公开(公告)号：WO1996021037A1

公开(公告)日：1996-07-11

申请号：PCT/US1996000182

申请日：1996-01-03

Applicant: MARTEK BIOSCIENCES CORPORATION ,  KYLE, David, J.

Inventor： MARTEK BIOSCIENCES CORPORATION

IPC: C12P07/40

CPC classification number: C12P7/6472 ,  A23C11/04 ,  A23D9/00 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K8/361 ,  A61K8/922 ,  A61K31/202 ,  A61K31/232 ,  A61Q19/00 ,  A61Q19/08 ,  C11B1/10 ,  A23V2250/1862 ,  A23V2250/187

Abstract: The present invention relates to processes for the production of arachidonic acid containing oils, which preferably are substantially free of eicosapentaneoic acid. The invention also relates to compositions containing oils having very high amounts of arachidonic acid in triglyceride form, and to uses of such oils. In a preferred embodiment, Mortierella alpina is cultivated using conditions which yield triglyceride oil having particularly high levels of arachidonic acid residues, biomass is harvested and the oil is extracted, recovered, and used as an additive for infant formula.

Abstract translation: 本发明涉及生产含花生四烯酸的油的方法，其优选基本上不含二十碳五烯酸。 本发明还涉及含有具有非常高量的甘油三酯形式的花生四烯酸的油以及这些油的用途的组合物。 在优选的实施方案中，使用产生具有特别高的花生四烯酸残留量的甘油三酯油的条件培养高山被孢霉，收获生物质并提取，回收油并用作婴儿配方的添加剂。

公开(公告)号：WO2012112902A1

公开(公告)日：2012-08-23

申请号：PCT/US2012/025666

申请日：2012-02-17

Applicant: MARTEK BIOSCIENCES CORPORATION ,  TANG, Xuejun

Inventor： TANG, Xuejun

IPC: A01N37/00 ,  C12P7/64 ,  A61K31/20

CPC classification number: A61K31/202 ,  C11C1/007 ,  C11C1/025 ,  C11C3/003

Abstract: Provided herein are methods of making compositions of free fatty acids and alkyl esters of polyunsaturated fatty acids (PUFAs). Also provided are compositions comprising a PUFA selected from a free fatty acid or a ester wherein the PUFA is made according to a method of the invention.

Abstract translation: 本文提供了制备游离脂肪酸组合物和多不饱和脂肪酸（PUFA）的烷基酯的方法。 还提供了包含选自游离脂肪酸或酯的PUFA的组合物，其中根据本发明的方法制备PUFA。

公开(公告)号：WO2011153246A2

公开(公告)日：2011-12-08

申请号：PCT/US2011/038768

申请日：2011-06-01

Applicant: MARTEK BIOSCIENCES CORPORATION ,  CHERINKO, Stephen, Robert ,  KERTIS, Robert, Cody ,  APT, Kirk, E. ,  BEHRENS, Paul, Warren ,  HANSEN, Jon, Milton ,  PFEIFER, Joseph, W., III ,  STAHL, Tracey, Lynn ,  ZIRKLE, Ross ,  BURKE, Nasrin Tabayeh ,  RAMAN, Krishna ,  LEININGER, Neil Francis

Inventor： CHERINKO, Stephen, Robert ,  KERTIS, Robert, Cody ,  APT, Kirk, E. ,  BEHRENS, Paul, Warren ,  HANSEN, Jon, Milton ,  PFEIFER, Joseph, W., III ,  STAHL, Tracey, Lynn ,  ZIRKLE, Ross ,  BURKE, Nasrin Tabayeh ,  RAMAN, Krishna ,  LEININGER, Neil Francis

CPC classification number: C11B1/10 ,  C11B3/02 ,  C11B3/16 ,  Y02E50/16

Abstract: The present: invention relates to processes for obtaining a lipid from a cell by lysing the cell, contacting the cell with a base and/or salt, and separating the lipid. The present invention is also directed to a lipid prepared by the processes of the present invention. The present invention is also directed to microbial lipids having a particular anisidine value, peroxide value, and/or phosphorus content.

Abstract translation: 本发明涉及通过裂解细胞，使细胞与碱和/或盐接触并分离脂质从细胞获得脂质的方法。 本发明还涉及通过本发明的方法制备的脂质。 本发明还涉及具有特定茴香胺值，过氧化值和/或磷含量的微生物脂质。

公开(公告)号：WO2011112948A1

公开(公告)日：2011-09-15

申请号：PCT/US2011/028122

申请日：2011-03-11

Applicant: MARTEK BIOSCIENCES CORPORATION ,  APT, Kirk, E. ,  BARCLAY, William, R. ,  BEHRENS, Paul, Warren

Inventor： APT, Kirk, E. ,  BARCLAY, William, R. ,  BEHRENS, Paul, Warren

IPC: C12N1/16 ,  C12N1/02 ,  C12P7/64

CPC classification number: C12N1/16 ,  C12P7/6409 ,  C12P7/6427 ,  C12R1/645

Abstract: The invention is directed to isolated microorganisms, as well as biomasses, cultures, microbial oils, and compositions thereof. The invention also provides methods of producing the microbial oils and methods of using the isolated microorganisms, biomasses, and microbial oils.

Abstract translation: 本发明涉及分离的微生物以及生物量，培养物，微生物油及其组合物。 本发明还提供了生产微生物油的方法和使用分离的微生物，生物质和微生物油的方法。

公开(公告)号：WO2011103512A1

公开(公告)日：2011-08-25

申请号：PCT/US2011/025554

申请日：2011-02-18

Applicant: MARTEK BIOSCIENCES CORPORATION ,  LEE, Jung ,  MIKRUT, Bernard, A. ,  TANG, Xuejun

Inventor： LEE, Jung ,  MIKRUT, Bernard, A. ,  TANG, Xuejun

IPC: A61K31/216 ,  A61K31/21

CPC classification number: A61K9/0019 ,  A61K9/107 ,  A61K31/202

Abstract: The present invention is directed to an emulsion comprising an emulsifier, an isotonic agent and a docosahexaenoic acid free fatty acid (DHA-FFA) wherein the emulsion is substantially free of eicosapentaenoic acid (EPA) and is suitable for parenteral administration.

Abstract translation: 本发明涉及包含乳化剂，等渗剂和二十二碳六烯酸游离脂肪酸（DHA-FFA）的乳液，其中所述乳液基本上不含二十碳五烯酸（EPA），并且适用于肠胃外给药。

公开(公告)号：WO2011090730A1

公开(公告)日：2011-07-28

申请号：PCT/US2010/062275

申请日：2010-12-28

Applicant: MARTEK BIOSCIENCES CORPORATION ,  LIPPMEIER, James Casey ,  APT, Kirk E.

Inventor： LIPPMEIER, James Casey ,  APT, Kirk E.

IPC: C12P7/58 ,  C12N15/74

CPC classification number: C12N1/10 ,  A23K50/00 ,  A23K50/80 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  C12N1/22 ,  C12N15/52 ,  C12N15/79 ,  C12P7/649 ,  Y02E50/13

Abstract: The present invention is directed to recombinant thraustochytrids that grow on xylose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

Abstract translation: 本发明涉及在包含重组破囊索的木糖和细胞培养物上生长的重组thraustochytrid以及使用重组thraustochytrids生产细胞培养物，生物质，微生物油，组合物和生物燃料的方法。

公开(公告)号：WO2011047095A1

公开(公告)日：2011-04-21

申请号：PCT/US2010/052564

申请日：2010-10-13

Applicant: MARTEK BIOSCIENCES CORPORATION ,  WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION OFFICE OF TECHNOLOGY TRANSFER ,  HADLEY, Kevin ,  FEALEY, Tim ,  BAILES, Julian, E.

Inventor： HADLEY, Kevin ,  FEALEY, Tim ,  BAILES, Julian, E.

IPC: A61K38/00

CPC classification number: A61K31/232 ,  A61K36/02 ,  A61K2300/00

Abstract: The present disclosure provides methods and compositions for reducing the risk of pathological effects of traumatic brain injury.

Abstract translation: 本公开提供了用于降低创伤性脑损伤的病理学作用的风险的方法和组合物。

公开(公告)号：WO2011047091A1

公开(公告)日：2011-04-21

申请号：PCT/US2010/052560

申请日：2010-10-13

Applicant: MARTEK BIOSCIENCES CORPORATION ,  WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION OFFICE OF TECHNOLOGY TRANSFER ,  HADLEY, Kevin ,  FEALEY, Tim ,  BAILES, Julian, E.

Inventor： HADLEY, Kevin ,  FEALEY, Tim ,  BAILES, Julian, E.

IPC: A61K38/00

CPC classification number: A61K31/20 ,  A61K31/232 ,  A61K2300/00

Abstract: The present disclosure provides methods of treating traumatic brain injury.

Abstract translation: 本公开提供了治疗创伤性脑损伤的方法。

公开(公告)号：WO2010107709A1

公开(公告)日：2010-09-23

申请号：PCT/US2010/027352

申请日：2010-03-15

Applicant: MARTEK BIOSCIENCES CORPORATION ,  APT, Kirk, E. ,  LIPPMEIER, James, Casey ,  SIMPSON, David ,  WANG, Jun ,  WYNN, James, P. ,  ZIRKLE, Ross

Inventor： APT, Kirk, E. ,  LIPPMEIER, James, Casey ,  SIMPSON, David ,  WANG, Jun ,  WYNN, James, P. ,  ZIRKLE, Ross

IPC: C07H21/04

CPC classification number: C12P21/00 ,  C07K14/37 ,  C07K14/705 ,  C12N9/2431 ,  C12N15/79 ,  C12N15/80 ,  C12P21/005 ,  C12R1/90 ,  C12Y302/01026

Abstract: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterlogous protein production. Novel promoter, terminator, and signal sequences for efficient production, and optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.

Abstract translation: 本发明涉及神经胶霉病菌门的重组细胞和微生物及其在异源蛋白质生产中的用途。 用于有效生产的新型启动子，终止子和信号序列，以及任选的来自重组宿主细胞和微生物的多肽的分泌也包括在本发明中。

公开(公告)号：WO2008144473A3

公开(公告)日：2008-11-27

申请号：PCT/US2008/063835

申请日：2008-05-16

Applicant: MARTEK BIOSCIENCES CORPORATION ,  WEAVER, Craig, A. ,  ZIRKLE, Ross ,  DOHERTY, Daniel, H. ,  METZ, James, G.

Inventor： WEAVER, Craig, A. ,  ZIRKLE, Ross ,  DOHERTY, Daniel, H. ,  METZ, James, G.

IPC: C12P7/64

Abstract: Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium . Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.