公开(公告)号：PH19675A

公开(公告)日：1986-06-09

申请号：PH29818

申请日：1983-11-11

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  BECKER REINHARD

IPC: C07D209/70 ,  A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/58 ,  C07D221/22 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  C07D209/42

Abstract: The invention relates to new derivatives of tricyclic aminoacids, of the formula I (I) in which n denotes 0 or 1, A denotes -CH=CH- or -CH2-CH2-, R denotes hydrogen, alkyl or aralkyl, R1 denotes hydrogen, or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, or alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, or aralkyl or aroylalkyl, both of which can be substituted as defined above, or a monocyclic or bicyclic S-, O- and/or N-heterocyclene radical, or a side chain of a naturally occurring aminoacid, which may be protected, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, and physiologically acceptable salts thereof, processes for their preparation, agents containing these compounds and their use, and new bicyclic aminoacids as intermediates and processes for their preparation.

公开(公告)号：CA1198118A

公开(公告)日：1985-12-17

申请号：CA424770

申请日：1983-03-29

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  URBACH HANSJOERG ,  GEIGER ROLF ,  TEETZ VOLKER ,  BECKER REINHARD

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/405 ,  A61K38/00 ,  A61P9/12 ,  C07D209/44 ,  C07D209/52 ,  C07D217/24 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81

Abstract: of the disclosure: Compounds of the formula I (I) in which n = 1, 2 or 3, R1 = hydrogen, optionally amino-, acylamino or benzoylamino-substituted by alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partly hydrogenated aryl, either of which can be substituted by alkyl, alkoxy or halogen, arylalkyl which can be substituted in the aryl radical as defined above, a monocyclic or bicyclic heterocyclic radical having up to 10 ring atoms of which 1 to 2 ring atoms represent sulfur or oxygen atoms, and/or of which 1 to 4 ring atoms represent nitrogen atoms, or an aminoacid side chain, R2 = hydrogen, alkyl, alkcenyl or arylalkyl, Y = hydrogen or hydroxyl, Z = hydrogen or Y and Z together = oxygen and X = alkyl, alkenyl, cycloalkyl, aryl which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol3-yl, a process for their preparation, agents containing these compounds, their use, and intermediates and a process for their preparation. Compounds of the Formula I, and their salts, can be used to control hypertension of various etiologies .

公开(公告)号：CA1197857A

公开(公告)日：1985-12-10

申请号：CA424488

申请日：1983-03-25

Applicant: HOECHST AG

Inventor： TEETZ VOLKER ,  URBACH HANSJOERG ,  BECKER REINHARD

IPC: A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  C07D209/54 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

Abstract: of the disclosure: The invention relates to compounds of the formula (I) in which n denotes 1, 2, 3 or 4, R is alkyl, alkenyl, cycloalkyl, aryl, optionally mono-, di- oder trisubstituted by alkyl, alkoxy, hydroxy, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol-3-yl, R1 denotes an optionally protected radical of a naturally occurring amino acid HOOC-CH(NH2)-R1, R2 denotes hydrogen, alkyl or optionally nitro-substituted aralkyl, R3 denotes hydrogen, alkyl or cycloalkyl or optionally nitro-substituted aralkyl and X denotes 2 hydrogen atoms or 1 oxygen atom, their physiologically tolerated salts with acids and, if R2 and/or R3 denote hydrogen, with bases, a process for their preparation, agents containing these derivatives and their use as medicaments.

公开(公告)号：ZA851793B

公开(公告)日：1985-11-27

申请号：ZA851793

申请日：1985-03-11

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  URBACH HANSJOERG ,  BECKER REINHARD ,  TEETZ VOLKER

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07K1/04 ,  C07K1/113 ,  C07K5/02 ,  C07K14/81 ,  C07D ,  A61K

公开(公告)号：CA1193607A

公开(公告)日：1985-09-17

申请号：CA459591

申请日：1984-07-24

Applicant: HOECHST AG

Inventor： TEETZ VOLKER ,  GEIGER ROLF ,  URBACH HANSJOERG ,  BECKER REINHARD ,  SCHOELKENS BERNWARD

IPC: C07D209/20 ,  C07D209/52 ,  C07D317/60

Abstract: Compounds of the formulae IIIa and IIIb IIIa IIIb wherein W denotes hydrogen, alkyl with 1 to 6 carbon atoms or aralkyl with 7 or 8 carbon atoms, or a salt thereof, and processes for their preparation, are provided. These compounds are useful starting materials for the preparation of cis, endoazabicyclo-¢3.3.0!-octanecarboxylic acids, which in turn are useful for their long-lasting intense hypotensive action.

公开(公告)号：ZA845160B

公开(公告)日：1985-02-27

申请号：ZA845160

申请日：1984-07-05

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  BECKER REINHARD

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/405 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07D221/04 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K14/81 ,  C07D ,  A61K

Abstract: The invention relates to compounds of the formula I (I) in which n denotes 0 or 1, R denotes hydrogen, alkyl, alkenyl or aralkyl, R1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, aralkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined previously, a monocyclic or bicyclic S- or O- and/or N-heterocyclic radical or a side chain of an aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen, X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, acylamino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, and to a process for their preparation, agents containing them and and their use, and to 2-azabicyclo[3.1.0]hexane derivatives as intermediates, and a process for their preparation.

公开(公告)号：ZA838378B

公开(公告)日：1984-06-27

申请号：ZA838378

申请日：1983-11-10

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  BECKER REINHARD

IPC: C07D209/70 ,  A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/58 ,  C07D221/22 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  C07D ,  A61K

Abstract: The invention relates to new derivatives of tricyclic aminoacids, of the formula I (I) in which n denotes 0 or 1, A denotes -CH=CH- or -CH2-CH2-, R denotes hydrogen, alkyl or aralkyl, R1 denotes hydrogen, or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, or alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, or aralkyl or aroylalkyl, both of which can be substituted as defined above, or a monocyclic or bicyclic S-, O- and/or N-heterocyclene radical, or a side chain of a naturally occurring aminoacid, which may be protected, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, and physiologically acceptable salts thereof, processes for their preparation, agents containing these compounds and their use, and new bicyclic aminoacids as intermediates and processes for their preparation.

公开(公告)号：AU2249583A

公开(公告)日：1984-06-21

申请号：AU2249583

申请日：1983-12-16

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  URBACH HANSJORG ,  BECKER REINHARD

IPC: A61K31/403 ,  A61K31/405 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07K5/02 ,  C07D403/12 ,  C07D405/12

Abstract: Derivatives of 2-azabicyclo[2.2.1]heptane of the formula I in which n = 0 or 1, R denotes hydrogen, alkyl or aralkyl, R denotes hydrogen or alkyl which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, or aralkyl or aroylalkyl which can both be substituted in the aryl radical as defined above, a mono- or bicyclic S- or O- and/or N-heterocycle radical or a side chain of an alpha -amino acid, R denotes hydrogen, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl which can be mono-, di- or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, process for their preparation, agents containing them and their use, and 2-azabicyclo[2.2.1]heptane derivatives as intermediates, and process for their preparation.

公开(公告)号：NO834626L

公开(公告)日：1984-06-18

申请号：NO834626

申请日：1983-12-15

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER ,  BECKER REINHARD

IPC: A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  C07D

Abstract: The invention relates to derivatives of cis,endo-2-azabicyclo[5.3.0]decane-3-carboxylic acid of the formula I (I) in which R denotes hydrogen, alkyl, alkenyl or aralkyl, R1 denotes hydrogen, allyl, vinyl or a side chain of an optionally protected naturally occurring alpha -aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen, X denotes alkyl, alkenyl, cycloalkyl, aryl which can be substituted once, twice or three times by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, and their physiologically acceptable salts, a process for their preparation, agents containing them and their use.

公开(公告)号：AU2119783A

公开(公告)日：1984-05-17

申请号：AU2119783

申请日：1983-11-11

Applicant: HOECHST AG

Inventor： URBACH HANSJORG ,  HENNING RAINER ,  BECKER REINHARD

IPC: C07D209/70 ,  A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/58 ,  C07D221/22 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  C07C103/52 ,  C07D209/94 ,  C07D403/12 ,  C07D405/12

Abstract: The invention relates to new derivatives of tricyclic aminoacids, of the formula I (I) in which n denotes 0 or 1, A denotes -CH=CH- or -CH2-CH2-, R denotes hydrogen, alkyl or aralkyl, R1 denotes hydrogen, or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, or alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, or aralkyl or aroylalkyl, both of which can be substituted as defined above, or a monocyclic or bicyclic S-, O- and/or N-heterocyclene radical, or a side chain of a naturally occurring aminoacid, which may be protected, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, and physiologically acceptable salts thereof, processes for their preparation, agents containing these compounds and their use, and new bicyclic aminoacids as intermediates and processes for their preparation.