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公开(公告)号：WO2004048881A8
公开(公告)日：2005-12-22
申请号：PCT/EP0312724
申请日：2003-11-14
Applicant: HOFFMANN LA ROCHE , ROCHE DIAGNOSTICS GMBH , KALVERAM STEFAN , ZIEGLER FRIEDRICH , HAAR HANS-PETER , LIST HANS , ASFOUR JEAN-MICHEL
Inventor： KALVERAM STEFAN , ZIEGLER FRIEDRICH , HAAR HANS-PETER , LIST HANS , ASFOUR JEAN-MICHEL
IPC: G01N21/86 , G01N33/487
CPC classification number: G01N21/8483 , G01N2201/0628 , H01L27/288
Abstract: The invention relates to a measuring device for the optical analysis of a diagnostic test strip (10). Said device comprises a light source (16), a photo-detector (24) and a device (12) for positioning the test strip (10) between the light source (16) and the photo-detector (24). The light source (16) comprises one or more organic light-emitting diodes (OLEDs) and the OLEDs (14) form a composite structure with imaging optics (20) and/or the photo-detector (24) by means of a support substrate (18).
Abstract translation: 本发明涉及一种用于诊断测试元件的光学检查具有光源的测量装置（10），（16），光电检测器（24）和用于光源之间的测试元件（10）定位的装置（12），（16）和光检测器（24）， 其中，所述光源（16）包括一个或多个有机发光二极管（OLED）和支撑衬底（18）上的有机发光二极管（14），其具有成像光学系统（20）和/或光检测器（24）形成复合结构。
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公开(公告)号：WO99060381A1
公开(公告)日：1999-11-25
申请号：PCT/US1999/011088
申请日：1999-05-17
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/0303 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
Abstract translation: 光学仪器监测具有温度循环阻滞的反应装置中DNA的PCR复制，所述反应装置具有小瓶的反应成分，包括在双链DNA存在下发荧光的染料。 分束器将激发光束传递到小瓶以使染料发荧光。 来自染料的发射光束通过分束器传递到CCD检测器，处理器从该检测器计算DNA浓度。 具有多个参考发射器的参考条发射不同强度的参考光束，处理器从该参考光束选择用于补偿漂移的最佳发射器。 自动调整曝光时间以保持CCD和处理器的最佳动态范围。 分束器和相关的滤光器的模块与选定的染料相关联，并且可替代不同的染料。
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公开(公告)号：US12025564B2
公开(公告)日：2024-07-02
申请号：US18312873
申请日：2023-05-05
Applicant: The Boeing Company
Inventor： Morteza Safai
IPC: G01N21/88 , B29C64/371 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02 , G01N21/95
CPC classification number: G01N21/8806 , B29C64/371 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02 , G01N21/8851 , G01N21/95 , G01N2201/06113 , G01N2201/0627 , G01N2201/0628
Abstract: A method for real-time surface imperfection detection for additive manufacturing and 3-D printing parts is provided. The method includes directing a first light radiation using one or more illumination sources, wherein the first light radiation illuminates a target area of a part being manufactured in a uniform chromatic light such that the target area appears to have a substantially uniform monochromatic color; capturing a current image of a second light radiation that is scattered or reflected by the target area using one or more feedback cameras; and analyzing the current image of the second light radiation using at least one of the one or more feedback camera with a previously acquired image to determine whether a surface imperfection exists or does not exist.
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公开(公告)号：US20180340889A1
公开(公告)日：2018-11-29
申请号：US16036646
申请日：2018-07-16
Applicant: Lester F. LUDWIG
Inventor： Lester F. LUDWIG , Karen HAO , Frank HU , Alice HUANG , Pooncharas TIPGUNLAKANT
IPC: G01N21/59 , G01N15/14 , G01N21/25 , G01N21/51 , G01N21/53 , G01N21/64 , G01N15/02 , G01N15/10 , G01N21/17
CPC classification number: G01N21/59 , G01N15/0227 , G01N15/1434 , G01N15/1459 , G01N15/1475 , G01N15/1484 , G01N21/253 , G01N21/51 , G01N21/534 , G01N21/6452 , G01N21/6458 , G01N2015/0294 , G01N2015/1006 , G01N2015/1445 , G01N2015/1493 , G01N2015/1497 , G01N2021/1787 , G01N2201/062 , G01N2201/0626 , G01N2201/0628
Abstract: Optical tomography arrangements are disclosed for performing optical tomography on the transparent or translucent contents of individual microplate wells comprising a light emitting array having a plurality of light emitting elements, a sample module, and a light sensing array including a plurality of light sensing elements, wherein the light sensing array is configured to sense light emitted from the light emitting array which has passed through the sample module. The light emitting elements can comprise light emitting diodes (LEDs), organic light emitting diodes (OLEDs), organic light emitting transistors (OLETs), and/or other optoelectronic devices. The light sensing array can comprise organic light sensing devices, photodiodes, phototransistors, CMOS photodetectors, or charge-coupled devices (CCDs). The light emitting array can be flat or curved, and the light sensing array can be flat or curved. The collection of measurement values can be overspecified, and a generalized inverse operation can provide solutions rendering computational tomography data.
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65.发明授权公开(公告)号：US09719925B2
公开(公告)日：2017-08-01
申请号：US14741319
申请日：2015-06-16
Applicant: APPLIED BIOSYSTEMS, LLC
Inventor： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
CPC classification number: G01N21/6428 , B01L7/52 , B01L2300/1805 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/062 , G01N2201/0627 , G01N2201/0628 , Y10S435/808
Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.
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Patent Agency Ranking
公开(公告)号：US09429521B2
公开(公告)日：2016-08-30
申请号：US14404338
申请日：2013-05-30
Inventor： David Kramer , Jeffrey Cruz , Christopher Hall , William Kent Kovac , Robert Zegarac
CPC classification number: G01N21/6486 , G01N21/6408 , G01N21/6456 , G01N33/0098 , G01N33/025 , G01N2021/635 , G01N2021/8466 , G01N2201/0221 , G01N2201/0627 , G01N2201/0628
Abstract: Chlorophyll fluorescence may be studied in response to a variety of environmental cues or conditions by growing phototrophic organisms under actinic illumination. Such illumination may be punctuated or disrupted to gain information about the photosynthetic properties or performance of the phototrophic organism. Instruments or devices for carrying out the method are also described.
Abstract translation: 可以通过在光化照射下生长光养生物来响应各种环境线索或条件来研究叶绿素荧光。 这种照明可能被打断或破坏以获得关于光合生物的光合性质或性能的信息。 还描述了用于执行该方法的仪器或装置。
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公开(公告)号：US20160216192A1
公开(公告)日：2016-07-28
申请号：US14916743
申请日：2013-09-05
Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC
Inventor： Yansong Gu
CPC classification number: G01N15/0205 , G01N15/1434 , G01N15/1468 , G01N21/6486 , G01N33/5008 , G01N2015/1006 , G01N2015/1493 , G01N2201/0628 , G02B21/06 , G02B21/26 , H05B33/0896
Abstract: Cell culturing and tracking systems using an array of organic light emitting diodes (OLEDs) to illuminate cells and/or other particles in a cell chamber are described. Compared to conventional light sources, the OLED array consumes very little energy and emits a small amount of waste heat, so it may be disposed near or on the cell chamber. For instance, it can be printed on one side of the cell chamber itself. In addition, the OLED array may be patterned into pixels or sub-pixels (individual OLEDs), each of which is as small as or smaller than an individual cell or particle. Because the pixels are so small, OLED illumination can be used to acquire images with a spatial resolution equal to or better than the cell or particle cell. As a result, the OLED array can be used to track, monitor, identify, and manipulate individual cells within the cell culture.
Abstract translation: 描述了使用有机发光二极管（OLED）阵列来照射细胞室中的细胞和/或其他颗粒的细胞培养和跟踪系统。 与常规光源相比，OLED阵列消耗的能量很少，并且会排放少量的余热，因此它可以靠近或放置在电池室上。 例如，它可以印刷在电池室本身的一侧。 此外，OLED阵列可以被图案化成像素或子像素（单独的OLED），其每一个都小于或小于单个单元或颗粒。 由于像素非常小，可以使用OLED照明来获取空间分辨率等于或优于单元格或粒子单元的图像。 结果，OLED阵列可用于跟踪，监测，识别和操纵细胞培养物中的各个细胞。
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公开(公告)号：US20130143310A1
公开(公告)日：2013-06-06
申请号：US13748508
申请日：2013-01-23
Applicant: Applied Biosystems, LLC
Inventor： Mark F. Oldham , Eugene F. Young
IPC: G01N21/64
CPC classification number: G01N21/6486 , B01L3/5085 , B01L7/52 , C12Q2545/101 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
Abstract translation: 提供了可以监测核酸序列扩增反应的仪器，例如DNA和DNA片段的PCR扩增。 仪器包括沿激发光束路径和发射光束路径中的一个或两个设置的多陷波滤波器。 还提供了使用包括沿着光束路径设置的多陷波滤波器的仪器来监测核酸序列扩增的方法。
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公开(公告)号：US08435797B2
公开(公告)日：2013-05-07
申请号：US12961675
申请日：2010-12-07
Applicant: Vincent P. Schnee
Inventor： Vincent P. Schnee
CPC classification number: G01N21/66 , G01N21/77 , G01N33/22 , G01N2201/0628 , Y10T436/17 , Y10T436/170769 , Y10T436/173076
Abstract: A senor uses a transduction mechanism of attenuating electroluminescence. Luminescence from a light emitting diode is attenuated as a consequence of direct interaction of an analyte and a electroluminescent material, An electroluminescent diode sensor (EDS) is fabricated in a way that allows the electroluminescent material in the diode to be exposed to gaseous, liquid or solid sample(s) which may affect the luminescence intensity of the diode.
Abstract translation: 传声器使用衰减电致发光的转导机制。 来自发光二极管的发光作为分析物和电致发光材料的直接相互作用的结果被衰减。电致发光二极管传感器（EDS）以允许二极管中的电致发光材料暴露于气体，液体或 可能影响二极管发光强度的固体样品。
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公开(公告)号：US20130011848A1
公开(公告)日：2013-01-10
申请号：US13611462
申请日：2012-09-12
Applicant: Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
Inventor： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
CPC classification number: G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
Abstract translation: 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。 光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。 根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。 还提供了使用光学仪器的分析方法。
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