公开(公告)号：US08680460B2

公开(公告)日：2014-03-25

申请号：US12346089

申请日：2008-12-30

Applicant: Peter T. Williams ,  Harvey Dean Loucks, Jr.

Inventor： Peter T. Williams ,  Harvey Dean Loucks, Jr.

IPC: H01J49/00

CPC classification number: G01N30/7246 ,  H01J49/0404 ,  H01J49/044 ,  H01J49/045

Abstract: A disruptor apparatus comprises a nozzle comprising: a converging section; a diverging section; and a throat between the converging section and the diverging section. The disruptor apparatus also comprises a holder configured to receive a fluid conduit, which comprises an outlet located in the converging section; and a channel disposed about the holder and configured to guide a gas past the outlet of the fluid conduit, through the converging section, through the throat and into the diverging section where the gas travels at supersonic speed and establishes a standing shock wave in the diverging section. A mass spectrometer and a method are also described.

Abstract translation: 一种破坏装置，包括：喷嘴，包括：会聚部; 分歧部分 以及在会聚部分和发散部分之间的喉部。 所述破坏装置还包括构造成接收流体导管的保持器，所述流体导管包括位于所述会聚部分中的出口; 以及设置在所述保持器周围并且被配置为引导气体通过所述会聚部分的气体经过所述喉部并且进入所述扩散部分，在所述扩散部分中所述气体以超音速行进，并且在所述发散中产生驻立冲击波 部分。 还描述了质谱仪和方法。

公开(公告)号：US20120318973A1

公开(公告)日：2012-12-20

申请号：US13164386

申请日：2011-06-20

Applicant: Harvey D. Loucks, JR. ,  Paul C. Goodley

Inventor： Harvey D. Loucks, JR. ,  Paul C. Goodley

IPC: H01J27/02 ,  H01J49/10

CPC classification number: H01J49/044 ,  H01J49/10

Abstract: An atmospheric pressure ionization apparatus includes a chamber, an ion inlet structure, an electrode, a sample emitter, and a gas passage. The ion inlet structure includes a sampling orifice. The electrode includes an electrode bore. An ionization region is defined between the ion inlet structure and the electrode. The flared structure is coaxially disposed about the ion inlet structure, and extends along an outward direction that includes a radial component relative to the sampling axis. The sample emitter is oriented at an angle to the sampling axis for directing a sample stream toward the ionization region. The gas passage directs a stream of gas from a gas source to the chamber. The flared structure and the wall cooperatively form an outward-directed portion of the gas passage that extends annularly about the sampling axis and along the outward direction. The gas flows through the outward-directed portion, around the flared structure, and toward the ionization region and the electrode bore.

Abstract translation: 大气压离子化装置包括室，离子入口结构，电极，样品发射体和气体通道。 离子入口结构包括采样孔。 电极包括电极孔。 在离子入口结构和电极之间限定电离区域。 扩口结构围绕离子入口结构同轴设置，并且沿着包括相对于采样轴线的径向分量的向外方向延伸。 样品发射器与采样轴成一角度定向，以将样品流引向电离区。 气体通道将气流从燃气源引导到腔室。 扩口结构和壁协同地形成气体通道的向外的部分，其环绕取样轴线并沿着向外方向延伸。 气体在扩张结构周围流过外向部分，并朝向电离区域和电极孔流动。

公开(公告)号：US20100163719A1

公开(公告)日：2010-07-01

申请号：US12346089

申请日：2008-12-30

Applicant: Harvey Dean Loucks, JR. ,  Peter T. Williams

Inventor： Harvey Dean Loucks, JR. ,  Peter T. Williams

IPC: H01J49/00 ,  G01N30/00

CPC classification number: G01N30/7246 ,  H01J49/0404 ,  H01J49/044 ,  H01J49/045

Abstract: A disrupter apparatus comprises a nozzle comprising: a converging section; a diverging section; and a throat between the converging section and the diverging section. The disrupter apparatus also comprises a holder configured to receive a fluid conduit, which comprises an outlet located in the converging section; and a channel disposed about the holder and configured to guide a gas past the outlet of the fluid conduit, through the converging section, through the throat and into the diverging section where the gas travels at supersonic speed and establishes a standing shock wave in the diverging section. A mass spectrometer and a method are also described.

Abstract translation: 一种破坏器装置，包括：喷嘴，包括：会聚部分; 分歧部分 以及在会聚部分和发散部分之间的喉部。 破碎器装置还包括保持器，其构造成接收流体导管，该流体导管包括位于会聚部分中的出口; 以及设置在所述保持器周围并且被配置为引导气体通过所述会聚部分的气体经过所述喉部并且进入所述扩散部分，在所述扩散部分中所述气体以超音速行进，并且在所述发散中产生驻立冲击波 部分。 还描述了质谱仪和方法。

公开(公告)号：US07462826B2

公开(公告)日：2008-12-09

申请号：US11447785

申请日：2006-06-06

Applicant: Bradley Schneider ,  Thomas R. Covey

Inventor： Bradley Schneider ,  Thomas R. Covey

IPC: H01J49/04

CPC classification number: H01J49/06 ,  H01J49/044

Abstract: An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

Abstract translation: 用于执行质谱的装置和方法使用离子界面来提供在离子流进入真空室之前从大气压离子源（例如电喷雾源或MALDI源）从离子流中除去不期望的微粒的功能， 质谱仪。 离子界面包括具有孔的入口单元，其可以在离子源是电喷雾源时被加热用于对带电液滴进行脱溶剂;以及颗粒鉴别单元，孔设置在入口单元的孔的下游，并且在通向孔 真空室。 颗粒鉴别池产生气体动态和电场条件，其使得能够从离子流中分离不期望的带电粒子。

公开(公告)号：US20080073555A1

公开(公告)日：2008-03-27

申请号：US11491439

申请日：2006-07-21

Applicant: Jean-Jacques Dunyach ,  Nigel P. Gore ,  Paul R. Atherton

Inventor： Jean-Jacques Dunyach ,  Nigel P. Gore ,  Paul R. Atherton

IPC: H01J27/00

CPC classification number: H01J49/167 ,  H01J49/044

Abstract: An on-axis ion source has an ionization chamber and an adjacent low-pressure region. The on-axis ion source also includes a capillary tube having an axial bore for supporting fluid communication between the ionization chamber and the adjacent low-pressure region, the axial bore of the capillary tube being substantially concentrically aligned with the orifice of a skimmer located downstream in the ion path from the capillary tube. A blocking element is provided in an aligned facing arrangement with the axial bore of the capillary tube and on an opposite side of the orifice relative to the capillary tube. The blocking element receives droplets or particles flowing through the axial bore of the capillary tube and passing through the orifice of the skimmer. The combination of an on-axis arrangement and the use of a blocking element results in improved signal-to-noise level due to enhanced ion transmission and reduction of noise arising from passage of undesolvated droplets and particles to the mass analyzer.

公开(公告)号：US07265362B2

公开(公告)日：2007-09-04

申请号：US11051608

申请日：2005-02-04

Applicant: Stevan Bajic ,  Robert Harold Bateman

Inventor： Stevan Bajic ,  Robert Harold Bateman

IPC: H01J27/00

CPC classification number: H01J49/168 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0468 ,  H01J49/165

Abstract: An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising two co-axial capillary tubes 2,3. A blue-flame gas torch 6 is provided downstream of the probe 1 as a combustion source. An analyte solution is sprayed from an inner capillary tube 2 of the probe 1 and a combustible gas is supplied to an outer capillary tube 3 of the probe 1. The combustible gas supplies heat to aid desolvation of the droplets emerging from the probe 1 via combustion with the surrounding oxygen-containing atmosphere when combusted by the blue flame torch 6.

Abstract translation: 公开了一种电喷雾离子源和大气压化学电离离子源，其包括包含两个同轴毛细管2,3的探针1。 蓝色火焰焰炬6设置在探头1的下游，作为燃烧源。 从探针1的内部毛细管2喷射分析物溶液，将可燃气体供给到探针1的外部毛细管3。 当由蓝色火焰焰炬6燃烧时，可燃气体通过与周围的含氧气氛的燃烧而提供热量以帮助从探针1出来的液滴的去溶剂化。

公开(公告)号：US07091477B2

公开(公告)日：2006-08-15

申请号：US10864106

申请日：2004-06-09

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

公开(公告)号：US20060131497A1

公开(公告)日：2006-06-22

申请号：US11015235

申请日：2004-12-17

Applicant: Zicheng Yang ,  Roger Tong

Inventor： Zicheng Yang ,  Roger Tong

IPC: H01J49/04

CPC classification number: H01J49/0477 ,  H01J49/044

Abstract: An apparatus for use in atmospheric pressure ionization includes a sample receiving chamber, a sample droplet source communicating with the sample receiving chamber, an outlet conduit, and a boundary. The outlet conduit defines a sampling orifice that communicates with the sample receiving chamber. The boundary is interposed between the sample receiving chamber and the sampling orifice and comprises an opening. The opening defines a first passage through which a drying gas is flowable into the sample receiving chamber in an elongated flow profile, and a second passage through which sample material is flowable from the sample receiving chamber toward the sampling orifice. The first passage is positioned in non-coaxial relation to the second passage. The first passage is configured to introduce the elongated flow profile of the drying gas into a pathway of droplets of the sample material flowing toward the second passage.

Abstract translation: 用于大气压离子化的装置包括样品接收室，与样品接收室连通的样品液滴源，出口导管和边界。 出口导管限定了与样品接收室连通的采样孔。 边界置于样品接收室和采样孔之间，并包括一个开口。 开口限定第一通道，干燥气体可以通过该第一通道以细长的流动分布流入样品接收室，以及第二通道，样品材料可以通过该第二通道从样品接收室朝向采样孔流动。 第一通道定位成与第二通道非同轴的关系。 第一通道构造成将干燥气体的细长流动剖面引入流向第二通道的样品材料液滴的通路。

公开(公告)号：US20050035287A1

公开(公告)日：2005-02-17

申请号：US10864106

申请日：2004-06-09

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/04 ,  H01J49/26 ,  H01J49/42

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

Abstract translation: 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。

公开(公告)号：US06815667B2

公开(公告)日：2004-11-09

申请号：US10362510

申请日：2003-02-25

Applicant: Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

Inventor： Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

IPC: H01J4900

CPC classification number: H01J49/061 ,  H01J49/044

Abstract: A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An inn-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles, whereby only ions pass on to the reaction/collision cell section. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

Abstract translation: 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供了一个inn-neutral去耦装置，以提供离子和中性粒子之间的实质性分离，从而只有离子传递到反应/碰撞电池部分。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。