公开(公告)号：WO2006102658A2

公开(公告)日：2006-09-28

申请号：PCT/US2006/011115

申请日：2006-03-24

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A45C11/04

CPC classification number: A45C11/005 ,  Y10S134/901

Abstract: A contact lens container includes a body defining a cavity that is sized to hold a contact lens. A stopper is in fluid communication with the cavity and the stopper includes a resealable portion . that is received into a channel. The resealable portion has a predetermined wall thickness in an axial direction thereof, the resealable portion defines a needle penetration region that is pierceable with a needle to form a needle aperture therethrough, and is heat resealable to hermetically seal the needle aperture.

Abstract translation: 隐形眼镜容器包括限定腔体的主体，其尺​​寸被设计成保持隐形眼镜。 止动器与空腔流体连通，止动件包括可重新密封的部分。 被接收到一个频道。 可重新密封的部分在其轴向上具有预定的壁厚，可重新密封部分限定了用针刺穿的针穿透区域，以形成穿过其中的针孔，并且是可热再密封的，以密封针孔。

公开(公告)号：WO2005014465A2

公开(公告)日：2005-02-17

申请号：PCT/US2004/023023

申请日：2004-07-17

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  CHAN, Julian, V. ,  RODRIGUEZ, Giovanni

Inventor： PY, Daniel ,  CHAN, Julian, V. ,  RODRIGUEZ, Giovanni

IPC: B67D

CPC classification number: B65D35/28 ,  A45D34/04 ,  A45D2034/007 ,  A45D2200/055

Abstract: A dispenser for dispensing a substance, such as a liquid lipstick or other product, has a body defining a variable-volume storage chamber for storing the product. A dispensing portion is connected with the body and defines a bore coupled in fluid communication with the storage chamber for receiving product therefrom, and an outlet aperture coupled in fluid communication with the bore. A piston is received within the bore, and a one-way valve is mounted on the dispensing portion for dispensing metered amounts of product therethrough. The one-way valve has an axially-extending valve seat, and an axially-extending visco-elastic valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat, and the seam is connectable in fluid communication with the outlet aperture to allow the passage of product through the seam and out of the dispenser. An actuator is drivingly connected to the piston for moving the piston within the bore and dispensing a predetermined amount of product within the bore through the outlet aperture.

Abstract translation: 用于分配诸如液体口红或其他产品的物质的分配器具有限定用于存储产品的可变容积储存室的主体。 分配部分与主体连接并且限定了与储存室流体连通以与其接收产品的孔，以及与孔流体连通的出口孔。 活塞被容纳在孔内，并且单向阀安装在分配部分上，用于分配计量的产品通过其中。 单向阀具有轴向延伸的阀座和位于阀座上的轴向延伸的粘弹性阀盖，并且在其间形成常闭的轴向延伸的接缝，在其之间形成流体密封的密封件 和阀座。 柔性阀盖可相对于阀座移动，并且接缝可与出口孔流体连通以允许产品通过接缝并从分配器中通过。 致动器驱动地连接到活塞上，用于在孔内移动活塞并且通过出口孔在孔内分配预定量的产品。

公开(公告)号：WO2004071878A2

公开(公告)日：2004-08-26

申请号：PCT/US2004/002339

申请日：2004-01-28

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: B65D

CPC classification number: A61J1/18 ,  A61J1/1406 ,  A61J1/1468 ,  A61L2/08 ,  A61M2207/00 ,  B29C65/16 ,  B29C65/1616 ,  B29C65/1654 ,  B29C65/1677 ,  B29C65/18 ,  B29C66/001 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/12461 ,  B29C66/1312 ,  B29C66/342 ,  B29C66/534 ,  B29C66/5344 ,  B29C66/612 ,  B29C66/71 ,  B29C66/73755 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/8322 ,  B29C67/004 ,  B29L2031/7158 ,  B29L2031/753 ,  B65B3/003 ,  B65B7/161 ,  B65D51/002 ,  B29C65/00 ,  B29K2025/08

Abstract: A resealable cap (110, 210) for a medicament vial (114, 214) has a base portion (112, 212) formed of vulcanized rubber or like material known for providing a stable environment for the medicament contained within the vial, and a resealable portion (126, 226) overlying the base portion. The resealable portion (126, 226) is made of low-density polyethylene or like material, and can be punctured by a needle or like injection member (140, 282) for dispensing medicament into the vial (114, 214). Prior to filling, the cap (110, 210) is assembled to the vial (114, 214) and the cap/vial assembly is sterilized. Then, a needle (140, 282) is inserted through the cap (110, 210) and medicament is introduced through the needle and into the vial. Upon withdrawal of the needle (140, 282), the penetrated region of the cap (248) is fused by laser (276) or direct heat sealing (264) to hermetically seal the needle hole (294) in the cap.

Abstract translation: 用于药物小瓶（114,214）的可重新密封的帽（110,210）具有由硫化橡胶或类似材料形成的基部（112,212），其已知用于为容纳在小瓶内的药物提供稳定的环境，并且可重新密封 覆盖基部的部分（126,226）。 可再密封部分（126,226）由低密度聚乙烯或类似材料制成，并且可以被针或类似的注射构件（140,282）刺穿，用于将药物分配到小瓶（114,214）中。 在填充之前，将帽（110,210）组装到小瓶（114,214）上，并且帽/瓶组件被灭菌。 然后，将针（140,282）插入穿过盖（110,210），药物通过针引入并进入小瓶。 在针（140,282）取出时，帽（248）的穿透区域通过激光（276）或直接热密封（264）熔合，以密封帽中的针孔（294）。

公开(公告)号：WO2004026695A2

公开(公告)日：2004-04-01

申请号：PCT/US2003/027545

申请日：2003-09-03

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: B65D

CPC classification number: B65B3/003 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/18 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2075 ,  A61J1/2096 ,  A61M2207/00 ,  A61M2209/045 ,  B65B3/027 ,  B65B7/161 ,  B65B51/10 ,  B65B55/08 ,  B65B2039/009 ,  B65D51/002

Abstract: Disclosed is a uniquely configured medicament vial assembly which includes a storage vial, a stopper member and a securing ring. The vial assembly is configured to improve healthcare worker safety by providing a shielded gripping location to aid in the reduction of accidental needle sticks. The storage vial has a body portion which defines an interior chamber for storing a predetermined medicament and a neck portion through which medicament is received into and withdrawn from the interior chamber. The stopper member is inserted into the mouth of the vial and establishes a first seal. The securing ring is engaged with the mouth of the vial and adapted and configured for retaining the stopper member within the vial mouth and effectuating a second seal. The securing ring is formed from a thermoplastic and/or elastic material. Preferably, the securing ring is formed by molding the thermoplastic and/or elastic material over a portion of the storage vial and stopper member when engaged within the vial mouth.

Abstract translation: 公开了一种独特构造的药物小瓶组件，其包括存储小瓶，止动构件和固定环。 小瓶组件配置为通过提供屏蔽的夹持位置来帮助减少意外的针杆来改善医护人员的安全性。 存储小瓶具有主体部分，其限定用于存储预定药物的内部腔室和颈部部分，药物通过所述颈部部分容纳到内部腔室中并从内部腔室中排出。 止动件插入小瓶的口中并建立第一密封。 固定环与小瓶的口接合并适于和构造成将止动件保持在小瓶口内并实现第二密封。 固定环由热塑性和/或弹性材料形成。 优选地，固定环通过在接合在小瓶口中时将热塑性和/或弹性材料模制在存储小瓶和止动构件的一部分上而形成。

公开(公告)号：WO2004000100A2

公开(公告)日：2003-12-31

申请号：PCT/US2003/019656

申请日：2003-06-19

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61B

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a heat resealable stopper and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the stopper and chamber for sterilizing the container. The previously sterilized containers are then transported through an e-beam chamber, wherein an electron beam is directed onto a penetrable surface of the stopper to sterilize the penetrable surface. A needle is mounted within the e-beam chamber and moved into engagement with the stopper to pierce the sterilized penetrable surface of the stopper and inject the substance through the needle and into the chamber of the container. The needle is then withdrawn from the stopper and the filled container is transported outside of the e-beam chamber. Laser energy is then transmitted onto the penetrated surface of the stopper to fuse the stopper material and hermetically re-seal the stopper.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可热再封塞的塞子和用于在其中容纳物质的腔室。 密封的空容器经受能够穿过塞子和室的辐射，以对容器进行灭菌。 先前灭菌的容器然后通过电子束室传送，其中电子束被引导到塞子的可穿透表面上以对可穿透表面进行消毒。 针安装在电子束室内并与止动器接合，以刺穿塞子的消毒的可渗透表面并将物质通过针头注入容器的腔室。 然后将针从止动器中取出，并将填充的容器运送到电子束室外部。 然后将激光能量传递到塞子的穿透表面上，以使塞子材料熔化并密封地重新密封塞子。

公开(公告)号：WO2003041763A3

公开(公告)日：2003-05-22

申请号：PCT/US2002/036617

申请日：2002-11-14

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  CHAN, Julian, V.

Inventor： PY, Daniel ,  CHAN, Julian, V.

IPC: A61M5/00

Abstract: The subject intradermal delivery (110) device provides for penetration to a fixed depth without requiring special expertise by the user. The device consists of a syringe (112) nested inside an inner shell (114) and an outer shell (116) . A elongated annular channel (120) is formed between the inner shell (114) and the outer shell (116). A housing (118) recieves the syringe (112) and concentric shells in a sliding engagement. A first seal (122) on the distal end of the housing forms a variable length channel in communication with the elongated annular channel via a port formed in the outer shell (116). When the device is applied to the skin, the housing and syringe (112) are slid towards the skin, and the variable length channel generates a vacuum which forces the skin to bulge into the elongated annular channel. As a result, the skin is tensioned across the inner shell to form a substantially planar, taut target area of skin. The taut target area of skin in combination with a stop on the housing determines the insertion depth of the syringe (112).

公开(公告)号：WO2002088780A2

公开(公告)日：2002-11-07

申请号：PCT/US2002/014116

申请日：2002-05-02

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: G02B

CPC classification number: A61F9/0061 ,  A45C11/005 ,  A45C15/00

Abstract: A contact lens applicator 10 has an elongated housing 12 defining an interior chamber 34 for storing contact lenses CL, first and second triggers 16, 18 mounted on the housing 12, a depressor 20 for depressing each eyelid where the roller 20 is drivingly coupled to the triggers 16, 18, a pair of opposing wing-shaped members 26 projecting outwardly from opposite sides of the roller 20 for providing a support surface 28 for facilitating locating the apparatus 10 over the eye, and a pusher 40 assembly slidably mounted within the interior chamber 34 for engaging a contact lens holder 75 and applying a contact lens CL thereon to the eye when the triggers 16, 18 are actuated. The contact lens CL is stored in a cartridge 36 within the housing 12. The lens holder 75 is movable within the cartridge 36 upon actuating the pusher 40, and includes a predetermined amount of saline or other solution for defining appropriate conditions for storing the contact lens CL.

Abstract translation: 接触镜施加器10具有限定用于存储隐形眼镜CL的内部腔室34的细长壳体12，安装在壳体12上的第一和第二触发器16,18，用于按压每个眼睑的压力器20，其中辊20驱动地联接到 触发器16,18，一对相对的翼形构件26，其从辊20的相对侧向外突出，用于提供支撑表面28，以便于将装置10定位在眼睛上方;以及推动器40组件，其可滑动地安装在内部腔室 34，用于在触发器16,18被致动时接合隐形眼镜保持器75并将其上的隐形眼镜CL施加到眼睛。 隐形眼镜CL被存储在壳体12内的盒36中。透镜保持器75可在启动推动器40时在盒36内移动，并且包括预定量的盐水或其它溶液，用于限定用于存储隐形眼镜的适当条件 CL。

公开(公告)号：WO2017127586A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014201

申请日：2017-01-19

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: A61M39/08 ,  F16L37/00 ,  F16L37/244 ,  F16L37/50

CPC classification number: B65B3/003 ,  A61J1/2048 ,  A61J3/002 ,  A61J2205/10 ,  A61J2205/60 ,  A61M39/10 ,  B65B3/12 ,  B65B3/28 ,  B65B3/30 ,  B65B3/36 ,  B65B55/08

Abstract: Apparatuses and methods for controlling transfer of substances to a formulation container to provide a predetermined formulation. A controller may utilize one or more of a flow time, flow rate or a volume of transfer of substance. Barcoded and RFID-containing components may be used to determine what connection or disconnection has been made, and/or time thereof. Process compliance may compare measured or determined flow or connection time, flow rate and/or the transfer volume to a predetermined time, flow rate and/or volume, and adjust one or more of the time, flow rate and/or the volume of the transfer. An optional holder or cradle is configured to receive therein a fluid transfer connector formed by the connection of first and second connector portions, each in fluid communication with a flow conduit or channel that delivers substance to or receives substance from its respective connector portion, only if the connector portions are properly connected together. One or more sensors may be used to determine identification information of the connector and/or flow rates of substance through the connector.

Abstract translation: 用于控制物质向制剂容器的转移以提供预定制剂的设备和方法。 控制器可利用流动时间，流量或物质转移量中的一个或多个。 条形码和包含RFID的组件可以用于确定已经进行了什么连接或断开，和/或其时间。 过程依从性可以将测量或确定的流量或连接时间，流量和/或传送体积与预定时间，流量和/或体积进行比较，并且调整流量或流量的一个或多个时间，流量和/或体积 转让。 可选的保持器或托架被构造成在其中容纳通过第一和第二连接器部分的连接而形成的流体传输连接器，每个流体传输连接器与流体导管或通道流体连通，该流体导管或通道仅在其相应的连接器部分传递物质或从其接收物质时， 连接器部分被适当地连接在一起。 一个或多个传感器可以用于确定连接器的识别信息和/或通过连接器的物质的流速。

公开(公告)号：WO2013188703A1

公开(公告)日：2013-12-19

申请号：PCT/US2013/045732

申请日：2013-06-13

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: A61B10/00

CPC classification number: B65D51/002 ,  A61J1/05 ,  A61J1/1406 ,  A61J1/1425 ,  B65B3/003 ,  B65D2251/0015 ,  B65D2251/009

Abstract: A device has a sealed chamber; a first penetrable septum in fluid communication with the chamber that is formed of an elastic material and is penetrable by a first injection member to fill the first chamber with a substance therethrough; and a second penetrable septum movable between first and second positions. In the first position, at least a portion of the second septum is spaced away from the first septum to allow the injection member to penetrate the first septum and aseptically or sterile fill the chamber with a substance therethrough. In the second position, the portion of the second septum overlies and seals a resulting injection aperture in the first septum after withdrawal of the first injection member therefrom, and is penetrable by a second injection member to penetrate the first and second septums and withdraw a filled substance from the chamber and through the second injection member.

Abstract translation: 装置具有密封室; 与腔室流体连通的第一穿透隔膜，其由弹性材料形成并且可被第一注射构件穿透以通过其中的物质填充第一腔室; 以及可在第一和第二位置之间移动的第二穿透隔膜。 在第一位置，第二隔膜的至少一部分与第一隔膜间隔开，以允许注射构件穿透第一隔膜，并通过其中的物质无菌或无菌地填充腔室。 在第二位置，第二隔膜的部分覆盖并密封第一隔膜中的所得注射孔，其中第一注射构件从其中取出之后，并且可被第二注射构件穿透以穿透第一和第二隔膜并撤回填充 物质从腔室通过第二注射构件。

公开(公告)号：WO2013166143A1

公开(公告)日：2013-11-07

申请号：PCT/US2013/039059

申请日：2013-05-01

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: F16L37/28

CPC classification number: F16L29/02 ,  A61M39/18 ,  A61M39/26 ,  A61M2039/268 ,  B65B3/003 ,  B65B39/001

Abstract: A valve comprises a shell, a flexible valve member sealingly mounted within the shell, and a valve body mounted atop the flexible valve member within the shell. The flexible member is moveable between closed and open positions to allow the flow of fluid therethrough. The valve is engageable with a filling device having flow ports and a surrounding closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). Alternatively, the valve may comprise a portion of a female connector and the filling device may comprise a portion of a male connector to form an aseptic fluid connector for the aseptic transfer of fluid therethrough.

Abstract translation: 阀包括壳体，密封地安装在壳体内的柔性阀构件和安装在壳体内的柔性阀构件顶部的阀体。 柔性构件可在闭合位置和打开位置之间移动以允许流体流过其中。 该阀可与具有流动端口和周围封闭件的填充装置接合。 所述封闭件和/或所述轴可在（i）第一位置和第二位置之间移动，所述第一位置是所述封闭件关闭所述端口，以及（ii）打开所述端口的第二位置。 或者，阀可以包括阴连接器的一部分，并且填充装置可以包括阳连接器的一部分，以形成无菌流体连接器，用于无菌地传输流体。