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    63.
    发明专利
    未知

    公开(公告)号：SE345258B

    公开(公告)日：1972-05-23

    申请号：SE727866

    申请日：1966-05-27

    Applicant: HOECHST AG

    Inventor： OTT H ,  EHRHART G ,  LINDNER E

    IPC: A61K31/195 ,  C07C101/04

    Abstract: The invention comprises compounds of formula wherein R represents an alkyl radical containing from 1 to 4 carbon atoms, and R1 and R2, which may be the same or different, each represent hydrogen, an alkyl radical containing from 1 to 4 carbon atoms or halogen, and salts thereof. The compounds may be made by (a) reacting with in which R1 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and reducing, simultaneously or subsequently, the reaction product, or (b) reacting in the presence of aldehyde of formula (C6H2)2CH-CH2-CHO or (C6H5)2C=CH-CHO and reducing, simultaneously or subsequently, the reaction product and hydrogenating any aliphatic C-C double linkage present, or (c) reacting (C6H5)2CH-CH2-CH2-Hal with wherein Hal represents a halogen atom and R3 represents a hydrogen atom or the benzyl radical, if desired or required in the presence of agents splitting off hydrogen halide, or (d) reacting diphenyl methane or diphenyl acetonitrile with a compound of formula in the presence of agents splitting off hydrogen halide and replacing the nitrile group which may be present in the reaction products by a hydrogen atom by heating with sodium amide in an inert organic solvent, and removing by catalytic hydrogenation the N-benzyl group which may be present, and if compounds of the general Formulae III, IV, VIII, and IX are used, in which R1 represents a hydrogen atom, esterifying the free carboxyl group by reaction with an alcohol containing from 1 to 4 carbon atoms, and, if desired, converting the basic compounds thus obtained into their salts by means of mineral or organic acids. Pharmaceutical compositions, for use in curing cardiac and circulatory disorders, comprise the above compounds, or salts, in admixture with a pharmaceutically suitable carrier. The compositions may be made up in the usual dosage unit forms for oral or parenteral administration, such as tablets, dragees, capsules, ampoules, solutions, emulsions or suspensions.

    65.
    发明专利
    未知

    公开(公告)号：SE338399B

    公开(公告)日：1971-09-06

    申请号：SE203668

    申请日：1968-02-16

    Applicant: HOECHST AG

    Inventor： GROEBEL A ,  LINDNER E

    IPC: A61K20060101 ,  A61K36/00 ,  A61K36/24 ,  C07G5/00 ,  A61K35/78

    Abstract: 1,211,564. Pharmacologically active substance. FARBWERKE HOECHST A.G. 16 Feb., 1968 [16 Feb., 1967], No. 7712/68. Heading C2C. A novel pharmacologically active substance is isolated from Cabucala madagascariensis by extracting it from the dried material of the plant, suitably by using an alcohol, and if desired converting the active substance isolated from the extract into a physiologically tolerable salt. The novel substance is characterized by the following data: Pharmaceutical compositions comprise the novel compound in conjunction with a suitable carrier or diluent for oral or parenteral administration and possess blood-pressure lowering properties.

    68.
    发明专利
    未知

    公开(公告)号：NO117860B

    公开(公告)日：1969-10-06

    申请号：NO16330466

    申请日：1966-06-04

    Applicant: HOECHST AG

    Inventor： EHRHART G ,  OTT H ,  LINDNER E ,  HAERTFELDER G

    IPC: C07C217/62 ,  C07D213/38

    Abstract: Compounds of the general Formula (I) (wherein R1 represents a phenyl, methoxyphenyl or 2-pyridyl group, R2 represents a hydrogen atom or a methyl group and R3 and R4 each represent a C1- 4 alkyl group) and their acid addition salts are prepared by standard methods, e.g. reducing a compound of the Formula (II) (wherein R represents a hydrogen atom) or a salt thereof, or condensing a compound of the Formula (III) with a compound of the Formula (IV) (wherein X represents and reducing the product, optionally followed in either case by salt formation. The preparation of starting materials of Formulae (II) and (IV) is described. The compounds of the invention are useful in the treatment of hypertonia, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

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