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    C12ORF48 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS
    1.
    发明专利
    C12ORF48 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS 未知

    公开(公告)号：CA2735145A1

    公开(公告)日：2010-03-04

    申请号：CA2735145

    申请日：2009-08-21

    Applicant: ONCOTHERAPY SCIENCE INC

    Inventor： NAKAMURA YUSUKE ,  NAKAGAWA HIDEWAKI ,  TOGASHI AKIRA

    IPC: C12N15/09

    Abstract: Objective methods for diagnosing a predisposition to developing pancreatic cancer and prostate cancer, particularly pancreatic ductal adenocarcinoma (PDAC) and castration-resistant prostate cancer, are described herein. In one embodiment, the diagnostic method involves the step of determining an expression level of C12ORF48 using siRNAs targeting the C12ORF48 gene. The invention also features products such as siRNAs as well as to compositions containing them. The present invention further provides methods of screening for therapeutic agents useful in the treatment of C12ORF48 associated disease, such as a cancer, e.g. pancreatic cancer and prostate cancer, as well as methods of inhibiting the cell growth and treating or alleviating one or more disease symptoms. The invention also features products such as double stranded molecules, as well as vectors and compositions containing them.

    METHOD FOR DIAGNOSING PROSTATE CANCER
    4.
    发明申请
    METHOD FOR DIAGNOSING PROSTATE CANCER 审中-公开
    诊断前列腺癌的方法

    公开(公告)号：WO2004031414A3

    公开(公告)日：2004-07-08

    申请号：PCT/JP0312073

    申请日：2003-09-22

    Applicant: ONCOTHERAPY SCIENCE INC ,  JAPAN AS REPRESENTED BY THE PR ,  NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKAGAWA HIDEWAKI ,  NAKATSURU SHUICHI

    Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKAGAWA HIDEWAKI ,  NAKATSURU SHUICHI

    IPC: C07K14/47 ,  C12Q1/68

    CPC classification number: C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

    Abstract: Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.

    Abstract translation: 本文描述了用于检测和诊断前列腺癌（PRC）或前列腺上皮内瘤变（PIN）的客观方法。 在一个实施方案中，诊断方法涉及确定区分PRC或PIN和正常细胞的PRC相关基因的表达水平。 本发明还提供筛选用于治疗PRC和PIN中的任一者或两者的治疗剂的方法，治疗PRC和PIN中的任一者或两者的方法以及针对PRC和PIN中的任一者或两者接种受试者的方法。

    GENES AND POLYPEPTIDES RELATING TO PROSTATE CANCERS
    6.
    发明专利
    GENES AND POLYPEPTIDES RELATING TO PROSTATE CANCERS 未知

    公开(公告)号：AU2003264881A1

    公开(公告)日：2004-04-23

    申请号：AU2003264881

    申请日：2003-09-22

    Applicant: ONCOTHERAPY SCIENCE INC

    Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKAGAWA HIDEWAKI ,  NAKATSURU SHUICHI

    IPC: C07K14/47 ,  C12Q1/68

    Abstract: The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.

    COMPOSITIONS AND METHODS FOR TREATING PANCREATIC CANCER
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING PANCREATIC CANCER 审中-公开
    用于治疗胰腺癌的组合物和方法

    公开(公告)号：WO2005090572A3

    公开(公告)日：2006-04-13

    申请号：PCT/JP2005005619

    申请日：2005-03-18

    Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO ,  NAKAMURA YUSUKE ,  NAKAGAWA HIDEWAKI

    Inventor： NAKAMURA YUSUKE ,  NAKAGAWA HIDEWAKI

    IPC: A61K31/7088 ,  C12N15/113

    CPC classification number: C12N15/1138 ,  C12N2310/14 ,  C12N2310/53

    Abstract: The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of a siRNA that inhibits expression of PCDH1, CDH3 or GPR107. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumor cell, for example pancreatic cancer cell, particularly pancreatic ductal adenocarcinoma (PDACa).

    Abstract translation: 本发明的特征在于通过使细胞与抑制PCDH1，CDH3或GPR107的表达的siRNA的组成接触来抑制癌细胞生长的方法。 治疗癌症的方法也在本发明的范围内。 本发明还包括可用于所提供的方法的产品，包括核酸序列和载体以及包含它们的组合物。 本发明还提供了抑制肿瘤细胞的方法，例如胰腺癌细胞，特别是胰腺导管腺癌（PDACa）。

    TREATING OR PREVENTING CANCERS OVER-EXPRESSING REG4 OR KIAA0101
    9.
    发明申请
    TREATING OR PREVENTING CANCERS OVER-EXPRESSING REG4 OR KIAA0101 审中-公开
    治疗或预防过度表达REG4或KIAA0101的癌症

    公开(公告)号：WO2008020596A3

    公开(公告)日：2008-06-12

    申请号：PCT/JP2007065873

    申请日：2007-08-08

    Applicant: ONCOTHERAPY SCIENCE INC ,  NAKAMURA YUSUKE ,  NAKAGAWA HIDEWAKI ,  NAKATSURU SHUICHI

    Inventor： NAKAMURA YUSUKE ,  NAKAGAWA HIDEWAKI ,  NAKATSURU SHUICHI

    IPC: A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/475 ,  C07K16/32 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/53

    CPC classification number: C12N15/1135 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/56 ,  C07K2317/565 ,  C12N2310/111 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

    Abstract: The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of an siRNA that inhibits expression of REG4 or KIAA0101. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumor cell, for example pancreatic cancer cell, prostatic cancer cell, breast cancer cell, and bladder cancer cell, particularly pancreatic ductal adenocarcinoma (PDAC) by inhibiting REG4 gene. The present invention also relates to methods of treating or preventing PDAC in a subject comprising the step of administering to said subject a pharmaceutically effective amount of an antibody or fragment thereof that binds to a protein encoded by REG4. The present invention also relates to methods of diagnosing chemo-radiation therapeutic resistance of a cancer. The present invention also provides therapeutic agents or methods for treating cancer using the polypeptides. The polypeptides of the present invention are composed of an amino acid sequence which comprises polypeptide which comprises QKGIGEFF/SEQ ID NO: 21. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine.

    Abstract translation: 本发明的特征在于通过使细胞与抑制REG4或KIAA0101表达的siRNA的组合物接触来抑制癌细胞生长的方法。 治疗癌症的方法也在本发明之内。 本发明的特征还在于提供的方法中有用的产品，包括核酸序列和载体以及包含它们的组合物。 本发明还提供了通过抑制REG4基因抑制肿瘤细胞，例如胰腺癌细胞，前列腺癌细胞，乳腺癌细胞和膀胱癌细胞，特别是胰腺导管腺癌（PDAC）的方法。 本发明还涉及在受试者中治疗或预防PDAC的方法，其包括向所述受试者施用药学有效量的与由REG4编码的蛋白质结合的抗体或其片段的步骤。 本发明还涉及诊断癌症的化学放射治疗抗性的方法。 本发明还提供了使用所述多肽治疗癌症的治疗剂或方法。 本发明的多肽由包含包含QKGIGEFF / SEQ ID NO：21的多肽的氨基酸序列组成。可以通过用转染剂如聚精氨酸修饰多肽将本发明的多肽引入癌细胞 。

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