Abstract:
The present invention relates to nucleic acids comprising a nucleotide sequence encoding at least a portion of an enzyme which catalyzes the synthesis of chitin in arthropods, inhibitors directed to said enzyme, and a method for developing said inhibitors.
Abstract:
This invention refers to an imaging method and apparatus capable of performing non-destructive, in situ analysis of art-objects. The invention relays on the comparison of diffuse reflectance and/or fluorescence spectra (intensity vs. wavelength), of painting material models of known composition, with the intensities emitted and captured at the same wavelengths and for any spatial point of the art-object of unknown composition. This composition, performed for any spatial point of the area of interest, improves notably the diagnostic information and enables the analysis of heterogeneous art-objects.
Abstract:
An assembly of optical elements for the control of light, comprising in order from a first side of the assembly: a light modulator (1) configured to actively modulate a wavefront of light passing though the assembly, the light modulator (1) comprising an electronic interface (2); a first polarization element (3) configured to define a polarization of the light received from the light modulator (1); an optical element (4) that has a region across which a value of a refractive index of the optical element (4) varies for passively modulating the wavefront of the light received from the first polarization modulator (3); a second polarization element (5) configured to define the polarization of the light received from the optical element (4). Also, there are claimed a method for controlling light, uses of the assembly, and a microscope comprising the assembly.
Abstract:
A processor-implemented method for regulating the flow rate of data packets in a network, including defining a global constant representing a regularly repeating time period common among flow sources in the network; transmitting current flow rate information from each of the flow sources, and for each flow, to the links traversed by each flow, exactly once during a current period; categorizing each of the flows passing through the links on the network into a category for the current period for each link by comparing the current flow rate information to a previously determined fair-share flow rate for the link; counting, in each link, the flows per category for the current period; determining a current fair-share flow rate for the current period in each link using the results of the categorizing and counting; and providing control instructions to each of the flow sources to regulate the rate of each flow.
Abstract:
The present invention concerns a non-human transgenic animal comprising a modification in its genome which results in the animal exhibiting a level of Erf expression and/or ERF activity which is reduced compared to a wildtype animal, wherein said animal has a defect in ossification. Further provided is a non-human transgenic animal comprising an insertion of a promoter-marker gene cassette in one or both Erf alleles wherein the cassette is present in an intron of Erf and wherein said animal exhibits an expression level of Erf and/or ERF activity which is reduced compared to a wildtype animal. Uses of these animals and of a non-human transgenic animal comprising a modification in its genome which results in the animal exhibiting a level of expression of Erf and/or ERF activity which is reduced compared to a wildtype animal for producing animals with ossification defects, for identifying treatments and as disease models are encompassed.
Abstract:
Disclosed is a method of investigating the conformation of biomolecules or changes in the conformation of biomolecules as a result of an interaction, in which biomolecules from a sample of biomolecules are adhered discretely to the sensing surface of an acoustic wave sensor operating in a liquid, and a conformation parameter which is related to the conformation of the biomolecules from the said sample which are adhered discretely to the sensing surface, but substantially independent of the resulting change in mass loading of the sensing surface, is calculated from the resulting change in the output signals of the acoustic wave sensor. The conformation parameter may the acoustic ratio or a parameter which is directly related to the acoustic ratio. There is also disclosed a method of investigating changes in the conformation of biomolecules which are adhered discretely to the sensing surface of an acoustic wave sensor operating in a liquid, in response to an interaction with an agent, by calculating a conformation parameter which is related to the change in conformation of biomolecules adhered discretely to the sensing surface as a result of an interaction with the agent, but which is substantially independent of any resulting change in mass loading of the sensing surface.
Abstract:
The present invention relates to nucleic acids comprising a nucleotide sequence encoding at least a portion of an enzyme which catalyzes the synthesis of chitin in arthropods, a screening to assay and identify new, and method for developing chitin synthesis inhibitors.