公开(公告)号：AU615612B2

公开(公告)日：1991-10-03

申请号：AU5295190

申请日：1990-04-05

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  DIELS GASTON STANISLAS MARCELL ,  LEENAERTS JOSEPH ELISABETH

IPC: A61K31/341 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/495 ,  A61K31/55 ,  A61P37/08 ,  A61P43/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  A61K31/505 ,  A61K31/50 ,  A61K31/52

Abstract: Hydroxylalkylfuranyl derivatives of formula wherein -A =A -A =A - is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH- or -CH=N-CH=N- ; D is C1-4alkanediyl ; R is hydrogen, C1-6alkyl, arylC1-6alkyl or C1-6alkylcarbonyl ; R and R are hydrogen or C1-6alkyl ; n is 0, 1 or 2 ; B is NR , O, S, SO2 or CH2; R is hydrogen, C1-6alkyl, C3-6cycloalkyl or arylC1-6alkyl ; L is hydrogen, C1-12alkyl, C3-6cycloalkyl, C3-6alkenyl optionally substituted with aryl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, arylcarbonyl, arylC1-6alkyloxycarbonyl, C1-6alkylsulfonyl, arylsulfonyl, or a radical of formula -Alk-R , -Alk-Y-R , -Alk-Z -C(=X)-Z -R , or -CH2-CHOH-CH2-O-R , the acid addition salts and stereochemically isomeric forms thereof, said compounds having antiallergic activity. Pharmaceutical compositions containing such compounds as an active ingredient; methods of preparing said compounds and pharmaceutical compositions.

公开(公告)号：NO901580L

公开(公告)日：1990-10-08

申请号：NO901580

申请日：1990-04-06

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  DIELS GASTON STANISLAS MARCELL ,  LEENAERTS JOSEPH ELISABETH

IPC: A61K31/341 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/495 ,  A61K31/55 ,  A61P37/08 ,  A61P43/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07D487/04

Abstract: Hydroxylalkylfuranyl derivatives of formula wherein -A =A -A =A - is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH- or -CH=N-CH=N- ; D is C1-4alkanediyl ; R is hydrogen, C1-6alkyl, arylC1-6alkyl or C1-6alkylcarbonyl ; R and R are hydrogen or C1-6alkyl ; n is 0, 1 or 2 ; B is NR , O, S, SO2 or CH2; R is hydrogen, C1-6alkyl, C3-6cycloalkyl or arylC1-6alkyl ; L is hydrogen, C1-12alkyl, C3-6cycloalkyl, C3-6alkenyl optionally substituted with aryl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, arylcarbonyl, arylC1-6alkyloxycarbonyl, C1-6alkylsulfonyl, arylsulfonyl, or a radical of formula -Alk-R , -Alk-Y-R , -Alk-Z -C(=X)-Z -R , or -CH2-CHOH-CH2-O-R , the acid addition salts and stereochemically isomeric forms thereof, said compounds having antiallergic activity. Pharmaceutical compositions containing such compounds as an active ingredient; methods of preparing said compounds and pharmaceutical compositions.

公开(公告)号：NO163956B

公开(公告)日：1990-05-07

申请号：NO862504

申请日：1986-06-23

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  DIELS GASTON STANISLAS MARCELL

IPC: C07D211/58 ,  A61K31/4188 ,  A61K31/4523 ,  A61K31/52 ,  A61P37/08 ,  A61P43/00 ,  C07D333/00 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D473/00 ,  C07D473/30 ,  C07D473/40 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: Novel (4-piperidinylmethyl and hetero)purines of formula … … wherein -A =A -A =A - is -N=CH-N=CH- or -CH=N-CH=N- and L is a radical L -CrH2r-T-CsH2s- or … … the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-allergic agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.

公开(公告)号：NO901580D0

公开(公告)日：1990-04-06

申请号：NO901580

申请日：1990-04-06

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  DIELS GASTON STANISLAS MARCELL ,  LEENAERTS JOSEPH ELISABETH

IPC: A61K31/341 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/495 ,  A61K31/55 ,  A61P37/08 ,  A61P43/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D473/00 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07D405/00 ,  C07D471/00 ,  C07D487/00 ,  C07D513/00 ,  C07D498/00 ,  C07D413/00

Abstract: Hydroxylalkylfuranyl derivatives of formula wherein -A =A -A =A - is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH- or -CH=N-CH=N- ; D is C1-4alkanediyl ; R is hydrogen, C1-6alkyl, arylC1-6alkyl or C1-6alkylcarbonyl ; R and R are hydrogen or C1-6alkyl ; n is 0, 1 or 2 ; B is NR , O, S, SO2 or CH2; R is hydrogen, C1-6alkyl, C3-6cycloalkyl or arylC1-6alkyl ; L is hydrogen, C1-12alkyl, C3-6cycloalkyl, C3-6alkenyl optionally substituted with aryl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, arylcarbonyl, arylC1-6alkyloxycarbonyl, C1-6alkylsulfonyl, arylsulfonyl, or a radical of formula -Alk-R , -Alk-Y-R , -Alk-Z -C(=X)-Z -R , or -CH2-CHOH-CH2-O-R , the acid addition salts and stereochemically isomeric forms thereof, said compounds having antiallergic activity. Pharmaceutical compositions containing such compounds as an active ingredient; methods of preparing said compounds and pharmaceutical compositions.

公开(公告)号：ZA884696B

公开(公告)日：1990-03-28

申请号：ZA884696

申请日：1988-06-30

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  FRANS EDUARD JANSSENS ,  DIELS GASTON STANISLAS MARCELL ,  GASTON STANISLAS MARCELLA DIEL ,  PILLE GEERT MARCEL ESTER ,  GEERT MARCEL ESTER PILLE

IPC: C07D401/12 ,  A61K31/415 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/52 ,  A61K31/55 ,  A61P11/00 ,  A61P27/16 ,  A61P37/08 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/26 ,  C07D519/00 ,  A61K ,  C07B ,  C07D

公开(公告)号：NZ223654A

公开(公告)日：1990-03-27

申请号：NZ22365488

申请日：1988-02-25

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  DIELS GASTON STANISLAS MARCELL ,  TORREMANS JOSEPH LEO GHISLANUS ,  SOMMEN FRANCOIS MARIA

IPC: C07D223/12 ,  A61K31/435 ,  A61K31/45 ,  A61K31/47 ,  A61K31/495 ,  A61K31/52 ,  A61K31/522 ,  A61P37/08 ,  A61P43/00 ,  C07D207/14 ,  C07D213/75 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/04 ,  C07D473/28 ,  C07D473/30 ,  C07D473/40 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00 ,  C07D235/02 ,  C07D207/12 ,  C07D211/44 ,  C07D211/54 ,  C07D211/58 ,  C07D403/02 ,  C07D401/02 ,  C07D233/08 ,  C07D233/12 ,  A61K31/445 ,  A61K31/505 ,  A61K31/55 ,  A61K31/415 ,  A61K31/44

Abstract: Novel 1-alkyl substituted benzimidazole derivatives of formula wherein -A =A -A =A - is a bivalent radical having the formula -CH=CH-CH=CH- (a-1), -N=CH-CH=CH- (a-2), -CH=N-CH=CH- (a-3), -CH=CH-N=CH- (a-4), -CH=CH-CH=N- (a-5), -N=CH-N=CH- (a-6), or -CH=N-CH=N- (a-7); B is NR , CH2, O, S, SO or SO2; L is hydrogen, C1-6alkylcarbonyl, C1-6alkylsulfonyl, C1-6alkyloxycarbonyl, Ar -C1-6alkyloxycarbonyl, Ar -carbonyl, Ar -sulfonyl, C3-6cycloalkyl, C2-6alkenyl optionally substituted with Ar , C1-12alkyl, a radical of formula -Alk-R (b-1), -Alk-Y-R (b-2), -Alk-Z -C(X)-Z -R (b-3), or -CH2-CHOH-CH2-O-R (b-4); the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, which compounds are anti-allergic agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.

公开(公告)号：ZA8804346B

公开(公告)日：1990-02-28

申请号：ZA8804346

申请日：1988-06-17

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  FRANS EDUARD JANSSENS ,  TORREMANS JOSEPH LEO GHISLANUS ,  JOSEPH LEO GHISLANUS TORREMANS ,  DIELS GASTON STANISLAS MARCELL ,  GASTON STANISLAS MARCELLA DIEL

IPC: C07D401/12 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P37/08 ,  A61P43/00 ,  C07D211/26 ,  C07D235/30 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/06 ,  C07D ,  A61K

CPC classification number: C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

公开(公告)号：FI883282A

公开(公告)日：1989-01-11

申请号：FI883282

申请日：1988-07-08

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  SOMMEN FRANCOIS MARIA ,  TORREMANS JOSEPH LEO GHISLANUS ,  DIELS GASTON STANISLAS MARCELL

IPC: A61K31/435 ,  A61K31/495 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61K31/55 ,  A61P37/08 ,  C07D471/04 ,  C07D473/00 ,  C07D473/06 ,  C07D473/28 ,  C07D473/30 ,  C07D473/40 ,  C07D519/00 ,  C07D

Abstract: Antiallergic 2-(heterocyclylalkyl)imidazopyridines of formula wherein -A =A -A =A - is -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH- or -CH=N-CH=N-; R is hydrogen, C1-10alkyl, C3-6cycloalkyl, Ar , C1-6alkyl or a radical of formula -Alk-G-R ; R is hydrogen or C1-6alkyl; m is 1 to 4; n is 1 or 2; L is hydrogen, C1-6alkylcarbonyl, C1-6alkylsulfonyl, C1-6alkyloxycarbonyl, Ar -C1-6alkyloxycarbonyl, Ar -carbonyl, Ar -sulfonyl, C3-6cycloalkyl, C2-6alkenyl optionally substituted with Ar , C1-12alkyl, a radical of formula -Alk-R , -Alk-Y-R , Alk-Z -C(X)-Z -R or -CH2-CHOH-CH2-O-R ; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, novel compounds of formula (I); pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.

公开(公告)号：DK382388A

公开(公告)日：1989-01-11

申请号：DK382388

申请日：1988-07-08

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  SOMMEN FRANCOIS MARIA ,  TORREMANS JOSEPH LEO GHISLANUS ,  DIELS GASTON STANISLAS MARCELL

IPC: A61K31/435 ,  A61K31/495 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61K31/55 ,  A61P37/08 ,  C07D471/04 ,  C07D473/00 ,  C07D473/06 ,  C07D473/28 ,  C07D473/30 ,  C07D473/40 ,  C07D519/00

Abstract: Antiallergic 2-(heterocyclylalkyl)imidazopyridines of formula wherein -A =A -A =A - is -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH- or -CH=N-CH=N-; R is hydrogen, C1-10alkyl, C3-6cycloalkyl, Ar , C1-6alkyl or a radical of formula -Alk-G-R ; R is hydrogen or C1-6alkyl; m is 1 to 4; n is 1 or 2; L is hydrogen, C1-6alkylcarbonyl, C1-6alkylsulfonyl, C1-6alkyloxycarbonyl, Ar -C1-6alkyloxycarbonyl, Ar -carbonyl, Ar -sulfonyl, C3-6cycloalkyl, C2-6alkenyl optionally substituted with Ar , C1-12alkyl, a radical of formula -Alk-R , -Alk-Y-R , Alk-Z -C(X)-Z -R or -CH2-CHOH-CH2-O-R ; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, novel compounds of formula (I); pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.

公开(公告)号：AU1835388A

公开(公告)日：1989-01-05

申请号：AU1835388

申请日：1988-06-24

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： JANSSENS FRANS EDUARD ,  DIELS GASTON STANISLAS MARCELL ,  PILLE GEERT MARCEL ESTER

IPC: C07D401/12 ,  A61K31/415 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/52 ,  A61K31/55 ,  A61P11/00 ,  A61P27/16 ,  A61P37/08 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/26 ,  C07D519/00 ,  A61K31/495 ,  C07D473/08 ,  C07D513/04