中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

886 records (took 0.022 seconds)

    PHARMACEUTICAL COMPOSITION FOR TREATING HYPERTENSION
    3.
    发明专利
    PHARMACEUTICAL COMPOSITION FOR TREATING HYPERTENSION 失效

    公开(公告)号：JPH10182456A

    公开(公告)日：1998-07-07

    申请号：JP31385097

    申请日：1997-11-14

    Applicant: HOECHST AG

    Inventor： BECKER REINHARD ,  HENNING RAINER ,  RUEGER WOLFGANG ,  TEETZ VOLKER ,  URBACH HANSJOERG

    IPC: A61K31/40 ,  A61K31/401 ,  A61K31/435 ,  A61K31/44 ,  A61K38/05 ,  A61K38/55 ,  A61K45/06 ,  A61P3/00 ,  A61P3/14 ,  A61P9/12 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject composition capable of enhancing effects of either one of an angiotensin converting enzyme inhibitor and a calcium antagonist with each other and administration of the both is reduced without manifesting adverse effects, by making the composition include both the substances. SOLUTION: This pharmaceutical composition comprises (A) an angiotensin converting enzyme inhibitor or its physiologically permissible salt, ramipril 2-[N-(1,S-ethoxycarbonyl-3-phenylpropyl-S-alanyl]-(1S,3S,5S)-2- azabicyclo-[3.3.0]octane-3-carbonic acid} represented formula I and (B) a calcium antagonist or its physiologically permissible salt felodipine [4-(2,3- dichlorophenyl)-2,6-dimethyl-3-methoxycarbonyl-5-ethoxycarbonyl-1,4- dihydropyridine] represented by formula II at a ratio of e.g. 1-5 pts.wt. ingredient A to 15-1 pts.wt. ingredient B.

    8.
    发明专利
    未知

    公开(公告)号：DE3588198D1

    公开(公告)日：1998-10-29

    申请号：DE3588198

    申请日：1985-04-03

    Applicant: HOECHST AG

    Inventor： HENNING RAINER ,  URBACH HANSJOERG ,  TEETZ VOLKER ,  GEIGER ROLF ,  SCHOELKENS BERNWARD

    IPC: C07K14/81 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07K5/02 ,  C07K5/06 ,  C12N9/99

    Abstract: The use of angiotensin-converting-enzyme (ACE) inhibitors of formula (I) or their salts in the prodn. of medicaments for treatment of cardiac insufficiency in mammals is claimed. n = 1 or 2; R = H, ORa, SRa or an opt. substd. 1-8C aliphatic, 3-9C alicyclic, 6-12C aromatic, 7-14C araliphatic or 7-14C alicyclic-aliphatic gp.; Ra = an opt. substd. 1-4C aliphatic, 6-12C aromatic or 5- to 12-membered heteroaromatic gp.; R1 = H, an opt. substd. 1-6C aliphatic, 3-9C alicyclic, 4-13C alicyclicaliphatic, 6-12C aromatic, 7-16C araliphatic or 5- to 12-membered heteroaromatic gp., or the opt. protected side chain of a natural alpha-amino acid; R2 and R3 = H or opt. substd. 1-6C aliphatic, 3-9C alicyclic, 6-12C aromatic or 7-16C araliphatic gps.; R4+R5 completes a 5-15C mono-, bi- or tricyclic heterocyclic ring system. (I) are described in DE 3211397, DE3227055 and EP 46953, 79022, 84164, 89637 and 90362.

    NEW DERIVATIVES OF BICYCLIC AMINO ACIDS, METHODS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR APPLICATION, AND NEW BICYCLIC AMINO ACIDS AS INTERMEDIATE PRODUCTS, AND METHODS FOR THEIR PREPARATION
    10.
    发明专利
    NEW DERIVATIVES OF BICYCLIC AMINO ACIDS, METHODS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR APPLICATION, AND NEW BICYCLIC AMINO ACIDS AS INTERMEDIATE PRODUCTS, AND METHODS FOR THEIR PREPARATION 未知

    公开(公告)号：BG60936B2

    公开(公告)日：1996-06-28

    申请号：BG9855194

    申请日：1994-02-24

    Applicant: HOECHST AG

    Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER ,  GEIGER ROLF ,  BECKER REINHARD ,  GAUL HOLGER

    IPC: A61K38/55 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  C07D209/02 ,  C07D209/08 ,  C07D209/32 ,  C07D209/34 ,  C07D209/42 ,  C07D209/52 ,  C07D215/22 ,  C07D215/227 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

    Abstract: 1. Claims for the Contracting states ; BE, CH, DE, FR, GB, IT, Li, Lu, NL, SE A compound of the formula I see diagramm : EP0084164,P21,F7 in which the hydrogen atoms on the bridgehead C atoms 3a and (6+n)a have the trans configuration relative to one another and wherein n denotes 0, 1 or 2, R1 denotes methyl, R2 denotes hydrogen, (C1 -C4 )-alkyl or benzyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes phenyl, and its physiologically acceptable salts. 1. Claims for the Contracting state : Austria A process for the preparation of the compounds of the formula I see diagramm : EP0084164,P24,F4 in which the hydrogen atoms on the bridgehead C atoms 3a and (6+n)a have the trans configuration relative to one another and wherein n denotes 0, 1 or 2, R1 denotes methyl, R2 denotes hydrogen, (C1 -C4 )-alkyl or benzyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes phenyl, and its physiologically acceptable salts, which a) comprises reacting a compound of the formula II see diagramm : EP0084164,P24,F6 wherein R1 , R2 , X, Y and Z have the meanings as in formula I, with a compound of the formula III see diagramm : EP0084164,P25,F1 in which the H atoms on the C atoms 3a and (6+n)a have the trans configuration relative to one another and wherein n denotes 0, 1 or 2 and W denotes a radical which can be cleaved off by hydrogenolysis or by acid, and subsequently splitting off the radical W and, if appropriate, the radical R2 to form the free carboxyl groups, or b) for the preparation of compounds of the formula I, in which Y and Z together denote oxygen, comprises b1 ) reacting a compound of the formula IV see diagramm : EP0084164,P25,F3 in which the H atoms on the C atoms 3a and (6+n)a have the trans configuration relative to one another and wherein n and R1 have the meanings as in formula I and W has the meaning as in formula III, with a compound of the formula V, R2 O2 C-CH = CH-CO-X wherein R2 and X have the meanings as in formula I, and subsequently splitting off the radical W and, if appropriate, also the radical R2 to form the free carboxyl groups, or, b2 ) reacting a compound of the formula IV mentioned under b1 ) with a compound of the general formula VI, wherein R2 has the meaning as in formula I, and with a compound of the general formula VII OHC-CO2 R2 X-CO-CH3 wherein X has the meaning as in formula I, subsequently splitting off the radical W and, if appropriate, the radical R2 to form the free carboxyl group, or c) for the preparation of compounds of the formula I, in which Y and Z each denote hydrogen, comprises c1 ) reacting a compound of the formula IV mentioned under b1 ) with a compound of the formula VIII see diagramm : EP0084164,P25,F2 wherein R2 and X have the meanings as in formula I, reducing the Schiff's bases obtained and subsequently splitting off the radical W and, if appropriate, the radical R2 to form the free carboxyl groups, or c2 ) catalytically reducing a compound of the formula I in which Y and Z together denote oxygen, with hydrogen, or d) for the preparation of compounds of the formula I, in which Y denotes hydroxyl and Z denotes hydrogen, comprises reducing a compound of the formula I, in which Y and Z together denote oxygen, catalytically with hydrogen or with a reducing agent, such as sodium borohydride, and, if appropriate, converting the compounds obtained according to (a)-(d) into their physiologically acceptable salts.

Patent Agency Ranking