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公开(公告)号：US3351683A
公开(公告)日：1967-11-07
申请号：US42885465
申请日：1965-01-28
Applicant: UNION CARBIDE CORP
Inventor： CHISUNG WU , WELCH FRANK J
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62.发明授权Reaction product of an alkylated phenol and a phosphate and process for making same 失效烷基化酚和磷酸酯的反应产物及其制备方法
公开(公告)号：US3330887A
公开(公告)日：1967-07-11
申请号：US37086664
申请日：1964-05-28
Applicant: FIRESTONE TIRE & RUBBER CO
Inventor： CONARD WENDELL R
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公开(公告)号：US3254027A
公开(公告)日：1966-05-31
申请号：US25445663
申请日：1963-01-28
Applicant: SINCLAIR RESEARCH INC
Inventor： MATSON HOWARD J , NELSON JOHN W
IPC: C07F9/165 , C07F9/201 , C10M141/10
CPC classification number: C10M141/10 , C07F9/1651 , C07F9/201 , C10M135/06 , C10M137/04 , C10M137/10 , C10M2203/108 , C10M2209/084 , C10M2219/024 , C10M2223/04 , C10M2223/041 , C10M2223/042 , C10M2223/045 , C10M2223/047 , C10M2223/065 , C10M2229/02 , C10M2229/05
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64.发明授权Method for controlling nematodes with phosphorothioites and phosphorothioates 失效用硫代磷酸酯和硫代磷酸酯控制线虫的方法
公开(公告)号：US3112244A
公开(公告)日：1963-11-26
申请号：US10452661
申请日：1961-04-21
Applicant: VIRGINIA CAROLINA CHEM CORP
Inventor： GOYETTE LEWIS E
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公开(公告)号：US2955803A
公开(公告)日：1960-10-11
申请号：US74054558
申请日：1958-06-09
Applicant: VIRGINIA CAROLINA CHEM CORP
Inventor： EDWARD GOYETTE LEWIS
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Patent Agency Ranking
公开(公告)号：US2769013A
公开(公告)日：1956-10-30
申请号：US30301152
申请日：1952-08-06
Applicant: EXXON RESEARCH ENGINEERING CO
Inventor： WALTER LOWENSTEIN-LOM
IPC: C07F9/08 , C07F9/201 , C07F9/6553 , C10M137/10
CPC classification number: C10M137/105 , C07F9/08 , C07F9/201 , C07F9/6553 , C07F9/655345 , C10M2223/04 , C10M2223/042 , C10M2223/047 , C10N2240/14
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公开(公告)号：US09102639B2
公开(公告)日：2015-08-11
申请号：US14099276
申请日：2013-12-06
Applicant: ARRAY BIOPHARMA INC.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D271/107 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D401/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US08623895B2
公开(公告)日：2014-01-07
申请号：US13538698
申请日：2012-06-29
Applicant: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC: A61K31/433 , A61K31/4439 , C07D417/12 , C07D285/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US07956073B2
公开(公告)日：2011-06-07
申请号：US12043456
申请日：2008-03-06
Applicant: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC: A61K31/433 , C07D285/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US6147244A
公开(公告)日：2000-11-14
申请号：US304252
申请日：1999-05-03
Applicant: Charles E. McKenna , Zengmin Li
Inventor： Charles E. McKenna , Zengmin Li
CPC classification number: C07F9/4065 , C07F9/201
Abstract: Improved methods for converting phosphite or phosphonate esters into corresponding thiophosphites or thiophosphonates and for synthesizing specific thiophosphite and thiophosphonate compounds so produced are disclosed and claimed. The methods start from phosphite diesters using P.sub.4 S.sub.10 as the thionation reagent. The reaction mixture is refluxed until the reaction is complete and may be followed by separation and chloroformate ester phosphonation steps to produce pure thiophosphonocarboxylate triesters. Alternatively, these esters may be prepared directly by action of P.sub.4 S.sub.10 on the corresponding phosphonocarboxylate esters. The former method was used to prepare dimethyl thiophosphite and thence trimethyl thiophosphonoformate, a key intermediate in synthesis of salts of thiophosphonoformic acid, which have anti-viral properties.
Abstract translation: 公开和要求保护的方法将亚磷酸酯或膦酸酯转化成相应的硫代亚磷酸酯或硫代膦酸酯并合成特定的硫代亚磷酸酯和硫代膦酸酯化合物。 该方法从使用P4S10作为硫化试剂的亚磷酸二酯开始。 将反应混合物回流直到反应完成，然后分离和氯甲酸酯膦酸化步骤以产生纯的硫代膦酰基羧酸酯三酯。 或者，这些酯可以通过P4S10在相应的膦酰基羧酸酯上的作用直接制备。 使用前一种方法制备二硫代亚磷酸二甲酯，然后制备硫代膦酰甲酸三甲酯，这是合成硫代膦酰甲酸盐的关键中间体，具有抗病毒性质。
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