-29
申请号：NZ71556211
申请日：2011-10-12
Applicant: ABBVIE BAHAMAS LTD
Inventor： DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , GAO YI , LIU DACHUN , PRATT JOHN K , ROCKWAY TODD W , MARING CLARENCE J , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , TUFANO MICHAEL D , BETEBENNER DAVID A , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , CARROLL WILLIAM A
IPC: C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61P31/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113
Abstract: Provided are compounds of general formula I, where the variables are as described in the specification. An example of the compounds is methyl { (2S)-1-[(2S)-2-{ 5-[(2R,5R)-5-{ 2-[(2S)-1-{ (2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl} pyrrolidin-2-yl]-1H-benzimidazol-5-yl} -1-(4-phenoxyphenyl)pyrrolidin-2-yl]-1H-benzimidazol-2-yl} pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl} carbamate. The compounds are inhibitors of hepatitis C virus (HCV). Further provided are processes and intermediates for preparing the compounds and pharmaceutical compositions comprising them. A preferred compound is methyl { (2S,3R)-1-[(2S)-2-{ 5-[(2R,5R)-1- { 3,5-difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]phenyl} -5-(6-fluoro-2-{ (2S)-1-[N-(methoxycarbonyl)-O-methyl-L-threonyl]pyrrolidin-2-yl} -1H-benzimidazol-5-yl)pyrrolidin-2-yl]-6-fluoro-1H-benzimidazol-2-yl} pyrrolidin-1-yl]-3-methoxy-1-oxobutan-2-yl} carbamate.
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公开(公告)号：CY1116060T1
公开(公告)日：2017-03-15
申请号：CY151100050
申请日：2015-01-16
Applicant: ABBVIE BAHAMAS LTD
Inventor： RANDOLPH JOHN T , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , DEGOEY DAVID A , LIU DACHUN , PRATT JOHN K , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , GAO YI , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V
IPC: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/4439 , A61P31/14 , C07D401/14 , C07D417/14
Abstract: Περιγράφονταιενώσειςαποτελεσματικέςστηναναστολήαντιγραφήςτουιούηπατίτιδας C («HCV»). Ηεφεύρεσηαυτήεπίσηςαφοράσεμεθόδουςκατασκευήςτέτοιωνενώσεων, συνθέσειςπουπεριλαμβάνουντέτοιεςενώσειςκαιμεθόδουςχρήσηςτέτοιωνενώσεωνγιαναθεραπεύεταιμόλυνση HCV.
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