公开(公告)号：EP1102749A1

公开(公告)日：2001-05-30

申请号：EP99938237.7

申请日：1999-07-14

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： GOLSCH, Dieter ,  KEIL, Michael ,  ISAK, Heinz ,  MAYER, Horst

IPC: C07D213/80 ,  C07D213/78 ,  C07B43/00

CPC classification number: C07D213/78 ,  C07D213/80

Abstract: The invention relates to a method for producing 2-halogen nicotinic acid derivatives of formula (I), in which X is bromine or chlorine and Y is hydroxy, bromine or chlorine.

公开(公告)号：EP0999999A1

公开(公告)日：2000-05-17

申请号：EP98938690.9

申请日：1998-07-20

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： WINGERT, Horst ,  GÖTZ, Norbert ,  KEIL, Michael ,  MÜLLER, Bernd

IPC: C07B39/00 ,  C07C17/14 ,  C07C201/12 ,  C07C67/307 ,  C07C253/30

CPC classification number: C07C253/30 ,  C07B39/00 ,  C07C17/14 ,  C07C67/307 ,  C07C201/12 ,  C07C25/13 ,  C07C25/02 ,  C07C69/76 ,  C07C205/11

Abstract: The invention concerns a method for preparing substituted benzyl bromides of general formula (I), wherein at least one substituent R1-5 represents an electroattractive group, such as fluorine, chlorine, bromine, C¿1?-C4 alkoxycarbonyl, cyano or nitro, and the remaining R?1-5¿ substituents represent hydrogen or methyl, by bromination of substituted toluenes of general formula (II) with a bromination agent at temperatures from 20 to 95 °C.

公开(公告)号：EP0711274B1

公开(公告)日：1998-05-06

申请号：EP94924726.6

申请日：1994-07-08

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： KLEIN, Ulrich ,  BUSCHMANN, Ernst ,  KEIL, Michael ,  GÖTZ, Norbert ,  HARREUS, Albrecht

IPC: C07C239/20

CPC classification number: C07C239/20

公开(公告)号：EP0794941A1

公开(公告)日：1997-09-17

申请号：EP95940223.0

申请日：1995-11-21

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： WINGERT, Horst ,  KEIL, Michael

IPC: C07C249 ,  C07C251

CPC classification number: C07C249/12

Abstract: The invention concerns a process for preparing oxime ethers of general formula (I), in which R1 means a C-organic group; R2 means hydrogen, alkoxy, cyano, nitro, SOR4, SO2R4, CO2-alkyl, P(O) (OR4)2 or a C-organic group; and R3, R4 mean optionally substituted C¿1?-C6 alkyl, by converting an oxime of general formula (II), in which the substituents R?1, R2¿ have the above meanings, optionally in the presence of an organic diluting agent with a base into the corresponding salt, and reacting the latter with a dialkylcarbonate of general formula (III), R3 having the above meaning.

公开(公告)号：EP0765304A1

公开(公告)日：1997-04-02

申请号：EP95921761.0

申请日：1995-05-26

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： BAYER, Herbert ,  ISAK, Heinz ,  WINGERT, Horst ,  SAUTER, Hubert ,  KEIL, Michael ,  NETT, Markus ,  BENOIT, Remy ,  MÜLLER, Ruth

IPC: C07C67 ,  C07C69 ,  C07C235 ,  C07C249 ,  C07C251 ,  C07C255 ,  C07D249 ,  C07D521

CPC classification number: C07D249/12 ,  C07C67/22 ,  C07C235/78 ,  C07C249/08 ,  C07C249/12 ,  C07C251/48 ,  C07C251/60 ,  C07C69/738

Abstract: The invention concerns a method of preparing α-methoxyiminocarboxylic acid methylamides of formula (I) (X = nitro, trifluoromethyl, halogen, alkyl or alkoxy; n = 0, 1, 2, 3 or 4; Y = an organic carbon group) by the Pinner reaction of a cyanoketone of formula (II) with an alcohol, followed by reaction of the ester of formula (IV) formed in the Pinner reaction with hydroxylamine to give an oxime of formula (V), methylation of (V) to give an oxime ether of formula (VI) and subsequent reaction of (VI) with methylamine. The invention also concerns the intermediates used in the method.

Abstract translation: 本发明涉及制备式（I）（X =硝基，三氟甲基，卤素，烷基或烷氧基; n = 0,1,2,3或4; Y =有机碳基团）的α-甲氧基亚氨基羧酸甲基酰胺的方法， 式（II）的氰基酮与醇的Pinner反应，然后使Pinner反应中形成的式（IV）的酯与羟胺反应，得到式（V）的肟，（V）的甲基化，得到 式（VI）的肟醚和随后的（VI）与甲胺的反应。 本发明还涉及该方法中使用的中间体。

公开(公告)号：EP0711274A1

公开(公告)日：1996-05-15

申请号：EP94924726.0

申请日：1994-07-08

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： KLEIN, Ulrich ,  BUSCHMANN, Ernst ,  KEIL, Michael ,  GÖTZ, Norbert ,  HARREUS, Albrecht

IPC: C07C239

CPC classification number: C07C239/20

Abstract: In order to prepare O-substituted hydroxylammonium salts having formula (I): R1-CHX-O-NH¿2? . HL, in which L = halogen, hydrogen sulphate; X = H, alkyl; R?1¿ = possibly substituted phenyl, thienyl, furanyl, pyrrolyl or -CR2=CR3R4, in which R?2, R3, R4¿ = H, halogen or alkyl, an acetonoxime-O-alkyl or acetonoxime-O-benzyl ether having formula (II) is reacted with water and a mineral acid H-L while the resulting acetone is continuously removed, and hydrolysis is intermittently carried out at 0-50 °C and under 10-500 mbar pressure. The O-substituted hydroxylammonium salts having the formula (I) are intermediate products for plant protective agents and pharmaceuticals.