中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

346 records (took 0.024 seconds)

    63.
    发明专利
    未知

    公开(公告)号：NO874572L

    公开(公告)日：1988-05-05

    申请号：NO874572

    申请日：1987-11-03

    Applicant: UCB SA

    Inventor： COSSEMENT ERIC ,  GEERTS JEAN-PIERRE ,  GOBERT JEAN ,  MICHEL PHILIPPE

    IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/58 ,  C07D233/64 ,  C07D405/06 ,  C07D413/06 ,  C07D233/00

    Abstract: New substituted 1H-imidazoles and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula wherein R1, R2, R3 and R5=hydrogen or C1-C4-alkyl; R4=hydrogen, C1-C4-alkyl or C1-C4-alkoxy; Y1=hydrogen and Y2=OZ2 or the reverse; Z1=Z2=hydrogen or C1-C4-alkyl or Z1 and Z2=-CH2- or -C(CH3)2-. These compounds are prepared either by reducing a corresponding imidazole compound having a hydroxyl or alkoxy group on the methyl bridge between the imidazole and phenyl rings, or by hydrolyzing a 4-[[2,2-dimethyl-4H-1,3-benzodioxin-6(or 8)-yl]methyl]-1H-imidazole, or yet by reducing an alkyl 3-[(1H-imidazol-4-yl)methyl]-2-hydroxybenzoate. These compounds have cardiac, cerebral and tissular anti-ischemic activities.

    64.
    发明专利
    未知

    公开(公告)号：PT86040A

    公开(公告)日：1987-11-01

    申请号：PT8604087

    申请日：1987-10-30

    Applicant: UCB SA

    Inventor： COSSEMENT ERIC ,  GEERTS JEAN-PIERRE ,  GOBERT JEAN ,  MICHEL PHILIPPE

    IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/58 ,  C07D233/64 ,  C07D405/06 ,  C07D413/06 ,  C07D233/00

    Abstract: New substituted 1H-imidazoles and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula wherein R1, R2, R3 and R5=hydrogen or C1-C4-alkyl; R4=hydrogen, C1-C4-alkyl or C1-C4-alkoxy; Y1=hydrogen and Y2=OZ2 or the reverse; Z1=Z2=hydrogen or C1-C4-alkyl or Z1 and Z2=-CH2- or -C(CH3)2-. These compounds are prepared either by reducing a corresponding imidazole compound having a hydroxyl or alkoxy group on the methyl bridge between the imidazole and phenyl rings, or by hydrolyzing a 4-[[2,2-dimethyl-4H-1,3-benzodioxin-6(or 8)-yl]methyl]-1H-imidazole, or yet by reducing an alkyl 3-[(1H-imidazol-4-yl)methyl]-2-hydroxybenzoate. These compounds have cardiac, cerebral and tissular anti-ischemic activities.

    65.
    发明专利
    未知

    公开(公告)号：PT80460B

    公开(公告)日：1987-08-19

    申请号：PT8046085

    申请日：1985-05-14

    Applicant: UCB SA

    Inventor： GEERTS JEAN-PIERRE ,  GOBERT JEAN ,  BODSON GUY

    IPC: A61K31/40 ,  A61K31/4015 ,  C07D207/26 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  C07D207/12 ,  C07D207/27 ,  C07D207/277 ,  C07D295/185

    Abstract: (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (S)-2-amino-butanamide of the formula X-CH2CH2-NHCH (C2H5)CONH2 wherein Y is a -CH2-radical when X represents a ZOOC-radical and Y is a -CO- radical when X represents a HalCH2-radical, Z being a C1-C4 alkyl radical and Hal a halogen atom. This laevorotatory enantiomer has been found to have significantly higher protective activity against hypoxia and ischemia than the corresponding racemate.

    67.
    发明专利
    未知

    公开(公告)号：DK212985D0

    公开(公告)日：1985-05-14

    申请号：DK212985

    申请日：1985-05-14

    Applicant: UCB SA

    Inventor： GOBERT JEAN ,  GEERTS JEAN-PIERRE ,  BODSON GUY

    IPC: C07D207/26 ,  A61K31/40 ,  A61K31/4015 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  C07D207/12 ,  C07D207/27 ,  C07D207/277 ,  C07D295/185 ,  C07D

    Abstract: (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (S)-2-amino-butanamide of the formula X-CH2CH2-NHCH (C2H5)CONH2 wherein Y is a -CH2-radical when X represents a ZOOC-radical and Y is a -CO- radical when X represents a HalCH2-radical, Z being a C1-C4 alkyl radical and Hal a halogen atom. This laevorotatory enantiomer has been found to have significantly higher protective activity against hypoxia and ischemia than the corresponding racemate.

    70.
    发明专利
    未知

    公开(公告)号：DK174289B1

    公开(公告)日：2002-11-18

    申请号：DK586589

    申请日：1989-11-22

    Applicant: UCB SA

    Inventor： BODSON GUY ,  COSSEMENT ERIC ,  GOBERT JEAN

    IPC: C07D295/08 ,  C07D295/088

    Abstract: A process for the preparation of 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid and its dihydrochloride, wherein 2-[4-[(4-chlorophenyl-phenylmethyl]-1-piperazinyl]1-1ethanol is reacted with an alkali metal halogenoacetate in the presence of an alkali metal alcoholate, the alkali metal salt thus obtained is converted into the corresponding acid and, if appropriate, into its dihydrochloride.

Patent Agency Ranking