Abstract:
PROBLEM TO BE SOLVED: To conduct light measurement by using light of an appropriate luminescence wavelength based on light transmission property of a part to be measured and the like. SOLUTION: Excitation light emitted from a semiconductor laser 102 is made incident on an optical fiber 101 of which core is evenly dispersed with lead sulfide nanoparticle group controlled to have a radius 5.75 nm to 7.1 nm. The nanoparticle group is optically excited, fluorescence is emitted and a wide band low coherence light L1 of 1 μm to 1.2 μm, most appropriate for measurement of a living body and the like is emitted from an end of the optical fiber 101 and introduced to a fiber 204 of a fiber joint optical system 20. By controlling the radius of the nanoparticle group, light of intended wavelength band and spectral width can be emitted from a light source 10. In a fiber coupler 201, the low coherence light L1 is separated into a measurement light L3 to be radiated to a part 1 to be measured and a reference light L2. A measurement light L4 reflected by a predetermined deep part of the part 1 to be measured and the reference light 2 are coupled and light intensity of an interference light is detected by a balance difference detection part 50 and image processing is conducted to obtain an optical tomographic image. COPYRIGHT: (C)2007,JPO&INPIT
Abstract:
A side illuminated multi point multi parameter optical fiber sensor that requires no sensitive coating is provided. This sensor comprises an optical fiber having at least one removed cladding section as the sensitive region, at least one probing light source that side illuminates the fiber, a power supply, a detector, a signal processor and a display. The sensitive optical fiber is optically affected by the presence of a measurand medium that can fluoresce, phosphoresce, absorb and/or scatter the probing light. This probing light is guided by the fiber core towards a detector which measures the light intensity and this light intensity is correlated with a measurand.
Abstract:
The invention provides novel non-invasive in vitro methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.
Abstract:
The present disclosure provides a method of characterising a dielectric material. The method comprises the step of providing a light source, a light collector and a sensor. The sensor is arranged so that an evanescent field of light penetrates through a surface of the sensor and surface plasmons are generated at the surface of the sensor when suitable light is directed along at least a portion of the sensor. The method also includes the step of exposing the surface of the sensor to the dielectric material so that an interface is formed between the surface and the dielectric material. Further, the method comprises guiding light along at least a portion of the sensor to generate the surface plasmons. In addition, the method comprises the step of collecting an intensity of light from the interface as a function of a spectral parameter of the light. Further, the present disclosure provides an apparatus for characterising the dielectric material in accordance with the method.
Abstract:
The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of a) providing conditions suitable for the biological marker to produce at least one first photon by luminescence b) providing a FUEL probe pair-upper (FPP-U) disposed in proximity to the cell, tissue or organism, wherein the at least one first photon of step a) excites the FPP-U, which emits at least one second photon. The FPP-U may be selected from the group of quantum dots, carbon nanotubes, fluorescent proteins, diamond nanocrystals, and metalloporphyrins. This method is characterized in that said biological marker and said FPP-U are not bound and in that each of the at least one second photon (s) are of a longer wavelength than each of the at least one first photon (s).
Abstract:
Die Erfindung betrifft ein Messsystem insbesondere zur Blutzuckerbestimmung mit einer photometrischen Messeinheit (16), die eine Lichtquelle (22) und einen Detektor (24) umfasst, und einem mit einer Probe, insbesondere einer Körperflüssigkeit beaufschlagbaren und für einen optischen Nachweis eines Analyten in einen Strahlengang (18) zwischen der Lichtquelle (22) und dem Detektor (24) bringbaren analytischen Testelement (14). Für eine verbesserte Mehrwellenlängenmessung wird vorgeschlagen, dass die Lichtquelle (22) einen in einem ersten Wellenlängenbereich zur Aussendung von pulsierendem Wechsellicht (28) ansteuerbaren ersten Strahler (26) und einen in einem zweiten Wellenlängenbereich zur Emission von Fluoreszenzlicht (32) anregbaren zweiten Strahler (30) aufweist.
Abstract:
The invention relates to a device for the detection of fluorescence emitted by chromophoric elements contained in the wells of a multiwell plate. The inventive device comprises means (54, 56) which are built into the transparent bases of the wells (12) of the plate (10) in order to limit the well penetration depth of a light beam used to excite the chromophoric elements (38) which are fixed to the bases (14) of the wells.
Abstract:
Provided herein are assays utilizing oxygen-sensitive fluorescent materials for the detection of oxygen. In particular, oxygen-sensitive fluorescent particles are provided for monitoring the oxygen consumption rate and metabolic fitness of living cells.