公开(公告)号：WO1992008809A1

公开(公告)日：1992-05-29

申请号：PCT/US1991008399

申请日：1991-11-19

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  CLEMMONS, Roger, M.

IPC: C12Q01/70

CPC classification number: G01N33/56988 ,  G01N33/54386

Abstract: An immunodiagnostic device for determining the presence of an antibody or antigen is provided which comprises a support member presenting a planar surface that comprises at least one delimited portion comprised of a material having a high surface area upon which a proteinaceous material can be immobilized in reactive form and, immobilized on said delimited portion, a proteinaceous material that binds the antibody or antigen. Also provided are immunoassay methods for detecting the presence of antibody and antigen in a fluid sample.

Abstract translation: 提供了用于确定抗体或抗原存在的免疫诊断装置，其包括呈现平坦表面的支撑构件，所述支撑构件包括至少一个限定部分，所述界定部分由具有高表面积的材料构成，蛋白质材料可以以该反应形式被固定 并且固定在所述限定部分上，结合抗体或抗原的蛋白质物质。 还提供了用于检测流体样品中抗体和抗原的存在的免疫测定方法。

公开(公告)号：WO1992005695A1

公开(公告)日：1992-04-16

申请号：PCT/US1991006730

申请日：1991-09-20

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GOLDBERG, Eugene, P. ,  BURNS, James, W. ,  KUMAR, G., Sudesh ,  OSBORN, David, C. ,  LARSON, Jeffrey, A. ,  SHEETS, John, W. ,  YAHIAOUI, Ali ,  ROBINSON, Richard

IPC: A01N01/02

CPC classification number: G02B1/043 ,  A61F2/16 ,  A61F2002/009 ,  A61L27/16 ,  A61L33/0088 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  C08L33/14 ,  C08L39/06 ,  Y10S623/921 ,  C08L51/06

Abstract: Improved medical devices and instruments prepared by an improved method of producing hydrophilic, gamma-irradiation or electron beam-irradiation induced polymerized and chemically grafted coatings or plastic surfaces of articles adapted for contacting living tissue, the improvement comprising carrying out the graft polymerisation in an aqueous solution under specific combinations of the following conditions: 1) monomer concentration in the range of from about 0.1 % to about 50 % by weight; 2) total gamma or electron beam irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad; and 3) gamma dose rate in the range of from about 10 to about 2500 rads/min or electron beam-irradiation dose rate in the range of from about 10 to about 10 rads/min.

Abstract translation: 改进的医疗装置和仪器通过改进的生产亲水性，γ射线照射或电子束照射的方法制备，所述方法适用于接触生物体组织的制品的聚合和化学接枝的涂层或塑料表面，其改进包括进行接枝聚合在水性 溶液在以下条件的特定组合下：1）单体浓度在约0.1重量％至约50重量％的范围内; 2）总伽马或电子束照射剂量在约0.001至小于约0.5Mrad范围内; 和3）在约10至约2500rad / min范围内的γ剂量率或约10至约10 8rad / min范围内的电子束照射剂量率。

公开(公告)号：WO1991017536A1

公开(公告)日：1991-11-14

申请号：PCT/US1991002983

申请日：1991-05-01

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GRIFFIS, Michael, W. ,  DUFFY, Joseph

IPC: G09B09/08

CPC classification number: B25J9/1623 ,  B23Q1/5462 ,  B25J17/0216 ,  F16F2230/0052 ,  G05B2219/37177 ,  G05B2219/41301 ,  G05B2219/50162 ,  G09B9/14

Abstract: A system, method and apparatus for controlling, via a closed-form forward displacement computation, the position and orientation of a movable platform of a parallel mechanism. A movable platform is supported above a base platform by a plurality of parallel support legs such as linear actuators. The dimensions of the base platform and the movable platform, as well as the lengths of the support legs, are provided to a control system. The control system is operative to compute at least one closed-form forward displacement solution (51) of the geometry of polyhedron (an octahedron for the disclosed embodiments) formed by the movable platform, the base platform, and the support legs. The control system determines a final position and orientation of the movable platform by eliminating imaginary roots of the closed-form solutions and roots which would result in discontinuous paths of travel for the movable platform. A novel special 6-6 parallel mechanism (Fig. 12) is also disclosed. The control system is suitable for controlling known 3-3 or 6-3 Stewart platforms in a novel manner, as well as controlling the novel special 6-6 parallel mechanism. The special 6-6 parallel mechanism is distinguished from a general 6-6 by the fact that it is geometrically reducible to an octahedron, and therefore it has a simple geometry, even though its legs possess distinct connections. Also disclosed is a method for reducing the novel special 6-6 parallel mechanism to a Stewart platform equivalent, which is then controlled by the disclosed closed-form forward displacement control system.

公开(公告)号：WO1991015767A1

公开(公告)日：1991-10-17

申请号：PCT/US1991002044

申请日：1991-03-29

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  CLEMMONS, Roger, M.

IPC: G01N33/53

CPC classification number: G01N33/5302 ,  G01N33/536 ,  G01N33/542 ,  G01N33/581

Abstract: Reagents for a liquid-phase immunodiagnostic assay (LIDA) method comprise a first enzyme; a second enzyme; a first agent which is capable of binding with an analyte to form a complex, said agent being attached to one of said first and second enzymes; and a complex-binding agent attached to the remaining enzyme, wherein said first enzyme is capable of interacting with a substrate for said first enzyme together with any necessary additional substrates for said first enzyme to produce a substrate for said second enzyme, and wherein said second enzyme is capable of interacting with said substrate produced by said first enzyme together with any necessary additional substrates, such that occurrence of the second of said interactions is detectable. The reagent optionally further comprises a scavenger substance capable of inactivating the substrate produced by the first enzyme.

Abstract translation: 用于液相免疫诊断测定（LIDA）方法的试剂包含第一种酶; 第二种酶; 能够与分析物结合以形成复合物的第一试剂，所述试剂连接到所述第一和第二酶之一; 以及与剩余酶连接的复合结合剂，其中所述第一酶能够与所述第一酶的底物和所述第一酶的任何必需的另外的底物相互作用以产生所述第二种酶的底物，并且其中所述第二种酶 酶能够与所述第一酶产生的所述底物与任何必需的另外的底物相互作用，使得所述相互作用中的第二种的发生是可检测的。 试剂任选地还包含能够使由第一酶产生的底物失活的清除剂物质。

公开(公告)号：WO1991000131A1

公开(公告)日：1991-01-10

申请号：PCT/US1990003324

申请日：1990-06-18

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  YOST, Richard, A. ,  HAIL, Mark, E.

IPC: B01D15/08

CPC classification number: G01N30/30 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/3061 ,  G01N2030/3069

Abstract: A system and method for high resolution gas chromatography involves the use of fused silica open tubular capillary columns (33) having a conductive exterior coating and an arrangement for electrically coupling a power source (21) to the coating to effect direct resistive heating of column (33) while controlling the temperature thereof. The control of temperature is achieved by measuring the resistance of the coating, correlating such resistance with the temperature of column (33), and increasing or decreasing the electrical power supplied to the coating to effect the adjustment in column (33) temperature. Because of the low thermal mass of column (33) and the conductive coating, temperature changes can be readily effected thereby improving the speed of separation and reducing the time interval between resolution of successive samples. The compact nature and low power demands of the system allow it to be operated as a portable unit.

Abstract translation: 用于高分辨率气相色谱的系统和方法包括使用具有导电外部涂层的熔融石英开放管状毛细管柱（33）和用于将电源（21）电耦合到涂层以实现柱的直接电阻加热（ 33）同时控制其温度。 通过测量涂层的电阻，将这种电阻与色谱柱（33）的温度相关联，并且增加或减少供给涂层的电力以实现色谱柱（33）温度的调节来实现温度的控制。 由于柱（33）和导电涂层的热质量低，因此可以容易地实现温度变化，从而提高分离速度并减少连续样品的分辨率之间的时间间隔。 系统的紧凑性和低功率需求使其能够作为便携式设备运行。

公开(公告)号：WO1991000115A1

公开(公告)日：1991-01-10

申请号：PCT/US1990003480

申请日：1990-06-20

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  MELKER, Richard, J. ,  MILLER, Gary, J.

IPC: A61M05/00

CPC classification number: A61M39/04 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150732 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/154

Abstract: A fluid transfer system, including a channel member (10), adapted for connection between an arterial or venus catheter and an IV fluid administration system. The channel member includes a duct (14) and an access port (20). An adapter (12) including a recessed needle (34) assembly is provided for mounting to the access port of the channel member. A syringe, IV tubing or and evacuated container may be mounted directly to the channel member via the adapter. Safety is substantially enhanced by recessing the needle assembly of the adapter.

公开(公告)号：WO1990013513A1

公开(公告)日：1990-11-15

申请号：PCT/US1990002614

申请日：1990-05-14

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  CLARK, David, E. ,  IFTIKHAR, Ahmad ,  DALTON, Robert, C.

IPC: C01B06/00

CPC classification number: C04B35/5611 ,  B01J19/126 ,  C01B6/00 ,  C01B32/90 ,  C01B32/921 ,  C01B33/06 ,  C01B35/04 ,  C01P2002/72 ,  C01P2004/80 ,  C04B35/65 ,  C04B35/651 ,  C22C1/058

Abstract: Combustion synthesis process using microwave energy. The process uses microwave energy to ignite at least two reactants which are capable of reacting exothermically to produce a reaction product. In accordance with one embodiment of the invention, combustion of the reactants is also controlled using microwave energy.

Abstract translation: 使用微波能量的燃烧合成过程。 该方法使用微波能量来点燃能够放热反应产生反应产物的至少两种反应物。 根据本发明的一个实施方案，还可以使用微波能量来控制反应物的燃烧。

公开(公告)号：WO1990011776A1

公开(公告)日：1990-10-18

申请号：PCT/US1990001812

申请日：1990-04-04

Applicant: UNIVERSITY OF FLORIDA ,  WASHINGTON STATE UNIVERSITY ,  UNITED STATES DEPARTMENT OF AGRICULTURE

Inventor： UNIVERSITY OF FLORIDA ,  WASHINGTON STATE UNIVERSITY ,  UNITED STATES DEPARTMENT OF AGRICULTURE ,  McELWAIN, Terry, F.; ,  HINES, Stephen, A. ,  McGUIRE, Travis, C. ,  PALMER, Guy, H. ,  JASMER, Douglas, P. ,  REDUKER, David, W. ,  GOFF, Will, L. ,  PERRYMAN, Lance, E. ,  DAVIS, William, C.

IPC: A61K39/018

CPC classification number: C07K16/20 ,  A61K39/00 ,  C07K14/44

Abstract: The subject invention concerns the identification of novel merozoite surface proteins of Babesia bovis. Also disclosed are monoclonal antibodies to these proteins as well genes which encode for the proteins. The invention further concerns the use of the novel proteins, recombinant DNA clones, and monoclonal antibodies in the detection, treatment, and prophylaxis of babesiosis.

Abstract translation: 本发明涉及确定牛蒡贝类新颖的裂殖子表面蛋白。 还公开了这些蛋白质的单克隆抗体以及编码蛋白质的基因。 本发明还涉及新型蛋白质，重组DNA克隆和单克隆抗体在检测，治疗和预防婴儿期中的用途。

公开(公告)号：WO1988007036A1

公开(公告)日：1988-09-22

申请号：PCT/US1988000386

申请日：1988-02-16

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BODOR, Nicholas, S.

IPC: C07C131/00

CPC classification number: C07D215/227 ,  C07C251/38 ,  C07D285/10

Abstract: Compound having beta-adrenergic blocking properties having formula (I), wherein X is -O-, -CH2- or -----; Y is =O or a derivatized keto group, each of which is hydrolyzable or enzymatically convertible to a ketonic group; R is alkyl having from 1 to 12 carbon atoms or aralkyl having from 7 to 20 carbon atoms, and Ar is the 3 residue of a 1-alkylamino-2-propanol having a cyclic substituent at the 3-position thereof, said substituted propanol having beta-adrenergic blocking properties; or an acid-addition salt thereof with a pharmaceutically acceptable acid. The invention also relates to pharmaceutical compositions containing the above compounds and methods of treatment.

公开(公告)号：WO1982000096A1

公开(公告)日：1982-01-21

申请号：PCT/US1981000719

申请日：1981-05-29

Applicant: UNIVERSITY OF FLORIDA ,  MAREN T

Inventor： UNIVERSITY OF FLORIDA

IPC: A61K31/425

CPC classification number: C07D285/135 ,  A61K31/41 ,  A61K31/425 ,  A61K31/63

Abstract: Procede et composition de reduction de la pression intraoculaire et de reduction de la formation d'humeur aqueuse en appliquant en surface sur la cornee une quantite effective d'une solution aqueuse d'un inhibiteur d'anhydrase carbonique comprenant un sulfonamide ayant les proprietes suivantes: a) suffisamment soluble a l'eau pour former une solution de 1 a 5% en poids ou un pka n'excedant pas 7,0; b) un coefficient de division de l'ether d'au moins 1,0; c) un coefficient de division du chloroforme d'au moins 0,01; d) constante de dissociation contre l'anhydrase carbonique n'excedant pas 3x10-8 molaire; e) constante de vitesse de premier ordre pour la penetration des sulfonamides au travers d'une cornee isolee d'un lapin d'au moins 0,002hr.-1; f) non nuisible a la cornee; et g) stable en solution aqueuse et en contact avec la cornee.