公开(公告)号：WO2011149972A3

公开(公告)日：2012-01-19

申请号：PCT/US2011037785

申请日：2011-05-24

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  YOO HONGKI ,  SHISHKOV MILEN ,  GARDECKI JOSEPH ,  SHUBOCHKIN ROMAN ,  MORSE THEODORE ,  JAFFER AMIN FAROUC

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  YOO HONGKI ,  SHISHKOV MILEN ,  GARDECKI JOSEPH ,  SHUBOCHKIN ROMAN ,  MORSE THEODORE ,  JAFFER AMIN FAROUC

IPC: A61B5/00 ,  G01B9/02 ,  G01N21/64

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Abstract translation: 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光学芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：WO2011109835A3

公开(公告)日：2011-12-29

申请号：PCT/US2011027450

申请日：2011-03-07

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

IPC: A61B5/05 ,  A61B1/00 ,  G01B9/02

CPC classification number: A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

Abstract: Exemplary embodiments of probes, apparatus, systems and methods can be provided which provide at least one electro-magnetic radiation to at least one sample. For example, a plurality of axicon lenses can be provided which are configured to provide the electro-magnetic radiation(s) having at least partially annulus shape. In addition or alternatively, at least one optical arrangement can be provided which is configured to forward at least one radiation to the sample therethrough having at least partially circularly-symmetric pattern. For example, at least one first portion of the radiation transmitted through a circular section of the pattern can have an optical path-length that is different from an optical path- length of at least one second portion of the radiation transmitted through at least one other section of the pattern.

Abstract translation: 可以提供探针，装置，系统和方法的示例性实施例，其向至少一个样品提供至少一个电磁辐射。 例如，可以提供多个旋转透镜，其构造成提供具有至少部分环形形状的电磁辐射。 另外或替代地，可以提供至少一个光学布置，其被配置为将至少一个辐射转发到具有至少部分圆对称图案的样品。 例如，透射通过图案的圆形部分的辐射的至少一个第一部分可以具有不同于透射通过至少一个其它的辐射的至少一个第二部分的光路长度的光路长度 部分图案。

公开(公告)号：WO2011044301A3

公开(公告)日：2011-06-30

申请号：PCT/US2010051715

申请日：2010-10-06

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  YOO HONGKI

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  YOO HONGKI

IPC: A61B5/055 ,  A61B5/00

CPC classification number: A61B5/411 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/037 ,  A61B5/4233 ,  A61B5/68 ,  A61B5/6852 ,  A61B5/6853 ,  G02B21/0064 ,  G02B21/0076

Abstract: An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation.

Abstract translation: 可以提供根据本公开的设备和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一电磁辐射引导到身体内的组织的至少一部分。 使用至少一个第二布置，可以接收从基于第一电磁辐射的部分提供的至少一个第二电磁辐射。 此外，使用至少一种第三种布置，可以将基于第二电磁辐射的至少一种特定细胞（嗜酸性粒细胞，肥大细胞，嗜碱性粒细胞，单核细胞和/或嗜酸性粒细胞）与其他细胞区分开。

公开(公告)号：WO2010068764A2

公开(公告)日：2010-06-17

申请号：PCT/US2009/067512

申请日：2009-12-10

Applicant: THE GENERAL HOSPITAL CORPORATION ,  VAKOC, Benjamin, J. ,  OH, Wang, Y. ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

Inventor： VAKOC, Benjamin, J. ,  OH, Wang, Y. ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

IPC: G01N21/17 ,  G01N21/47 ,  G01B9/02 ,  G01N33/483

CPC classification number: A61B5/6852 ,  A61B5/0066

Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

Abstract translation: 可以提供可以生成与至少一个样本相关联的数据的系统和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一辐射转发到样品，以便使得至少一个第二辐射从可以基于该样品的样品提供 第一次辐射。 另外，使用至少一个第二布置，可以从样品接收第二辐射，基于第二辐射产生关于样品的至少一部分的多个不同的测量结果， 并且通过与不同测量相关联的多个连续可分辨深度点来表征部分。 此外，可以在多个不同的测量值的多个深度点上分辨和明确地表征至少一个部分的表征。

公开(公告)号：WO2009036453A1

公开(公告)日：2009-03-19

申请号：PCT/US2008/076447

申请日：2008-09-15

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  MOTZ, Jason, T. ,  GARDECKI, Joseph, A. ,  CHAU, Alexandra, H.

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  MOTZ, Jason, T. ,  GARDECKI, Joseph, A. ,  CHAU, Alexandra, H.

IPC: A61B5/00 ,  A61B6/00 ,  G06F17/00

CPC classification number: A61B5/0075 ,  A61B5/0084 ,  A61B5/02007

Abstract: Exemplary apparatus and method can be provided for controlling at least one electro-magnetic radiation. For example, it is possible to rotate and/or translate at least one optical waveguide. At least one of the optical waveguide(s) can receive a first radiation at a first wavelength and transmit the first radiation to at least one sample. Such optical waveguide and/or another optical waveguide may receive a second radiation at a second wavelength that is different from the first wavelength. For example, the second radiation may be produced based on an inelastic scattering of the first radiation. In addition, exemplary apparatus and method can be provided which can also be used to receive data associated with the second radiation, determine at least one characteristic of the at least one sample based on the data, and generate the image and/or the map of a portion of the arterial sample based on the at least one characteristic. Further, exemplary computer-accessible medium can be provided which includes a software arrangement thereon. When a processing arrangement executes the software arrangement, the processing arrangement is configured to modify at least one characteristic of an arrangement using certain procedures. These exemplary procedures include simulating at least one electro-magnetic radiation provided into and out of the arrangement, simulating an inelastic scattering radiation from at least one simulated sample, receiving the simulated inelastic scattering radiation into and out of the simulated arrangement, and determining a simulated characteristic of the simulated arrangement as a function of the simulated inelastic scattering radiation.

Abstract translation: 可以提供示例性的装置和方法来控制至少一个电磁辐射。 例如，可以旋转和/或平移至少一个光波导。 至少一个光波导可以接收第一波长的第一辐射并将第一辐射传输到至少一个样本。 这种光波导和/或另一光波导可以接收与第一波长不同的第二波长的第二辐射。 例如，可以基于第一辐射的非弹性散射来产生第二辐射。 此外，可以提供示例性的装置和方法，其还可以用于接收与第二辐射相关联的数据，基于数据确定至少一个样本的至少一个特征，并且生成图像和/或 基于至少一个特征的动脉样本的一部分。 此外，可以提供示例性的计算机可访问介质，其中包括其上的软件布置。 当处理装置执行软件装置时，处理装置被配置为使用某些程序来修改装置的至少一个特性。 这些示例性程序包括模拟提供入和排出的至少一个电磁辐射，模拟来自至少一个模拟样本的非弹性散射辐射，将模拟的非弹性散射辐射接收到模拟装置中和从模拟装置中取出，以及确定模拟 作为模拟非弹性散射辐射的函数的模拟布置的特征。

公开(公告)号：WO2008016927A2

公开(公告)日：2008-02-07

申请号：PCT/US2007074873

申请日：2007-07-31

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  MOTZ JASON T

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  MOTZ JASON T

IPC: G01N21/65

CPC classification number: G01J3/44 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/02 ,  G01J3/0218 ,  G01N21/65

Abstract: According to an exemplary embodiment, a system can be provided which can have at least one fiber arrangement and at least one receiving arrangement. The fiber arrangement may have optical transmitting characteristics, and may be configured to transmit there through at least one electromagnetic radiation and forward the at least one electromagnetic radiation to at least one sample. At least one portion of the fiber arrangement may be composed of or can include therein sapphire, diamond, clear graphite, Chalcogenide, borosilicate, zirconium fluoride, silver halide, a liquid core light guide, a gas core light guide, a hollow core waveguide, and/or a solid core photonic crystal fiber. The receiving arrangement may be configured to receive the electromagnetic radiation that is filtered and received from the sample. According to another exemplary embodiment, a method can be provided for obtaining information associated with the sample. For example, at least one first electromagnetic radiation can be forwarded to the sample via at least one optical fiber. At least one first characteristic of at least one portion of the optical fiber can be controlled so as to modify at least one second characteristic of at least one second electromagnetic radiation generated within the optical fiber. The second electromagnetic radiation can be associated with the first electromagnetic radiation.

Abstract translation: 根据示例性实施例，可以提供一种可以具有至少一个光纤布置和至少一个接收装置的系统。 光纤布置可以具有光学传输特性，并且可以被配置成通过至少一个电磁辐射传送到那里，并将至少一个电磁辐射转发到至少一个样本。 纤维布置的至少一部分可以由蓝宝石，金刚石，透明石墨，硫族化物，硼硅酸盐，氟化锆，卤化银，液芯导光体，气芯光导，中空芯波导， 和/或固体核心光子晶体光纤。 接收装置可以被配置为接收从样品过滤和接收的电磁辐射。 根据另一示例性实施例，可以提供用于获得与样本相关联的信息的方法。 例如，可以经由至少一根光纤将至少一个第一电磁辐射送到样品。 可以控制光纤的至少一部分的至少一个第一特征，以便修改在光纤内产生的至少一个第二电磁辐射的至少一个第二特性。 第二电磁辐射可以与第一电磁辐射相关联。

公开(公告)号：WO2007143236A3

公开(公告)日：2007-12-13

申请号：PCT/US2007/061463

申请日：2007-02-01

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  SHISHKOV, Millen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

Inventor： TEARNEY, Guillermo, J. ,  SHISHKOV, Millen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

IPC: A61B18/20

Abstract: In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro- magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.

公开(公告)号：WO2007101026A3

公开(公告)日：2007-10-25

申请号：PCT/US2007062465

申请日：2007-02-21

Applicant: GEN HOSPITAL CORP ,  DESJARDINS ADRIEN E ,  VAKOC BENJAMIN J ,  TEANEY GUILLERMO J ,  BOUMA BRETT E

Inventor： DESJARDINS ADRIEN E ,  VAKOC BENJAMIN J ,  TEANEY GUILLERMO J ,  BOUMA BRETT E

IPC: G01B9/02 ,  A61B5/00 ,  G01N21/47

CPC classification number: G01N21/4795 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02043 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70 ,  G01N2021/4714

Abstract: Angle-resolved Fourier-domain optical coherence tomography for measuring spatially-resolved angular backscattering distributions from transparent and turbid samples is presented. Speckle reduction and generating image contrast are shown. A wave length- swept laser source and line- scan camera are used. The input beam on the sample to be measured is collimated, with the reference beam being spatially expanded. The backscattered light from the sample interferes with the spatially expanded reference beam.

Abstract translation: 提出了用于测量透明和浊度样本的空间分辨角度后向散射分布的角度分辨傅立叶域光学相干断层扫描。 显示斑点减少和生成图像对比度。 使用波长扫描的激光源和扫描线相机。 要测量的样品上的输入光束被准直，参考光束在空间上展开。 来自样品的反向散射光干涉空间扩展的参考光束。

公开(公告)号：WO2007084933A3

公开(公告)日：2007-10-25

申请号：PCT/US2007060657

申请日：2007-01-18

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E

IPC: G01N21/35

CPC classification number: G01N21/3563 ,  G01J3/02 ,  G01J3/021 ,  G01J3/42 ,  G01N21/031 ,  G01N21/45 ,  G01N21/4795 ,  G01N2021/1787

Abstract: Exemplary systems and processes for generating information associated with at least one portion of a sample are provided. In one exemplary embodiment, at least one electro-magnetic radiation can be received from the at least one portion, whereas the electro-magnetic radiation has a wavenumber that is between approximately 5,000 cm -1 and 600 cm -1 . The information can be generated which includes structural data, molecular data and/or chemical data of the portion. The information can be generated based on (a) at least one phase of the at least one electro-magnetic radiation, and/or (b) at least one refractive index of the at least one portion. According to another exemplary embodiment, the electro-magnetic radiation having a first wavenumber can be transmitted to the portion which has at least two substances, whereas a refractive index of one of the substances at a second wavenumber is approximately the same as a refractive index of another one of the substances at the second wavenumber. The electro-magnetic radiation can be controlled such that the first wavenumber substantially matches the first wavenumber to reduce scattering within the portion.

Abstract translation: 提供了用于产生与样本的至少一部分相关联的信息的示例性系统和过程。 在一个示例性实施例中，可以从至少一个部分接收至少一个电磁辐射，而电磁辐射具有在约5000cm -1至600cm -1之间的波数， SUP> -1 。 可以生成包括该部分的结构数据，分子数据和/或化学数据的信息。 可以基于（a）至少一个电磁辐射的至少一个相位和/或（b）至少一个部分的至少一个折射率来生成信息。 根据另一示例性实施例，具有第一波数的电磁辐射可以传输到具有至少两种物质的部分，而第二波数处的物质之一的折射率大致与折射率相同 第二个波数的另一个物质。 可以控制电磁辐射使得第一波数基本上与第一波数匹配以减少该部分内的散射。

公开(公告)号：WO2007118129A1

公开(公告)日：2007-10-18

申请号：PCT/US2007/066017

申请日：2007-04-05

Applicant: THE GENERAL HOSPITAL CORPORATION ,  YUN, Seok-hyun ,  DE BOER, Johannes, F. ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

Inventor： YUN, Seok-hyun ,  DE BOER, Johannes, F. ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

IPC: A61B5/00 ,  G01B9/02 ,  G01N21/47

CPC classification number: G01N21/4795 ,  G01B9/02002 ,  G01B9/02004 ,  G01B9/02011 ,  G01B9/02091 ,  G01B2290/70

Abstract: Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro¬ magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.

Abstract translation: 提供了用于获取与样本相关的数据的安排和方法。 例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。 这种辐射的频率可以在第一特征周期内随时间重复地变化。 此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的极化状态可以重复地 随着时间而变化，其具有比第一周期短的第二特征周期。 用于成像至少一部分样品的数据可以作为偏振态的函数提供。 另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。