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    HIGH RESOLUTION IMAGING APPARATUS AND METHOD
    71.
    发明申请
    HIGH RESOLUTION IMAGING APPARATUS AND METHOD 有权

    公开(公告)号：US20210118661A1

    公开(公告)日：2021-04-22

    申请号：US17253538

    申请日：2019-06-18

    Applicant: Paul Corkum ,  Fluidigm Canada Inc.

    Inventor： Paul Corkum ,  Alexander V. Loboda

    IPC: H01J49/04 ,  H01J49/00 ,  H01J49/10 ,  H01J49/06 ,  H01J49/40 ,  H01J49/02 ,  G02B21/33 ,  H01J37/28 ,  H01J37/20 ,  G01N33/68

    Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMCTM) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.

    CELL ANALYSIS BY MASS CYTOMETRY
    74.
    发明申请
    CELL ANALYSIS BY MASS CYTOMETRY 审中-公开

    公开(公告)号：US20190353576A1

    公开(公告)日：2019-11-21

    申请号：US16432355

    申请日：2019-06-05

    Applicant: Fluidigm Canada Inc.

    Inventor： Vladimir Baranov

    IPC: G01N15/10 ,  G01N33/483 ,  G01N33/569 ,  G01N1/04

    Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.

    STABILIZED CELL ACQUISITION FOR ELEMENTAL ANALYSIS
    75.
    发明申请
    STABILIZED CELL ACQUISITION FOR ELEMENTAL ANALYSIS 审中-公开

    公开(公告)号：US20190317082A1

    公开(公告)日：2019-10-17

    申请号：US16383241

    申请日：2019-04-12

    Applicant: Fluidigm Canada Inc.

    Inventor： Vladimir Baranov ,  Alexander Loboda ,  Michael Sullivan

    IPC: G01N33/53 ,  G01N33/58 ,  H01J49/10

    Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.

    Laser Ablation System
    76.
    发明申请
    Laser Ablation System 审中-公开

    公开(公告)号：US20190180996A1

    公开(公告)日：2019-06-13

    申请号：US16322418

    申请日：2017-08-02

    Applicant: Fluidigm Canada Inc.

    Inventor： Alexander V. LOBODA

    IPC: H01J49/04 ,  H01J49/10 ,  H01J49/00

    Abstract: The invention relates to methods and devices for analysis of samples using laser ablation imaging mass cytometry and mass spectrometry. The invention provides methods and devices in which individual ablation plumes are distinctively captured and rapidly transferred to the ionization system, followed by analysis by mass spectrometry. A transfer conduit can be used to convey ablation plumes to an ionization system. The transfer conduit can include an asymmetric cone. The transfer conduit can be tapered. A flow sacrificing system can be adapted to divert a part of the sheath flow out a sacrificial outlet while the core of the sheath flow containing ablation plumes enters the ionization system.

    CELL ANALYSIS BY MASS CYTOMETRY
    77.
    发明申请
    CELL ANALYSIS BY MASS CYTOMETRY 审中-公开

    公开(公告)号：US20190094121A1

    公开(公告)日：2019-03-28

    申请号：US16137057

    申请日：2018-09-20

    Applicant: Fluidigm Canada Inc.

    Inventor： Vladimir Baranov

    IPC: G01N15/10 ,  G01N33/569 ,  G01N1/04 ,  G01N33/483 ,  C12M1/34

    Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.

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