公开(公告)号：US07285420B2

公开(公告)日：2007-10-23

申请号：US10993565

申请日：2004-11-18

Applicant: Norman H. Fontaine ,  Prantik Mazumder ,  Mark A. Quesada ,  Eric J. Mozdy ,  Po Ki Yuen

Inventor： Norman H. Fontaine ,  Prantik Mazumder ,  Mark A. Quesada ,  Eric J. Mozdy ,  Po Ki Yuen

IPC: G01N21/00 ,  G01N35/08 ,  B32B5/02 ,  G01F25/00 ,  G01N31/22 ,  G01N27/00

CPC classification number: G01N21/7743 ,  G01N21/05 ,  G01N21/276 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2201/108 ,  G01N2201/1211 ,  G01N2201/1217 ,  G01N2201/127 ,  G01N2201/12723 ,  G01N2201/128 ,  Y10T436/117497 ,  Y10T436/2575

Abstract: A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.

Abstract translation: 本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。

公开(公告)号：US06922247B2

公开(公告)日：2005-07-26

申请号：US10333990

申请日：2001-07-26

Applicant: Naoki Inamoto ,  Yoshimi Sawamura ,  Shinji Fujimura ,  Kunikazu Taguchi

Inventor： Naoki Inamoto ,  Yoshimi Sawamura ,  Shinji Fujimura ,  Kunikazu Taguchi

IPC: G01N21/55 ,  G01N21/27 ,  G01N21/35

CPC classification number: G01N21/55 ,  G01N21/276 ,  G01N21/4785 ,  G01N2021/4745 ,  G01N2201/128

Abstract: In an automatic optical measurement method according to the invention, with a movable reflection plate 6 moved to place under an optical axis, light projected from a light projecting portion 3a is received by a light receiving portion 3b via the movable reflection plate 6, a stationary reflection plate 11 and the movable reflection plate 6, whereas with the movable reflection plate 6 moved away from the optical axis and a reference 8 set on a sample stage 10, light projected from the light projecting portion 3a is received by the light receiving portion 3b via the reference 8 whereby a ratio between the intensities of the received lights is determined. During a sample measurement, light projected from the light projecting portion 3a with the movable reflection plate 6 moved to place under the optical axis is received by the light receiving portion 3b via the movable reflection plate 6, stationary reflection plate 11 and movable reflection plate 6 so that the intensity of light thus received and the above ratio are used for estimating an intensity of light to be measured with the reference, the estimated intensity of light being used for correcting an intensity of light received via a sample.

Abstract translation: 在根据本发明的自动光学测量方法中，通过可移动的反射板6移动到光轴的下方，从光投射部分3a突出的光经由可动反射板6被光接收部分3b接收， 固定反射板11和可动反射板6，而当可移动反射板6远离光轴移动并且设置在样品台10上的基准8时，由光投射部分3a投射的光被光接收 接收部分3b经由参考8，由此确定接收到的光的强度之间的比率。 在采样测量期间，由可移动反射板6移动到光轴下方的从投光部分3a射出的光由光接收部分3b通过可移动反射板6，固定反射板11和可移动反射镜 板6，使得如此接收的光的强度和上述比率用于估计用于参考的待测光的强度，估计的光强度用于校正经由样品接收的光的强度。

公开(公告)号：US5422703A

公开(公告)日：1995-06-06

申请号：US262619

申请日：1994-06-20

Applicant: Masahiro Horie ,  Nariaki Fujiwara ,  Masahiko Kokubo

Inventor： Masahiro Horie ,  Nariaki Fujiwara ,  Masahiko Kokubo

IPC: G01B9/04 ,  G01B11/00 ,  G01B11/02 ,  G01B11/06 ,  G02B21/00

CPC classification number: G01B11/02 ,  G01B11/0616 ,  G01B11/0625 ,  G01N21/55 ,  G01N2201/064 ,  G01N2201/128

Abstract: A method of measuring light reflected by a test sample with a microscopic photometric system. The test sample placed in an in-focus position of an objective is irradiated, and light reflected by the test sample is measured. Stray light generated by microscopic optics including the objective is measured with the test sample placed in an out-of-focus position of the objective. Light actually reflected by the test sample is determined from a difference between the reflected light and the stray light measured.

Abstract translation: 用微观光度测量系统测量由测试样品反射的光的方法。 照射放置在物体的聚焦位置的测试样品，并测量由测试样品反射的光。 用包含物镜的微观光学器件产生的杂散光通过放置在物镜的焦点外位置的测试样品进行测量。 由测试样本实际反射的光由反射光和测量的杂散光之间的差确定。

公开(公告)号：US5351563A

公开(公告)日：1994-10-04

申请号：US044605

申请日：1993-04-09

Applicant: Hellfried Karpf ,  M. Jean-Pierre Leiner ,  Anton Mostl ,  Klaus Reichenberger ,  Bernhard Schaffar ,  Werner E. Ziegler

Inventor： Hellfried Karpf ,  M. Jean-Pierre Leiner ,  Anton Mostl ,  Klaus Reichenberger ,  Bernhard Schaffar ,  Werner E. Ziegler

IPC: G01N21/11 ,  G01N1/00 ,  G01N21/05 ,  G01N21/64 ,  G01N21/77 ,  G01N27/07 ,  G01N27/28 ,  G01N27/416 ,  G01N33/00 ,  G01N33/49 ,  G01N1/10 ,  G01N1/22

CPC classification number: G01N35/1097 ,  G01N21/05 ,  G01N33/0006 ,  G01N33/0026 ,  G01N2021/0346 ,  G01N2201/128

Abstract: Method for analyzing gaseous or liquid samples, utilizing a one-way measuring element with a measuring channel containing at least one optical or electrochemical sensor and being provided with sealing elements on either end. In order to obtain accurate measurements in a simple manner the proposal is put forward that for measuring purposes a storage medium in the measuring channel be replaced by a separating medium which should then be replaced by the sample. Sample and storage medium will remain in the measuring element when it is discarded.

Abstract translation: 用于分析气体或液体样品的方法，利用具有包含至少一个光学或电化学传感器的测量通道的单向测量元件，并且在任一端上设置有密封元件。 为了以简单的方式获得准确的测量结果，提出了用于测量目的的测量通道中的存储介质被分离介质所替代，该分离介质应由样品代替。 当被丢弃时，样品和存储介质将保留在测量元件中。

公开(公告)号：US5255072A

公开(公告)日：1993-10-19

申请号：US820146

申请日：1992-01-13

Applicant: Hajime Mikasa ,  Ichiro Asano ,  Nobutaka Kihara ,  Shuichi Ishimoto ,  Isao Fujita ,  Norio Kada ,  Takeshi Aoki ,  Takao Imaki ,  Masahiko Fujiwara ,  Naohito Shimizu ,  Junji Kato

Inventor： Hajime Mikasa ,  Ichiro Asano ,  Nobutaka Kihara ,  Shuichi Ishimoto ,  Isao Fujita ,  Norio Kada ,  Takeshi Aoki ,  Takao Imaki ,  Masahiko Fujiwara ,  Naohito Shimizu ,  Junji Kato

IPC: G01J1/44 ,  G01N21/31 ,  G01N21/35 ,  G01N21/37 ,  G01N33/00 ,  G01N21/85

CPC classification number: G01N21/3504 ,  G01J2001/4242 ,  G01N2021/1723 ,  G01N2021/1725 ,  G01N2021/3129 ,  G01N2021/3536 ,  G01N21/37 ,  G01N2201/128 ,  Y10T436/117497

Abstract: A method and apparatus for analyzing fluid by a multi-fluid modulation mode is characterized by subjecting a plurality of sample fluids (which may be different or a single sample fluid divided into a plurality of systems) to a fluid modulation by reference fluids at various frequencies, respectively. An analytical portion provided with only one sensor is simultaneously and continuously supplied with the respective sample fluids. An output signal from the sensor in the analytical portion is divided into signal components of the respective modulation frequencies for the respective sample fluids to rectify and level, whereby obtaining analyzed values about the respective sample fluids is achieved.

Abstract translation: 用于通过多流体调制模式分析流体的方法和装置的特征在于，将多个样品流体（其可以是不同的或分离成多个系统的单个样品流体）以各种频率的参考流体进行流体调制 ， 分别。 仅提供一个传感器的分析部分同时且连续地供应相应的样品流体。 将来自分析部分中的传感器的输出信号分成各个样品流体的相应调制频率的信号分量以进行整流和平衡，由此获得关于各个样品流体的分析值。

公开(公告)号：US5146294A

公开(公告)日：1992-09-08

申请号：US678118

申请日：1991-04-01

Applicant: Roland Grisar ,  Wolfgang Riedel

Inventor： Roland Grisar ,  Wolfgang Riedel

IPC: G01N21/39 ,  G01N33/00

CPC classification number: G01N33/0026 ,  G01N21/39 ,  G01N2201/128

Abstract: A process and device for measuring the isotope ratio, specifically of stable isotopes, of chemical substances in a gas to be examined, the process including alternately charging a sample cell with a reference gas and a measuring gas containing the gas to be examined; adding a metrologically neutral gas to the gas to be examined; varying the mixing ratio of this measuring gas by changing the share of neutral gas being added; and calculation of the isotope ratio V.sub.p of the substance according to the equation: ##EQU1## The device includes a White cell having mirrors on each end of the longitudinal length of the cell, a pair of first beam openings located on a longitudinal end, a pair of second beam openings in spaced parallelism on the longitudinal sides of the White cell and a gas inlet and gas outlet located near each mirror.

Abstract translation: 一种用于测量待检气体中化学物质的同位素比率，特别是稳定同位素的方法和装置，所述方法包括：将参考气体和包含待检气体的测量气体交替地装入样品池; 向被检气体添加计量中性气体; 通过改变添加的中性气体的份数来改变该测量气体的混合比; 以及根据以下等式计算物质的同位素比值Vp：该装置包括在电池的纵向长度的每一端具有反射镜的白色电池，位于纵向端部的一对第一光束开口， 一对在白色电池的纵向侧面上间隔开的平行的第二光束开口和位于每个反射镜附近的气体入口和气体出口。

公开(公告)号：US5102806A

公开(公告)日：1992-04-07

申请号：US278046

申请日：1988-11-30

Applicant: Hajime Mikasa ,  Ichiro Asano ,  Nobutaka Kihara ,  Shuichi Ishimoto ,  Isao Fujita ,  Norio Kada ,  Takeshi Aoki ,  Takao Imaki ,  Masahiko Fujiwara ,  Naohito Shimizu ,  Junji Kato

Inventor： Hajime Mikasa ,  Ichiro Asano ,  Nobutaka Kihara ,  Shuichi Ishimoto ,  Isao Fujita ,  Norio Kada ,  Takeshi Aoki ,  Takao Imaki ,  Masahiko Fujiwara ,  Naohito Shimizu ,  Junji Kato

IPC: G01J1/44 ,  G01N21/31 ,  G01N21/35 ,  G01N21/37 ,  G01N33/00

CPC classification number: G01N33/0062 ,  G01N21/3504 ,  G01J2001/4242 ,  G01N2021/1723 ,  G01N2021/1725 ,  G01N2021/3129 ,  G01N2021/3536 ,  G01N21/37 ,  G01N2201/128 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/18 ,  Y10T436/204998 ,  Y10T436/214 ,  Y10T436/218

Abstract: A method for analyzing fluid by a multi-fluid modulation mode is characterized by subjecting a plurality of sample fluids (which may be different or a single sample fluid divided into a plurality of systems) to a fluid modulation by reference fluids at various frequencies, respectively. An analytical portion provided with only one sensor is simultaneously and continuously supplied with the respective sample fluids. An output signal from the sensor in the analytical portion is divided into signal components of the respective modulation frequencies for the respective sample fluids to rectify and level, whereby obtaining analyzed values about the respective sample fluids is achieved.

Abstract translation: 通过多流体调制模式分析流体的方法的特征在于，将分别被分成多个系统的多个样品流体（其可以是不同的或单个样品流体）分别以各种频率的参考流体进行流体调制 。 仅提供一个传感器的分析部分同时且连续地供应相应的样品流体。 将来自分析部分中的传感器的输出信号分成各个样品流体的相应调制频率的信号分量以进行整流和平衡，由此获得关于各个样品流体的分析值。

公开(公告)号：US4953390A

公开(公告)日：1990-09-04

申请号：US351215

申请日：1989-05-15

Applicant: Peter W. Krempl ,  Wolfgang Schindler ,  Erich J. Schiefer

Inventor： Peter W. Krempl ,  Wolfgang Schindler ,  Erich J. Schiefer

IPC: G01M15/10 ,  G01N21/3504 ,  G01N21/3554 ,  G01N21/3563

CPC classification number: G01M15/108 ,  G01N21/3504 ,  G01N21/3554 ,  G01N21/3563 ,  G01N2201/128

Abstract: A method and device for delay-free measurement of the air/fuel ratio of combustion systems, especially internal combustion engines, by measuring individual components of the fuel, the ambient air used for fuel combustion, and the exhaust gas, wherein the water vapor concentrations of the exhaust gas and, preferably, the ambient air or the gas supplied for fuel combustion are measured, and wherein the air/fuel ratio are computed by the obtained values and data on fuel composition.

Abstract translation: 一种用于通过测量燃料的单独部件，用于燃料燃烧的环境空气和废气来对燃烧系统，特别是内燃机的空气/燃料比进行无时间测量的方法和装置，其中水蒸汽浓度 并且优选地，测量用于燃料燃烧供给的环境空气或气体，并且其中通过获得的值和关于燃料组成的数据来计算空气/燃料比。

公开(公告)号：US4902896A

公开(公告)日：1990-02-20

申请号：US47650

申请日：1987-05-08

Applicant: Glenn H. Fertig, Sr. ,  Adrian C. Billetdeaux

Inventor： Glenn H. Fertig, Sr. ,  Adrian C. Billetdeaux

IPC: A61M16/10 ,  G01N21/01 ,  G01N21/35

CPC classification number: G01N21/3504 ,  A61M16/104 ,  G01N2021/0168 ,  G01N2201/1211 ,  G01N2201/128

Abstract: An infrared fluid analyzer for the detection of end tidal CO.sub.2. The analyzer is comprised of an IR source that irradiates a chamber filled with gas. CO.sub.2 present in the chamber absorbs the IR radiation at a certain wavelength. An IR detector determines the amount of IR radiation passing through the chamber unabsorbed and produces a signal corresponding to the CO.sub.2 in the chamber. At predetermined intervals a zero gas is reintroduced into the chamber for the system to be recalibrated. A span gas is only needed initially for calibration purposes.

Abstract translation: 用于检测尾气CO2的红外流体分析仪。 分析仪由辐射充满气体的室的IR源组成。 存在于腔室中的CO 2以一定波长吸收IR辐射。 IR检测器确定通过腔室的IR辐射量未被吸收并产生对应于腔室中的CO 2的信号。 以预定间隔，将零气体重新引入室中，以使系统被重新校准。 最初仅需要量程气体用于校准目的。

公开(公告)号：US4878755A

公开(公告)日：1989-11-07

申请号：US881708

申请日：1986-07-03

Applicant: Hans-Joachim Siegmund ,  Horst Schwiecker

Inventor： Hans-Joachim Siegmund ,  Horst Schwiecker

IPC: C23C14/54 ,  G01B11/06 ,  G01N21/59 ,  G01N21/84

CPC classification number: C23C14/54 ,  G01B11/0683 ,  G01N21/59 ,  G01N21/8422 ,  G01N2201/128

Abstract: Process for measuring the optical properties of thin layers while they are being built up in vacuum coating installations. For this purpose, at least one test object is passed through a stationary measuring light beam and the transmission behavior of the test object is evaluated by measurement. A reference point for the measurements is fixed in each case by reference measurements at intervals of time. In addition, at least one opaque measurement zone and at least one measuring zone, which does not attenuate the measuring light beam, are disposed in path of motion of the test object. The ratio of the measured value of the test object, decreased by the measured value of the opaque measuring zone, to the measured value of the nonattenuating measuring zone, decreased by the measured value of the opaque measuring zone, is formed by an arithmetic logic unit.

Abstract translation: 在真空涂层装置中建立薄层的光学性能的测量方法。 为此，至少一个测试对象通过静止的测量光束，并通过测量来评估测试对象的传输行为。 在每种情况下，通过参考测量在时间间隔固定测量的参考点。 此外，至少一个不透明测量区域和至少一个不衰减测量光束的测量区域被设置在测试对象的运动路径中。 通过算术逻辑单元形成测试对象的测量值与不透明测量区域的测量值相比减小到不透明测量区域的测量值的比例， 。