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    HIGH FLUX SOLAR ENERGY TRANSFORMATION
    61.
    发明申请
    HIGH FLUX SOLAR ENERGY TRANSFORMATION 审中-公开
    高通量太阳能转换

    公开(公告)号：WO1989008271A1

    公开(公告)日：1989-09-08

    申请号：PCT/US1989000878

    申请日：1989-03-03

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  WINSTON, Roland ,  GLECKMANN, Philip, L. ,  O'GALLAGHER, Joseph, J.

    IPC: G02B05/10

    CPC classification number: G02B19/0033 ,  F24S23/00 ,  F24S23/79 ,  G02B19/0023 ,  G02B19/0028 ,  G02B19/0042 ,  Y02E10/44

    Abstract: Disclosed are multi-stage systems (10) for high flux transformation of solar energy allowing for uniform solar intensification by a factor of 60,000 suns or more. Preferred systems employ a focusing mirror (20) as a primary concentrative device and a non-imaging concentrator (30) as a secondary concentrative device with concentrative capabilities of primary and secondary stages (20, 30) selected to provide for net solar flux intensification of greater than 2000 over 95 percent of the concentration area. Systems of the invention are readily applied as energy sources for layer pumping and in other photothermal energy utilization processes.

    Abstract translation: 公开了用于太阳能高通量转换的多级系统（10），其允许太阳能集中度达到6万以上的太阳能。 优选的系统使用聚焦反射镜（20）作为主要集中装置，而非成像浓缩器（30）作为次级浓缩装置，其具有初级和次级级（20,30）的集中能力，以提供净太阳能通量增强 超过2000多个集中区域的95％以上。 本发明的系统容易用作层泵送的能源和其它光热能利用过程。

    METHODS AND COMPOSITIONS FOR INHIBITING 5'alpha'-REDUCTASE ACTIVITY
    65.
    发明申请
    METHODS AND COMPOSITIONS FOR INHIBITING 5'alpha'-REDUCTASE ACTIVITY 审中-公开
    抑制5种α - 淀粉酶活性的方法和组合物

    公开(公告)号：WO1996037201A2

    公开(公告)日：1996-11-28

    申请号：PCT/US1996007137

    申请日：1996-05-16

    Applicant: ARCH DEVELOPMENT CORPORATION ,  LIAO, Shutsung ,  LIANG, Theming

    Inventor： ARCH DEVELOPMENT CORPORATION

    IPC: A61K31/20

    CPC classification number: A61K8/361 ,  A61K8/37 ,  A61K8/498 ,  A61K8/67 ,  A61K31/216 ,  A61K31/353 ,  A61K31/565 ,  A61K45/06 ,  A61K2800/782 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/06 ,  C07C53/21 ,  C07C57/52 ,  C07C57/56 ,  C07C61/16 ,  C07C61/40 ,  C07C69/88 ,  A61K31/35 ,  A61K31/235 ,  A61K31/20 ,  A61K31/19 ,  A61K2300/00

    Abstract: Disclosed are novel classes of antiandrogenic compounds including saturated and unsaturated fatty acids, catechin gallates, their derivatives, and synthetic analogs, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of compositions not previously known for their antiandrogenic activity in treating disorders related to androgenic activities and cancers. Methods are disclosed for the treatment of breast cancer, prostate cancer, and other tumors using compositions comprising testosterone compositions in combination with 5 alpha -reductase inhibitors such as fatty acids and catechin compositions. Compositions and methods are also disclosed for use in reducing lipid production in an animal, reducing organ and body weight, treating hair loss, benign prostatic hyperplasia, reducing sebum production, and other related disorders.

    Abstract translation: 公开了新型的抗雄激素化合物，包括饱和和不饱和脂肪酸，儿茶素没食子酸酯，其衍生物和合成类似物，以及它们在治疗与雄激素活性相关的疾病中的用途。 还公开了在治疗与雄激素活性和癌症有关的疾病中使用先前已知的抗雄激素活性的组合物。 公开了用于使用包含睾丸酮组合物与5种α-还原酶抑制剂如脂肪酸和儿茶素组合物组合的组合物来治疗乳腺癌，前列腺癌和其它肿瘤的方法。 还公开了组合物和方法用于减少动物中的脂质生成，减少器官和体重，治疗脱发，良性前列腺增生，减少皮脂产生和其它相关疾病。

    INDUCTION OF E-SELECTIN FOR TARGETTING THERAPEUTIC AGENTS
    66.
    发明申请
    INDUCTION OF E-SELECTIN FOR TARGETTING THERAPEUTIC AGENTS 审中-公开
    诱导用于靶向治疗药物的E-选择素

    公开(公告)号：WO1996025947A2

    公开(公告)日：1996-08-29

    申请号：PCT/US1996002796

    申请日：1996-02-21

    Applicant: ARCH DEVELOPMENT CORPORATION ,  HALLAHAN, Dennis, E. ,  WEICHSELBAUM, Ralph, R.

    Inventor： ARCH DEVELOPMENT CORPORATION

    IPC: A61K41/00

    CPC classification number: C12N15/86 ,  A61K41/00 ,  A61K47/68 ,  A61K47/6849 ,  A61K48/00 ,  A61K51/1027 ,  A61K51/1234 ,  C07K14/525 ,  C07K14/7056 ,  C07K16/2854 ,  C12N2710/10343 ,  C12N2830/008

    Abstract: The present invention provides methods and compositions for use in specifically targetting tumor vasculature endothelial cells, thereby delivering selected therapeutic and diagnostic agents to the tumor vasculature. The invention requires the induction of the molecule E-selectin in tumor vasculature endothelial cells, as may be achieved using ionizing radiation, which then allows the selecting to be targeted using specific binding compositions and selected agents. The invention therefore provides methods for delivering a selected agent to the vasculature of an animal or human subject comprising inducing E-selecting expression in vascular endothelial cells and administering to the animal a composition comprising an E-selectin targetting component operatively associated with or attached to a selected agent. The currently preferred methods involve E-selectin induction.

    Abstract translation: 本发明提供用于特异性靶向肿瘤血管内皮细胞的方法和组合物，从而将选定的治疗和诊断剂递送至肿瘤血管系统。 本发明需要在肿瘤血管内皮细胞中诱导分子E-选择蛋白，这可以使用电离辐射来实现，然后电离辐射然后允许使用特异性结合组合物和所选择的试剂进行选择。 因此，本发明提供了将所选择的药剂递送至动物或人类受试者的脉管系统的方法，包括在血管内皮细胞中诱导E-选择表达，并向动物施用包含与选择蛋白靶向组分可操作地连接或连接至 选择代理。 目前优选的方法涉及E-选择素诱导。

    STABILIZED PROSTHETIC KNEE
    67.
    发明申请
    STABILIZED PROSTHETIC KNEE 审中-公开
    稳定的预感知

    公开(公告)号：WO1996024311A1

    公开(公告)日：1996-08-15

    申请号：PCT/US1996001725

    申请日：1996-02-05

    Applicant: ARCH DEVELOPMENT CORPORATION ,  DRAGANICH, Louis, F. ,  POTTENGER, Lawrence, A.

    Inventor： ARCH DEVELOPMENT CORPORATION

    IPC: A61F02/38

    CPC classification number: A61F2/3868 ,  A61F2/3886 ,  A61F2002/30156 ,  A61F2002/304 ,  A61F2002/30434 ,  A61F2002/30878 ,  A61F2220/0025 ,  A61F2220/0041 ,  A61F2230/0023 ,  A61F2310/00029

    Abstract: A semi-constrained prosthetic knee (10) for surgical replacement of a dysfunctional knee includes a tibial platform (22), a movable bearing element (16), and a femoral component (12). The femoral and tibial components are typically constructed of a cobalt/chromium alloy and each includes an extension for securing the component to the bone. The femoral component includes a polycentric convex bearing which slidably engages a movable bearing, typically constructed of high molecular weight polyethylene. The superior surface of the bearing element is designed to congruently slidably engage the inferior surface of the bearing portion of the femoral component throughout the flexion/extension range of the knee. The inferior surface of the femoral component is generally convex with two or more offset portions of varying radii of curvature matching complementary superior surfaces of the bearing element. The superior surface of the tibial platform is generally flat and includes at least one protrusion for controlling the movement of the bearing element.

    Abstract translation: 用于手术替代功能不全膝盖的半约束假体膝盖（10）包括胫骨平台（22），可移动轴承元件（16）和股骨部件（12）。 股骨和胫骨部件通常由钴/铬合金构成，并且每个包括用于将部件固定到骨头的延伸部。 股骨部件包括可以与通常由高分子量聚乙烯构成的可移动轴承滑动接合的多中心凸形轴承。 轴承元件的上表面被设计成在膝盖的整个屈曲/伸展范围内一致滑动地接合股骨部件的支承部分的下表面。 股骨部件的下表面通常是凸起的，具有两个或更多个具有不同曲率半径的偏移部分，其匹配轴承元件的互补的上表面。 胫骨平台的上表面通常是平坦的，并且包括至少一个用于控制轴承元件运动的突起。

    FEATURE GUIDED METHOD AND APPARATUS FOR OBTAINING AN IMAGE OF AN OBJECT
    69.
    发明申请
    FEATURE GUIDED METHOD AND APPARATUS FOR OBTAINING AN IMAGE OF AN OBJECT 审中-公开
    特征指导方法和获取对象图像的设备

    公开(公告)号：WO1996004614A1

    公开(公告)日：1996-02-15

    申请号：PCT/US1995009913

    申请日：1995-08-04

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  LEVIN, David, N.

    IPC: G06T11/00

    CPC classification number: G06T11/005 ,  G01R33/5608 ,  G01R33/561 ,  G01R33/56545

    Abstract: A method and apparatus for obtaining an image from an object by acquiring training signal measurements which represent images of a plurality of training objects having at least one predetermined feature in common with the object and derive, from the training signal measurements, a set of basis functions that provide a convergent series expansion of the images. The method and apparatus determine a signal measurement prescription for the object based on the basis functions. A signal measurement acquiring device is controlled to acquire signal measurements of the object as determined by the signal measurement prescription. A truncated basis function expansion of the image is generated from the acquired signal measurements. Estimates of additional signal measurements are carried out based on the truncated basis function expansion. The image is reconstructed using the obtained signal measurements and the estimated additional signal measurements. The training signals may also be generated synthetically without the use of training objects.

    Abstract translation: 一种用于通过获取训练信号测量来获得图像的方法和装置，所述训练信号测量表示具有与所述对象共同的至少一个预定特征的多个训练对象的图像，并从所述训练信号测量中导出一组基本函数 提供图像的收敛系列扩展。 该方法和装置基于基础函数来确定对象的信号测量处方。 信号测量获取装置被控制以获取由信号测量处方确定的对象的信号测量。 从所获取的信号测量中产生图像的截断基函数扩展。 基于截断的基函数扩展进行附加信号测量的估计。 使用获得的信号测量和估计的附加信号测量来重建图像。 也可以在不使用训练对象的情况下综合地生成训练信号。

    CONTROL OF WOUND SCAR PRODUCTION WITH CALCIUM ANTAGONISTS ALONE OR IN A COMBINATION WITH A STEROID
    70.
    发明申请
    CONTROL OF WOUND SCAR PRODUCTION WITH CALCIUM ANTAGONISTS ALONE OR IN A COMBINATION WITH A STEROID 审中-公开
    用钙拮抗剂进行创伤发作的控制，或与STEROID组合

    公开(公告)号：WO1994002130A1

    公开(公告)日：1994-02-03

    申请号：PCT/US1993006804

    申请日：1993-07-20

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  ARCH DEVELOPMENT CORPORATION

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  ARCH DEVELOPMENT CORPORATION ,  LEE, Raphael, C.

    IPC: A61K31/275

    CPC classification number: A61K31/57 ,  A61K31/135 ,  A61K31/275 ,  A61K31/44 ,  A61K31/54 ,  A61K31/55 ,  A61K33/24 ,  A61K2300/00

    Abstract: This invention pertains to a method for controlling wound scar production by administering a calcium antagonist, alone or in a combination with or followed by a steroid, to the wound site. The method can be used to minimize wound scars, such as hypertrophic wound healing disorders, keloids and burn scar contractures in humans or other mammals, particularly those individually prone to excessive scarring. Calcium antagonist treatment can also be used to control diseases associated with excessive scarring, such as cirrhosis of the liver, constructive pericarditis, Dupuytren's disease of the hand, plantar fibrosis of the foot, and various other fibromatoses.

    Abstract translation: 本发明涉及一种通过向伤口部位施用单独或与类固醇组合或与之结合的钙拮抗剂来控制伤口瘢痕产生的方法。 该方法可以用于最小化人或其它哺乳动物，特别是单独容易发生过度瘢痕形成的伤口瘢痕，例如增生性伤口愈合障碍，瘢痕疙瘩和烧伤瘢痕挛缩。 钙拮抗剂治疗也可用于控制与过度瘢痕形成相关的疾病，如肝硬化，建构性心包炎，手杜邦氏病，脚足底纤维化和各种其他纤维瘤病。

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