公开(公告)号：CN106918567A

公开(公告)日：2017-07-04

申请号：CN201710188941.6

申请日：2017-03-27

Applicant: 中南大学

Inventor： 阳春华 ,  龚娟 ,  吴书君 ,  朱红求 ,  李勇刚 ,  陈俊名

IPC: G01N21/31 ,  G06F17/18 ,  G06F17/16 ,  G06F17/10

CPC classification number: G01N21/31 ,  G01N2201/1217 ,  G06F17/10 ,  G06F17/16 ,  G06F17/18

Abstract: 本发明提供了一种测量痕量金属离子浓度的方法和装置，该方法包括：S1，根据包含痕量金属离子的溶液在全波段的吸光度，使用预测均方根误差获取所述全波段内的最优波长区间；S2，通过相关系数法获取所述最优波长区间内测量所述痕量金属离子浓度的有效波长点。通过采用间隔‑相关系数偏最小二乘法，快速高效地去除高浓度基体离子的敏感区域和空白信息区域，剔除非线性强、信息量少、被基体离子掩蔽的波长点，最大程度地保留痕量待测离子完整可用的信息，减小高浓度基体离子对痕量待测离子的干扰，同时保持待测离子的灵敏度，减少变量个数，提高模型的精度和实时性。

公开(公告)号：US20240361245A1

公开(公告)日：2024-10-31

申请号：US18571834

申请日：2022-02-21

Applicant: Sony Group Corporation

Inventor： Sakiko Yasukawa ,  Noriyuki Kishii ,  Kazuhiro Nakagawa

IPC: G01N21/64

CPC classification number: G01N21/6458 ,  G01N2201/1217 ,  G01N2201/1247

Abstract: Provided is an advantageous technique for determining a positive threshold value for use in analyzing a stained specimen fluorescence spectrum.
An information processing apparatus includes a threshold value determination unit configured to determine a positive threshold value that is to be compared with image data of a plurality of image sections included in a stained fluorescence component image, in which the positive threshold value is a criterion for determining whether or not each of the plurality of image sections corresponds to a positive cell image. The threshold value determination unit determines the positive threshold value on the basis of an unstained fluorescence component image.

公开(公告)号：US08021613B2

公开(公告)日：2011-09-20

申请号：US11900263

申请日：2007-09-11

Applicant: Norman H. Fontaine ,  Prantik Mazumder ,  Mark A. Quesada ,  Eric J. Mozdy ,  Po Ki Yuen

Inventor： Norman H. Fontaine ,  Prantik Mazumder ,  Mark A. Quesada ,  Eric J. Mozdy ,  Po Ki Yuen

IPC: G01N15/06 ,  G01N21/00 ,  G01N21/76

CPC classification number: G01N21/7743 ,  G01N21/05 ,  G01N21/276 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2201/108 ,  G01N2201/1211 ,  G01N2201/1217 ,  G01N2201/127 ,  G01N2201/12723 ,  G01N2201/128 ,  Y10T436/117497 ,  Y10T436/2575

Abstract: A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.

Abstract translation: 本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。

公开(公告)号：US5017008A

公开(公告)日：1991-05-21

申请号：US328030

申请日：1989-03-23

Applicant: Koichi Akiyama

Inventor： Koichi Akiyama

IPC: G01N15/14 ,  G01N15/02 ,  G01N21/01 ,  G01N21/03 ,  G01N21/05 ,  G01N21/41 ,  G01N21/51 ,  G01N21/53

CPC classification number: G01N21/05 ,  G01N15/0205 ,  G01N2021/0392 ,  G01N2021/4707 ,  G01N2021/513 ,  G01N21/4133 ,  G01N2201/1217

Abstract: Disclosed is an apparatus for measuring particles or particulates in a fluid in a measuring cell provided with a measuring window through which a laser beam is projected or through which light scattered from the particles passes. The surface of the measuring window is spherical with a radius of curvature whose center is at a point on which the laser beam converges for measurement. With this arrangement, light focused on the convergence point or light coming from the point always passes through the interface between the window and the fluid in the cell at an angle that is normal thereto. Thus no reflection of the light passing through the window occurs at the interface with the result that fluctuations of the refractive index of the fluid in the cell do not effect the focusing point of the light.

公开(公告)号：US07453573B2

公开(公告)日：2008-11-18

申请号：US11905029

申请日：2007-09-27

Applicant: Nobuhiko Ogura

Inventor： Nobuhiko Ogura

IPC: G01J1/00 ,  G01N21/01 ,  B01L3/00

CPC classification number: G01N21/553 ,  G01N2201/1217

Abstract: A measuring apparatus and a measuring method are configured to measure a concentration of an organic solvent in a sample solution, measure a concentration of the organic solvent in a concentration control solution, calculate a mixture amount by which the concentration control solution is mixed into the sample solution of a preset amount so that the concentration of the organic solvent in the sample solution is equal to a preset concentration based on the two concentrations, mix the concentration control solution of the calculated mixture amount with the sample solution of the preset amount, supply a mixture solution obtained by the mixing unit to a measurement region in which a bioactive substance is immobilized in advance, and measure an interaction between the bioactive substance and the sample substance in the mixture solution based on a result of measuring a refraction index of a light incident on the measurement region.

Abstract translation: 配置测定装置和测定方法，测定样品溶液中的有机溶剂的浓度，测定浓度对照溶液中的有机溶剂的浓度，算出将浓度对照溶液混合到样品中的混合量 溶液，使得样品溶液中的有机溶剂的浓度基于两种浓度等于预设浓度，将计算出的混合物量的浓度对照溶液与预先设定量的样品溶液混合，供给 通过混合单元获得的混合溶液预先固定有生物活性物质的测量区域，并且基于测量光入射的折射率的结果测量混合溶液中生物活性物质与样品物质之间的相互作用 在测量区域。

公开(公告)号：US20060106557A1

公开(公告)日：2006-05-18

申请号：US10993565

申请日：2004-11-18

Applicant: Norman Fontaine ,  Prantik Mazumder ,  Mark Quesada ,  Eric Mozdy ,  Po Yuen

Inventor： Norman Fontaine ,  Prantik Mazumder ,  Mark Quesada ,  Eric Mozdy ,  Po Yuen

IPC: G01R35/00

CPC classification number: G01N21/7743 ,  G01N21/05 ,  G01N21/276 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2201/108 ,  G01N2201/1211 ,  G01N2201/1217 ,  G01N2201/127 ,  G01N2201/12723 ,  G01N2201/128 ,  Y10T436/117497 ,  Y10T436/2575

Abstract: A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.

Abstract translation: 本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。

公开(公告)号：US20170067826A1

公开(公告)日：2017-03-09

申请号：US15123258

申请日：2015-02-18

Applicant: BioNavis Oy

Inventor： Janusz SADOWSKI ,  Niko GRANQVIST ,  Jussi TUPPURAINEN ,  Annika JOKINEN

IPC: G01N21/552 ,  G01N33/543 ,  G01N21/77

CPC classification number: G01N21/553 ,  G01N21/43 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2201/1217 ,  G01N2201/126

Abstract: A method for monitoring surface phenomena includes measuring a first surface plasmon resonance angle value (φSPR,REF) of a sample region (REG1), measuring a first critical angle value (φTIR,REF) of the sample region (REG1), causing a change of surface concentration (cM1,SRF) of an analyte (M1) at the sample region (REG1), changing the bulk composition at the sample region (REG1), measuring a second surface plasmon resonance angle value (φSPR(t)) of the sample region (REG1), measuring a second critical angle value (φTIR(t)) of the sample region (REG1), and determining an indicator value (φAUX(t)) indicative of the change of the surface concentration (cM1,SRF), wherein the indicator value (φAUX(t)) is determined from the second surface plasmon resonance angle value (φSPR(t)) by compensating an effect of the bulk composition, and wherein the magnitude (φCOMP) of said effect is determined by using the second critical angle value (φTIR(t)).

Abstract translation: 一种用于监测表面现象的方法包括： - 测量样品区域（REG1）的第一表面等离子体共振角值（φSPR，REF）， - 测量样品区域（REG1）的第一临界角度值（φTIR，REF） - 引起样品区域（REG1）处的分析物（M1）的表面浓度（cM1，SRF）的变化， - 改变样品区域（REG1）处的体积组分， - 测量第二表面等离子体共振角值（φSPR （t））， - 测量样本区域（REG1）的第二临界角度值（φTIR（t）），以及 - 确定指示变化的指标值（φAUX（t）） 通过补偿本体组合物的影响，从第二表面等离子体共振角度值（φSPR（t））确定指标值（φAUX（t））的表面浓度（cM1，SRF），其中大小（φCOMP ）通过使用第二临界角度值（φTIR（t））来确定。

公开(公告)号：US20110305598A1

公开(公告)日：2011-12-15

申请号：US13213744

申请日：2011-08-19

Applicant: Norman H. Fontaine ,  Prantik Mazumder ,  Mark A. Quesada ,  Eric J. Mozdy ,  Po Ki Yuen

Inventor： Norman H. Fontaine ,  Prantik Mazumder ,  Mark A. Quesada ,  Eric J. Mozdy ,  Po Ki Yuen

IPC: G01N33/48

CPC classification number: G01N21/7743 ,  G01N21/05 ,  G01N21/276 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2201/108 ,  G01N2201/1211 ,  G01N2201/1217 ,  G01N2201/127 ,  G01N2201/12723 ,  G01N2201/128 ,  Y10T436/117497 ,  Y10T436/2575

Abstract: A microfluidic device is described herein which comprises a micron-sized deep flow channel and a sensor. The micron-sized deep flow channel is configured such that a sample solution and a reference solution flow side-by-side to one another in a single sensing region of the sensor. The single sensing region is divided into a detection region and a reference region which are contiguous to one another and which are respectively interfaced with the sample solution and the reference solution that flow side-by-side to one another in a longitudinal direction within the micron-sized deep flow channel.

Abstract translation: 本文描述了一种微流体装置，其包括微米级的深流动通道和传感器。 微米尺寸深流通道被配置为使得样品溶液和参比溶液在传感器的单个感测区域中彼此并排流动。 单个感测区域被分成彼此邻接的检测区域和参考区域，它们分别与样品溶液和在微米内沿纵向彼此并排流动的参比溶液接合。 深流道。

公开(公告)号：EP1906170A3

公开(公告)日：2010-03-03

申请号：EP07018835.4

申请日：2007-09-25

Applicant: FUJIFILM Corporation

Inventor： Ogura, Nobuhiko, c/o Fujifilm Corporation

IPC: G01N21/55 ,  G01N33/543

CPC classification number: G01N21/553 ,  G01N2201/1217

Abstract: A measuring apparatus and a measuring method are configured to measure a concentration of an organic solvent in a sample solution, measure a concentration of the organic solvent in a concentration control solution, calculate a mixture amount by which the concentration control solution is mixed into the sample solution of a preset amount so that the concentration of the organic solvent in the sample solution is equal to a preset concentration based on the two concentrations, mix the concentration control solution of the calculated mixture amount with the sample solution of the preset amount, supply a mixture solution obtained by the mixing unit to a measurement region in which a bioactive substance is immobilized in advance, and measure an interaction between the bioactive substance and the sample substance in the mixture solution based on a result of measuring a refraction index of a light incident on the measurement region.

公开(公告)号：US20080079944A1

公开(公告)日：2008-04-03

申请号：US11905029

申请日：2007-09-27

Applicant: Nobuhiko Ogura

Inventor： Nobuhiko Ogura

IPC: G01J1/00 ,  G01N21/01

CPC classification number: G01N21/553 ,  G01N2201/1217

Abstract: A measuring apparatus and a measuring method are configured to measure a concentration of an organic solvent in a sample solution, measure a concentration of the organic solvent in a concentration control solution, calculate a mixture amount by which the concentration control solution is mixed into the sample solution of a preset amount so that the concentration of the organic solvent in the sample solution is equal to a preset concentration based on the two concentrations, mix the concentration control solution of the calculated mixture amount with the sample solution of the preset amount, supply a mixture solution obtained by the mixing unit to a measurement region in which a bioactive substance is immobilized in advance, and measure an interaction between the bioactive substance and the sample substance in the mixture solution based on a result of measuring a refraction index of a light incident on the measurement region.