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    Self-encoding sensor with microspheres
    61.
    发明授权
    Self-encoding sensor with microspheres 有权
    具有微球的自编码传感器

    公开(公告)号：US07348181B2

    公开(公告)日：2008-03-25

    申请号：US09287573

    申请日：1999-04-06

    Applicant: David R. Walt ,  Todd A. Dickinson

    Inventor： David R. Walt ,  Todd A. Dickinson

    IPC: G01N21/76

    CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

    Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

    Cross-reactive sensors
    62.
    发明授权
    Cross-reactive sensors 有权
    交叉反应传感器

    公开(公告)号：US07250267B2

    公开(公告)日：2007-07-31

    申请号：US10221815

    申请日：2001-03-14

    Applicant: David R. Walt ,  Caroline L. Schauer ,  Frank J. Steemers

    Inventor： David R. Walt ,  Caroline L. Schauer ,  Frank J. Steemers

    IPC: C12Q1/48 ,  C12Q1/34 ,  C12Q1/44 ,  C12Q1/37 ,  C12Q1/00

    CPC classification number: C12Q1/44 ,  C12Q1/37

    Abstract: The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements reacts in a different manner with each of said one or more species of liquid analytes of interest to produce a detectable agent of each analyte of interest, whereby said detectable agent is analyzed and the information is processed for data acquisition and interpretation. In certain preferred embodiments, the detectable agent and/or change is detected directly, while in certain other preferred embodiments, the detectable agent and/or change is detected with the help of a transducing agent capable of relaying information about each detectable agent generated for each of said species of liquid analyte of interest, whereby said information is processed for data acquisition and interpretation. The present invention also provides method for the analysis of analytes comprising contacting one or more analytes with the inventive system described above.

    Abstract translation: 本发明提供了一种利用交叉反应识别元件的新型交叉反应传感器系统。 在本发明的系统中，所述一个或多个交叉反应性识别元件中的每一个能够与多于一种的感兴趣的液体分析物相互作用，由此所述一个或多个交叉反应性识别元件中的每一个以不同的方式与每个 的所述一种或多种感兴趣的液体分析物种类以产生感兴趣的每种分析物的可检测试剂，由此分析所述可检测试剂，并且对所述信息进行处理以进行数据采集和解释。 在某些优选的实施方案中，直接检测可检测的试剂和/或变化，而在某些其它优选的实施方案中，可检测的试剂和/或变化是借助于能够中继关于每个可产生的每种可检测试剂的信息的转导剂 的所述物质的感兴趣的液体分析物，由此所述信息被处理用于数据采集和解释。 本发明还提供了用于分析分析物的方法，包括使一种或多种分析物与上述本发明的系统接触。

    Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure
    65.
    发明授权
    Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure 失效
    用于制造三维，图案化聚合物微结构的光沉积方法

    公开(公告)号：US06200737B1

    公开(公告)日：2001-03-13

    申请号：US08519062

    申请日：1995-08-24

    Applicant: David R. Walt ,  Brian G. Healey

    Inventor： David R. Walt ,  Brian G. Healey

    IPC: G02B608

    CPC classification number: G03F7/2043 ,  G02B6/06 ,  G03F7/2008

    Abstract: The present invention is a photodeposition methodology for fabricating a three-dimensional patterned polymer microstructure. A variety of polymeric structures can be fabricated on solid substrates using unitary fiber optic arrays for light delivery. The methodology allows micrometer-scale photopatterning for the fabricated structures using masks substantially larger than the desired dimensions of the microstructure.

    Abstract translation: 本发明是用于制造三维图案化聚合物微结构的光沉积方法。 可以使用单一光纤阵列在固体基板上制造各种聚合物结构，用于光输送。 该方法允许使用基本上大于微结构的所需尺寸的掩模的制造结构的微米级光图案化。

    Surface-bound fluorescent polymers and related methods of synthesis and use
    67.
    发明授权
    Surface-bound fluorescent polymers and related methods of synthesis and use 失效
    表面结合荧光聚合物及相关的合成和使用方法

    公开(公告)号：US5354825A

    公开(公告)日：1994-10-11

    申请号：US116878

    申请日：1993-09-07

    Applicant: Stanley M. Klainer ,  David R. Walt ,  Amos J. Gottlieb

    Inventor： Stanley M. Klainer ,  David R. Walt ,  Amos J. Gottlieb

    IPC: C09K11/06 ,  G01N21/64 ,  G01N21/77 ,  G01N21/81 ,  G01N33/552 ,  C08F224/00

    CPC classification number: C09K11/06 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/552 ,  G01N2021/6432 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N21/81 ,  Y10T428/31645 ,  Y10T428/31855

    Abstract: A fiber optic sensing device for measuring a chemical or physiological parameter of a body fluid or tissue is provided. To one end of the fiber is attached a polymer including a plurality of photoactive moieties selected from the group consisting of chromophores and lumophores, the photoactive moieties spaced apart so as to minimize chemical or physical interaction therebetween while optimizing the density of photoactive moieties. In one embodiment, a polymer chain is covalently bound to photoactive moieties through functional groups such as esters, amides, or the like. In a second embodiment, a polymer chain is inherently fluorescent and is formed from at least one monomeric unit. These devices are particularly useful as pH and oxygen sensors.

    Abstract translation: 提供了一种用于测量体液或组织的化学或生理参数的光纤感测装置。 纤维的一端连接聚合物，该聚合物包括选自发色团和间隙基团的多个光活性部分，间隔开的光活性部分，以使其间的化学或物理相互作用最小化，同时优化光活性部分的密度。 在一个实施方案中，聚合物链通过官能团如酯，酰胺等与光活性部分共价结合。 在第二个实施方案中，聚合物链固有地是荧光的并且由至少一个单体单元形成。 这些装置特别适用于pH和氧传感器。

    Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
    68.
    发明授权
    Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample 失效
    使成像光纤传感器同时检测流体样品中感兴趣的多个分析物的方法

    公开(公告)号：US5250264A

    公开(公告)日：1993-10-05

    申请号：US994552

    申请日：1992-12-21

    Applicant: David R. Walt ,  Steven M. Barnard

    Inventor： David R. Walt ,  Steven M. Barnard

    IPC: G01N21/77 ,  G02B6/06 ,  G01N21/00 ,  A61B5/00 ,  G02B6/24

    CPC classification number: G02B6/06 ,  G01N21/7703 ,  G01N2021/6434 ,  G01N2021/773 ,  G01N2021/7793

    Abstract: The present invention provides a unique fiber optic sensor which is able to conduct multiple assays and analyses concurrently using a plurality of different dyes immobilized at individual spatial positions on the surface of the sensor. The present invention also provides apparatus for making precise optical determinations and measurements for multiple analytes of interest concurrently and provides methods of detection for multiple analytes of interest which can be correlated with specific parameters or other ligands for specific applications and purposes.

    Abstract translation: 本发明提供了一种独特的光纤传感器，其能够使用固定在传感器表面上的各个空间位置的多种不同染料同时进行多个测定和分析。 本发明还提供用于同时进行多个感兴趣分析物的精确光学测定和测量的装置，并且提供可以针对特定应用和目的与特定参数或其它配体相关联的多个感兴趣分析物的检测方法。

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