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    Heterocyclic ethers of piperazine n alkanols
    1.
    发明授权
    Heterocyclic ethers of piperazine n alkanols 失效
    哌嗪N醇的杂环化合物

    公开(公告)号：US3787411A

    公开(公告)日：1974-01-22

    申请号：US3787411D

    申请日：1970-09-08

    Applicant: HOECHST AG

    Inventor： MOHLER W ,  GOEBEL A ,  RUSCHIG H ,  SCHMITT K ,  LINDNER E

    IPC: C07D237/14 ,  C07D213/64 ,  C07D215/22 ,  C07D237/30 ,  C07D239/34 ,  C07D239/72 ,  C07D241/18 ,  C07D277/20 ,  C07D277/34 ,  C07D277/68 ,  C07D295/04 ,  C07D295/067 ,  C07D295/185 ,  C07D51/70

    CPC classification number: C07D213/64 ,  C07D241/18 ,  C07D295/067 ,  C07D295/185 ,  Y10S514/921

    Abstract: A HECTEROCYCLIC ETHER OF THE FORMULA

    1-(R1-O-A-),4-(R2-)-PIPERAZINE

    IN WHICH R1 IS 3-, 4- OR 6-ALKOXY-PYRIDYL-(2); 2-, 4- 5OR 6-ALKOXY-PYRIDYL-(3); 2- OR 3-ALKOXY-PYRIDYL-(4) WHICH HAVE 1-4 CARBON AOMS IN THE ALKOXY RADICAL: 3-, 4-, 5OR 6-METHYL-PYRIDYL-(2); 6 - ETHYL - PYRIDYL - (4)-; 2,6-DIMETHYL-PYRIDYL-(4); R2 IS PHENYL, O-TOLYL, M-TOLYL, P-TOLYL, O-AANISYL, M-ANISYL, P-ANISYL, O-CHLOROPHENYL, M-CHLOROPHENYL, P-CHLOROPHENYL, PYRIDYL (2), PYRIDYL (3), PYRIDYL (4); 2-CHLORO-4-METHYL-PHENYL, 2-CHLORO - 4 - METHOXYPHENYL AND 2-METHOXY-4 - METHYL - PHENYL, 6 - METHOXYPYRIDYL (2), 2-METHYL-PYRIDYL (4), 4,6-DIMETHYL-PYRIDYL (2) OR THEIR POSITION ISOMERS, AND A IS ALKYLENE HAVING FROM 2 TO 6 CARBON ATOMS WHEREIN THE SAME IS ETHYLENE, TRIMETHYLENE, 2-METHYL-ETHYLENE, 3-METHYL-ETHYLENE, TETRAMETHYLENE, 3-METHYL-TRIMETHYLENE, 2 - ETHYL - ETHYLENE, 1ETHYL-ETHYLENE, PENTAMETHYLENE, 4 - METHYL - TETRAMETHYLENE, 3-ETHYL-TRIMETHYLENE, 1-PROPYL - ETHYLENE, 1 - ISOPROPYL-ETHYLENE, 1,2-DIMETHYL - ETHYLENE, 1 HEXAMETHYLENE, 5METHYL-PETAMETHYLENE, 4 - ETHYL - TETRAMETHYLENE, 3 - PROPYL-TRIMETHYLENE, 2-BUTYL-ETHYLENE, 1 - BUTYL - ETHYLENE OR 1-METHYL-3-ETHYL-TRIMETHYLENE; AND PHYSIOLOGICALLY TOLERABLE ACID ADDITION SALTS THEREOF; THESE COMPOUNDS HAVE AN A-SYMPATHOLYTIC ACTION AND ARE USEFUL IN THE TREATMENT OF SHOCKS, MIGRAINE, HYPERTONIA AND BLOOD CIRCULATION DISORDERS OF THE EXTREMITIES.

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