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    Method and system of array imaging
    3.
    发明授权
    Method and system of array imaging 有权
    阵列成像的方法和系统

    公开(公告)号：US07595473B2

    公开(公告)日：2009-09-29

    申请号：US11209432

    申请日：2005-08-22

    Applicant: David R. Walt ,  Sandra Bencic-Nagale

    Inventor： David R. Walt ,  Sandra Bencic-Nagale

    IPC: G01N21/00

    CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J2001/0276 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/088

    Abstract: The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching.

    Abstract translation: 本发明涉及阵列成像的方法和系统，该方法和系统通过最小化光漂白的影响来延长或最大化传感器阵列的寿命。 成像系统具有光源，可变曝光孔径和可变过滤器系统。 该系统通过（1）使用可变曝光孔径来延长传感器的寿命，以选择性地暴露包含每种类型的传感器的代表数的传感器阵列的部分，和/或（2）使用可变过滤器系统来控制传感器的强度 激发光，仅提供诱导适当激发所需的强度，并根据需要随时间增加强度以抵消光漂白的影响。

    Spectroscopic Imaging Microscopy
    4.
    发明申请
    Spectroscopic Imaging Microscopy 有权
    光谱成像显微镜

    公开(公告)号：US20090201499A1

    公开(公告)日：2009-08-13

    申请号：US12239628

    申请日：2008-09-26

    Applicant: David J. Monk ,  David R. Walt

    Inventor： David J. Monk ,  David R. Walt

    IPC: G01J3/04

    CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/0264 ,  G01J3/14 ,  G01J3/32 ,  G02B21/06 ,  G02B21/367

    Abstract: Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light received from the objective lens system to pass as input light; (c) a first lens positioned to transmit the input light received from the first aperture; (d) a dispersive element configured to spatially disperse the input light received from the first lens in a first plane; (e) a second lens positioned to transmit the spatially dispersed light; (f) a second aperture positioned to allow a portion of the spatially dispersed light received from the second lens to pass as detection light; and (g) a detector positioned to receive the detection light and configured to form at least one image of the sample.

    Abstract translation: 这里公开的系统包括：（a）被配置为收集来自样品的光的物镜系统; （b）第一孔，定位成允许从物镜系统接收的一部分收集的光作为输入光通过; （c）第一透镜，定位成透射从第一孔接收的输入光; （d）分散元件，被配置为在第一平面中将从第一透镜接收的输入光空间分散; （e）定位成透射空间分散的光的第二透镜; （f）第二孔，定位成允许从第二透镜接收的部分空间分散的光作为检测光通过; 和（g）定位成接收检测光并被配置成形成样品的至少一个图像的检测器。

    Self-encoding fiber optic sensor
    7.
    发明授权
    Self-encoding fiber optic sensor 失效
    自编光纤传感器

    公开(公告)号：US07115884B1

    公开(公告)日：2006-10-03

    申请号：US08944850

    申请日：1997-10-06

    Applicant: David R. Walt ,  Todd A. Dickinson

    Inventor： David R. Walt ,  Todd A. Dickinson

    IPC: G01N21/64

    CPC classification number: G01N21/6452 ,  B01J2219/00317 ,  B01J2219/00524 ,  B01J2219/00648 ,  B01J2219/00659 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N33/54373 ,  G01N33/54393 ,  G01N2021/6484 ,  G01N2021/7786

    Abstract: Self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme, resulting in a microsphere-based analytic chemistry system. Individual microsphere sensors are disposed in microwells at a distal end of a fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle to form an optical fiber bundle sensor. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    Abstract translation: 具有针对特定目标分析物的特征性光学响应特征的自编码微球可以混合在一起，同时保留能力以在传感器阵列中使用光学方法识别大量这种传感器的随机色散中的每个传感器的传感器类型和位置 可询问的编码方案，导致基于微球的分析化学系统。 单个微球传感器设置在纤维束的远端处的微孔中，并且光学耦合到束内的离散纤维或纤维组，以形成光纤束传感器。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可以携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

    Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
    10.
    发明授权
    Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample 有权
    用于选择性地检测混合流体样品中的寡核苷酸种类的光纤生物传感器

    公开(公告)号：US06482593B2

    公开(公告)日：2002-11-19

    申请号：US09187289

    申请日：1998-11-05

    Applicant: David R. Walt ,  Brian G. Healey

    Inventor： David R. Walt ,  Brian G. Healey

    IPC: C12Q168

    CPC classification number: G01N21/7703 ,  G01N2201/0833 ,  Y10S977/924

    Abstract: The present invention provides biosensors, apparatus and methods for selectively detecting at least one complementary oligonucleotide target specie in a fluid sample containing a mixture of different oligonucleotide fragments. One preferred embodiment of the biosensor is as a unitary fiber optic array having species of single stranded nucleic acid disposed as individual deposits in aligned organization upon multiple strand end faces at differing spatial positions on the distal array end surface.

    Abstract translation: 本发明提供用于选择性检测含有不同寡核苷酸片段的混合物的流体样品中的至少一种互补寡核苷酸靶物种的生物传感器，装置和方法。 生物传感器的一个优选实施方案是作为单一的光纤阵列，其具有作为单独沉积物的单链核酸的种类，其排列组织在远端阵列端表面上的不同空间位置处的多股端面上。

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