公开(公告)号：CS9103948A3

公开(公告)日：1992-06-17

申请号：CS394891

申请日：1991-12-20

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  JAUNIN ROLAND ,  MARKI HANS PETER ,  MARTI FRANZI ,  RAMUZ HENRI

IPC: A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/55 ,  A61K31/551 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/14 ,  C07D235/26 ,  C07D243/14 ,  C07D277/62 ,  C07D277/64 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00 ,  A61K31/395 ,  C07D235/04 ,  C07D243/10 ,  C07D275/04 ,  C07D487/02

CPC classification number: C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D235/14 ,  C07D235/26 ,  C07D243/14 ,  C07D249/08 ,  C07D277/64 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04

公开(公告)号：NO921520D0

公开(公告)日：1992-04-15

申请号：NO921520

申请日：1992-04-15

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  HEITZ MARIE-PAULE ,  NEIDHART WERNER ,  STADLER HEINZ ,  VIEIRA ERIC ,  WOSTL WOLFGANG

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/215 ,  A61K31/22 ,  A61K31/415 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/535 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07C317/44 ,  C07C317/50 ,  C07C323/51 ,  C07D207/08 ,  C07D207/12 ,  C07D211/22 ,  C07D213/40 ,  C07D213/53 ,  C07D213/56 ,  C07D231/12 ,  C07D233/54 ,  C07D233/56 ,  C07D233/58 ,  C07D233/60 ,  C07D233/61 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D295/088 ,  C07D295/185 ,  C07D295/205 ,  C07D307/54 ,  C07D317/24 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D521/00 ,  C07H15/12 ,  C07C

Abstract: The compounds of the formula in which A, R , R , R , R and R have the meaning given in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates and pharmaceutically utilisable salts thereof inhibit the action of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be prepared by various processes known per se.

公开(公告)号：ZA914808B

公开(公告)日：1992-03-25

申请号：ZA914808

申请日：1991-06-21

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  QUIRICO BRANCA ,  MUELLER MARCEL ,  MARCEL MUELLER ,  STADLER HEINZ ,  HEINZ STADLER ,  WOSTL WOLFGANG ,  WOLFGANG WOSTL ,  HEITZ MARIE-PAULE ,  MARIE-PAULE HEITZ ,  NEIDHART WERNER ,  WERNER NEIDHART ,  VIEIRA ERIC ,  ERIC VIEIRA

IPC: A61K31/435 ,  A61K31/495 ,  A61K31/50 ,  A61P9/00 ,  A61P9/12 ,  C07D263/06 ,  C07D471/04 ,  C07D487/04 ,  A61K ,  C07C ,  C07D

Abstract: The compounds of the formula in which A, B, X, Y, R , R , R , R and R have the meaning given in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates and pharmaceutically utilisable salts thereof inhibit the action of the natural enzyme renin and can therefore be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be prepared by various processes known per se.

公开(公告)号：NO912537A

公开(公告)日：1991-12-30

申请号：NO912537

申请日：1991-06-27

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  HEITZ MARIE-PAULE ,  MUELLER MARCEL ,  NEIDHART WERNER ,  STADLER HEINZ ,  VIEIRA ERIC ,  WOSTL WOLFGANG

IPC: A61K31/435 ,  A61K31/495 ,  A61K31/50 ,  A61P9/00 ,  A61P9/12 ,  C07D263/06 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D263/06 ,  C07D487/04

公开(公告)号：FI913179A

公开(公告)日：1991-12-29

申请号：FI913179

申请日：1991-06-28

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  HEITZ MARIE-PAULE ,  MUELLER MARCEL ,  NEIDHART WERNER ,  STADLER HEINZ ,  VIEIRA ERIC ,  WOSTL WOLFGANG

IPC: A61K31/435 ,  A61K31/495 ,  A61K31/50 ,  A61P9/00 ,  A61P9/12 ,  C07D263/06 ,  C07D471/04 ,  C07D487/04 ,  C07D

Abstract: The compounds of the formula in which A, B, X, Y, R , R , R , R and R have the meaning given in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates and pharmaceutically utilisable salts thereof inhibit the action of the natural enzyme renin and can therefore be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be prepared by various processes known per se.

公开(公告)号：CA2044564A1

公开(公告)日：1991-12-29

申请号：CA2044564

申请日：1991-06-13

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  HEITZ MARIE-PAULE ,  MULLER MARCEL ,  NEIDHART WERNER ,  STADLER HEINZ ,  VIEIRA ERIC ,  WOSTL WOLFGANG

IPC: A61K31/435 ,  A61K31/495 ,  A61K31/50 ,  A61P9/00 ,  A61P9/12 ,  C07D263/06 ,  C07D471/04 ,  C07D487/04

Abstract: RAN 4019/111 The compounds of the formula I wherein A, B, X, Y, R1, R2, R3. R4 and R5 have the significance given in claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be manufactured according to various methods which are known per se.

公开(公告)号：AU617429B2

公开(公告)日：1991-11-28

申请号：AU3079789

申请日：1989-02-28

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  NEIDHART WERNER ,  RAMUZ HENRI ,  STADLER HEINZ ,  WOSTL WOLFGANG

IPC: A61K31/16 ,  A61K31/41 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K38/00 ,  A61P9/04 ,  A61P9/12 ,  C07C215/26 ,  C07C231/02 ,  C07C237/00 ,  C07C237/22 ,  C07C317/44 ,  C07C323/60 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D263/04 ,  C07D263/06 ,  C07D263/24 ,  C07D277/20 ,  C07D277/30 ,  C07D307/52 ,  C07D333/24 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07F9/6506 ,  C07K5/06 ,  C07K14/81 ,  A61K37/64

Abstract: The compounds of the formula I wherein A, R1, R2, R3, R4, R5 and R6 are as set forth above, are described. The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency.

公开(公告)号：ZA9006856B

公开(公告)日：1991-06-26

申请号：ZA9006856

申请日：1990-08-28

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  QUIRICO BRANCA ,  NEIDHART WERNER ,  WERNER NEIDHART ,  RAMUZ HENRI ,  HENRI RAMUZ ,  STADLER HEINZ ,  HEINZ STADLER ,  WOSTL WOLFGANG ,  WOLFGANG WOSTL

IPC: A61K20060101 ,  C07C20060101 ,  C07D20060101 ,  C07F20060101 ,  C07K20060101 ,  C07C ,  A61K ,  C07D ,  C07F ,  C07K

公开(公告)号：NO903832L

公开(公告)日：1991-03-05

申请号：NO903832

申请日：1990-09-03

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  NEIDHART WERNER ,  RAMUZ HENRI ,  STADLER HEINZ ,  WOSTL WOLFGANG

IPC: C12N9/99 ,  A61K31/195 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/435 ,  A61K31/54 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/06 ,  C07C237/08 ,  C07C237/10 ,  C07D207/34 ,  C07D231/12 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D277/20 ,  C07D277/30 ,  C07D277/68 ,  C07D333/24 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07F9/6512 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: The compounds of the formula in which A, R , R , R , R , R , R , R and R have the meaning given in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates and pharmaceutically utilisable salts thereof inhibit the action of the natural enzyme rennin and can therefore be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be prepared by various processes which are known per se.

公开(公告)号：CA2023099A1

公开(公告)日：1991-03-05

申请号：CA2023099

申请日：1990-08-10

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  NEIDHART WERNER ,  RAMUZ HENRI ,  STADLER HEINZ ,  WOSTL WOLFGANG

IPC: C12N9/99 ,  A61K31/195 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/435 ,  A61K31/54 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/06 ,  C07C237/08 ,  C07C237/10 ,  C07D207/34 ,  C07D231/12 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D277/20 ,  C07D277/30 ,  C07D277/68 ,  C07D333/24 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07F9/6512 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07D401/06 ,  C07D405/06 ,  C07D413/06 ,  A61K31/41 ,  A61K31/445 ,  A61K31/535

Abstract: RAN 4019/109 The compounds of the formula I wherein A, R1, R2, R3, R4, R5, R6, R7 and R8 have the significance given in claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be manufactured according to various methods which are known per se.