公开(公告)号：AU2003264881A1

公开(公告)日：2004-04-23

申请号：AU2003264881

申请日：2003-09-22

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKAGAWA HIDEWAKI ,  NAKATSURU SHUICHI

IPC: C07K14/47 ,  C12Q1/68

Abstract: The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.

公开(公告)号：CA2500482A1

公开(公告)日：2004-04-15

申请号：CA2500482

申请日：2003-09-17

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO

Inventor： KATAGIRI TOYOMASA ,  NAKAMURA YUSUKE

IPC: A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574

Abstract: Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

公开(公告)号：CA2500472A1

公开(公告)日：2004-04-15

申请号：CA2500472

申请日：2003-09-12

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574 ,  C07K14/82

Abstract: The present application provides novel human genes C1958V1 or C1958V2 whose expression is markedly elevated in pancreatic cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by t he genes can be used, for example, in the diagnosis of pancreatic cancer, and a s target molecules for developing drugs against the disease.

公开(公告)号：AU2003256079A8

公开(公告)日：2004-03-19

申请号：AU2003256079

申请日：2003-08-21

Applicant: ONCOTHERAPY SCIENCE INC ,  JAPAN GOVERNMENT

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: C07K16/30 ,  C12Q1/68

公开(公告)号：AU2003256079A1

公开(公告)日：2004-03-19

申请号：AU2003256079

申请日：2003-08-21

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: C07K16/30 ,  C12Q1/68

公开(公告)号：AU2018302855B2

公开(公告)日：2022-08-18

申请号：AU2018302855

申请日：2018-07-18

Applicant: ONCOTHERAPY SCIENCE INC ,  TOKUSHIMA UNIV

Inventor： KATAGIRI TOYOMASA ,  YOSHIMARU TETSURO ,  MIYAMOTO TAKASHI ,  OKAMOTO YASUHIDE

IPC: C07K7/08 ,  A61K38/10 ,  A61P13/08 ,  A61P15/08 ,  A61P15/14 ,  A61P35/00 ,  A61P43/00

Abstract: The present invention provides a peptide having a structure in which a portion of a dominant-negative peptide of BIG3 which inhibits interaction between BIG3 and PHB2, is replaced by at least two stapling structures. The peptide according to the present invention has excellent cell growth inhibiting activity. The cell growth inhibiting activity is sustained for a long period of time, compared to a single-stapled peptide. Therefore, the peptide according to the present invention has a feature suitable for clinical applications in cancer therapy.

公开(公告)号：AT491044T

公开(公告)日：2010-12-15

申请号：AT05768832

申请日：2005-07-29

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

IPC: C12Q1/68 ,  A61P35/00 ,  C07K14/47 ,  C12N15/11 ,  C12N15/12

Abstract: The present application provides novel human genes B1194, A2282V1, A2282V2, and A2282V3 whose expression is markedly elevated in breast cancer. These genes and polypeptides encoded thereby can be used, for example, in the diagnosis of breast cancer, and as target molecules for developing drugs against breast cancer.

公开(公告)号：AT419391T

公开(公告)日：2009-01-15

申请号：AT03799104

申请日：2003-09-12

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: C12Q1/68 ,  A61K38/00 ,  C07K14/47 ,  C07K14/82 ,  G01N33/574

Abstract: Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

公开(公告)号：AT419390T

公开(公告)日：2009-01-15

申请号：AT03799106

申请日：2003-09-17

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: C12Q1/68 ,  A61K38/00 ,  C07K14/47 ,  G01N33/574

Abstract: Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

公开(公告)号：AT397098T

公开(公告)日：2008-06-15

申请号：AT03795220

申请日：2003-08-12

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: C12Q1/68 ,  G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P15/00 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/53 ,  G01N33/68 ,  G01N37/00