公开(公告)号：EP0551309B1

公开(公告)日：1998-01-21

申请号：EP91916707.2

申请日：1991-09-20

Applicant: UNIVERSITY OF FLORIDA

Inventor： GOLDBERG, Eugene P. ,  BURNS, James, W. ,  KUMAR, G. Sudesh ,  OSBORN, David, C. ,  LARSON, Jeffrey, A. ,  SHEETS, John, W. ,  YAHIAOUI, Ali ,  ROBINSON, Richard

IPC: A61L27/00 ,  A61L33/00

CPC classification number: G02B1/043 ,  A61F2/16 ,  A61F2002/009 ,  A61L27/16 ,  A61L33/0088 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  C08L33/14 ,  C08L39/06 ,  Y10S623/921 ,  C08L51/06

Abstract: A method is disclosed for modifying a plastic surface of ocular implants, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma-irradiation induced or the electron beam-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethyl-methacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt%, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophillic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), ÄP(NVP-HEMA)Ü, or IV. a copolymer of (NVP), (HEMA), or (NVP-HEMA) and said ionic monomer, on said surface, the improvement comprising: conducting said gamma-irradiation induced graft polymerisation in an aqueous solution under the following conditions: a) monomer concentration in the range of from about 0.1% to about 50% by weight; b) total gamma (or total electron beam irradiation) dose in the range of from about 0.001 to less than about 0.50 Mrad; and c) gamma dose rate in the range of from about 10 to about 2500 rads/min or an electron beam irradiation dose rate in the range of from about 10 to about 10 rads/min.

公开(公告)号：EP0551383A1

公开(公告)日：1993-07-21

申请号：EP91918249.0

申请日：1991-09-20

Applicant: UNIVERSITY OF FLORIDA

Inventor： GOLDBERG, Eugene, P. Dept. of Materials Sci. ,  BURNS, James, W. ,  KUMAR, G., Sudesh Alchemie Research Center ,  OSBORN, David, C. ,  LARSON, Jeffrey, A. ,  SHEETS, John, W. ,  YAHIAOUI, Ali Department of Materials Science ,  ROBINSON, Richard

IPC: A61F2 ,  A61L27 ,  B05D7 ,  C08F291 ,  C08J7 ,  G02B1 ,  B05D3

CPC classification number: A61F2/16 ,  A61F2/14 ,  A61F2/1648 ,  A61F2002/0086 ,  A61L27/16 ,  A61L27/34 ,  A61L2400/18 ,  A61L2430/16 ,  B05D3/068 ,  B05D7/02 ,  G02B1/043 ,  C08L51/06 ,  C08L39/06 ,  C08L33/14

Abstract: Procédé de modification d'une surface polymère d'implant oculaire (10) par polymérisation induite par rayonnement gamma ou de faisceau d'électrons sur ladite surface de N-vinylpyrrolidone, 2-hydroxyéthylméthacrylate ou d'un mélange de ceux-ci tout en maintenant les conditions suivantes: (a) concentration de monomères situés dans la plage comprise entre environ 0,1 % et environ 50 % en poids; (b) dose de rayonnement gamma total dans la plage comprise entre environ 0, 001 et moins de 0,50 Mrad; et (c) taux de la dose de rayonnement gamma dans la plage comprise entre environ 10 et environ 2500 rads/minute ou taux de la dose de rayonnement du faisceau d'électrons dans la plage comprise entre environ 10 et 108 rads/minute.

公开(公告)号：EP0551309A1

公开(公告)日：1993-07-21

申请号：EP91916707.0

申请日：1991-09-20

Applicant: UNIVERSITY OF FLORIDA

Inventor： GOLDBERG, Eugene P. ,  BURNS, James, W. ,  KUMAR, G. Sudesh ,  OSBORN, David, C. ,  LARSON, Jeffrey, A. ,  SHEETS, John, W. ,  YAHIAOUI, Ali ,  ROBINSON, Richard

IPC: A61L27 ,  A61L33 ,  C08F291 ,  C08J7 ,  G02B1 ,  A61F2

CPC classification number: G02B1/043 ,  A61F2/16 ,  A61F2002/009 ,  A61L27/16 ,  A61L33/0088 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  C08L33/14 ,  C08L39/06 ,  Y10S623/921 ,  C08L51/06

Abstract: A method is disclosed for modifying a plastic surface of ocular implants, said surface adapted for contact with living tissue of a human or non-human animal, by the gamma-irradiation induced or the electron beam-irradiation induced polymerized chemically grafted coating thereon of: 1) a monomer comprising N-vinylpyrrolidone (NVP), 2) a monomer comprising 2-hydroxyethyl-methacrylate (HEMA), 3) a mixture of (NVP) and (HEMA), (NVP-HEMA), or 4) a mixture of 1), 2) or 3) with up to about 50 wt%, based on the total monomer weight, of an ionic monomer, salt of an ionic monomer or mixture thereof; so as to form a hydrophillic graft polymer coating of: I. polyvinylpyrrolidone (PVP), II. poly-2-hydroxyethylmethacrylate (PHEMA), III. a copolymer of (NVP) and (HEMA), ÄP(NVP-HEMA)Ü, or IV. a copolymer of (NVP), (HEMA), or (NVP-HEMA) and said ionic monomer, on said surface, the improvement comprising: conducting said gamma-irradiation induced graft polymerisation in an aqueous solution under the following conditions: a) monomer concentration in the range of from about 0.1% to about 50% by weight; b) total gamma (or total electron beam irradiation) dose in the range of from about 0.001 to less than about 0.50 Mrad; and c) gamma dose rate in the range of from about 10 to about 2500 rads/min or an electron beam irradiation dose rate in the range of from about 10 to about 10 rads/min.

公开(公告)号：WO1992005694A1

公开(公告)日：1992-04-16

申请号：PCT/US1991006729

申请日：1991-09-20

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GOLDBERG, Eugene, P. ,  BURNS, James, W. ,  KUMAR, G., Sudesh ,  OSBORN, David, C. ,  LARSON, Jeffrey, A. ,  SHEETS, John, W. ,  YAHIAOUI, Ali ,  ROBINSON, Richard

IPC: A01N01/02

CPC classification number: A61F2/16 ,  A61F2/14 ,  A61F2/1648 ,  A61F2002/0086 ,  A61L27/16 ,  A61L27/34 ,  A61L2400/18 ,  A61L2430/16 ,  B05D3/068 ,  B05D7/02 ,  G02B1/043 ,  C08L51/06 ,  C08L39/06 ,  C08L33/14

Abstract: A method for modifying an ocular implant polymer surface (10) by the gamma-irradiation or electron beam irradiation induced polymerization thereon of N-vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture thereof while maintaining the following conditions: (a) monomer concentration in the range of from about 0.1 % to about 50 % by weight; (b) total gamma dose in the range of from about 0.001 to less than 0.50 Mrad; and (c) gamma dose rate in the range of from about 10 to about 2500 rads/minute or electron beam irradiation dose rate in the range of from about 10 to about 10 rads/minute.

Abstract translation: 通过γ-照射或电子束照射来修饰眼睛植入物聚合物表面（10）的方法，其中使N-乙烯基吡咯烷酮，甲基丙烯酸2-羟基乙酯或其混合物在其上聚合，同时保持以下条件：（a）单体浓度范围 为约0.1％至约50％; （b）在约0.001至小于0.50Mrad范围内的总伽马剂量; 和（c）约10至约2500rad /分钟范围内的γ剂量率或约10至约10弧度/分钟范围内的电子束照射剂量率。

公开(公告)号：WO1992005695A1

公开(公告)日：1992-04-16

申请号：PCT/US1991006730

申请日：1991-09-20

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GOLDBERG, Eugene, P. ,  BURNS, James, W. ,  KUMAR, G., Sudesh ,  OSBORN, David, C. ,  LARSON, Jeffrey, A. ,  SHEETS, John, W. ,  YAHIAOUI, Ali ,  ROBINSON, Richard

IPC: A01N01/02

CPC classification number: G02B1/043 ,  A61F2/16 ,  A61F2002/009 ,  A61L27/16 ,  A61L33/0088 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  C08L33/14 ,  C08L39/06 ,  Y10S623/921 ,  C08L51/06

Abstract: Improved medical devices and instruments prepared by an improved method of producing hydrophilic, gamma-irradiation or electron beam-irradiation induced polymerized and chemically grafted coatings or plastic surfaces of articles adapted for contacting living tissue, the improvement comprising carrying out the graft polymerisation in an aqueous solution under specific combinations of the following conditions: 1) monomer concentration in the range of from about 0.1 % to about 50 % by weight; 2) total gamma or electron beam irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad; and 3) gamma dose rate in the range of from about 10 to about 2500 rads/min or electron beam-irradiation dose rate in the range of from about 10 to about 10 rads/min.

Abstract translation: 改进的医疗装置和仪器通过改进的生产亲水性，γ射线照射或电子束照射的方法制备，所述方法适用于接触生物体组织的制品的聚合和化学接枝的涂层或塑料表面，其改进包括进行接枝聚合在水性 溶液在以下条件的特定组合下：1）单体浓度在约0.1重量％至约50重量％的范围内; 2）总伽马或电子束照射剂量在约0.001至小于约0.5Mrad范围内; 和3）在约10至约2500rad / min范围内的γ剂量率或约10至约10 8rad / min范围内的电子束照射剂量率。